Published in Science on January 08, 2004
WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci U S A (2007) 4.97
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev (2005) 3.67
Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Mol Cell Biol (2006) 2.63
Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin. J Cell Biol (2006) 2.32
Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat Biotechnol (2012) 2.09
Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J Cell Biol (2005) 2.00
Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. Genes Dev (2007) 1.98
Assembling neural crest regulatory circuits into a gene regulatory network. Annu Rev Cell Dev Biol (2010) 1.72
Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease. J Neurosci (2009) 1.72
Winding through the WNT pathway during cellular development and demise. Histol Histopathol (2006) 1.50
Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells. Proc Natl Acad Sci U S A (2005) 1.50
Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev (2005) 1.50
Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling. J Cell Biol (2005) 1.44
Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells. J Biol (2005) 1.40
The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol Ther (2008) 1.38
Craniofacial birth defects: The role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention. Am J Med Genet A (2010) 1.38
Primary support cultures of hippocampal and substantia nigra neurons. Nat Protoc (2009) 1.33
Impaired neural development caused by inducible expression of Axin in transgenic mice. Mech Dev (2006) 1.32
Induction of neurogenesis in nonconventional neurogenic regions of the adult central nervous system by niche astrocyte-produced signals. Stem Cells (2008) 1.32
Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development. Dev Biol (2006) 1.29
Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates. Development (2011) 1.25
Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons. Development (2009) 1.23
WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway. Mol Cancer Res (2012) 1.21
Signals and switches in Mammalian neural crest cell differentiation. Cold Spring Harb Perspect Biol (2013) 1.17
Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell Stem Cell (2008) 1.15
N-cadherin is required for neural crest remodeling of the cardiac outflow tract. Dev Biol (2006) 1.13
WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development (2012) 1.12
A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells. Neural Dev (2008) 1.10
Ovarian cancer: emerging concept on cancer stem cells. J Ovarian Res (2008) 1.08
Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells: induction, maintenance, and differentiation into functional schwann cells. Stem Cells Transl Med (2012) 1.05
Sonic Hedgehog promotes the development of multipotent neural crest progenitors endowed with both mesenchymal and neural potentials. Proc Natl Acad Sci U S A (2007) 1.05
Dynamic alterations in gene expression after Wnt-mediated induction of avian neural crest. Mol Biol Cell (2005) 1.03
Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3. Stem Cells (2011) 1.01
Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervous system. Dev Biol (2006) 1.00
Repair and regeneration: opportunities for carcinogenesis from tissue stem cells. J Cell Mol Med (2006) 0.98
Derivation of cranial neural crest-like cells from human embryonic stem cells. Biochem Biophys Res Commun (2008) 0.97
Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. Elife (2015) 0.95
Uterine glands: development, function and experimental model systems. Mol Hum Reprod (2013) 0.94
The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. Development (2010) 0.94
How Schwann Cells Sort Axons: New Concepts. Neuroscientist (2015) 0.93
CaMKII represses transcriptionally active β-catenin to mediate acute ethanol neurodegeneration and can phosphorylate β-catenin. J Neurochem (2013) 0.92
En1 and Wnt signaling in midbrain dopaminergic neuronal development. Neural Dev (2011) 0.92
Dynamic signaling for neural stem cell fate determination. Cell Adh Migr (2009) 0.91
Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures. BMC Dev Biol (2007) 0.90
Specification of neural crest into sensory neuron and melanocyte lineages. Dev Biol (2012) 0.88
Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A (2013) 0.88
Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects. Dev Biol (2010) 0.87
Protein tyrosine phosphatase receptor type O regulates development and function of the sensory nervous system. Mol Cell Neurosci (2009) 0.86
Canonical Wnt/β-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development. Dev Dyn (2010) 0.86
Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision. Science (2016) 0.85
CTNNB1 signaling in sertoli cells downregulates spermatogonial stem cell activity via WNT4. PLoS One (2012) 0.85
Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1. Biomaterials (2013) 0.85
EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy. Basic Res Cardiol (2010) 0.84
Recycling signals in the neural crest. J Biol (2005) 0.83
Osteoblasts Have a Neural Origin in Heterotopic Ossification. Clin Orthop Relat Res (2015) 0.83
Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7. Proc Natl Acad Sci U S A (2005) 0.83
The multi-potentiality of skin-derived stem cells in pigs. Theriogenology (2010) 0.82
The adenomatous polyposis coli tumor suppressor and Wnt signaling in the regulation of apoptosis. Adv Exp Med Biol (2009) 0.82
Roles of Wnt/β-catenin signaling in retinal neuron-like differentiation of bone marrow mesenchymal stem cells from nonobese diabetic mice. J Mol Neurosci (2012) 0.82
Molecular Mechanisms Involved in Schwann Cell Plasticity. Front Mol Neurosci (2017) 0.80
ABCD2 is a direct target of β-catenin and TCF-4: implications for X-linked adrenoleukodystrophy therapy. PLoS One (2013) 0.80
Mice in the world of stem cell biology. Nat Genet (2005) 0.80
Macrophage migration inhibitory factor promotes proliferation and neuronal differentiation of neural stem/precursor cells through Wnt/β-catenin signal pathway. Int J Biol Sci (2013) 0.79
Wnt-5a expression in the rat neuronal progenitor cell line ST14A. Exp Brain Res (2004) 0.79
The role of Wnt signaling members in the uterus and embryo during pre-implantation and implantation. J Assist Reprod Genet (2014) 0.78
The Wnt7's Tale: A story of an orphan who finds her tie to a famous family. Cancer Sci (2016) 0.78
A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus. PLoS One (2013) 0.78
Molecular control of the neural crest and peripheral nervous system development. Curr Top Dev Biol (2015) 0.78
Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. J Cell Mol Med (2014) 0.77
Modulation of COUP-TF expression in a cnidarian by ectopic Wnt signalling and allorecognition. PLoS One (2011) 0.77
The Proto-oncogene Transcription Factor Ets1 Regulates Neural Crest Development through Histone Deacetylase 1 to Mediate Output of Bone Morphogenetic Protein Signaling. J Biol Chem (2015) 0.76
Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol (2015) 0.76
Delamination of neural crest cells requires transient and reversible Wnt inhibition mediated by Dact1/2. Development (2016) 0.76
Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathways. Oncotarget (2016) 0.76
Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton. Dev Biol (2015) 0.75
Choices choices: regulation of precursor differentiation during enteric nervous system development. Neurogastroenterol Motil (2013) 0.75
Role of Wnt5a in the differentiation of human embryonic stem cells into endometrium-like cells. Int J Clin Exp Pathol (2015) 0.75
Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application. Stem Cells Int (2016) 0.75
An ongoing role for Wnt signaling in differentiating melanocytes in vivo. Pigment Cell Melanoma Res (2016) 0.75
The Neural Crest Migrating into the Twenty-First Century. Curr Top Dev Biol (2016) 0.75
Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors. PLoS One (2017) 0.75
Development. Making sense of the sensory lineage. Science (2004) 0.75
Activation of Six1 Expression in Vertebrate Sensory Neurons. PLoS One (2015) 0.75
Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling. PLoS One (2015) 0.75
Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain. Database (Oxford) (2014) 0.75
Targeting the perpetrator: breast cancer stem cell therapeutics. Curr Drug Targets (2010) 0.75
Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma. Proc Natl Acad Sci U S A (2017) 0.75
Strategies for retinal cell generation from human pluripotent stem cells. Stem Cell Investig (2017) 0.75
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell (2005) 6.90
Subtypes of medulloblastoma have distinct developmental origins. Nature (2010) 5.94
Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev (2004) 4.78
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell (2012) 4.58
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science (2012) 4.51
Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol (2005) 4.34
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell (2011) 4.04
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol (2006) 3.98
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell (2007) 3.54
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell (2002) 3.37
Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol (2011) 3.25
Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol (2008) 3.22
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci (2009) 3.18
Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol (2006) 3.17
Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med (2004) 3.16
Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell (2003) 3.15
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature (2012) 3.09
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J (2002) 3.06
Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol (2003) 2.92
beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev Biol (2003) 2.85
The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol (2003) 2.77
E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J (2005) 2.72
E-cadherin is a survival factor for the lactating mouse mammary gland. Mech Dev (2002) 2.63
Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A (2007) 2.61
Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A (2007) 2.56
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis. Nature (2012) 2.54
Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin. Cell (2009) 2.53
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol (2005) 2.50
Stabilization of beta-catenin impacts pancreas growth. Development (2006) 2.44
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood (2004) 2.44
Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet (2006) 2.43
Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene. J Cell Sci (2007) 2.41
Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell (2006) 2.40
CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell (2010) 2.40
SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nat Genet (2007) 2.39
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev (2003) 2.34
Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet (2012) 2.33
Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin. J Cell Biol (2006) 2.32
Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease. J Cell Biol (2005) 2.32
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol (2007) 2.26
Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A (2006) 2.25
β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell (2011) 2.17
Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A). Nat Med (2003) 2.17
Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm. Dev Cell (2002) 2.14
Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest (2007) 2.12
Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth. Cancer Res (2011) 2.08
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol (2003) 2.07
Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis. Blood (2007) 2.06
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res (2002) 2.05
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development (2004) 2.04
Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. Proc Natl Acad Sci U S A (2008) 2.04
Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci (2009) 2.03
Reptin and pontin antagonistically regulate heart growth in zebrafish embryos. Cell (2002) 2.03
The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell (2010) 2.01
Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations. Cancer Res (2004) 2.01
Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res (2002) 2.00
Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet (2003) 1.99
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
Dicer in Schwann cells is required for myelination and axonal integrity. J Neurosci (2010) 1.96
Wnt signals mediate a fate decision between otic placode and epidermis. Development (2006) 1.94
Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination. J Neurosci (2010) 1.93
Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol (2005) 1.93
Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal. Hum Mol Genet (2008) 1.90
Lineage-specific requirements of beta-catenin in neural crest development. J Cell Biol (2002) 1.87
F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function. Proc Natl Acad Sci U S A (2006) 1.86
Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol Cell Neurosci (2003) 1.84
Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells. J Neurosci (2008) 1.81
Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A (2007) 1.80
Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary. Hum Mol Genet (2008) 1.80
Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease. Neuromolecular Med (2006) 1.79
Protocadherins. Curr Opin Cell Biol (2002) 1.77
Molecular mechanisms regulating myelination in the peripheral nervous system. Trends Neurosci (2011) 1.74
Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development (2003) 1.73
Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling. Eur J Neurosci (2004) 1.71
Notch1 is required for neuronal and glial differentiation in the cerebellum. Development (2002) 1.69
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development. J Cell Biol (2007) 1.69
HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells. Nat Neurosci (2011) 1.69
Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal. EMBO J (2005) 1.68
Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern. Dev Biol (2006) 1.68
Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell (2008) 1.67
Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol (2005) 1.66
Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol (2002) 1.65
Lineage specification of parietal epithelial cells requires β-catenin/Wnt signaling. J Am Soc Nephrol (2011) 1.64
Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal. Stem Cells (2009) 1.63
Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation. Development (2007) 1.63
Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Cancer Res (2002) 1.62
Wt1 negatively regulates beta-catenin signaling during testis development. Development (2008) 1.61
JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Δ716) mice. Gastroenterology (2011) 1.61
Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis. Proc Natl Acad Sci U S A (2007) 1.60
Stromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer. J Biol Chem (2008) 1.60
Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res (2002) 1.60