Published in Nat Rev Mol Cell Biol on December 01, 2012
Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol (2014) 1.74
Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42
Interplay between viruses and host sumoylation pathways. Nat Rev Microbiol (2013) 1.26
Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors. Mol Cell (2014) 1.19
Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways. Nat Struct Mol Biol (2014) 1.16
Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage. Mol Cell (2014) 1.15
Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction. Physiol Rev (2014) 1.02
SUMO chain-induced dimerization activates RNF4. Mol Cell (2014) 0.98
Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation. Cell Death Differ (2014) 0.96
Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc Natl Acad Sci U S A (2014) 0.96
c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4. Cell Cycle (2015) 0.92
SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. Cell Rep (2015) 0.92
Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Genes Dev (2016) 0.91
Mosaic genome of endobacteria in arbuscular mycorrhizal fungi: Transkingdom gene transfer in an ancient mycoplasma-fungus association. Proc Natl Acad Sci U S A (2015) 0.91
The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair. EMBO Rep (2013) 0.91
It takes two to tango: Ubiquitin and SUMO in the DNA damage response. Front Genet (2013) 0.90
Novel mechanisms of endothelial mechanotransduction. Arterioscler Thromb Vasc Biol (2014) 0.89
Starting and stopping SUMOylation. What regulates the regulator? Chromosoma (2013) 0.88
Advances in the development of SUMO specific protease (SENP) inhibitors. Comput Struct Biotechnol J (2015) 0.88
The SUMO system: a master organizer of nuclear protein assemblies. Chromosoma (2013) 0.88
Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration. PLoS Genet (2014) 0.87
Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism. Cell Signal (2014) 0.86
Measuring activity in the ubiquitin-proteasome system: from large scale discoveries to single cells analysis. Cell Biochem Biophys (2013) 0.85
SUMOylation is essential for sex-specific assembly and function of the Caenorhabditis elegans dosage compensation complex on X chromosomes. Proc Natl Acad Sci U S A (2013) 0.85
SUMO-specific proteases/isopeptidases: SENPs and beyond. Genome Biol (2014) 0.85
SUMO Pathway Modulation of Regulatory Protein Binding at the Ribosomal DNA Locus in Saccharomyces cerevisiae. Genetics (2016) 0.85
Analysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during infection. PLoS One (2014) 0.84
Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization. Glia (2014) 0.84
A comprehensive compilation of SUMO proteomics. Nat Rev Mol Cell Biol (2016) 0.84
Emerging roles of sumoylation in the regulation of actin, microtubules, intermediate filaments, and septins. Cytoskeleton (Hoboken) (2015) 0.83
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression. Nat Commun (2015) 0.83
System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability. Mol Cell Proteomics (2015) 0.83
Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. Proc Natl Acad Sci U S A (2014) 0.83
Cystic fibrosis transmembrane conductance regulator degradation: cross-talk between the ubiquitylation and SUMOylation pathways. FEBS J (2013) 0.83
Molecular Circuitry of the SUMO (Small Ubiquitin-like Modifier) Pathway in Controlling Sumoylation Homeostasis and Suppressing Genome Rearrangements. J Biol Chem (2016) 0.82
Emerging role of SUMOylation in plant development. Plant Signal Behav (2013) 0.82
The eukaryotic ancestor had a complex ubiquitin signaling system of archaeal origin. Mol Biol Evol (2014) 0.82
Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4). J Biol Chem (2015) 0.82
Multiple crosstalks between mRNA biogenesis and SUMO. Chromosoma (2013) 0.81
Post-translational modification: A SUMO protease for stress protection. Nat Rev Mol Cell Biol (2013) 0.81
The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function. Mol Biol Cell (2013) 0.81
E2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex. J Biol Chem (2014) 0.81
SUMO-Targeted Ubiquitin Ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin. Mol Biol Cell (2016) 0.80
Kinase-SUMO networks in diabetes-mediated cardiovascular disease. Metabolism (2016) 0.80
Substrate specificity of the ubiquitin and Ubl proteases. Cell Res (2016) 0.80
Analysis of SUMOylated proteins using SUMO-traps. Sci Rep (2013) 0.80
Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast. Nucleic Acids Res (2015) 0.80
An Arabidopsis SUMO E3 Ligase, SIZ1, Negatively Regulates Photomorphogenesis by Promoting COP1 Activity. PLoS Genet (2016) 0.80
Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development. Sci Rep (2016) 0.79
SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle. Diabetes (2015) 0.79
Structural insights into the SENP6 Loop1 structure in complex with SUMO2. Protein Sci (2014) 0.79
SUMOylation of Argonaute-2 regulates RNA interference activity. Biochem Biophys Res Commun (2015) 0.79
The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF). J Biol Chem (2013) 0.79
The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2. PLoS One (2014) 0.79
Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose. J Neurochem (2016) 0.79
The SUMO Protease SENP3 Orchestrates G2-M Transition and Spindle Assembly in Mouse Oocytes. Sci Rep (2015) 0.78
mTOR signaling regulates nucleolar targeting of the SUMO-specific isopeptidase SENP3. Mol Cell Biol (2014) 0.78
Sumoylation of the GTPase Ran by the RanBP2 SUMO E3 Ligase Complex. J Biol Chem (2015) 0.78
The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial-mesenchymal transition in a sumoylation-regulated manner. Cell Death Differ (2015) 0.78
Sumoylation of HDAC2 promotes NF-κB-dependent gene expression. Oncotarget (2015) 0.78
High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification. Sci Rep (2015) 0.78
Interconnection between flowering time control and activation of systemic acquired resistance. Front Plant Sci (2015) 0.78
SUMOylation of Rb enhances its binding with CDK2 and phosphorylation at early G1 phase. Cell Cycle (2016) 0.77
SUMOylation of the ING1b tumor suppressor regulates gene transcription. Carcinogenesis (2014) 0.77
Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases. J Biomol Screen (2013) 0.77
SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation. Protein Cell (2015) 0.77
Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO. Cancers (Basel) (2014) 0.77
SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α. Mol Med Rep (2016) 0.77
Stability of small ubiquitin-like modifier (SUMO) proteases OVERLY TOLERANT TO SALT1 and -2 modulates salicylic acid signalling and SUMO1/2 conjugation in Arabidopsis thaliana. J Exp Bot (2015) 0.77
Characterization of a novel posttranslational modification in polypyrimidine tract-binding proteins by SUMO1. BMB Rep (2014) 0.77
Pli1(PIAS1) SUMO ligase protected by the nuclear pore-associated SUMO protease Ulp1SENP1/2. J Biol Chem (2015) 0.77
Mapping the SUMOylated landscape. FEBS J (2015) 0.77
A Review of Functional Motifs Utilized by Viruses. Proteomes (2016) 0.77
SUMOylation occurs in acute kidney injury and plays a cytoprotective role. Biochim Biophys Acta (2014) 0.77
In Vitro Studies Reveal a Sequential Mode of Chain Processing by the Yeast SUMO (Small Ubiquitin-related Modifier)-specific Protease Ulp2. J Biol Chem (2015) 0.76
Functional characterization of DnSIZ1, a SIZ/PIAS-type SUMO E3 ligase from Dendrobium. BMC Plant Biol (2015) 0.76
Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family. PLoS One (2015) 0.76
Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. J Virol (2016) 0.76
Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis. Neuromolecular Med (2013) 0.76
Sumoylation and transcription regulation at nuclear pores. Chromosoma (2014) 0.76
Wheat gene TaS3 contributes to powdery mildew susceptibility. Plant Cell Rep (2013) 0.76
Sumoylation in Synaptic Function and Dysfunction. Front Synaptic Neurosci (2016) 0.75
Biosynthesis of SUMOylated Proteins in Bacteria Using the Trypanosoma brucei Enzymatic System. PLoS One (2015) 0.75
SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease. Sci Rep (2016) 0.75
SUMOylation of sPRDM16 promotes the progression of acute myeloid leukemia. BMC Cancer (2015) 0.75
Flow signaling and atherosclerosis. Cell Mol Life Sci (2016) 0.75
SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing. PLoS Pathog (2017) 0.75
Genome maintenance in Saccharomyces cerevisiae: the role of SUMO and SUMO-targeted ubiquitin ligases. Nucleic Acids Res (2017) 0.75
Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN. BMC Cancer (2015) 0.75
Divergent signaling via SUMO modification: potential for CFTR modulation. Am J Physiol Cell Physiol (2015) 0.75
SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current. Front Mol Neurosci (2017) 0.75
Adaptive aneuploidy counters a dysregulated SUMO system. Cell Cycle (2016) 0.75
Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism. Elife (2016) 0.75
The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity. Sci Rep (2017) 0.75
SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes. J Ophthalmol (2016) 0.75
Degradation elements coincide with cofactor binding sites in a short-lived transcription factor. Cell Logist (2016) 0.75
Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes. Epigenetics Chromatin (2017) 0.75
Ubiquitin-dependent and independent roles of SUMO in proteostasis. Am J Physiol Cell Physiol (2016) 0.75
GPER1 stimulation alters posttranslational modification of RGSz1 and induces desensitization of 5-HT1A receptor signaling in the rat hypothalamus. Neuroendocrinology (2014) 0.75
Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85
Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast. Mol Cell (2000) 6.39
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature (2003) 6.31
A new protease required for cell-cycle progression in yeast. Nature (1999) 5.44
Nucleophosmin and cancer. Nat Rev Cancer (2006) 4.82
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. Nat Rev Mol Cell Biol (2010) 4.72
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell (2007) 4.46
Origin and function of ubiquitin-like proteins. Nature (2009) 4.22
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
Principles of ubiquitin and SUMO modifications in DNA repair. Nature (2009) 4.10
Modification in reverse: the SUMO proteases. Trends Biochem Sci (2007) 3.84
Specification of SUMO1- and SUMO2-interacting motifs. J Biol Chem (2006) 3.59
Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem (2004) 3.53
System-wide changes to SUMO modifications in response to heat shock. Sci Signal (2009) 3.50
Ubiquitin-like proteins: new wines in new bottles. Gene (2000) 3.46
The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Mol Cell Biol (2000) 3.24
Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission. Curr Biol (2004) 3.21
SUMO promotes HDAC-mediated transcriptional repression. Mol Cell (2004) 2.97
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis. Nature (2012) 2.86
The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Mol Cell (2002) 2.85
SUMO-targeted ubiquitin ligases in genome stability. EMBO J (2007) 2.77
Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem (2004) 2.60
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J (2007) 2.59
SUMO junction-what's your function? New insights through SUMO-interacting motifs. EMBO Rep (2007) 2.58
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell (2010) 2.52
Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation. J Biol Chem (2005) 2.44
Ubiquitin-dependent proteolytic control of SUMO conjugates. J Biol Chem (2007) 2.44
The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeast. J Biol Chem (2003) 2.38
Differential regulation of sentrinized proteins by a novel sentrin-specific protease. J Biol Chem (2000) 2.34
Association of the human SUMO-1 protease SENP2 with the nuclear pore. J Biol Chem (2002) 2.33
A proteome-wide approach identifies sumoylated substrate proteins in yeast. J Biol Chem (2004) 2.31
Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses. J Biol Chem (2004) 2.27
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev (2012) 2.16
Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. J Biol Chem (2006) 2.15
A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex. Structure (2004) 2.15
The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation. J Biol Chem (2007) 2.14
The SUMO protease SENP5 is required to maintain mitochondrial morphology and function. J Cell Sci (2007) 2.12
Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. Mol Cell (2010) 2.10
Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates. Nat Struct Mol Biol (2006) 2.07
Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease. Nucleic Acids Res (1998) 2.06
The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity. J Cell Biol (2003) 1.97
SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev (2012) 1.90
Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae. Genetics (2001) 1.89
SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol (2006) 1.89
The SUMO-specific protease SENP5 is required for cell division. Mol Cell Biol (2006) 1.81
A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase. Eur J Biochem (2000) 1.75
Purification and identification of endogenous polySUMO conjugates. EMBO Rep (2011) 1.72
DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J Biol Chem (2003) 1.72
A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation. Biochem Biophys Res Commun (2005) 1.68
SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. J Cell Biol (2006) 1.67
Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation. Genetics (2001) 1.65
NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem (2003) 1.64
Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins. Nat Cell Biol (2003) 1.63
Identification and characterization of DEN1, a deneddylase of the ULP family. J Biol Chem (2003) 1.62
Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nat Struct Mol Biol (2011) 1.59
The yeast SUMO isopeptidase Smt4/Ulp2 and the polo kinase Cdc5 act in an opposing fashion to regulate sumoylation in mitosis and cohesion at centromeres. Cell Cycle (2009) 1.57
A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. J Biol Chem (2000) 1.56
Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis. Proc Natl Acad Sci U S A (2010) 1.53
Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex. Mol Cell (2010) 1.50
The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem J (2006) 1.49
Identification of sumoylated proteins by systematic immunoprecipitation of the budding yeast proteome. Mol Cell Proteomics (2004) 1.47
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. EMBO Rep (2008) 1.47
Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. J Biol Chem (2008) 1.47
A role for SUMO modification in transcriptional repression and activation. Biochem Soc Trans (2007) 1.46
Reversible SUMOylation of TBL1-TBLR1 regulates β-catenin-mediated Wnt signaling. Mol Cell (2011) 1.45
Novel predicted peptidases with a potential role in the ubiquitin signaling pathway. Cell Cycle (2004) 1.42
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J (2009) 1.41
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells. J Biol Chem (2007) 1.41
Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation. J Biol Chem (2001) 1.40
Genetic analysis connects SLX5 and SLX8 to the SUMO pathway in Saccharomyces cerevisiae. Genetics (2005) 1.40
Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Proc Natl Acad Sci U S A (2010) 1.40
Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis. J Biol Chem (2009) 1.37
Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation. FASEB J (2007) 1.35
Activation of the Slx5-Slx8 ubiquitin ligase by poly-small ubiquitin-like modifier conjugates. J Biol Chem (2008) 1.35
A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Mol Cell (2004) 1.34
Distribution and paralogue specificity of mammalian deSUMOylating enzymes. Biochem J (2010) 1.33
Formation and nuclear export of preribosomes are functionally linked to the small-ubiquitin-related modifier pathway. Traffic (2006) 1.27
Quality control of a transcriptional regulator by SUMO-targeted degradation. Mol Cell Biol (2009) 1.25
Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. Biochem J (2005) 1.25
The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex. EMBO J (2011) 1.24
Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. Mol Cell (2009) 1.22
DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger. J Cell Biol (2012) 1.22
The SUMO protease SENP6 is essential for inner kinetochore assembly. J Cell Biol (2010) 1.21
Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. J Cell Biol (2008) 1.18
DeSUMOylating isopeptidase: a second class of SUMO protease. EMBO Rep (2012) 1.18
Wss1 is a SUMO-dependent isopeptidase that interacts genetically with the Slx5-Slx8 SUMO-targeted ubiquitin ligase. Mol Cell Biol (2010) 1.16
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. EMBO Rep (2012) 1.15
The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint. Mol Cell Biol (2007) 1.13
Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3. Cell Cycle (2008) 1.13
Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. EMBO J (2010) 1.11
NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell (2011) 1.09
SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. Cell Death Differ (2008) 1.09
Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin. Mol Cell Biol (2002) 1.08
Insights into high affinity small ubiquitin-like modifier (SUMO) recognition by SUMO-interacting motifs (SIMs) revealed by a combination of NMR and peptide array analysis. J Biol Chem (2011) 1.06
Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis. J Biol Chem (2010) 1.06
Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression. EMBO J (2011) 1.05
Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins. J Biochem (2000) 1.02
Structural analysis of papain-like NlpC/P60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites. PLoS One (2011) 1.01
A novel mechanism for SUMO system control: regulated Ulp1 nucleolar sequestration. Mol Cell Biol (2010) 0.97
SUMOylation of RORalpha potentiates transcriptional activation function. Biochem Biophys Res Commun (2008) 0.96
Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu Rev Cell Dev Biol (2006) 10.74
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell (2009) 6.16
Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta (2004) 4.54
Diversity of degradation signals in the ubiquitin-proteasome system. Nat Rev Mol Cell Biol (2008) 4.42
Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem (2004) 3.53
A superfamily of protein tags: ubiquitin, SUMO and related modifiers. Trends Biochem Sci (2003) 3.19
Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways. EMBO J (2006) 2.58
Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein. J Biol Chem (2004) 2.41
Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly. Mol Cell (2010) 2.35
Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Nat Cell Biol (2007) 2.32
A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat Struct Mol Biol (2008) 2.20
The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation. J Biol Chem (2007) 2.14
Molecular architecture and assembly of the eukaryotic proteasome. Annu Rev Biochem (2013) 2.04
The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity. J Cell Biol (2003) 1.97
Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell (2009) 1.85
Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature (2006) 1.78
Ubiquitin-dependent degradation of the yeast Mat(alpha)2 repressor enables a switch in developmental state. Genes Dev (2003) 1.76
Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). J Biol Chem (2005) 1.68
Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing. Proc Natl Acad Sci U S A (2005) 1.55
beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J (2007) 1.52
Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability. J Cell Sci (2004) 1.42
An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. Proc Natl Acad Sci U S A (2006) 1.35
Plasticity in eucaryotic 20S proteasome ring assembly revealed by a subunit deletion in yeast. EMBO J (2004) 1.34
A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance. J Cell Biol (2007) 1.29
SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor. Genes Dev (2010) 1.28
Structure-dependent DNA damage and repair in a trinucleotide repeat sequence. Biochemistry (2009) 1.22
Small epitope-linker modules for PCR-based C-terminal tagging in Saccharomyces cerevisiae. Yeast (2009) 1.20
Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis. Biol Chem (2008) 1.16
The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint. Mol Cell Biol (2007) 1.13
A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel. Structure (2009) 1.11
Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II. Hepatology (2008) 1.07
A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor binding. Nat Struct Mol Biol (2011) 1.05
Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion. DNA Repair (Amst) (2011) 1.04
A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function. J Cell Biol (2006) 1.04
Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase. J Cell Biol (2012) 1.03
Order of the proteasomal ATPases and eukaryotic proteasome assembly. Cell Biochem Biophys (2011) 1.03
An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme. J Biol Chem (2011) 1.02
Incorporation of the Rpn12 subunit couples completion of proteasome regulatory particle lid assembly to lid-base joining. Mol Cell (2011) 0.98
The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks. Cell Cycle (2009) 0.97
Essential role of nuclear localization for yeast Ulp2 SUMO protease function. Mol Biol Cell (2009) 0.95
Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit Rev Biochem Mol Biol (2014) 0.92
Ubiquitin signalling: what's in a chain? Nat Cell Biol (2004) 0.92
The short-lived Matalpha2 transcriptional repressor is protected from degradation in vivo by interactions with its corepressors Tup1 and Ssn6. Mol Cell Biol (2006) 0.89
Designed proteins to modulate cellular networks. ACS Chem Biol (2010) 0.89
Analysis of protein ubiquitination. Curr Protoc Protein Sci (2011) 0.88
N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates. Mol Biol Cell (2013) 0.88
Assembly of the 20S proteasome. Biochim Biophys Acta (2013) 0.88
Redundancy and variation in the ubiquitin-mediated proteolytic targeting of a transcription factor. Cell Cycle (2010) 0.88
Introduction to intracellular protein degradation. Chem Rev (2009) 0.87
A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. J Biol Chem (2013) 0.86
Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway. Mol Cell Biol (2011) 0.85
Ulp2 and the DNA damage response: desumoylation enables safe passage through mitosis. Cell Cycle (2007) 0.83
Identification of SUMO-interacting proteins by yeast two-hybrid analysis. Methods Mol Biol (2009) 0.82
Analysis of protein ubiquitination. Curr Protoc Protein Sci (2002) 0.82
Assaying protein ubiquitination in Saccharomyces cerevisiae. Methods Enzymol (2002) 0.82
A WLM protein with SUMO-directed protease activity. Mol Cell Biol (2010) 0.79
NF-kappaB signaling: flipping the switch with polyubiquitin chains. Curr Biol (2004) 0.78
Preparation and characterization of yeast and human desumoylating enzymes. Methods Enzymol (2005) 0.78
Ubiquitin-dependent control of development in Saccharomyces cerevisiae. Curr Opin Microbiol (2004) 0.77
Split-Doa10: a naturally split polytopic eukaryotic membrane protein generated by fission of a nuclear gene. PLoS One (2012) 0.76
A new class of SUMO proteases. EMBO Rep (2012) 0.76
Varshavsky's contributions. Science (2004) 0.75