Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma.

PubWeight™: 2.52‹?› | Rank: Top 2%

🔗 View Article (PMID 1717155)

Published in Cell on September 20, 1991

Authors

J Kandel1, E Bossy-Wetzel, F Radvanyi, M Klagsbrun, J Folkman, D Hanahan

Author Affiliations

1: Department of Surgery, Children's Hospital, Boston, Massachusetts 02115.

Articles citing this

Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer (2010) 8.55

Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol (1995) 4.37

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell (1993) 4.33

Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest (1997) 3.39

Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes. Mol Cell Biol (1995) 3.02

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A (1997) 2.88

Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. Mol Cell Biol (1993) 2.29

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc Natl Acad Sci U S A (1996) 2.07

Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. J Clin Invest (1997) 2.04

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment. Am J Pathol (1996) 1.86

An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am J Pathol (2003) 1.80

Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation. J Cell Biol (2000) 1.78

Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Mol Med (1995) 1.78

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. Proc Natl Acad Sci U S A (1998) 1.77

Translation of CUG- but not AUG-initiated forms of human fibroblast growth factor 2 is activated in transformed and stressed cells. J Cell Biol (1996) 1.73

T lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: differential production and release by CD4+ and CD8+ T cells. Proc Natl Acad Sci U S A (1994) 1.68

A new pathway for protein export in Saccharomyces cerevisiae. J Cell Biol (1996) 1.66

A new 34-kilodalton isoform of human fibroblast growth factor 2 is cap dependently synthesized by using a non-AUG start codon and behaves as a survival factor. Mol Cell Biol (1999) 1.61

Increased perfusion and angiogenesis in a hindlimb ischemia model with plasmid FGF-2 delivered by noninvasive electroporation. Gene Ther (2010) 1.56

Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation. J Virol (1993) 1.54

Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor-resistant human lung adenocarcinoma. J Clin Invest (2011) 1.52

Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells. Proc Natl Acad Sci U S A (1998) 1.47

Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells. Proc Natl Acad Sci U S A (1992) 1.44

Matrix metalloproteinase inhibitors. Invest New Drugs (1997) 1.43

Quantitative analysis of basic fibroblast growth factor and vascular endothelial growth factor in human colorectal cancer. Br J Cancer (1998) 1.40

Pancreatic beta cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: a potentially general technique for isolating physiologically representative cell lines. Mol Cell Biol (1993) 1.34

Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. J Clin Invest (1993) 1.33

Fgf-8, activated by proviral insertion, cooperates with the Wnt-1 transgene in murine mammary tumorigenesis. J Virol (1995) 1.32

Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis. Am J Pathol (2009) 1.24

Angiogenesis inhibitors generated by tumors. Mol Med (1995) 1.24

Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis. Proc Natl Acad Sci U S A (1999) 1.24

Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases. J Clin Invest (1998) 1.22

The role of the vascular phase in solid tumor growth: a historical review. Neoplasia (1999) 1.20

Endothelial-monocyte activating polypeptide II, a novel antitumor cytokine that suppresses primary and metastatic tumor growth and induces apoptosis in growing endothelial cells. J Exp Med (1999) 1.13

Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression. Proc Natl Acad Sci U S A (2001) 1.02

Impact of fibroblast growth factor-2 on tumor microvascular architecture. A tridimensional morphometric study. Am J Pathol (1998) 1.02

Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury. Am J Pathol (1993) 1.01

Leukocyte adhesion in angiogenic blood vessels. Role of E-selectin, P-selectin, and beta2 integrin in lymphotoxin-mediated leukocyte recruitment in tumor microvessels. J Clin Invest (1997) 0.99

Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma. Br J Cancer (2002) 0.99

N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface. Biochem J (2000) 0.99

Requirement of posttranslational modifications for the generation of biologic activity of glycosylation-inhibiting factor. Proc Natl Acad Sci U S A (1994) 0.95

Induction of vascular endothelial tubular morphogenesis by human glioma cells. A model system for tumor angiogenesis. J Clin Invest (1993) 0.94

Bombesin antagonists inhibit proangiogenic factors in human experimental breast cancers. Br J Cancer (2004) 0.92

A transition in transcriptional activation by the glucocorticoid and retinoic acid receptors at the tumor stage of dermal fibrosarcoma development. EMBO J (1995) 0.92

Angiogenesis and antiangiogenic agents in cervical cancer. Onco Targets Ther (2014) 0.91

Suppression of hypoxia-induced HIF-1alpha and of angiogenesis in endothelial cells by myo-inositol trispyrophosphate-treated erythrocytes. Proc Natl Acad Sci U S A (2006) 0.90

Low levels of basic fibroblast growth factor (bFGF) are associated with a poor prognosis in human breast carcinoma. Br J Cancer (1997) 0.89

Positive effects of phenytoin on experimental colonic anastomoses. Int J Colorectal Dis (2003) 0.88

The Roles of Angiogenesis in Malignant Melanoma: Trends in Basic Science Research over the Last 100 Years. ISRN Oncol (2012) 0.88

Effects of AGM-1470 and pentosan polysulphate on tumorigenicity and metastasis of FGF-transfected MCF-7 cells. Br J Cancer (1996) 0.88

Tumor angiogenesis as a target for dietary cancer prevention. J Oncol (2011) 0.86

Interferon-alpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth. J Clin Invest (1993) 0.85

MicroRNA-410 reduces the expression of vascular endothelial growth factor and inhibits oxygen-induced retinal neovascularization. PLoS One (2014) 0.85

From antiangiogenesis to hypoxia: current research and future directions. Cancer Manag Res (2010) 0.84

The location of acidic fibroblast growth factor in the breast is dependent on the activity of proteases present in breast cancer tissue. Br J Cancer (1997) 0.84

Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activation. Mol Cell Biol (2007) 0.83

CNTF receptor alpha is expressed by magnocellular neurons and expression is upregulated in the rat supraoptic nucleus during axonal sprouting. Exp Neurol (2008) 0.81

Cloning of a cDNA for the FAD-linked glycerol-3-phosphate dehydrogenase from rat liver and its regulation by thyroid hormones. Proc Natl Acad Sci U S A (1994) 0.80

Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation. J Oncol (2011) 0.79

Beta-Adrenoceptor Activation Reduces Both Dermal Microvascular Endothelial Cell Migration via a cAMP-Dependent Mechanism and Wound Angiogenesis. J Cell Physiol (2015) 0.79

A case of large solitary fibrous tumor in the retroperitoneum. Clin Med Case Rep (2009) 0.77

Angiogenesis induced by signal transducer and activator of transcription 5A (STAT5A) is dependent on autocrine activity of proliferin. J Biol Chem (2011) 0.77

Effect of fibroblast growth factor saporin mitotoxins on human bladder cell lines. Clin Exp Metastasis (1997) 0.76

Understanding Dupuytren's Disease Using Systems Biology: A Move Away from Reductionism. Front Physiol (2012) 0.76

The preclinical evaluation of angiogenesis inhibitors. Invest New Drugs (1997) 0.76

Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review. J Exp Clin Cancer Res (2016) 0.75

Accelerating nonlinear reconstruction in laminar optical tomography by use of recursive SVD inversion. Biomed Opt Express (2017) 0.75

Angiogenesis in Endocrine Neoplasms. Endocr Pathol (1997) 0.75

A novel way to get out of the cell. Cytotechnology (1993) 0.75

Ultrastructural immunolocalization of basic fibroblast growth factor in endothelial cells: morphologic evidence for unconventional secretion of a novel protein. J Mol Histol (2011) 0.75

Articles by these authors

Studies on transformation of Escherichia coli with plasmids. J Mol Biol (1983) 116.81

Tumor angiogenesis: therapeutic implications. N Engl J Med (1971) 35.36

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell (1996) 23.99

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Engl J Med (1991) 19.46

Plasmid screening at high colony density. Gene (1980) 16.47

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science (1997) 15.25

Angiogenic factors. Science (1987) 15.22

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell (1997) 13.94

Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell (1994) 13.76

What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst (1990) 13.41

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol (2000) 13.29

Role of cell shape in growth control. Nature (1978) 12.46

Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants. Proc Natl Acad Sci U S A (1990) 10.46

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell (1998) 10.32

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature (1985) 9.78

MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell (1998) 9.70

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell (1991) 8.99

Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst (1992) 8.69

MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell (2000) 8.00

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature (1997) 7.66

Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med (1995) 7.37

Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature (1989) 7.30

Isolation of a tumor factor responsible for angiogenesis. J Exp Med (1971) 7.12

Genetic and physical linkage of exogenous sequences in transformed cells. Cell (1980) 6.67

Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol (1993) 6.55

Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci U S A (1994) 6.48

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res (2000) 6.42

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev (1999) 6.10

Human vascular endothelial cells in culture. Growth and DNA synthesis. J Cell Biol (1974) 5.95

Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol (1994) 5.76

McrA and McrB restriction phenotypes of some E. coli strains and implications for gene cloning. Nucleic Acids Res (1988) 5.76

Long-term culture of capillary endothelial cells. Proc Natl Acad Sci U S A (1979) 5.70

Tumor angiogenesis. Adv Cancer Res (1985) 5.66

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nat Genet (1999) 5.29

Plasmid screening at high colony density. Methods Enzymol (1983) 5.24

Plasmid transformation of Escherichia coli and other bacteria. Methods Enzymol (1991) 5.21

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res (1977) 5.19

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature (1990) 5.15

A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science (1991) 5.14

Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas. Nat Genet (2001) 4.96

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science (1999) 4.91

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix. J Cell Biol (1989) 4.85

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. Proc Natl Acad Sci U S A (1987) 4.83

Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med (1992) 4.76

Angiogenesis in vitro. Nature (1980) 4.46

Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg (1972) 4.37

Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature (1980) 4.37

Tumor dormancy in vivo by prevention of neovascularization. J Exp Med (1972) 4.34

Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science (1984) 4.27

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc Natl Acad Sci U S A (1988) 4.19

Tumor growth and neovascularization: an experimental model using the rabbit cornea. J Natl Cancer Inst (1974) 4.05

Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol (1994) 3.76

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane. Am J Pathol (1988) 3.72

Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell. Cell (1980) 3.66

Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat Med (1996) 3.64

Inhibition of angiogenesis in vivo by interleukin 12. J Natl Cancer Inst (1995) 3.53

Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation (1999) 3.53

A model of angiogenesis in the mouse cornea. Invest Ophthalmol Vis Sci (1996) 3.49

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. Proc Natl Acad Sci U S A (1989) 3.45

Construction and characterization of a 2.5-kilobase procollagen clone. Proc Natl Acad Sci U S A (1978) 3.26

Relation of vascular proliferation to tumor growth. Int Rev Exp Pathol (1976) 3.21

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction. Nat Med (1997) 3.03

Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation. Development (1994) 3.02

Tumor behavior in isolated perfused organs: in vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg (1966) 3.00

Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165. J Cell Biol (1999) 3.00

Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell (1988) 2.99

Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest (1994) 2.97

Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch Ophthalmol (1996) 2.95

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells. Nature (1987) 2.90

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A (1997) 2.88

Self-regulation of growth in three dimensions. J Exp Med (1973) 2.87

The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol. J Cell Biol (1999) 2.85

How does extracellular matrix control capillary morphogenesis? Cell (1989) 2.84

Polymers for the sustained release of proteins and other macromolecules. Nature (1976) 2.81

Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Proc Natl Acad Sci U S A (2001) 2.81

BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity (2000) 2.79

Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J Virol (1994) 2.73

Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab Invest (1993) 2.71

How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture. Cancer Res (1986) 2.69

Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression. EMBO J (2000) 2.66

Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. J Biol Chem (1999) 2.65

Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy. Cancer Res (1999) 2.58

Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells. Biochem Biophys Res Commun (1993) 2.56

Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor. Proc Natl Acad Sci U S A (1986) 2.55

Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumors. Am J Pathol (2001) 2.55

Tumor angiogenesis: a quantitative method for histologic grading. J Natl Cancer Inst (1972) 2.52

Cellular transformation and malignancy induced by ras require c-jun. Mol Cell Biol (1996) 2.51

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature (1994) 2.51

Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury. Proc Natl Acad Sci U S A (1993) 2.51

Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J Natl Cancer Inst (1994) 2.50

Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose. J Biol Chem (1986) 2.50

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry (1989) 2.49

Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood (1999) 2.49

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest (1999) 2.48

Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy. J Exp Med (1997) 2.47