Published in N Engl J Med on May 28, 1992
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A (1998) 13.39
Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med (1995) 2.99
Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest (1994) 2.97
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci U S A (2003) 2.20
Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin (2010) 1.98
Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc Natl Acad Sci U S A (1995) 1.87
Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis. Blood (2007) 1.79
Fibrosis and diseases of the eye. J Clin Invest (2007) 1.79
Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle-sized T antigen: implications for the pathogenesis of opportunistic vascular tumors. Proc Natl Acad Sci U S A (1994) 1.78
A fragment of human TrpRS as a potent antagonist of ocular angiogenesis. Proc Natl Acad Sci U S A (2002) 1.64
Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells. Am J Pathol (2001) 1.40
Heterogeneous vascular dependence of tumor cell populations. Am J Pathol (2001) 1.31
Platelet-derived growth factor receptor-beta in Gorham's disease. Nat Clin Pract Oncol (2006) 1.23
Angiogenesis in epithelian ovarian cancer. Mol Pathol (2002) 1.21
Inhibition of choroidal neovascularization by intravenous injection of adenoviral vectors expressing secretable endostatin. Am J Pathol (2001) 1.18
The antitumor effects of IFN-alpha are abrogated in a STAT1-deficient mouse. J Clin Invest (2003) 1.17
Classification and imaging of vascular malformations in children. Eur Radiol (2002) 1.17
Sirolimus for the treatment of children with various complicated vascular anomalies. Eur J Pediatr (2015) 1.17
Primary PEComa of the bladder treated with primary excision and adjuvant interferon-alpha immunotherapy: a case report. BMC Urol (2006) 1.16
Vasculogenesis in infantile hemangioma. Angiogenesis (2009) 1.11
Angiogenesis and its therapeutic opportunities. Mediators Inflamm (2013) 1.09
Phase I trial of pegylated interferon-alpha-2b in young patients with plexiform neurofibromas. Neurology (2011) 1.08
GI-Associated Hemangiomas and Vascular Malformations. Clin Colon Rectal Surg (2011) 1.08
Successful treatment with propranolol in a patient with a segmental hemangioma: a case report. Turk J Haematol (2012) 1.02
Management of cardiovascular disease risk in chronic inflammatory disorders. Nat Rev Rheumatol (2009) 0.98
Clinical experience with infantile hepatic hemangioendothelioma. World J Surg (2009) 0.97
Genomic imprinting of IGF2 is maintained in infantile hemangioma despite its high level of expression. Mol Med (2006) 0.94
Vascular cutaneous anomalies in children: malformations and hemangiomas. Pediatr Surg Int (1996) 0.94
Interferon-alpha-2a for the treatment of complex hemangiomas of infancy and childhood. Ann Surg (1994) 0.93
A phase 2 trial of bevacizumab and high-dose interferon alpha 2B in metastatic melanoma. J Immunother (2011) 0.93
Potential therapeutic strategies for lymphatic metastasis. Microvasc Res (2007) 0.92
Novel molecular pathways in Gorham disease: implications for treatment. Pediatr Blood Cancer (2013) 0.91
Judah Folkman, a pioneer in the study of angiogenesis. Angiogenesis (2008) 0.90
Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha. Neoplasia (2001) 0.90
Evaluation of intralesional propranolol for periocular capillary hemangioma. Clin Ophthalmol (2011) 0.88
Neovascularization of the optic disc in Behçet's disease. Jpn J Ophthalmol (2006) 0.87
Kasabach merritt syndrome: management with interferon. Indian J Dermatol (2010) 0.86
Ipsilateral facial and uveal arteriovenous and capillary angioma, microphthalmos, heterochromia of the iris, and hypotony: an oculocutaneous syndrome simulating Sturge-Weber syndrome. Trans Am Ophthalmol Soc (1996) 0.86
Interferon-alpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth. J Clin Invest (1993) 0.85
Infantile hemangiomas: A review. Saudi J Ophthalmol (2012) 0.85
Progenitor cells in infantile hemangioma. J Craniofac Surg (2009) 0.84
Mice with hemangiomas induced by transgenic endothelial cells. A model for the Kasabach-Merritt syndrome. Am J Pathol (1994) 0.83
Embolization in the head and neck. Semin Intervent Radiol (2008) 0.82
Use of propranolol in treating hemangiomas. Can Fam Physician (2011) 0.82
AIDS-associated Kaposi's sarcoma: is there still a role for interferon alfa? Cytokine Growth Factor Rev (2007) 0.82
An overview of clinical trials involving inhibitors of angiogenesis and their mechanism of action. Invest New Drugs (1997) 0.82
Treatment of alarming head and neck infantile hemangiomas with interferon-α2a: a clinical study in eleven consecutive patients. Drug Des Devel Ther (2015) 0.81
Interferon (IFN)-beta gene transfer into TS/A adenocarcinoma cells and comparison with IFN-alpha: differential effects on tumorigenicity and host response. Am J Pathol (1999) 0.81
Argon and YAG laser photocoagulation and excision of hemangiomas and vascular malformations of the nose. West J Med (1995) 0.81
Anti-angiogenic effects of the thienopyridine SR 25989 in vitro and in vivo in a murine pulmonary metastasis model. Br J Cancer (2002) 0.79
Surgical treatment of hemangiomas and vascular malformations in functional areas. Pediatr Surg Int (1996) 0.79
A pilot study of bevacizumab and interferon-α2b in ocular melanoma. Am J Clin Oncol (2011) 0.79
Oral propranolol for the treatment of periorbital infantile hemangioma: a preliminary report from oman. Middle East Afr J Ophthalmol (2011) 0.79
Obstructive jaundice caused by a giant liver hemangioma with Kasabach-Merritt syndrome: a case report. Surg Case Rep (2015) 0.79
Efficacy of bleomycin treatment for symptomatic hemangiomas in children. Pediatr Surg Int (1997) 0.78
Neoadjuvant and conversion treatment of patients with colorectal liver metastasis: the potential role of bevacizumab and other antiangiogenic agents. Target Oncol (2015) 0.78
Postcricoid hemangioma: an overlooked cause of dysphagia in infants?-a case report. Dysphagia (2004) 0.78
Interferons--expanding therapeutic roles. N Engl J Med (1992) 0.78
Animal models and the tumor microenvironment: studies of tumor-host symbiosis. Semin Oncol (2014) 0.78
Gorham's Disease With Chest Wall Involvement: A Case Report and a Review of the Literature. Iran Red Crescent Med J (2014) 0.77
Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma. J Neurosurg Pediatr (2008) 0.77
Interferon-β inhibits glioma angiogenesis through downregulation of vascular endothelial growth factor and upregulation of interferon inducible protein 10. Int J Oncol (2014) 0.77
Hemangiomas of the pelvis. Clin Colon Rectal Surg (2006) 0.76
Recombinant human interferon alpha 2b prevents and reverses experimental pulmonary hypertension. PLoS One (2014) 0.76
Biological response modifiers in cancer. MedGenMed (2006) 0.76
The preclinical evaluation of angiogenesis inhibitors. Invest New Drugs (1997) 0.76
Emergent medical and surgical management of mediastinal infantile hemangioma with symptomatic spinal cord compression: case report and literature review. Childs Nerv Syst (2010) 0.76
Treatment of hemangiomas in children using a Nd:YAG laser in conjunction with ice cooling of the epidermis: techniques and results. BMC Pediatr (2003) 0.75
Interferon alfa-2a modifies the course of subfoveal and juxtafoveal choroidal neovascularisation. Br J Ophthalmol (1994) 0.75
Sub-Tenon's Steroid Irrigation for Treatment of Intraorbital Capillary Hemangioma. Interv Neuroradiol (2008) 0.75
Caution in regard to treatment of hemangiomas with interferon alfa-2a. N Engl J Med (1992) 0.75
Interferon-alpha therapy for refractory kaposiform hemangioendothelioma: a single-center experience. Sci Rep (2016) 0.75
Evaluation of the efficacy and safety of topical timolol maleate combined with oral propranolol treatment for parotid mixed infantile hemangiomas. Oncol Lett (2016) 0.75
Propranolol therapy for infantile hemangioma: our experience. Drug Des Devel Ther (2017) 0.75
Tetrathiomolybdate as an antiangiogenesis therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration. Trans Am Ophthalmol Soc (2002) 0.75
Extended applications of endoscopic sinus surgery and its reference to cranial base and pituitary fossa. Indian J Otolaryngol Head Neck Surg (2010) 0.75
Medication Repurposing in Pediatric Patients: Teaching Old Drugs New Tricks. J Pediatr Pharmacol Ther (2016) 0.75
Kaposi's sarcoma in two primary liver allograft recipients occurring under FK506 immunosuppression. Clin Transplant (1993) 0.75
Cavernous haemangioma with Kasabach-Merritt syndrome: treatment with alpha-interferon. J R Soc Med (1996) 0.75
Management of capillary hemangiomas. West J Med (1994) 0.75
Interferon-alpha therapy for multiple hemangiomas associated with coarctation of the aorta. Heart Vessels (1996) 0.75
Imaging and percutaneous treatment of vascular anomalies. Semin Intervent Radiol (2008) 0.75
[Renal cell carcinoma]. Urologe A (2006) 0.75
Infantile Periocular Hemangioma. J Ophthalmic Vis Res (2017) 0.75
Tumor angiogenesis: therapeutic implications. N Engl J Med (1971) 35.36
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell (1996) 23.99
Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Engl J Med (1991) 19.46
Angiogenic factors. Science (1987) 15.22
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell (1997) 13.94
Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell (1994) 13.76
What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst (1990) 13.41
Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg (1982) 12.85
Role of cell shape in growth control. Nature (1978) 12.46
Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst (1992) 8.69
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature (1997) 7.66
Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell (1997) 7.47
Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med (1995) 7.37
Isolation of a tumor factor responsible for angiogenesis. J Exp Med (1971) 7.12
Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol (1993) 6.55
Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci U S A (1994) 6.48
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res (2000) 6.42
Human vascular endothelial cells in culture. Growth and DNA synthesis. J Cell Biol (1974) 5.95
Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol (1994) 5.76
Long-term culture of capillary endothelial cells. Proc Natl Acad Sci U S A (1979) 5.70
Tumor angiogenesis. Adv Cancer Res (1985) 5.66
Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res (1977) 5.19
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature (1990) 5.15
Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell (1996) 5.10
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science (1999) 4.91
Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix. J Cell Biol (1989) 4.85
Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. Proc Natl Acad Sci U S A (1987) 4.83
Angiogenesis in vitro. Nature (1980) 4.46
Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg (1972) 4.37
Tumor dormancy in vivo by prevention of neovascularization. J Exp Med (1972) 4.34
Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science (1984) 4.27
Tumor growth and neovascularization: an experimental model using the rabbit cornea. J Natl Cancer Inst (1974) 4.05
Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol (1994) 3.76
Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med (1996) 3.64
Inhibition of angiogenesis in vivo by interleukin 12. J Natl Cancer Inst (1995) 3.53
Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation (1999) 3.53
A model of angiogenesis in the mouse cornea. Invest Ophthalmol Vis Sci (1996) 3.49
Arteriovenous malformations of the head and neck: natural history and management. Plast Reconstr Surg (1998) 3.42
Relation of vascular proliferation to tumor growth. Int Rev Exp Pathol (1976) 3.21
Proteus syndrome: diagnostic criteria, differential diagnosis, and patient evaluation. Am J Med Genet (1999) 3.02
Tumor behavior in isolated perfused organs: in vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg (1966) 3.00
Sclerotherapy of craniofacial venous malformations: complications and results. Plast Reconstr Surg (1999) 2.99
Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest (1994) 2.97
Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch Ophthalmol (1996) 2.95
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A (1997) 2.88
Self-regulation of growth in three dimensions. J Exp Med (1973) 2.87
How does extracellular matrix control capillary morphogenesis? Cell (1989) 2.84
Polymers for the sustained release of proteins and other macromolecules. Nature (1976) 2.81
Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Proc Natl Acad Sci U S A (2001) 2.81
A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis. Cell (1993) 2.80
Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab Invest (1993) 2.71
How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture. Cancer Res (1986) 2.69
Hemangiomas and vascular malformations of infancy and childhood. Pediatr Clin North Am (1993) 2.69
Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy. Cancer Res (1999) 2.58
Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells. Biochem Biophys Res Commun (1993) 2.56
Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell (1991) 2.52
Tumor angiogenesis: a quantitative method for histologic grading. J Natl Cancer Inst (1972) 2.52
Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J Natl Cancer Inst (1994) 2.50
Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry (1989) 2.49
Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood (1999) 2.49
Vascular tumors and vascular malformations (new issues). Adv Dermatol (1997) 2.48
Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Science (1983) 2.47
A simple procedure for the long-term cultivation of chicken embryos. Dev Biol (1974) 2.46
Tumor angiogenesis. Adv Cancer Res (1974) 2.38
Protamine is an inhibitor of angiogenesis. Nature (1982) 2.30
Mast cell heparin stimulates migration of capillary endothelial cells in vitro. J Exp Med (1980) 2.27
A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome. Am J Hum Genet (1997) 2.22
Congenital vascular lesions: clinical application of a new classification. J Pediatr Surg (1983) 2.20
Clonality and altered behavior of endothelial cells from hemangiomas. J Clin Invest (2001) 2.20
Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border. Cell (1998) 2.17
Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium. Nature (1969) 2.16
Fine structure of vascular endothelium in culture. J Ultrastruct Res (1975) 2.15
Nonsyndromic cleft lip with or without cleft palate: evidence of linkage to BCL3 in 17 multigenerational families. Am J Hum Genet (1995) 2.12
Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alfa-2a. Pediatrics (1999) 2.12
Betacellulin: a mitogen from pancreatic beta cell tumors. Science (1993) 2.10
Heterogeneity of angiogenic activity in a human liposarcoma: a proposed mechanism for "no take" of human tumors in mice. J Natl Cancer Inst (2001) 2.10
Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc Natl Acad Sci U S A (1996) 2.07
Involvement of platelets in tumour angiogenesis? Lancet (1998) 2.03
Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am J Pathol (1997) 1.98
Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases. Pediatr Dermatol (1991) 1.96
Tumor angiogenesis: iris neovascularization at a distance from experimental intraocular tumors. J Natl Cancer Inst (1973) 1.95
Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy. J Pediatr (1998) 1.95
Isolation and characterization of endothelial progenitor cells from mouse embryos. Development (1998) 1.94
Endothelial growth factors and extracellular matrix regulate DNA synthesis through modulation of cell and nuclear expansion. In Vitro Cell Dev Biol (1987) 1.93
Application of the biological principle of induced osteogenesis for craniofacial defects. Lancet (1981) 1.92
Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes. Am J Hum Genet (1999) 1.88
Proceedings: Tumor angiogenesis factor. Cancer Res (1974) 1.86
Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis. Hum Mol Genet (2000) 1.84
Assignment of a locus for dominantly inherited venous malformations to chromosome 9p. Hum Mol Genet (1994) 1.83
Soft-tissue vascular anomalies: utility of US for diagnosis. Radiology (2000) 1.82
Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK. Am J Hum Genet (2001) 1.81
Influence of geometry on control of cell growth. Biochim Biophys Acta (1975) 1.79
Isolations of a cartilage factor that inhibits tumor neovascularization. Science (1976) 1.79
Regulation of angiostatin production by matrix metalloproteinase-2 in a model of concomitant resistance. J Biol Chem (1999) 1.78
Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Mol Med (1995) 1.78