Published in J Mol Biol on July 11, 2003
Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling. Cell Host Microbe (2017) 1.40
The IsdG-family of haem oxygenases degrades haem to a novel chromophore. Mol Microbiol (2010) 1.40
Comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2. J Biol Chem (2007) 1.04
Electronic properties of the highly ruffled heme bound to the heme degrading enzyme IsdI. Proc Natl Acad Sci U S A (2011) 0.97
Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network. Biochemistry (2006) 0.95
New light on NO bonding in Fe(III) heme proteins from resonance Raman spectroscopy and DFT modeling. J Am Chem Soc (2010) 0.93
Spectroscopic insights into axial ligation and active-site H-bonding in substrate-bound human heme oxygenase-2. J Biol Inorg Chem (2010) 0.86
1H NMR study of the magnetic properties and electronic structure of the hydroxide complex of substrate-bound heme oxygenase from Neisseria meningitidis: influence of the axial water deprotonation on the distal H-bond network. J Am Chem Soc (2006) 0.86
Heme utilization by pathogenic bacteria: not all pathways lead to biliverdin. Acc Chem Res (2014) 0.85
A hydrogen-bonding network formed by the B10-E7-E11 residues of a truncated hemoglobin from Tetrahymena pyriformis is critical for stability of bound oxygen and nitric oxide detoxification. J Biol Inorg Chem (2011) 0.81
The orbital ground state of the azide-substrate complex of human heme oxygenase is an indicator of distal H-bonding: implications for the enzyme mechanism. Biochemistry (2009) 0.81
Isoporphyrin intermediate in heme oxygenase catalysis. Oxidation of alpha-meso-phenylheme. J Biol Chem (2008) 0.80
Coupling of the distal hydrogen bond network to the exogenous ligand in substrate-bound, resting state human heme oxygenase. Biochemistry (2009) 0.79
1H NMR study of the effect of variable ligand on heme oxygenase electronic and molecular structure. J Inorg Biochem (2008) 0.79
Solution 1H NMR characterization of substrate-free C. diphtheriae heme oxygenase: pertinence for determining magnetic axes in paramagnetic substrate complexes. J Inorg Biochem (2010) 0.78
Crystal structures of the G139A, G139A-NO and G143H mutants of human heme oxygenase-1. A finely tuned hydrogen-bonding network controls oxygenase versus peroxidase activity. J Biol Inorg Chem (2005) 0.77
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74
The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99
Population genomics of early events in the ecological differentiation of bacteria. Science (2012) 4.67
A novel scheme for DVL-aided SINS in-motion alignment using UKF techniques. Sensors (Basel) (2013) 4.51
Rate-gyro-integral constraint for ambiguity resolution in GNSS attitude determination applications. Sensors (Basel) (2013) 4.22
Ecology drives a global network of gene exchange connecting the human microbiome. Nature (2011) 3.64
Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol (2013) 3.32
Host lifestyle affects human microbiota on daily timescales. Genome Biol (2014) 2.99
Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy. Nat Biotechnol (2012) 2.98
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med (2005) 2.62
Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. JAMA (2011) 2.61
Cellular mechanisms of brain state-dependent gain modulation in visual cortex. Nat Neurosci (2013) 2.36
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J Biol Chem (2002) 2.04
A new curb detection method for unmanned ground vehicles using 2D sequential laser data. Sensors (Basel) (2013) 1.96
Function, structure, and evolution of the RubisCO-like proteins and their RubisCO homologs. Microbiol Mol Biol Rev (2007) 1.89
Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors. Cancer Res (2010) 1.80
Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism. J Biol Chem (2005) 1.77
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits. J Biol Chem (2004) 1.76
Prevalence and predictors of the prone sleep position among inner-city infants. JAMA (1998) 1.74
Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science (2003) 1.73
Structure-function studies on nitric oxide synthases. J Inorg Biochem (2005) 1.69
Observability analysis of a matrix Kalman filter-based navigation system using visual/inertial/magnetic sensors. Sensors (Basel) (2012) 1.67
The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis. Biochemistry (2002) 1.65
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann Neurol (2009) 1.58
Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome. Circ Res (2008) 1.55
Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. J Am Chem Soc (2008) 1.47
Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model. J Am Chem Soc (2010) 1.45
Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase. Nat Struct Mol Biol (2003) 1.45
High-resolution crystal structures and spectroscopy of native and compound I cytochrome c peroxidase. Biochemistry (2003) 1.44
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc Natl Acad Sci U S A (2008) 1.44
Evolutionary history of a specialized p450 propane monooxygenase. J Mol Biol (2008) 1.40
Photoreduction of the active site of the metalloprotein putidaredoxin by synchrotron radiation. Acta Crystallogr D Biol Crystallogr (2007) 1.37
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir. Proc Natl Acad Sci U S A (2010) 1.37
Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping. J Med Chem (2009) 1.37
Structural basis for novel delta-regioselective heme oxygenation in the opportunistic pathogen Pseudomonas aeruginosa. Biochemistry (2004) 1.36
An expanded multilocus sequence typing scheme for propionibacterium acnes: investigation of 'pathogenic', 'commensal' and antibiotic resistant strains. PLoS One (2012) 1.34
Pan-genome and comparative genome analyses of propionibacterium acnes reveal its genomic diversity in the healthy and diseased human skin microbiome. MBio (2013) 1.33
Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives. J Med Chem (2010) 1.31
Structural studies of constitutive nitric oxide synthases with diatomic ligands bound. J Biol Inorg Chem (2006) 1.28
Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J Biol Chem (2010) 1.28
Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. J Med Chem (2006) 1.28
2.3 A X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis. Biochemistry (2008) 1.26
Caenorhabditis elegans and human dual oxidase 1 (DUOX1) "peroxidase" domains: insights into heme binding and catalytic activity. J Biol Chem (2009) 1.25
Crystal structures of the ferrous dioxygen complex of wild-type cytochrome P450eryF and its mutants, A245S and A245T: investigation of the proton transfer system in P450eryF. J Biol Chem (2005) 1.24
Crystallographic and single-crystal spectral analysis of the peroxidase ferryl intermediate. Biochemistry (2010) 1.23
Looking for Darwin's footprints in the microbial world. Trends Microbiol (2009) 1.22
Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3. Chem Res Toxicol (2006) 1.21
Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1. J Biol Chem (2002) 1.20
A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-Wei-Di-Huang pill as a case study. Mol Biosyst (2014) 1.19
Prevalence and predictors of immunization among inner-city infants: a birth cohort study. Pediatrics (2001) 1.19
Holo- and apo-bound structures of bacterial periplasmic heme-binding proteins. J Biol Chem (2007) 1.18
Computer-assisted design of selective imidazole inhibitors for cytochrome p450 enzymes. J Med Chem (2004) 1.18
Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses. J Biol Chem (2010) 1.17
Crystal structure and characterization of a cytochrome c peroxidase-cytochrome c site-specific cross-link. Proc Natl Acad Sci U S A (2004) 1.17
The Mycobacterium tuberculosis cytochrome P450 system. Arch Biochem Biophys (2009) 1.16
Postoperative stereotactic radiosurgery without whole-brain radiation therapy for brain metastases: potential role of preoperative tumor size. Int J Radiat Oncol Biol Phys (2012) 1.16
Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors. J Med Chem (2003) 1.15
Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase. J Med Chem (2011) 1.15
Structural basis for effector control and redox partner recognition in cytochrome P450. Science (2013) 1.15
Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2009) 1.13
Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide. Biochemistry (2009) 1.13
Crystal structure of putidaredoxin reductase from Pseudomonas putida, the final structural component of the cytochrome P450cam monooxygenase. J Mol Biol (2004) 1.12
Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo. FEBS Lett (2004) 1.10
Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase. J Am Chem Soc (2010) 1.10
Redox-dependent structural changes in the Azotobacter vinelandii bacterioferritin: new insights into the ferroxidase and iron transport mechanism. Biochemistry (2006) 1.09
Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding. J Biol Chem (2004) 1.09
Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation. J Biol Chem (2003) 1.09
The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG): autocatalytic formation and effect on enzyme catalysis and spectroscopic properties. J Biol Chem (2005) 1.08
Responses of antioxidant gene, protein and enzymes to salinity stress in two genotypes of perennial ryegrass (Lolium perenne) differing in salt tolerance. J Plant Physiol (2011) 1.08
Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. Br J Pharmacol (2011) 1.07
Cyclopropyl containing fatty acids as mechanistic probes for cytochromes P450. J Org Chem (2005) 1.05
Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization. J Biol Chem (2002) 1.05
EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme. Biochemistry (2004) 1.04
Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor. Proc Natl Acad Sci U S A (2004) 1.03
The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design. J Biol Chem (2002) 1.03
Crystal structure of putidaredoxin, the [2Fe-2S] component of the P450cam monooxygenase system from Pseudomonas putida. J Mol Biol (2003) 1.02