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Reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1. Bioorg Med Chem Lett (2010) 0.85

A highly conserved mycobacterial cholesterol catabolic pathway. Environ Microbiol (2013) 0.85

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Inhibition of the M. tuberculosis 3β-hydroxysteroid dehydrogenase by azasteroids. Bioorg Med Chem Lett (2011) 0.81

The redox cofactor F420 protects mycobacteria from diverse antimicrobial compounds and mediates a reductive detoxification system. Appl Environ Microbiol (2016) 0.80

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Identification and functional analysis of cytochrome P450 complement in Streptomyces virginiae IBL14. BMC Genomics (2013) 0.79

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α-Methyl Acyl CoA Racemase Provides Mycobacterium tuberculosis Catabolic Access to Cholesterol Esters. Biochemistry (2015) 0.75

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. J Biol Chem (2016) 0.75

Cytochrome P450 125A4, the Third Cholesterol C-26 Hydroxylase from Mycobacterium smegmatis. Biochemistry (2015) 0.75

Production of Superoxide in Bacteria Is Stress- and Cell State-Dependent: A Gating-Optimized Flow Cytometry Method that Minimizes ROS Measurement Artifacts with Fluorescent Dyes. Front Microbiol (2017) 0.75

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Detection of mutations associated with isoniazid resistance in Mycobacterium tuberculosis isolates from China. J Clin Microbiol (2005) 1.78

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Multiple paralogous genes related to the Streptomyces coelicolor developmental regulatory gene whiB are present in Streptomyces and other actinomycetes. Microbiology (2000) 1.75

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Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis. Antimicrob Agents Chemother (2008) 1.53

The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development. Mol Microbiol (2007) 1.49

Inhibition of cytochromes P450 by antifungal imidazole derivatives. Drug Metab Dispos (2002) 1.47

Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids. Nat Prod Rep (2007) 1.46

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Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes. Microbiology (2002) 1.40

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Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2009) 1.38

Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties. J Inorg Biochem (2002) 1.37

Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv. J Biol Chem (2008) 1.37

Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs. J Biol Chem (2007) 1.33

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Functional genomics reveals extended roles of the Mycobacterium tuberculosis stress response factor sigmaH. J Bacteriol (2009) 1.29

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Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode. J Biol Chem (2006) 1.21

Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography. Antimicrob Agents Chemother (2007) 1.20

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A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2006) 1.16

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Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis. J Inorg Biochem (2002) 1.15

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Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide. Biochemistry (2009) 1.13

The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J Biol Chem (2002) 2.04

Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one. Mol Microbiol (2010) 1.49

Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis. Trends Microbiol (2011) 1.30

Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. J Med Chem (2006) 1.28

2.3 A X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis. Biochemistry (2008) 1.26

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A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection. Antimicrob Agents Chemother (2010) 1.22

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The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design. J Biol Chem (2002) 1.03

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The Sulfolobus solfataricus electron donor partners of thermophilic CYP119: an unusual non-NAD(P)H-dependent cytochrome P450 system. Arch Biochem Biophys (2005) 0.95

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The diagnostic substrate bicyclohexane reveals a radical mechanism for bacterial cytochrome P450 in whole cells. Angew Chem Int Ed Engl (2006) 0.91

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Perturbed heme binding is responsible for the blistering phenotype associated with mutations in the Caenorhabditis elegans dual oxidase 1 (DUOX1) peroxidase domain. J Biol Chem (2010) 0.89

Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine. J Am Chem Soc (2008) 0.89

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Functional expression and characterization of cytochrome P450 52A21 from Candida albicans. Arch Biochem Biophys (2007) 0.87

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Autocatalytic modification of the prosthetic heme of horseradish but not lactoperoxidase by thiocyanate oxidation products. A role for heme-protein covalent cross-linking. J Am Chem Soc (2005) 0.87

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A highly conserved mycobacterial cholesterol catabolic pathway. Environ Microbiol (2013) 0.85

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Aromatic stacking as a determinant of the thermal stability of CYP119 from Sulfolobus solfataricus. Arch Biochem Biophys (2003) 0.85

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Covalent attachment of heme to the protein moiety in an insect E75 nitric oxide sensor. Biochemistry (2012) 0.84

A novel intermediate in the reaction of seleno CYP119 with m-chloroperbenzoic acid. Biochemistry (2011) 0.84

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Solution NMR study of environmental effects on substrate seating in human heme oxygenase: influence of polypeptide truncation, substrate modification and axial ligand. J Inorg Biochem (2005) 0.83

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Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase. J Med Chem (2008) 0.83

Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1. Bioorg Med Chem (2012) 0.82

Covalent heme attachment to the protein in human heme oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand. J Inorg Biochem (2008) 0.82

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Calculated and experimental spin state of seleno cytochrome P450. Angew Chem Int Ed Engl (2009) 0.82

CYP119 plus a Sulfolobus tokodaii strain 7 ferredoxin and 2-oxoacid:ferredoxin oxidoreductase constitute a high-temperature cytochrome P450 catalytic system. J Am Chem Soc (2002) 0.82

Proximal ligand electron donation and reactivity of the cytochrome P450 ferric-peroxo anion. J Am Chem Soc (2012) 0.81

Photosystem I from plants as a bacterial cytochrome P450 surrogate electron donor: terminal hydroxylation of branched hydrocarbon chains. Biotechnol Lett (2011) 0.81

The orbital ground state of the azide-substrate complex of human heme oxygenase is an indicator of distal H-bonding: implications for the enzyme mechanism. Biochemistry (2009) 0.81

Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone. Chembiochem (2009) 0.80

Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis. Biochemistry (2011) 0.80

Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress. Antimicrob Agents Chemother (2004) 0.80

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Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations. Chem Commun (Camb) (2004) 0.80

Coupling of the distal hydrogen bond network to the exogenous ligand in substrate-bound, resting state human heme oxygenase. Biochemistry (2009) 0.79

The P450cam G248E mutant covalently binds its prosthetic heme group. Biochemistry (2005) 0.79

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Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. J Med Chem (2014) 0.75

Electron supply and catalytic oxidation of nitrogen by cytochrome P450 and nitric oxide synthase. Drug Metab Rev (2002) 0.75