Published in Scott Med J on June 01, 1992
Nucleotide sequence of bacteriophage phi X174 DNA. Nature (1977) 95.69
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care (1997) 23.95
Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors. Methods Enzymol (1983) 17.47
Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template. DNA (1984) 14.55
The nucleotide sequence of bacteriophage phiX174. J Mol Biol (1978) 13.55
Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA. Nucleic Acids Res (1982) 13.52
A general method for defining restriction enzyme cleavage and recognition sites. Methods Enzymol (1980) 13.26
Sequence of the gene for iso-1-cytochrome c in Saccharomyces cerevisiae. Cell (1979) 10.86
Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial. Lancet (2009) 7.96
Mutagenesis at a specific position in a DNA sequence. J Biol Chem (1978) 7.56
Report of the Committee on the Genetic Constitution of Chromosomes 7, 8 and 9. Cytogenet Cell Genet (1985) 7.28
The specific non-symmetrical sequence recognized by restriction endonuclease MboII. J Mol Biol (1980) 6.36
Deletion mapping of sequences essential for in vivo transcription of the iso-1-cytochrome c gene. Proc Natl Acad Sci U S A (1981) 6.26
Environmental lead and children's intelligence: a systematic review of the epidemiological evidence. BMJ (1994) 5.55
The sequence of the DNAs coding for the mating-type loci of Saccharomyces cerevisiae. Cell (1981) 5.23
A position effect in the control of transcription at yeast mating type loci. Nature (1981) 5.23
The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence. Cell (1984) 5.10
The alcohol use disorder and associated disabilities interview schedule (AUDADIS): reliability of alcohol and drug modules in a clinical sample. Drug Alcohol Depend (1997) 5.10
Four mating-type genes control sexual differentiation in the fission yeast. EMBO J (1988) 5.00
Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: II. In vitro selection of mutant DNA. Gene (1979) 4.99
14 years of follow-up from the Edinburgh randomised trial of breast-cancer screening. Lancet (1999) 4.80
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron (1999) 4.68
Edinburgh Artery Study: prevalence of asymptomatic and symptomatic peripheral arterial disease in the general population. Int J Epidemiol (1991) 4.67
HIV-1 protease inhibitors. A review for clinicians. JAMA (1997) 4.34
Day care after operations for hernia or varicose veins: a controlled trial. Br J Surg (1978) 4.30
Work system design for patient safety: the SEIPS model. Qual Saf Health Care (2006) 4.21
How biomedical investigators use library books. Bull Med Libr Assoc (1966) 4.20
Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart). Circulation (1998) 3.99
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83
Report of the committee on the genetic constitution of chromosomes 9 and 10. Cytogenet Cell Genet (1989) 3.79
Familial Hypercholesterolaemia Regression Study: a randomised trial of low-density-lipoprotein apheresis. Lancet (1995) 3.74
Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1980) 3.62
Undergraduate research. Genomics Education Partnership. Science (2008) 3.45
Identification and isolation of the yeast cytochrome c gene. Cell (1978) 3.39
The mapping and sequence determination of the single site in phiX174am3 replicative form DNA cleaved by restriction endonuclease Pst I. FEBS Lett (1976) 3.31
Twelve-year comparison of a Bjork-Shiley mechanical heart valve with porcine bioprostheses. N Engl J Med (1991) 3.31
Anticoagulation for three versus six months in patients with deep vein thrombosis or pulmonary embolism, or both: randomised trial. BMJ (2007) 3.26
Prostate Testing for Cancer and Treatment (ProtecT) feasibility study. Health Technol Assess (2003) 3.25
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet (1999) 3.25
Mutations of the yeast SUP4 tRNATyr locus: transcription of the mutant genes in vitro. Cell (1980) 3.24
Management of acute stroke in the elderly: preliminary results of a controlled trial. Br Med J (1980) 3.15
Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis. Proc Natl Acad Sci U S A (1989) 3.13
The base-pairing specificity of cellulose-pdT9. Nucleic Acids Res (1975) 3.11
The Epstein-Barr virus BMLF1 promoter contains an enhancer element that is responsive to the BZLF1 and BRLF1 transactivators. J Virol (1989) 3.11
In vitro mutation analysis of the mating-type locus in yeast. Cell (1981) 3.09
Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: I. Optimum conditions and minimum ologodeoxyribonucleotide length. Gene (1979) 3.05
Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nat Genet (1994) 2.93
Characterization of a short, cis-acting DNA sequence which conveys cell cycle stage-dependent transcription in Saccharomyces cerevisiae. Mol Cell Biol (1991) 2.91
Multisystem involvement in chronic liver disease. Studies on the incidence and pathogenesis. Am J Med (1973) 2.88
Nucleotide sequence of the yeast alcohol dehydrogenase II gene. J Biol Chem (1983) 2.82
Structure of the 3' hairpin termini of four rodent parvovirus genomes: nucleotide sequence homology at origins of DNA replication. Cell (1979) 2.78
Randomised controlled trial of conservation therapy for breast cancer: 6-year analysis of the Scottish trial. Scottish Cancer Trials Breast Group. Lancet (1996) 2.78
Uptake and acceptability of antenatal HIV testing: randomised controlled trial of different methods of offering the test. BMJ (1998) 2.73
In vitro mutagenesis. Annu Rev Genet (1985) 2.72
Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation. Mol Cell Biol (1988) 2.70
Management of acute stroke in the elderly: follow-up of a controlled trial. Br Med J (1980) 2.67
Hormone replacement therapy and breast cancer: what are the facts? Med J Aust (1995) 2.66
Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding. Nature (1982) 2.63
Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle. J Biol Chem (1994) 2.62
Treatment decision-making at the end of life: a survey of Australian doctors' attitudes towards patients' wishes and euthanasia. Med J Aust (1996) 2.59
Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template. Methods Enzymol (1987) 2.59
British Thoracic Society Sarcoidosis study: effects of long term corticosteroid treatment. Thorax (1996) 2.58
DNA sequences of two yeast promoter-up mutants. Nature (1983) 2.50
Regional gene assignment of human porphobilinogen deaminase and esterase A4 to chromosome 11q23 leads to 11qter. Proc Natl Acad Sci U S A (1981) 2.50
How white and African Americans view their health and social problems. Different experiences, different expectations. JAMA (1995) 2.48
Psychiatric Research Interview for Substance and Mental Disorders (PRISM): reliability for substance abusers. Am J Psychiatry (1996) 2.47
The prevalence of diabetic impotence. Diabetologia (1980) 2.47
Nucleotide sequence of salmon testes and salmon liver cytoplasmic initiator tRNA. Cell (1975) 2.46
Cryptosporidiosis in hospital patients with gastroenteritis. Am J Trop Med Hyg (1983) 2.45
The role of emotionality and regulation in children's social functioning: a longitudinal study. Child Dev (1995) 2.43
The DNA sequence and biological annotation of human chromosome 1. Nature (2006) 2.42
Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff. Mol Cell Biol (2000) 2.41
Transcription initiation of the Saccharomyces cerevisiae iso-1-cytochrome c gene. Multiple, independent T-A-T-A sequences. J Mol Biol (1986) 2.36
Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region. Mol Cell Biol (1986) 2.36
The sequence of a region of bacteriophage phiX174 DNA coding for parts of genes A and B. J Mol Biol (1977) 2.33
Cloning of several cDNA segments coding for human liver proteins. EMBO J (1983) 2.32
Evidence of activity-dependent withdrawal of corticospinal projections during human development. Neurology (2001) 2.32
Elective versus symptomatic antibiotic treatment in cystic fibrosis patients with chronic Pseudomonas infection of the lungs. Thorax (2000) 2.31
The relations of emotionality and regulation to dispositional and situational empathy-related responding. J Pers Soc Psychol (1994) 2.31
Management of the axilla in operable breast cancer treated by breast conservation: a randomized clinical trial. Edinburgh Breast Unit. Br J Surg (2000) 2.30
The 3' terminal sequence of chicken ovalbumin messenger RNA and its comparison with other messenger RNA molecules. J Mol Biol (1976) 2.29
A numerical prognostic index for clinical use in identification of poor-risk patients with Hodgkin's disease at diagnosis. The Scotland and Newcastle Lymphoma Group (SNLG) Therapy Working Party. Leuk Lymphoma (1992) 2.23
Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer. Proc Natl Acad Sci U S A (2000) 2.23
Putting on the style: what patients think of the way their doctor dresses. Br J Gen Pract (1991) 2.23
Detection of herpesvirus DNA in the large intestine of patients with ulcerative colitis and Crohn's disease using the nested polymerase chain reaction. J Med Virol (1992) 2.22
International Morquio A Registry: clinical manifestation and natural course of Morquio A disease. J Inherit Metab Dis (2007) 2.21
Mutagenesis of Fujinami sarcoma virus: evidence that tyrosine phosphorylation of P130gag-fps modulates its biological activity. Cell (1984) 2.18
Laparoscopic total mesorectal excision (TME) for rectal cancer surgery: long-term outcomes. Surg Endosc (2003) 2.18
Macrophage migration inhibitory factor in rheumatoid arthritis: evidence of proinflammatory function and regulation by glucocorticoids. Arthritis Rheum (1999) 2.17
A comparison of dermatologists', surgeons' and general practitioners' surgical management of cutaneous melanoma. Br J Dermatol (2004) 2.14
Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding nitrate reductase, a metalloflavoprotein with three functional domains. Proc Natl Acad Sci U S A (1988) 2.12
Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis. Cell (1984) 2.12
Uncoupling Phosphorylation in Spinach Chloroplasts by Absence of Cations. Plant Physiol (1962) 2.12
Multicystic, peritoneal mesothelioma: a report with electron microscopy of a case mimicking intra-abdominal cystic hygroma (lymphangioma). Cancer (1979) 2.11