Published in Toxicol Appl Pharmacol on April 17, 2009
Environmental chemical exposures and human epigenetics. Int J Epidemiol (2011) 1.97
Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium. Metallomics (2009) 1.96
Chromium in drinking water: sources, metabolism, and cancer risks. Chem Res Toxicol (2011) 1.34
The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal (2011) 1.24
Inhalable metal-rich air particles and histone H3K4 dimethylation and H3K9 acetylation in a cross-sectional study of steel workers. Environ Health Perspect (2011) 1.24
Chromium genotoxicity: A double-edged sword. Chem Biol Interact (2010) 1.14
Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium. Metallomics (2012) 1.12
Environmental epigenetics in metal exposure. Epigenetics (2011) 1.08
The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals. Free Radic Biol Med (2012) 1.08
Developmental neurotoxicants in e-waste: an emerging health concern. Environ Health Perspect (2010) 1.07
Comparison of gene expression profiles in chromate transformed BEAS-2B cells. PLoS One (2011) 1.03
Application of the U.S. EPA mode of action Framework for purposes of guiding future research: a case study involving the oral carcinogenicity of hexavalent chromium. Toxicol Sci (2010) 1.00
Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9. J Biol Chem (2010) 0.97
Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: implications for carcinogenic modes of action. Toxicol Sci (2011) 0.94
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Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation. Carcinogenesis (2013) 0.92
Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges. Front Genet (2014) 0.90
Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels. Mutagenesis (2012) 0.90
Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1. Toxicol Appl Pharmacol (2012) 0.88
Alzheimer's disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics. Curr Alzheimer Res (2012) 0.86
Role of DNA methylation in cell cycle arrest induced by Cr (VI) in two cell lines. PLoS One (2013) 0.85
Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans. Crit Rev Toxicol (2013) 0.84
Epigenetic Contributions to the Relationship between Cancer and Dietary Intake of Nutrients, Bioactive Food Components, and Environmental Toxicants. Front Genet (2012) 0.82
Cytogenomics of hexavalent chromium (Cr 6+) exposed cells: a comprehensive review. Indian J Med Res (2014) 0.80
Cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity. Toxicol Sci (2015) 0.79
Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects. Clin Epigenetics (2012) 0.79
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Traffic-derived particulate matter exposure and histone H3 modification: A repeated measures study. Environ Res (2016) 0.77
Involvement of p53 mutation and mismatch repair proteins dysregulation in NNK-induced malignant transformation of human bronchial epithelial cells. Biomed Res Int (2014) 0.76
Histone Methylation in Nickel-Smelting Industrial Workers. PLoS One (2015) 0.76
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Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB. Oncotarget (2016) 0.75
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Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature (2002) 9.51
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JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell (2006) 5.54
Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication. Genes Dev (2006) 5.15
Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet (2003) 4.56
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59
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Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island. Cancer Cell (2007) 3.15
Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol (2003) 2.72
Lung cancer among workers in chromium chemical production. Am J Ind Med (2000) 2.55
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Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis (2007) 2.27
Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center. J Biol Chem (2003) 2.25
Toxicity and carcinogenicity of chromium compounds in humans. Crit Rev Toxicol (2006) 2.24
Importance of chromium-DNA adducts in mutagenicity and toxicity of chromium(VI). Chem Res Toxicol (2005) 1.99
Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol (2006) 1.77
Emerging connections between DNA methylation and histone acetylation. Cell Mol Life Sci (2001) 1.57
Mechanisms of chromium toxicity, carcinogenicity and allergenicity: review of the literature from 1985 to 2000. Hum Exp Toxicol (2001) 1.56
Arsenite alters global histone H3 methylation. Carcinogenesis (2008) 1.53
Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells. Mutat Res (2005) 1.40
Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX. Carcinogenesis (2004) 1.37
Mismatch repair proteins are activators of toxic responses to chromium-DNA damage. Mol Cell Biol (2005) 1.32
Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis (2006) 1.32
Reaction of chromium(VI) with ascorbate produces chromium(V), chromium(IV), and carbon-based radicals. Chem Res Toxicol (1994) 1.31
Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. Mol Cell Biol (2007) 1.31
Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair. Nucleic Acids Res (2006) 1.28
Oxidative stress and apoptosis in metal ion-induced carcinogenesis. Free Radic Biol Med (2004) 1.25
Nickel carcinogenesis: epigenetics and hypoxia signaling. Mutat Res (2005) 1.19
Cellular vitamin C increases chromate toxicity via a death program requiring mismatch repair but not p53. Carcinogenesis (2007) 1.19
Microsatellite instability and protein expression of the DNA mismatch repair gene, hMLH1, of lung cancer in chromate-exposed workers. Mol Carcinog (2005) 1.13
Carcinogenicity and mutagenicity of chromium compounds: the association between bronchial metaplasia and neoplasia. Carcinogenesis (1986) 1.11
Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin. J Biol Chem (2003) 1.10
Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. Toxicol Appl Pharmacol (2003) 1.08
The role of chromium(V) in the mechanism of chromate-induced oxidative DNA damage and cancer. J Environ Pathol Toxicol Oncol (2000) 1.08
The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer. Lung Cancer (2006) 1.03
Histone demethylation by hydroxylation: chemistry in action. ACS Chem Biol (2006) 1.01
Chromate-induced epimutations in mammalian cells. Environ Health Perspect (2002) 0.98
Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage. Biochem J (2002) 0.96
Ascorbate is a pro-oxidant in chromium-treated human lung cells. Mutat Res (2006) 0.95
Genetic and DNA-methylation changes induced by potassium dichromate in Brassica napus L. Chemosphere (2004) 0.94
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Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines. World J Gastroenterol (2007) 0.87
Identification of human cell responses to hexavalent chromium. Environ Mol Mutagen (2007) 0.87
Gene expression profile in response to chromium-induced cell stress in A549 cells. Mol Cell Biochem (2001) 0.86
Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. Toxicol Appl Pharmacol (2003) 0.86
Selective induction of gene expression in rat lung by hexavalent chromium. Mol Carcinog (2002) 0.85
hMLH1 promoter methylation and silencing in primary endometrial cancers are associated with specific alterations in MBDs occupancy and histone modifications. Gynecol Oncol (2006) 0.83
Alterations in the prooxidant and antioxidant status of human leukemic T-lymphocyte MOLT4 cells treated with potassium chromate. Mol Cell Biochem (1995) 0.77
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev (2007) 5.83
Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol (2006) 4.71
The draft genome of a diploid cotton Gossypium raimondii. Nat Genet (2012) 3.18
Adaptive evolution of UGT2B17 copy-number variation. Am J Hum Genet (2008) 2.58
A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol (2012) 2.54
Principal axis-based correspondence between multiple cameras for people tracking. IEEE Trans Pattern Anal Mach Intell (2006) 2.47
Viral evolution as a tool to improve the tetracycline-regulated gene expression system. J Biol Chem (2004) 2.06
p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell (2012) 2.04
NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. Mol Cell (2004) 2.02
Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J Biol Chem (2001) 1.97
Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium. Metallomics (2009) 1.96
Requirements for efficient correction of ΔF508 CFTR revealed by analyses of evolved sequences. Cell (2012) 1.81
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res (2006) 1.78
Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol (2006) 1.77
Molecular mechanisms of arsenic carcinogenesis. Mol Cell Biochem (2004) 1.66
Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia. Ann Neurol (2005) 1.65
Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype. J Biol Chem (2007) 1.56
Variability of myocardial ischemic responses to mental versus exercise or adenosine stress in patients with coronary artery disease. J Nucl Cardiol (2008) 1.55
Arsenite alters global histone H3 methylation. Carcinogenesis (2008) 1.53
Generation of a monkey with MECP2 mutations by TALEN-based gene targeting. Neurosci Bull (2014) 1.52
Levodopa improves motor deficits but can further disrupt cognition in a macaque Parkinson model. Mov Disord (2012) 1.51
Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology (2009) 1.50
Effect of prophylaxis on fungal infection and costs for high-risk liver transplant recipients. Liver Transpl (2007) 1.49
The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol (2002) 1.48
A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype. EMBO J (2008) 1.47
Epigenetics and the environment. Ann N Y Acad Sci (2003) 1.47
NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states. Carcinogenesis (2007) 1.47
Complete genome sequence of the nitrogen-fixing and rhizosphere-associated bacterium Pseudomonas stutzeri strain DSM4166. J Bacteriol (2011) 1.46
Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population. Rheumatol Int (2012) 1.45
L-DOPA impairs proteasome activity in parkinsonism through D1 dopamine receptor. J Neurosci (2012) 1.43
Mental stress-induced myocardial ischemia in coronary artery disease patients with left ventricular dysfunction. J Nucl Cardiol (2007) 1.43
Repetitive oocyte donation does not decrease serum anti-Müllerian hormone levels. Fertil Steril (2009) 1.42
Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. Gastroenterology (2009) 1.37
RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's disease. J Neurosci (2007) 1.35
A comparison of the tube forming potentials of early and late endothelial progenitor cells. Exp Cell Res (2007) 1.32
Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. J Biol Chem (2011) 1.32
Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis (2006) 1.32
Insect-Specific microRNA Involved in the Development of the Silkworm Bombyx mori. PLoS One (2009) 1.31
Phosphorylation of H3S10 blocks the access of H3K9 by specific antibodies and histone methyltransferase. Implication in regulating chromatin dynamics and epigenetic inheritance during mitosis. J Biol Chem (2008) 1.27
The potential protective effects of taurine on coronary heart disease. Atherosclerosis (2009) 1.27
Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions. Cancer Res (2008) 1.26
Retinopathy online challenge: automatic detection of microaneurysms in digital color fundus photographs. IEEE Trans Med Imaging (2009) 1.26
Exosomes containing glycoprotein 350 released by EBV-transformed B cells selectively target B cells through CD21 and block EBV infection in vitro. J Immunol (2010) 1.24
Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease. Sci Transl Med (2010) 1.23
accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca2+ pump SERCA1. Development (2004) 1.23
Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol Appl Pharmacol (2009) 1.23
A mind-body program for older adults with chronic low back pain: results of a pilot study. Pain Med (2009) 1.21
Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2. Crit Rev Biochem Mol Biol (2012) 1.20
Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells. Traffic (2010) 1.20
Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel. Environ Health Perspect (2011) 1.20
Nickel carcinogenesis: epigenetics and hypoxia signaling. Mutat Res (2005) 1.19
Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia. Brain (2008) 1.19
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. Nat Genet (2013) 1.19
DMT1: which metals does it transport? Biol Res (2006) 1.19
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest (2011) 1.18
Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase. Cancer Res (2010) 1.18
JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res (2010) 1.18
Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. J Biol Chem (2009) 1.17
Peripheral blood fibrocytes: enhancement of wound healing by cell proliferation, re-epithelialization, contraction, and angiogenesis. Ann Surg (2011) 1.17
Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol Carcinog (2006) 1.17
Covalent modifications of histones during mitosis and meiosis. Cell Cycle (2009) 1.16
Histone modifications and cancer: biomarkers of prognosis? Am J Cancer Res (2012) 1.15
Borate transport and cell growth and proliferation. Not only in plants. Cell Cycle (2005) 1.15
An aqueous route to multicolor photoluminescent carbon dots using silica spheres as carriers. Angew Chem Int Ed Engl (2009) 1.14
Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway. Carcinogenesis (2008) 1.14
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis (2010) 1.14
Evaluation of Dimebon in cellular model of Huntington's disease. Mol Neurodegener (2008) 1.14
Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res (2004) 1.13
Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus. PLoS One (2012) 1.13
Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium. Metallomics (2012) 1.12
Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease. Neurobiol Dis (2008) 1.12
Multicomponent anthrax toxin display and delivery using bacteriophage T4. Vaccine (2006) 1.12
Soluble nickel interferes with cellular iron homeostasis. Mol Cell Biochem (2005) 1.11
Impact of the soak and the malt on the physicochemical properties of the sorghum starches. Int J Mol Sci (2010) 1.11
Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs. Dev Cell (2013) 1.11
Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo. Dev Biol (2003) 1.09
Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C. Cancer Res (2002) 1.09
Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia. PLoS One (2010) 1.08
Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. Toxicol Appl Pharmacol (2003) 1.08
A new mode of Ca2+ signaling by G protein-coupled receptors: gating of IP3 receptor Ca2+ release channels by Gbetagamma. Curr Biol (2003) 1.08
The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals. Free Radic Biol Med (2012) 1.08
Visible light photocatalytic H₂-production activity of CuS/ZnS porous nanosheets based on photoinduced interfacial charge transfer. Nano Lett (2011) 1.07
Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol Appl Pharmacol (2004) 1.07
Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia. J Neurosci (2006) 1.07
Carcinogenic effect of nickel compounds. Mol Cell Biochem (2005) 1.07
The promotion of bone regeneration by nanofibrous hydroxyapatite/chitosan scaffolds by effects on integrin-BMP/Smad signaling pathway in BMSCs. Biomaterials (2013) 1.07
Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter. Cancer Res (2007) 1.07
Altered D(1) dopamine receptor trafficking in parkinsonian and dyskinetic non-human primates. Neurobiol Dis (2007) 1.06
Anti-inflammation effects of picroside 2 in cerebral ischemic injury rats. Behav Brain Funct (2010) 1.05
A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys. Neurobiol Dis (2010) 1.04
Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals (2008) 1.04
Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis. J Exp Clin Cancer Res (2012) 1.03