Published in Cell on March 19, 1999
The hippo signaling pathway in development and cancer. Dev Cell (2010) 10.54
Regulation of cadherin adhesive activity. J Cell Biol (2000) 5.63
Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene (2008) 3.63
Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularization. J Cell Biol (2000) 3.07
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci U S A (2005) 2.96
Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J Cell Biol (2000) 2.77
CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells. Mol Biol Cell (2004) 2.61
The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci U S A (2010) 2.43
The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. J Cell Biol (2002) 2.37
Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryo. J Cell Biol (2000) 2.27
PATJ regulates tight junction formation and polarity in mammalian epithelial cells. J Cell Biol (2005) 1.92
DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol (2004) 1.87
Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe. Neural Dev (2007) 1.87
Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis. J Cell Biol (2000) 1.84
Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. J Cell Biol (2004) 1.74
Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila. J Cell Biol (2003) 1.63
Spatiotemporal ablation of myelinating glia-specific neurofascin (Nfasc NF155) in mice reveals gradual loss of paranodal axoglial junctions and concomitant disorganization of axonal domains. J Neurosci Res (2009) 1.61
Ten years of enhancer detection: lessons from the fly. Plant Cell (1999) 1.61
Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. J Cell Biol (2002) 1.60
Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila. J Cell Biol (2002) 1.50
Plasma membrane polarity and compartmentalization are established before cellularization in the fly embryo. Dev Cell (2009) 1.49
Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics (2000) 1.49
Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery. J Cell Biol (2000) 1.43
Regulated expression of nullo is required for the formation of distinct apical and basal adherens junctions in the Drosophila blastoderm. J Cell Biol (2000) 1.41
Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye. Dev Biol (2007) 1.33
Drosophila Varicose, a member of a new subgroup of basolateral MAGUKs, is required for septate junctions and tracheal morphogenesis. Development (2007) 1.33
Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-secretase activity. EMBO Rep (2006) 1.31
Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila. Nat Cell Biol (2013) 1.31
Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene (2008) 1.27
Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epithelium. Mol Biol Cell (2004) 1.24
Discs-Large and Strabismus are functionally linked to plasma membrane formation. Nat Cell Biol (2003) 1.22
Maintaining epithelial integrity: a function for gigantic spectraplakin isoforms in adherens junctions. J Cell Biol (2003) 1.11
Crumbs is required to achieve proper organ size control during Drosophila head development. Development (2010) 1.10
Dynein-mediated apical localization of crumbs transcripts is required for Crumbs activity in epithelial polarity. J Cell Biol (2008) 1.10
Antagonistic functions of Par-1 kinase and protein phosphatase 2A are required for localization of Bazooka and photoreceptor morphogenesis in Drosophila. Dev Biol (2007) 1.04
Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization. Development (2010) 1.01
Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins. Mol Cell Biol (2009) 1.00
Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. J Cell Biol (2007) 0.97
Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster. J Cell Biol (2010) 0.96
Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries. Dev Biol (2012) 0.94
Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes. EMBO J (2004) 0.93
dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions. J Cell Biol (2012) 0.88
Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila. Dev Biol (2008) 0.87
Conserved miR-8/miR-200 defines a glial niche that controls neuroepithelial expansion and neuroblast transition. Dev Cell (2013) 0.86
Drosophila Patj plays a supporting role in apical-basal polarity but is essential for viability. Development (2012) 0.83
Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity. J Cell Biol (2012) 0.82
Role of spastin in apical domain control along the rhabdomere elongation in Drosophila photoreceptor. PLoS One (2010) 0.81
Role of kinesin heavy chain in Crumbs localization along the rhabdomere elongation in Drosophila photoreceptor. PLoS One (2011) 0.80
Dynamin regulates metaphase furrow formation and plasma membrane compartmentalization in the syncytial Drosophila embryo. Biol Open (2015) 0.80
Novel neuroprotective function of apical-basal polarity gene crumbs in amyloid beta 42 (aβ42) mediated neurodegeneration. PLoS One (2013) 0.78
Abelson tyrosine kinase is required for Drosophila photoreceptor morphogenesis and retinal epithelial patterning. Dev Dyn (2011) 0.78
Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor. PLoS One (2011) 0.78
A Deep Insight into the Sialome of Male and Female Aedes aegypti Mosquitoes. PLoS One (2016) 0.77
α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium. Development (2016) 0.77
Role of spectraplakin in Drosophila photoreceptor morphogenesis. PLoS One (2011) 0.77
Drosophila gene tao-1 encodes proteins with and without a Ste20 kinase domain that affect cytoskeletal architecture and cell migration differently. Open Biol (2015) 0.76
Establishing and maintaining cell polarity with mRNA localization in Drosophila. Bioessays (2016) 0.75
The ups and downs of life in an epithelium. J Cell Biol (2000) 0.75
Rab14 specifies the apical membrane through Arf6-mediated regulation of lipid domains and Cdc42. Sci Rep (2016) 0.75
Cross talk between the Crumbs complex and Hippo signaling in renal epithelial cells. Pflugers Arch (2017) 0.75
Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies. J Virol (1999) 9.11
RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell (1999) 8.55
Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage (2004) 8.50
The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. EMBO J (2001) 7.97
Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection. Nat Med (2000) 7.48
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature (2000) 6.70
PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet (1999) 6.18
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science (1999) 6.04
Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts. Nat Med (1998) 5.54
Math1: an essential gene for the generation of inner ear hair cells. Science (1999) 5.49
Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int (1995) 5.22
Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet (1995) 4.45
Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell (2000) 4.20
Math1 is essential for genesis of cerebellar granule neurons. Nature (1997) 4.16
Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release. Cell (1993) 4.01
Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid. Neuropharmacology (2006) 3.93
Integrating primary medical care with addiction treatment: a randomized controlled trial. JAMA (2001) 3.91
pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. Genes Dev (1998) 3.88
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A (2000) 3.61
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet (1996) 3.58
Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science (1996) 3.54
Latent and active p53 are identical in conformation. Nat Struct Biol (2001) 3.47
P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes Dev (1989) 3.45
Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II. Cell (1996) 3.39
A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev (1999) 3.25
Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron (2001) 3.20
Hypocholesterolemia is associated with immune dysfunction in early human immunodeficiency virus-1 infection. Am J Med (1993) 2.96
Assessment of rheumatoid arthritis using a modified scoring method on digitized and original radiographs. Arthritis Rheum (1998) 2.91
RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response. Genes Immun (2002) 2.88
Position effects on eukaryotic gene expression. Annu Rev Cell Biol (1990) 2.82
Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis. Neuron (1998) 2.78
A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. Cell (1996) 2.75
Sextant localization of prostate cancer: comparison of sextant biopsy, magnetic resonance imaging and magnetic resonance spectroscopic imaging with step section histology. J Urol (2000) 2.73
Contrast extravasation on CT predicts mortality in primary intracerebral hemorrhage. AJNR Am J Neuroradiol (2007) 2.69
Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant (2007) 2.61
Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239. J Virol (1997) 2.59
The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J Dent Res (2003) 2.48
Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res (1996) 2.47
Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest (2001) 2.45
Identification of a putative alternate sigma factor and characterization of a multicomponent regulatory cascade controlling the expression of Pseudomonas syringae pv. syringae Pss61 hrp and hrmA genes. J Bacteriol (1994) 2.45
Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J (1996) 2.39
Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. Neuron (1996) 2.39
Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice. Am J Pathol (2001) 2.33
Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission. Cell (1995) 2.31
Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila. Neuron (1995) 2.30
The Alzheimer's peptide a beta adopts a collapsed coil structure in water. J Struct Biol (2000) 2.26
Functional conservation of atonal and Math1 in the CNS and PNS. Development (2000) 2.18
Regulation of the Bacillus subtilis pyrimidine biosynthetic (pyr) gene cluster by an autogenous transcriptional attenuation mechanism. J Bacteriol (1994) 2.17
Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants. Proc Natl Acad Sci U S A (1994) 2.15
Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse. Development (1993) 2.15
A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. Proc Natl Acad Sci U S A (1995) 2.10
Comparisons of noninvasive bone mineral measurements in assessing age-related loss, fracture discrimination, and diagnostic classification. J Bone Miner Res (1997) 2.09
Cryptococcosis in apparently immunocompetent patients. QJM (2006) 2.09
Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough. Ir J Med Sci (2012) 2.06
Organization and environmental regulation of the Pseudomonas syringae pv. syringae 61 hrp cluster. J Bacteriol (1992) 2.02
High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections. Clin Infect Dis (2013) 2.02
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol (1996) 1.98
Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes. Genes Dev (1998) 1.97
Correlation of dynamic contrast-enhanced MR imaging with histologic tumor grade: comparison of macromolecular and small-molecular contrast media. AJR Am J Roentgenol (1998) 1.94
Identification of confounders in the assessment of the relationship between lead exposure and child development. Ann Epidemiol (2001) 1.93
Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. J Immunol (2001) 1.89
The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers. Cancer Res (1998) 1.88
Proprioceptor pathway development is dependent on Math1. Neuron (2001) 1.86
Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strength. Bone (1997) 1.84
Anterior-posterior and rotational displacement of the tibia elicited by quadriceps contraction. Am J Sports Med (1992) 1.84
miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. Cell Death Differ (2009) 1.82
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase. J Biol Chem (2001) 1.82
Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest (2000) 1.82
Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 1.82
Outcomes of adults hospitalised with severe influenza. Thorax (2010) 1.80
In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme. Nucleic Acids Res (2000) 1.80
A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli. J Nat Prod (2000) 1.74
MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. Oncogene (2012) 1.74
Universal standardization of bone density measurements: a method with optimal properties for calibration among several instruments. J Bone Miner Res (1997) 1.73
ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosage-dependent manner. EMBO J (1998) 1.70
Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. J Biol Chem (1994) 1.69
Novel signaling from the peripodial membrane is essential for eye disc patterning in Drosophila. Cell (2000) 1.69
Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus. Proc Natl Acad Sci U S A (1999) 1.68
P-element mutations affecting embryonic peripheral nervous system development in Drosophila melanogaster. Genetics (1995) 1.65
Receptor for advanced glycation end products mediates inflammation and enhanced expression of tissue factor in vasculature of diabetic apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol (2001) 1.64
p21(WAF1) and transforming growth factor-alpha mediate dietary phosphate regulation of parathyroid cell growth. Kidney Int (2001) 1.63
Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells. Proc Natl Acad Sci U S A (1986) 1.62
An open-label, parallel, multiple-dose study comparing the pharmacokinetics and gastric acid suppression of rabeprazole extended-release with esomeprazole 40 mg and rabeprazole delayed-release 20 mg in healthy volunteers. Aliment Pharmacol Ther (2011) 1.61
rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo. Neuron (1994) 1.60
P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: mutations affecting embryonic PNS development. Genetics (1997) 1.60
Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5. Learn Mem (1999) 1.59
Doing the MATH: is the mouse a good model for fly development? Genes Dev (2000) 1.59
Focal fatty infiltration of the liver: analysis of prevalence and CT findings in children and young adults. AJR Am J Roentgenol (2001) 1.59
atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron (2000) 1.58
Hypercytokinemia and hyperactivation of phospho-p38 mitogen-activated protein kinase in severe human influenza A virus infection. Clin Infect Dis (2007) 1.57
Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. Hum Mol Genet (1996) 1.57
Effect of a lipidic extract from lepidium meyenii on sexual behavior in mice and rats. Urology (2000) 1.56
The ligamento-muscular stabilizing system of the spine. Spine (Phila Pa 1976) (1998) 1.56