Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border.

PubWeight™: 2.17‹?› | Rank: Top 2%

🔗 View Article (PMID 9630209)

Published in Cell on May 29, 1998

Authors

G D Yancopoulos1, M Klagsbrun, J Folkman

Author Affiliations

1: Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.

Articles citing this

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev (1999) 4.75

Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest (2002) 3.70

Endothelial cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A (2002) 3.66

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol (2009) 3.27

Angiogenesis modulates adipogenesis and obesity. J Clin Invest (2007) 3.23

Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165. J Cell Biol (1999) 3.00

Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol (2002) 2.99

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res (2003) 2.91

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol (2005) 2.75

3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon. Br J Cancer (2001) 1.92

The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev (2000) 1.74

Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes Dev (1999) 1.52

Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Mol Cell Biol (2010) 1.50

Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Genes Dev (2007) 1.49

A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development. Dev Biol (2009) 1.45

Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation. Mol Cell Biol (2000) 1.38

Involvement of notch signaling in wound healing. PLoS One (2007) 1.35

Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathy. PLoS One (2008) 1.31

Targeted disruption of mouse fibroblast activation protein. Mol Cell Biol (2000) 1.28

Lymphatics at the crossroads of angiogenesis and lymphangiogenesis. J Anat (2004) 1.22

Angiogenesis in epithelian ovarian cancer. Mol Pathol (2002) 1.21

Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry. Respir Res (2003) 1.20

Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. EMBO J (2003) 1.17

Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 protein activation. J Biol Chem (2012) 1.16

Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells. Mol Biol Cell (2002) 1.09

Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation state. Am J Pathol (1999) 1.09

VEGF increases engraftment of bone marrow-derived endothelial progenitor cells (EPCs) into vasculature of newborn murine recipients. Proc Natl Acad Sci U S A (2002) 1.06

Tumor angiogenesis: insights and innovations. J Oncol (2010) 1.04

The role of angiogenesis in rheumatoid arthritis: recent developments. Ann Rheum Dis (2000) 1.02

Target therapy using a small molecule inhibitor against angiogenic receptors in pancreatic cancer. Neoplasia (2007) 0.96

Identifying transient protein-protein interactions in EphB2 signaling by blue native PAGE and mass spectrometry. Proteomics (2011) 0.96

Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling. Development (2009) 0.93

Microvascular repair: post-angiogenesis vascular dynamics. Microcirculation (2012) 0.92

HGF-MET cascade, a key target for inhibiting cancer metastasis: the impact of NK4 discovery on cancer biology and therapeutics. Int J Mol Sci (2013) 0.92

Sulindac inhibits neointimal formation after arterial injury in wild-type and apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A (2000) 0.88

Regression and persistence: remodelling in a tissue engineered axial vascular assembly. J Cell Mol Med (2009) 0.87

Human tears reveal insights into corneal neovascularization. PLoS One (2012) 0.86

Vessel arterial-venous plasticity in adult neovascularization. PLoS One (2011) 0.86

Targeting angiogenesis and the tumor microenvironment. Surg Oncol Clin N Am (2013) 0.85

Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved. Eur Arch Otorhinolaryngol (2008) 0.84

Role of JNK in network formation of human lung microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol (2008) 0.84

COX-2 expression and tumor angiogenesis in colorectal cancer. World J Gastroenterol (2004) 0.84

Microvascular assembly and cell invasion in chick mesonephros grafted onto chorioallantoic membrane. J Anat (2003) 0.83

Significance of vascular endothelial growth factor and epidermal growth factor in development of papillary thyroid cancer. Langenbecks Arch Surg (2005) 0.82

Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization. PLoS One (2011) 0.81

Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood. J Vis Exp (2015) 0.78

Multifunctional nanoassemblies of block copolymers for future cancer therapy. Sci Technol Adv Mater (2010) 0.77

Modulating Astrocyte Transition after Stroke to Promote Brain Rescue and Functional Recovery: Emerging Targets Include Rho Kinase. Int J Mol Sci (2016) 0.76

Endometriosis, angiogenesis and tissue factor. Scientifica (Cairo) (2012) 0.76

Small interfering RNA knockdown of mini-TyrRS and mini-TrpRS effects angiogenesis in human umbilical vein endothelial cells in hypoxic culture. Cytotechnology (2008) 0.75

Membrane-mediated regulation of vascular identity. Birth Defects Res C Embryo Today (2016) 0.75

Cloning and expression of human vascular endothelial growth factor gene and inhibition of its expression by antisense in prokaryotic system. Daru (2010) 0.75

AngioDB: database of angiogenesis and angiogenesis-related molecules. Nucleic Acids Res (2002) 0.75

ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery. Blood (2017) 0.75

Articles by these authors

Tumor angiogenesis: therapeutic implications. N Engl J Med (1971) 35.36

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell (1996) 23.99

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Engl J Med (1991) 19.46

Angiogenic factors. Science (1987) 15.22

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell (1997) 13.94

Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell (1994) 13.76

What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst (1990) 13.41

Role of cell shape in growth control. Nature (1978) 12.46

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell (1998) 10.32

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell (1991) 8.99

Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst (1992) 8.69

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature (1997) 7.66

Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med (1995) 7.37

Isolation of a tumor factor responsible for angiogenesis. J Exp Med (1971) 7.12

Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol (1993) 6.55

Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci U S A (1994) 6.48

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res (2000) 6.42

Human vascular endothelial cells in culture. Growth and DNA synthesis. J Cell Biol (1974) 5.95

Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol (1994) 5.76

Long-term culture of capillary endothelial cells. Proc Natl Acad Sci U S A (1979) 5.70

Tumor angiogenesis. Adv Cancer Res (1985) 5.66

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res (1977) 5.19

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature (1990) 5.15

A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science (1991) 5.14

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science (1999) 4.91

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix. J Cell Biol (1989) 4.85

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. Proc Natl Acad Sci U S A (1987) 4.83

Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med (1992) 4.76

Angiogenesis in vitro. Nature (1980) 4.46

Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg (1972) 4.37

Tumor dormancy in vivo by prevention of neovascularization. J Exp Med (1972) 4.34

Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science (1984) 4.27

Tumor growth and neovascularization: an experimental model using the rabbit cornea. J Natl Cancer Inst (1974) 4.05

Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol (1994) 3.76

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane. Am J Pathol (1988) 3.72

Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med (1996) 3.64

Inhibition of angiogenesis in vivo by interleukin 12. J Natl Cancer Inst (1995) 3.53

Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation (1999) 3.53

A model of angiogenesis in the mouse cornea. Invest Ophthalmol Vis Sci (1996) 3.49

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. Proc Natl Acad Sci U S A (1989) 3.45

Relation of vascular proliferation to tumor growth. Int Rev Exp Pathol (1976) 3.21

Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation. Development (1994) 3.02

Tumor behavior in isolated perfused organs: in vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg (1966) 3.00

Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165. J Cell Biol (1999) 3.00

Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest (1994) 2.97

Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch Ophthalmol (1996) 2.95

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A (1997) 2.88

Self-regulation of growth in three dimensions. J Exp Med (1973) 2.87

How does extracellular matrix control capillary morphogenesis? Cell (1989) 2.84

Polymers for the sustained release of proteins and other macromolecules. Nature (1976) 2.81

Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Proc Natl Acad Sci U S A (2001) 2.81

Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab Invest (1993) 2.71

How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture. Cancer Res (1986) 2.69

Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy. Cancer Res (1999) 2.58

Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells. Biochem Biophys Res Commun (1993) 2.56

Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor. Proc Natl Acad Sci U S A (1986) 2.55

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell (1991) 2.52

Tumor angiogenesis: a quantitative method for histologic grading. J Natl Cancer Inst (1972) 2.52

Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury. Proc Natl Acad Sci U S A (1993) 2.51

Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J Natl Cancer Inst (1994) 2.50

Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose. J Biol Chem (1986) 2.50

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry (1989) 2.49

Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood (1999) 2.49

Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Science (1983) 2.47

A simple procedure for the long-term cultivation of chicken embryos. Dev Biol (1974) 2.46

Tumor angiogenesis. Adv Cancer Res (1974) 2.38

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein. J Biol Chem (1992) 2.37

Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol (2001) 2.35

Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis. Cancer Res (1995) 2.34

Protamine is an inhibitor of angiogenesis. Nature (1982) 2.30

Mast cell heparin stimulates migration of capillary endothelial cells in vitro. J Exp Med (1980) 2.27

Heparin affinity of anionic and cationic capillary endothelial cell growth factors: analysis of hypothalamus-derived growth factors and fibroblast growth factors. Proc Natl Acad Sci U S A (1985) 2.21

Heparin-binding EGF-like growth factor. Biochim Biophys Acta (1997) 2.19

Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium. Nature (1969) 2.16

Fine structure of vascular endothelium in culture. J Ultrastruct Res (1975) 2.15

Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain. J Biol Chem (1996) 2.12

Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alfa-2a. Pediatrics (1999) 2.12

Heterogeneity of angiogenic activity in a human liposarcoma: a proposed mechanism for "no take" of human tumors in mice. J Natl Cancer Inst (2001) 2.10

Betacellulin: a mitogen from pancreatic beta cell tumors. Science (1993) 2.10

Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. J Biol Chem (1995) 2.09

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc Natl Acad Sci U S A (1996) 2.07

Basic fibroblast growth factor fused to a signal peptide transforms cells. Nature (1988) 2.04

Involvement of platelets in tumour angiogenesis? Lancet (1998) 2.03

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. EMBO J (1997) 2.02

Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proc Natl Acad Sci U S A (1994) 2.02

Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate. J Cell Biol (1993) 2.02

A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem (1997) 1.99

The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor. J Cell Biol (1995) 1.99

Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am J Pathol (1997) 1.98

Isolation and characterization of a macrophage-derived heparin-binding growth factor. Cell Regul (1990) 1.96

Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity. Mol Biol Cell (1995) 1.96

Tumor angiogenesis: iris neovascularization at a distance from experimental intraocular tumors. J Natl Cancer Inst (1973) 1.95

Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy. J Pediatr (1998) 1.95

Isolation and characterization of endothelial progenitor cells from mouse embryos. Development (1998) 1.94

Endothelial growth factors and extracellular matrix regulate DNA synthesis through modulation of cell and nuclear expansion. In Vitro Cell Dev Biol (1987) 1.93