Published in Am J Physiol Regul Integr Comp Physiol on May 04, 2006
Perioperative cognitive decline in the aging population. Mayo Clin Proc (2011) 1.66
In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Mol Med (2006) 1.25
Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice. PLoS One (2011) 1.20
Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Shock (2009) 1.17
Milk fat globule epidermal growth factor-factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway. J Immunol (2009) 1.12
Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming. Shock (2012) 1.11
LPS-induced murine systemic inflammation is driven by parenchymal cell activation and exclusively predicted by early MCP-1 plasma levels. Am J Pathol (2011) 1.04
Models of lower extremity damage in mice: time course of organ damage and immune response. J Surg Res (2010) 1.04
Functional significance of gene polymorphisms in the promoter of myeloid differentiation-2. Ann Surg (2007) 1.01
Toll-like receptor-4 mediates intestinal barrier breakdown after thermal injury. Surg Infect (Larchmt) (2010) 0.95
Selective roles for toll-like receptors 2, 4, and 9 in systemic inflammation and immune dysfunction following peripheral tissue injury. J Trauma Acute Care Surg (2013) 0.95
Identification and description of a novel murine model for polytrauma and shock. Crit Care Med (2013) 0.94
Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury. J Leukoc Biol (2010) 0.90
Racial disparities and sex-based outcomes differences after severe injury. J Am Coll Surg (2012) 0.89
Toll-like receptor deficiency worsens inflammation and lymphedema after lymphatic injury. Am J Physiol Cell Physiol (2011) 0.89
Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study. Clin Orthop Relat Res (2013) 0.88
Disparate roles of marrow- and parenchymal cell-derived TLR4 signaling in murine LPS-induced systemic inflammation. Sci Rep (2012) 0.88
Pathoanatomy and clinical correlates of the immunoinflammatory response following orthopaedic trauma. J Am Acad Orthop Surg (2009) 0.86
DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma. Am J Physiol Gastrointest Liver Physiol (2011) 0.86
Toll-like receptors and myocardial ischemia/reperfusion, inflammation, and injury. Curr Cardiol Rev (2009) 0.85
Toll-like receptor 4 and high-mobility group box 1 are critical mediators of tissue injury and survival in a mouse model for heatstroke. PLoS One (2012) 0.84
Altered adherent leukocyte profile on biomaterials in Toll-like receptor 4 deficient mice. Biomaterials (2009) 0.82
Novel model of peripheral tissue trauma-induced inflammation and gastrointestinal dysmotility. Neurogastroenterol Motil (2011) 0.81
Local inflammation in fracture hematoma: results from a combined trauma model in pigs. Mediators Inflamm (2015) 0.80
Toll-like receptor 4 mediates the regenerative effects of bone grafts for calvarial bone repair. Tissue Eng Part A (2015) 0.79
X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury. Ann Surg (2014) 0.79
Breaking the co-operation between bystander T-cells and natural killer cells prevents the development of immunosuppression after traumatic skeletal muscle injury in mice. Clin Sci (Lond) (2015) 0.78
Bone Components Downregulate Expression of Toll-Like Receptor 4 on the Surface of Human Monocytic U937 Cells: A Cell Model for Postfracture Immune Dysfunction. Mediators Inflamm (2015) 0.76
Dendritic Cell-Like Cells Accumulate in Regenerating Murine Skeletal Muscle after Injury and Boost Adaptive Immune Responses Only upon a Microbial Challenge. PLoS One (2016) 0.75
TLR4-defective (C3H/HeJ) mice are not protected from cast immobilization-induced muscle atrophy. Physiol Rep (2017) 0.75
Knockdown of toll-like receptor 4 signaling pathways ameliorate bone graft rejection in a mouse model of allograft transplantation. Sci Rep (2017) 0.75
In Reply. Anesthesiology (2016) 0.75
The Role of NIGMS P50 Sponsored Team Science in Our Understanding of Multiple Organ Failure. J Trauma Acute Care Surg (2017) 0.75
Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39
Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A (2003) 7.14
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med (2005) 6.86
A genomic storm in critically injured humans. J Exp Med (2011) 6.67
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med (2004) 6.38
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med (2007) 5.65
The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. Crit Care Med (2004) 5.23
Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA (2002) 4.09
HMGB1: endogenous danger signaling. Mol Med (2008) 4.02
HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med (2007) 3.72
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A (2002) 3.68
Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J Exp Med (2006) 3.66
Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response. Proc Natl Acad Sci U S A (2001) 3.29
HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology (2002) 2.95
Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol (2005) 2.78
Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67
Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage. Shock (2006) 2.61
Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma (2009) 2.49
Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int (2009) 2.35
Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion. J Trauma Acute Care Surg (2012) 2.32
Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med (2003) 2.30
Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol Med (2006) 2.27
An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma (2008) 2.15
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med (2003) 2.15
Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol (2007) 2.12
Critical care medicine training and certification for emergency physicians. Crit Care Med (2005) 2.12
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Crit Care Med (2005) 2.11
A comparison of critical care research funding and the financial burden of critical illness in the United States. Crit Care Med (2012) 2.07
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07
Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol (2006) 2.06
Targeting mitochondria. Acc Chem Res (2008) 2.03
Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. J Immunol (2007) 2.02
Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000. Crit Care Med (2003) 2.01
Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism. Hepatology (2009) 1.98
High-mobility group box 1 is essential for mitochondrial quality control. Cell Metab (2011) 1.89
Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. Crit Care Med (2004) 1.88
Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect Immun (2002) 1.85
The acute inflammatory response in diverse shock states. Shock (2005) 1.83
Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. J Heart Lung Transplant (2009) 1.78
In silico design of clinical trials: a method coming of age. Crit Care Med (2004) 1.78
Genetic improvement for phosphorus efficiency in soybean: a radical approach. Ann Bot (2010) 1.77
Nitric oxide and wound repair: role of cytokines? Nitric Oxide (2002) 1.73
Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice. J Lab Clin Med (2003) 1.71
Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol (2002) 1.70
IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice. Am J Physiol Gastrointest Liver Physiol (2003) 1.70
Agent-based models in translational systems biology. Wiley Interdiscip Rev Syst Biol Med (2010) 1.70
A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine. Crit Care Med (2012) 1.69
A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation. J Theor Biol (2006) 1.68
The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis. Shock (2007) 1.65
A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration. J Theor Biol (2006) 1.65
Early events in the recognition of danger signals after tissue injury. J Leukoc Biol (2007) 1.65
Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix. J Trauma Acute Care Surg (2012) 1.60
Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species. FASEB J (2007) 1.60
The dynamics of acute inflammation. J Theor Biol (2004) 1.60
Pivotal advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms. J Leukoc Biol (2010) 1.59
Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology (2012) 1.59
Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation. Circulation (2009) 1.58
Resetting the transcription factor network reverses terminal chronic hepatic failure. J Clin Invest (2015) 1.58
Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans. Crit Care Med (2015) 1.58
Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. J Am Coll Surg (2006) 1.57
Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma. Crit Care Med (2014) 1.57
3D reconstruction and dynamic modeling of root architecture in situ and its application to crop phosphorus research. Plant J (2009) 1.57
Physiologic responses to severe hemorrhagic shock and the genesis of cardiovascular collapse: can irreversibility be anticipated? J Surg Res (2012) 1.53
Genotypic recognition and spatial responses by rice roots. Proc Natl Acad Sci U S A (2013) 1.52
HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers. Am J Physiol Cell Physiol (2005) 1.51
Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65. J Pharmacol Exp Ther (2004) 1.51
Male gender is associated with excessive IL-6 expression following severe injury. J Trauma (2008) 1.51
Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates. J Am Chem Soc (2005) 1.50
Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia. Crit Care Med (2005) 1.49
Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes. J Biol Chem (2008) 1.49