Published in Biochemistry on January 13, 2004
Crystal structure of the putidaredoxin reductase x putidaredoxin electron transfer complex. J Biol Chem (2010) 0.87
Regioselective biooxidation of (+)-valencene by recombinant E. coli expressing CYP109B1 from Bacillus subtilis in a two-liquid-phase system. Microb Cell Fact (2009) 0.81
Efficient catalytic turnover of cytochrome P450(cam) is supported by a T252N mutation. Arch Biochem Biophys (2008) 0.75
Partial fusion of a cytochrome P450 system by carboxy-terminal attachment of putidaredoxin reductase to P450cam (CYP101A1). Catal Sci Technol (2016) 0.75
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics. J Am Chem Soc (2002) 3.07
Tunneling and dynamics in enzymatic hydride transfer. Chem Rev (2006) 2.53
A 21st century revisionist's view at a turning point in enzymology. Nat Chem Biol (2009) 2.42
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics. Eur J Biochem (2002) 2.14
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J Biol Chem (2002) 2.04
Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (I553) in soybean lipoxygenase-1. Proc Natl Acad Sci U S A (2008) 1.80
Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species. J Biol Chem (2003) 1.74
Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase. Proc Natl Acad Sci U S A (2004) 1.73
Update 1 of: Tunneling and dynamics in enzymatic hydride transfer. Chem Rev (2010) 1.60
Catalysis of electron transfer during activation of O2 by the flavoprotein glucose oxidase. Proc Natl Acad Sci U S A (2002) 1.53
Kinetic studies of oxygen reactivity in soybean lipoxygenase-1. Biochemistry (2003) 1.46
Hydrogen tunneling in peptidylglycine alpha-hydroxylating monooxygenase. J Am Chem Soc (2002) 1.42
Modeling temperature dependent kinetic isotope effects for hydrogen transfer in a series of soybean lipoxygenase mutants: The effect of anharmonicity upon transfer distance. Chem Phys (2005) 1.41
Pyrroloquinoline quinone biogenesis: demonstration that PqqE from Klebsiella pneumoniae is a radical S-adenosyl-L-methionine enzyme. Biochemistry (2009) 1.34
Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. J Med Chem (2006) 1.28
2.3 A X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis. Biochemistry (2008) 1.26
Caenorhabditis elegans and human dual oxidase 1 (DUOX1) "peroxidase" domains: insights into heme binding and catalytic activity. J Biol Chem (2009) 1.25
Exploring molecular oxygen pathways in Hansenula polymorpha copper-containing amine oxidase. J Biol Chem (2007) 1.25
Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3. Chem Res Toxicol (2006) 1.21
Enzymatic methyl transfer: role of an active site residue in generating active site compaction that correlates with catalytic efficiency. J Am Chem Soc (2011) 1.20
Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1. J Biol Chem (2002) 1.20
Catalytic mechanism of the topa quinone containing copper amine oxidases. Biochemistry (2002) 1.18
Computer-assisted design of selective imidazole inhibitors for cytochrome p450 enzymes. J Med Chem (2004) 1.18
Oxygen isotope effects on electron transfer to O2 probed using chemically modified flavins bound to glucose oxidase. J Am Chem Soc (2004) 1.17
Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses. J Biol Chem (2010) 1.17
Structural bases of hydrogen tunneling in enzymes: progress and puzzles. Curr Opin Struct Biol (2004) 1.17
The Mycobacterium tuberculosis cytochrome P450 system. Arch Biochem Biophys (2009) 1.16
Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors. Proc Natl Acad Sci U S A (2011) 1.14
Crystal structure and amide H/D exchange of binary complexes of alcohol dehydrogenase from Bacillus stearothermophilus: insight into thermostability and cofactor binding. Biochemistry (2004) 1.13
Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications. Biochemistry (2003) 1.13
Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2009) 1.13
Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide. Biochemistry (2009) 1.13
18O kinetic isotope effects in non-heme iron enzymes: probing the nature of Fe/O2 intermediates. J Am Chem Soc (2008) 1.13
Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone. Proc Natl Acad Sci U S A (2004) 1.13
Impact of protein flexibility on hydride-transfer parameters in thermophilic and psychrophilic alcohol dehydrogenases. J Am Chem Soc (2004) 1.12
Evidence for increased local flexibility in psychrophilic alcohol dehydrogenase relative to its thermophilic homologue. Biochemistry (2004) 1.11
Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo. FEBS Lett (2004) 1.10
Distribution and properties of the genes encoding the biosynthesis of the bacterial cofactor, pyrroloquinoline quinone. Biochemistry (2012) 1.10
The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG): autocatalytic formation and effect on enzyme catalysis and spectroscopic properties. J Biol Chem (2005) 1.08
Investigation of the pathway for inter-copper electron transfer in peptidylglycine alpha-amidating monooxygenase. J Am Chem Soc (2004) 1.08
Extremely elevated room-temperature kinetic isotope effects quantify the critical role of barrier width in enzymatic C-H activation. J Am Chem Soc (2014) 1.07
Cyclopropyl containing fatty acids as mechanistic probes for cytochromes P450. J Org Chem (2005) 1.05
Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization. J Biol Chem (2002) 1.05
EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme. Biochemistry (2004) 1.04
Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues. Biochemistry (2005) 1.03
Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor. Proc Natl Acad Sci U S A (2004) 1.03
The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design. J Biol Chem (2002) 1.03
The mechanism of Mycobacterium tuberculosis alkylhydroperoxidase AhpD as defined by mutagenesis, crystallography, and kinetics. J Biol Chem (2003) 1.02
Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK. J Biol Chem (2003) 1.02
Autocatalytic radical reactions in physiological prosthetic heme modification. Chem Rev (2003) 1.01
Structural control of cytochrome P450-catalyzed ω-hydroxylation. Arch Biochem Biophys (2010) 1.01
Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes. Biochemistry (2006) 1.01
Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications. J Mol Biol (2003) 1.01
Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures. Biochemistry (2012) 1.00
Comparison of rates and kinetic isotope effects using PEG-modified variants and glycoforms of glucose oxidase: the relationship of modification of the protein envelope to C-H activation and tunneling. Biochemistry (2002) 0.99
Mechanism of post-translational quinone formation in copper amine oxidases and its relationship to the catalytic turnover. Arch Biochem Biophys (2005) 0.99
Nitric-oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity. J Biol Chem (2003) 0.99
The structure of a biosynthetic intermediate of pyrroloquinoline quinone (PQQ) and elucidation of the final step of PQQ biosynthesis. J Am Chem Soc (2004) 0.98
DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy. Biochemistry (2009) 0.98
Enhanced electron transfer and lauric acid hydroxylation by site-directed mutagenesis of CYP119. J Am Chem Soc (2002) 0.97
Crystal structure of human heme oxygenase-1 in a complex with biliverdin. Biochemistry (2004) 0.96
Role of the Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG) as revealed by KatG(M255I). Biochemistry (2005) 0.96
Binding of dioxygen to non-metal sites in proteins: exploration of the importance of binding site size versus hydrophobicity in the copper amine oxidase from Hansenula polymorpha. Biochemistry (2002) 0.96
The Sulfolobus solfataricus electron donor partners of thermophilic CYP119: an unusual non-NAD(P)H-dependent cytochrome P450 system. Arch Biochem Biophys (2005) 0.95
Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily. Chem Commun (Camb) (2010) 0.95
An active-site phenylalanine directs substrate binding and C-H cleavage in the alpha-ketoglutarate-dependent dioxygenase TauD. J Am Chem Soc (2010) 0.95
Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network. Biochemistry (2006) 0.95
The catalytic role of the copper ligand H172 of peptidylglycine alpha-hydroxylating monooxygenase: a kinetic study of the H172A mutant. Biochemistry (2006) 0.95
The nature of O2 activation by the ethylene-forming enzyme 1-aminocyclopropane-1-carboxylic acid oxidase. Proc Natl Acad Sci U S A (2008) 0.95
Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency. Proc Natl Acad Sci U S A (2010) 0.94
Correlation between isoniazid resistance and superoxide reactivity in mycobacterium tuberculosis KatG. J Am Chem Soc (2005) 0.94
Identification of a long-range protein network that modulates active site dynamics in extremophilic alcohol dehydrogenases. J Biol Chem (2013) 0.94
The copper centers of tyramine β-monooxygenase and its catalytic-site methionine variants: an X-ray absorption study. J Biol Inorg Chem (2010) 0.93
Interaction of nitric oxide with human heme oxygenase-1. J Biol Chem (2002) 0.92
Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy. J Biol Chem (2012) 0.92
Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. J Pharmacol Exp Ther (2003) 0.92
Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases. Chem Biol Interact (2010) 0.92
Oxidation of carboxylic acids by horseradish peroxidase results in prosthetic heme modification and inactivation. J Am Chem Soc (2004) 0.92
Synthesis and characterization of model compounds of the lysine tyrosyl quinone cofactor of lysyl oxidase. J Am Chem Soc (2003) 0.91
Galactose oxidase as a model for reactivity at a copper superoxide center. J Am Chem Soc (2009) 0.91
The diagnostic substrate bicyclohexane reveals a radical mechanism for bacterial cytochrome P450 in whole cells. Angew Chem Int Ed Engl (2006) 0.91
Enzyme dynamics: Control of active-site compression. Nat Chem (2010) 0.91
Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. Bioorg Med Chem (2007) 0.90
Prosthetic heme modification during halide ion oxidation. Demonstration of chloride oxidation by horseradish peroxidase. J Am Chem Soc (2005) 0.90
Nitric oxide dioxygenation reaction in DevS and the initial response to nitric oxide in Mycobacterium tuberculosis. Biochemistry (2011) 0.90
Modular behavior of tauD provides insight into the origin of specificity in alpha-ketoglutarate-dependent nonheme iron oxygenases. Proc Natl Acad Sci U S A (2009) 0.90
Autoreduction of ferryl myoglobin: discrimination among the three tyrosine and two tryptophan residues as electron donors. Biochemistry (2004) 0.90
Mechanism of the insect enzyme, tyramine beta-monooxygenase, reveals differences from the mammalian enzyme, dopamine beta-monooxygenase. J Biol Chem (2007) 0.90
Perturbed heme binding is responsible for the blistering phenotype associated with mutations in the Caenorhabditis elegans dual oxidase 1 (DUOX1) peroxidase domain. J Biol Chem (2010) 0.89
Role of heme-protein covalent bonds in mammalian peroxidases. Protection of the heme by a single engineered heme-protein link in horseradish peroxidase. J Biol Chem (2006) 0.89
Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine. J Am Chem Soc (2008) 0.89
Picosecond-resolved fluorescent probes at functionally distinct tryptophans within a thermophilic alcohol dehydrogenase: relationship of temperature-dependent changes in fluorescence to catalysis. J Phys Chem B (2014) 0.88
Mechanistic investigations of 1-aminocyclopropane 1-carboxylic acid oxidase with alternate cyclic and acyclic substrates. Biochemistry (2006) 0.88
Autocatalytic modification of the prosthetic heme of horseradish but not lactoperoxidase by thiocyanate oxidation products. A role for heme-protein covalent cross-linking. J Am Chem Soc (2005) 0.87
Functional expression and characterization of cytochrome P450 52A21 from Candida albicans. Arch Biochem Biophys (2007) 0.87
Crystal structures of ferrous and ferrous-NO forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage. J Inorg Biochem (2004) 0.87
Asp-225 and glu-375 in autocatalytic attachment of the prosthetic heme group of lactoperoxidase. J Biol Chem (2001) 0.86
2,4,5-Trihydroxyphenylalanine quinone biogenesis in the copper amine oxidase from Hansenula polymorpha with the alternate metal nickel. Biochemistry (2005) 0.86
Mechanistic comparison of the cobalt-substituted and wild-type copper amine oxidase from Hansenula polymorpha. Biochemistry (2002) 0.85