Published in Curr Biol on February 17, 2004
The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol (2011) 7.40
Mitochondrial dynamics and apoptosis. Genes Dev (2008) 6.07
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell (2008) 5.67
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci U S A (2008) 4.89
Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep (2007) 4.73
Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci (2008) 4.32
The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J Cell Biol (2007) 3.83
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J Cell Biol (2007) 3.61
Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One (2008) 3.59
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci U S A (2011) 3.49
MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology. EMBO Rep (2006) 3.19
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J (2014) 2.93
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem (2009) 2.64
Function and regulation of SUMO proteases. Nat Rev Mol Cell Biol (2012) 2.55
A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J (2006) 2.52
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J (2010) 2.12
An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship. EMBO J (2010) 2.01
Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction. Nat Rev Neurosci (2007) 1.97
SUMOsp: a web server for sumoylation site prediction. Nucleic Acids Res (2006) 1.88
MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep (2009) 1.80
The molecular mechanism and cellular functions of mitochondrial division. Biochim Biophys Acta (2008) 1.67
Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic Biol Med (2012) 1.67
Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases. Brain Res Rev (2010) 1.64
Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep (2010) 1.61
Mitochondrial morphology and cardiovascular disease. Cardiovasc Res (2010) 1.51
Mitochondrial fusion and division: Regulation and role in cell viability. Semin Cell Dev Biol (2009) 1.51
Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochim Biophys Acta (2009) 1.49
Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells. J Mol Cell Cardiol (2009) 1.48
Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. J Cell Sci (2010) 1.47
SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia. EMBO J (2013) 1.47
Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology. Kidney Int (2013) 1.46
Mitochondrial dynamics in diabetes. Antioxid Redox Signal (2010) 1.46
SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. FASEB J (2009) 1.45
Targets and consequences of protein SUMOylation in neurons. Brain Res Rev (2010) 1.44
Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes. Am J Physiol Heart Circ Physiol (2011) 1.41
Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Proc Natl Acad Sci U S A (2010) 1.40
Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis. J Biol Chem (2009) 1.37
Role for SUMO modification in facilitating transcriptional repression by BKLF. Mol Cell Biol (2005) 1.31
Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine. Chem Biol (2010) 1.30
Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology. Proc Natl Acad Sci U S A (2006) 1.30
Two close, too close: sarcoplasmic reticulum-mitochondrial crosstalk and cardiomyocyte fate. Circ Res (2010) 1.24
A systematic characterization of mitochondrial proteome from human T leukemia cells. Mol Cell Proteomics (2004) 1.24
Mitochondrial regulation of cell cycle and proliferation. Antioxid Redox Signal (2012) 1.19
Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism. Bioessays (2010) 1.12
Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Alzheimers Dis (2013) 1.11
Regulation of mitochondrial fission by intracellular Ca2+ in rat ventricular myocytes. Biochim Biophys Acta (2010) 1.10
Mitochondrial biogenesis and turnover. Cell Calcium (2008) 1.10
Mitochondrial dynamics and mitochondrial quality control. Redox Biol (2014) 1.09
SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. Diabetes (2011) 1.09
Mitochondrial fragmentation is involved in methamphetamine-induced cell death in rat hippocampal neural progenitor cells. PLoS One (2009) 1.09
Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. Genome Res (2007) 1.07
Organellar vs cellular control of mitochondrial dynamics. Semin Cell Dev Biol (2010) 1.07
Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. Mol Biol Cell (2011) 1.07
Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species. Free Radic Biol Med (2011) 1.06
The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics. Int J Biochem Cell Biol (2009) 1.05
Organelle dynamics and dysfunction: A closer link between peroxisomes and mitochondria. J Inherit Metab Dis (2008) 1.05
Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease. Neurobiol Dis (2012) 1.05
Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction. Physiol Rev (2014) 1.02
Functional characterization of phosphorylation sites in dynamin-related protein 1. Methods Enzymol (2009) 0.99
Mitochondrial morphology in metabolic diseases. Antioxid Redox Signal (2012) 0.98
A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease. J Alzheimers Dis (2010) 0.98
Death by committee: organellar trafficking and communication in apoptosis. Traffic (2009) 0.97
MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. Elife (2014) 0.97
Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells. Int J Med Sci (2011) 0.96
Mitochondrial function in vascular endothelial cell in diabetes. J Smooth Muscle Res (2012) 0.96
Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies. Drugs Aging (2010) 0.95
CRISPR/Cas9-mediated endogenous protein tagging for RESOLFT super-resolution microscopy of living human cells. Sci Rep (2015) 0.94
Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates. Cell Mol Life Sci (2012) 0.93
SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors. J Cell Biol (2012) 0.93
The mitochondrial proteome: a dynamic functional program in tissues and disease states. Environ Mol Mutagen (2010) 0.93
Mitochondrial dynamics and neurodegeneration. Curr Neurol Neurosci Rep (2009) 0.93
Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease? Mol Neurobiol (2010) 0.92
Physiological and pathological significance of dynamin-related protein 1 (drp1)-dependent mitochondrial fission in the nervous system. Exp Neurobiol (2013) 0.92
Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. PLoS One (2012) 0.90
SUMO and Alzheimer's disease. Neuromolecular Med (2013) 0.89
A dynamin-related protein required for nuclear remodeling in Tetrahymena. Curr Biol (2008) 0.89
Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration. PLoS Genet (2014) 0.87
Down-regulation of mortalin exacerbates Aβ-mediated mitochondrial fragmentation and dysfunction. J Biol Chem (2013) 0.86
Proteins that fuse and fragment mitochondria in apoptosis: con-fissing a deadly con-fusion? J Bioenerg Biomembr (2005) 0.86
Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis. Biochim Biophys Acta (2015) 0.86
Cardiac function and disease: emerging role of small ubiquitin-related modifier. Wiley Interdiscip Rev Syst Biol Med (2010) 0.85
Emerging roles of SUMO modification in arthritis. Gene (2010) 0.84
TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. PLoS One (2012) 0.84
Mitochondrial protein quality control in health and disease. Br J Pharmacol (2014) 0.84
Alterations in Mitochondrial Quality Control in Alzheimer's Disease. Front Cell Neurosci (2016) 0.83
A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases. J Biol Chem (2013) 0.82
Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction. Conference on Mitochondrial Assembly and Dynamics in Health and Disease. EMBO Rep (2009) 0.82
The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention. Curr Pharm Des (2011) 0.81
DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals. Biomolecules (2012) 0.80
CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death. Hum Mol Genet (2015) 0.79
Mitochondrial dynamics in neuronal injury, development and plasticity. J Cell Sci (2017) 0.79
Mitochondrial dynamics in diabetic cardiomyopathy. Antioxid Redox Signal (2015) 0.79
New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases. J Mol Med (Berl) (2015) 0.79
Dynamin-related protein 1 as a therapeutic target in cardiac arrest. J Mol Med (Berl) (2015) 0.79
Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction. Front Aging Neurosci (2015) 0.78
Novel role of androgens in mitochondrial fission and apoptosis. Mol Cancer Res (2011) 0.78
Mitochondrial remodeling: Rearranging, recycling, and reprogramming. Cell Calcium (2016) 0.77
Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. Mol Endocrinol (2015) 0.77
The SUMO arena goes mitochondrial with MAPL. EMBO Rep (2009) 0.76
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J Cell Biol (2007) 3.61
Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers. Curr Biol (2008) 2.67
Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization. J Biol Chem (2005) 2.57
A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr Biol (2012) 2.45
Vps35 mediates vesicle transport between the mitochondria and peroxisomes. Curr Biol (2010) 1.82
MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep (2009) 1.80
Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology. Proc Natl Acad Sci U S A (2006) 1.30
A novel cell-free mitochondrial fusion assay amenable for high-throughput screenings of fusion modulators. BMC Biol (2010) 1.04
Using unsupervised analysis to constrain generalization bounds for support vector classifiers. IEEE Trans Neural Netw (2010) 1.00
Quantum optimization for training support vector machines. Neural Netw (2003) 0.95
Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. J Biol Chem (2011) 0.89
Matrix protein of Vesicular stomatitis virus harbours a cryptic mitochondrial-targeting motif. J Gen Virol (2006) 0.86
The interaction and cellular localization of HSP27 and ERbeta are modulated by 17beta-estradiol and HSP27 phosphorylation. Mol Cell Endocrinol (2007) 0.85
Specific contribution of lamin A and lamin C in the development of laminopathies. Exp Cell Res (2008) 0.85
The dynamics of cardiolipin synthesis post-mitochondrial fusion. Biochim Biophys Acta (2010) 0.82
Mitochondrial dynamics and physiology. Biochim Biophys Acta (2012) 0.80
Trafficking of macromolecules and organelles in cultured Dystonia musculorum sensory neurons is normal. J Comp Neurol (2006) 0.79
Heidi McBride: mitochondria are well connected. J Cell Biol (2014) 0.75
In memoriam: Stewart Charles Whitman (1964-2010). J Lipid Res (2010) 0.75