Published in Mol Cell Biochem on November 01, 2005
Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol (2007) 2.59
Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol (2006) 1.77
Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions. Cancer Res (2008) 1.26
Substrate profile and metal-ion selectivity of human divalent metal-ion transporter-1. J Biol Chem (2012) 1.24
Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: short and long-term studies in mice. Nanotoxicology (2010) 1.20
Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. J Biol Chem (2009) 1.17
Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium. Metallomics (2012) 1.12
Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci (2011) 1.10
The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals. Free Radic Biol Med (2012) 1.08
Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals (2008) 1.04
Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol (2008) 1.00
The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II). Free Radic Biol Med (2007) 0.97
Elucidating the mechanisms of nickel compound uptake: a review of particulate and nano-nickel endocytosis and toxicity. Toxicol Appl Pharmacol (2011) 0.94
Nickel and the microbial toxin, MALP-2, stimulate proangiogenic mediators from human lung fibroblasts via a HIF-1alpha and COX-2-mediated pathway. Toxicol Sci (2008) 0.88
MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells. Cell Death Dis (2014) 0.84
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. J Biol Chem (2012) 0.83
Mitochondrial Ca2+ uptake from plasma membrane Cav3.2 protein channels contributes to ischemic toxicity in PC12 cells. J Biol Chem (2013) 0.80
Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein. Toxicol Sci (2008) 0.79
Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells. Int J Oncol (2013) 0.79
Competitive binding of Fe3+, Cr3+, and Ni2+ to transferrin. J Biol Inorg Chem (2011) 0.77
Toxicogenomic effect of nickel and beyond. Arch Toxicol (2014) 0.77
Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol (2006) 4.71
Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium. Metallomics (2009) 1.96
Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc Natl Acad Sci U S A (2008) 1.93
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res (2006) 1.78
Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol (2006) 1.77
Molecular mechanisms of arsenic carcinogenesis. Mol Cell Biochem (2004) 1.66
Arsenite alters global histone H3 methylation. Carcinogenesis (2008) 1.53
The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol (2002) 1.48
Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese. Biochem Pharmacol (2003) 1.48
Epigenetics and the environment. Ann N Y Acad Sci (2003) 1.47
NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states. Carcinogenesis (2007) 1.47
Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis (2006) 1.32
Iron and iron-responsive proteins in the cardiomyopathy of Friedreich's ataxia. Cerebellum (2006) 1.28
Phosphorylation of H3S10 blocks the access of H3K9 by specific antibodies and histone methyltransferase. Implication in regulating chromatin dynamics and epigenetic inheritance during mitosis. J Biol Chem (2008) 1.27
The dentate nucleus in Friedreich's ataxia: the role of iron-responsive proteins. Acta Neuropathol (2007) 1.27
Iron Imports. II. Iron uptake at the apical membrane in the intestine. Am J Physiol Gastrointest Liver Physiol (2005) 1.27
The potential protective effects of taurine on coronary heart disease. Atherosclerosis (2009) 1.27
Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions. Cancer Res (2008) 1.26
Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators. Am J Physiol Gastrointest Liver Physiol (2008) 1.23
Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol Appl Pharmacol (2009) 1.23
Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel. Environ Health Perspect (2011) 1.20
Nickel carcinogenesis: epigenetics and hypoxia signaling. Mutat Res (2005) 1.19
DMT1: which metals does it transport? Biol Res (2006) 1.19
Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase. Cancer Res (2010) 1.18
JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res (2010) 1.18
Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. J Biol Chem (2009) 1.17
Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol Carcinog (2006) 1.17
Covalent modifications of histones during mitosis and meiosis. Cell Cycle (2009) 1.16
Histone modifications and cancer: biomarkers of prognosis? Am J Cancer Res (2012) 1.15
Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway. Carcinogenesis (2008) 1.14
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis (2010) 1.14
Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res (2004) 1.13
Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium. Metallomics (2012) 1.12
Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium. Toxicol Appl Pharmacol (2009) 1.12
Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C. Cancer Res (2002) 1.09
Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. Toxicol Appl Pharmacol (2003) 1.08
The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals. Free Radic Biol Med (2012) 1.08
Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol Appl Pharmacol (2004) 1.07
Carcinogenic effect of nickel compounds. Mol Cell Biochem (2005) 1.07
Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter. Cancer Res (2007) 1.07
Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. Neurotoxicology (2002) 1.06
Detection of intracellular iron by its regulatory effect. Am J Physiol Cell Physiol (2004) 1.06
Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals (2008) 1.04
TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2005) 1.04
The iron cycle and oxidative stress in the lung. Free Radic Biol Med (2004) 1.04
Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway. J Biol Chem (2006) 1.03
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells. J Cell Biol (2004) 1.03
Molecular responses to hypoxia-inducible factor 1α and beyond. Mol Pharmacol (2014) 1.03
Comparison of gene expression profiles in chromate transformed BEAS-2B cells. PLoS One (2011) 1.03
The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res (2003) 1.02
Analysis of the hypoxia-sensing pathway in Drosophila melanogaster. Biochem J (2006) 1.01
Nutritionally mediated oxidative stress and inflammation. Oxid Med Cell Longev (2013) 1.01
Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity. Toxicol Appl Pharmacol (2007) 1.00
Hypoxia induces changes in expression of isoforms of the divalent metal transporter (DMT1) in rat pheochromocytoma (PC12) cells. Biochem Pharmacol (2005) 1.00
Mechanisms of c-myc degradation by nickel compounds and hypoxia. PLoS One (2009) 0.99
Associations between arsenic exposure and global posttranslational histone modifications among adults in Bangladesh. Cancer Epidemiol Biomarkers Prev (2012) 0.99
Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics (2012) 0.97
Essential role of ROS-mediated NFAT activation in TNF-alpha induction by crystalline silica exposure. Am J Physiol Lung Cell Mol Physiol (2006) 0.97
Basic mechanics of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis. Crit Rev Toxicol (2013) 0.97
Altered N-myc downstream-regulated gene 1 protein expression in African-American compared with caucasian prostate cancer patients. Clin Cancer Res (2004) 0.97
Effects of nickel treatment on H3K4 trimethylation and gene expression. PLoS One (2011) 0.96
Fluorescent tracking of nickel ions in human cultured cells. Toxicol Appl Pharmacol (2006) 0.96
The full-length unprocessed hedgehog protein is an active signaling molecule. J Biol Chem (2009) 0.95
Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha. J Biol Chem (2010) 0.94
Elucidating the mechanisms of nickel compound uptake: a review of particulate and nano-nickel endocytosis and toxicity. Toxicol Appl Pharmacol (2011) 0.94
Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes. Toxicol Appl Pharmacol (2006) 0.93
Transport of divalent transition-metal ions is lost in small-intestinal tissue of b/b Belgrade rats. Biochemistry (2005) 0.93
A genome-wide screen in Saccharomyces cerevisiae reveals pathways affected by arsenic toxicity. Genomics (2009) 0.93
Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation. J Cell Physiol (2009) 0.92
Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis. Blood (2010) 0.92
Divalent metal transporter-1 decreases metal-related injury in the lung. Am J Physiol Lung Cell Mol Physiol (2005) 0.92
Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway. J Biol Chem (2006) 0.92
Molecular mechanisms in nickel carcinogenesis: modeling Ni(II) binding site in histone H4. Environ Health Perspect (2002) 0.91
Heterochromatinization as a potential mechanism of nickel-induced carcinogenesis. Biochemistry (2009) 0.91
Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. Mol Pharmacol (2003) 0.91
JNK1, but not JNK2, is required for COX-2 induction by nickel compounds. Carcinogenesis (2006) 0.91
Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2002) 0.91
Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis. Cancer Cell Int (2010) 0.91
Activation of nuclear factor-kappaB and not activator protein-1 in cellular response to nickel compounds. Environ Health Perspect (2002) 0.90
Effect of soluble nickel on cellular energy metabolism in A549 cells. Exp Biol Med (Maywood) (2006) 0.90
Differential role of hydrogen peroxide in UV-induced signal transduction. Mol Cell Biochem (2002) 0.90
Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma. Invest New Drugs (2009) 0.89
Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway. Toxicol Appl Pharmacol (2008) 0.89
The effect of exposure to carcinogenic metals on histone tail modifications and gene expression in human subjects. J Trace Elem Med Biol (2012) 0.89
Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells. Mutat Res (2006) 0.88
Exposure to chromium (VI) in the drinking water increases susceptibility to UV-induced skin tumors in hairless mice. Toxicol Appl Pharmacol (2004) 0.88
Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites. Carcinogenesis (2005) 0.88