Published in Proc Natl Acad Sci U S A on November 20, 2006
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci U S A (2008) 4.89
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem (2009) 2.64
PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet (2010) 2.30
Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases. Genome Res (2007) 1.79
Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One (2011) 1.62
Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping. PLoS Genet (2008) 1.25
An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion. Genes Dev (2008) 1.15
Structure and mechanism of intramembrane protease. Semin Cell Dev Biol (2008) 1.09
A novel cell-free mitochondrial fusion assay amenable for high-throughput screenings of fusion modulators. BMC Biol (2010) 1.04
The PARL family of mitochondrial rhomboid proteases. Semin Cell Dev Biol (2010) 1.01
Genome-wide linkage scan and association study of PARL to the expression of LHON families in Thailand. Hum Genet (2010) 0.97
TRAP1 rescues PINK1 loss-of-function phenotypes. Hum Mol Genet (2013) 0.93
Hax1 lacks BH modules and is peripherally associated to heavy membranes: implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis. Cell Death Differ (2009) 0.93
Mitochondrial dynamics and neurodegeneration. Curr Neurol Neurosci Rep (2009) 0.93
Rhomboid domain containing 2 (RHBDD2): a novel cancer-related gene over-expressed in breast cancer. Biochim Biophys Acta (2009) 0.91
Changes in brain gene expression during migration in the white-crowned sparrow. Brain Res Bull (2008) 0.87
The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels. PLoS One (2014) 0.86
The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock. Biochim Biophys Acta (2012) 0.86
The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease. Parkinsons Dis (2012) 0.84
Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes. Nature (2017) 0.83
Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery disease. Hum Genet (2008) 0.81
Structural and mechanistic basis of Parl activity and regulation. Cell Death Differ (2011) 0.80
Nanoparticle-based targeted therapeutics in head-and-neck cancer. Int J Med Sci (2015) 0.79
Plasmids for variable expression of proteins targeted to the mitochondrial matrix or intermembrane space. Cell Logist (2016) 0.76
Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China. Sci Rep (2016) 0.75
The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space. Cell Logist (2017) 0.75
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell (2006) 7.72
Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Annu Rev Genet (2005) 6.03
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51
OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A (2004) 5.34
Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ (2003) 3.75
Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis. Mol Cell (2004) 3.28
Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission. Curr Biol (2004) 3.21
Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. Nature (2003) 3.20
Emerging functions of mammalian mitochondrial fusion and fission. Hum Mol Genet (2005) 2.84
Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem (2003) 2.75
Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization. J Biol Chem (2005) 2.57
Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol (2003) 2.44
Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor. J Cell Biol (2004) 2.36
The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett (2002) 2.30
Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space. EMBO J (2005) 2.27
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. Proc Natl Acad Sci U S A (2004) 1.84
Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology. J Biol Chem (2002) 1.75
Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. Prog Nucleic Acid Res Mol Biol (2001) 1.68
Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion. Biochem Biophys Res Commun (2003) 1.62
Reverse transcription-associated dephosphorylation of hepadnavirus nucleocapsids. Proc Natl Acad Sci U S A (2005) 1.57
Characterization of peptides released from mitochondria: evidence for constant proteolysis and peptide efflux. J Biol Chem (2004) 1.53
The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation. Proc Natl Acad Sci U S A (2002) 1.49
How mitochondria fuse. Curr Opin Cell Biol (2005) 1.47
Indel-based evolutionary distance and mouse-human divergence. Genome Res (2004) 1.47
Stabilization of mitochondrial functions with digitonin. Methods Enzymol (1979) 1.36
Studies on the regulation of the mitochondrial alpha-ketoacid dehydrogenase complexes and their kinases. Adv Enzyme Regul (1997) 1.23
Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs. Proc Natl Acad Sci U S A (2006) 1.21
Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide. J Biol Chem (2004) 1.21
Combined top-down and bottom-up proteomics identifies a phosphorylation site in stem-loop-binding proteins that contributes to high-affinity RNA binding. Proc Natl Acad Sci U S A (2006) 1.20
Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8. J Biol Chem (1999) 1.15
PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2. J Alzheimers Dis (2001) 1.11
Purification and characterization of a substrate protein for mitochondrial ATP-dependent protease in bovine adrenal cortex. J Biochem (1994) 0.93
The cutting edge of mitochondrial fusion. Nat Cell Biol (2003) 0.86
The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J Cell Biol (2007) 3.61
Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission. Curr Biol (2004) 3.21
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. EMBO J (2003) 2.95
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J (2014) 2.93
Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers. Curr Biol (2008) 2.67
Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis. EMBO J (2005) 2.63
Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization. J Biol Chem (2005) 2.57
A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr Biol (2012) 2.45
The SUMO protease SENP5 is required to maintain mitochondrial morphology and function. J Cell Sci (2007) 2.12
An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis. Nat Struct Mol Biol (2007) 2.08
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. EMBO Rep (2012) 2.08
The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers. Genome Biol (2003) 1.91
Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats. Nat Struct Mol Biol (2007) 1.89
Vps35 mediates vesicle transport between the mitochondria and peroxisomes. Curr Biol (2010) 1.82
MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep (2009) 1.80
Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death. J Biol Chem (2007) 1.73
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer. DNA Repair (Amst) (2003) 1.72
A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange. Nucleic Acids Res (2006) 1.68
Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. EMBO J (2006) 1.59
Reverse transcription-associated dephosphorylation of hepadnavirus nucleocapsids. Proc Natl Acad Sci U S A (2005) 1.57
The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. Biochemistry (2004) 1.57
3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases. EMBO J (2009) 1.56
The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex. J Cell Biol (2003) 1.55
Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis. Mol Cell Biol (2006) 1.49
Positioning mitochondrial plasticity within cellular signaling cascades. Biochim Biophys Acta (2008) 1.48
Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches. J Biol Chem (2002) 1.44
Structure of the heterodimeric core primase. Nat Struct Mol Biol (2005) 1.44
Neuronal apoptosis is accompanied by amyloid beta-protein accumulation in the endoplasmic reticulum. J Alzheimers Dis (2002) 1.42
The intracellular redox state is a core determinant of mitochondrial fusion. EMBO Rep (2012) 1.40
Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis. J Biol Chem (2009) 1.37
Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2. Mol Cell (2003) 1.33
Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site. J Biol Chem (2011) 1.31
Reconstitution of mitochondria derived vesicle formation demonstrates selective enrichment of oxidized cargo. PLoS One (2012) 1.27
Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide. J Biol Chem (2004) 1.21
Medical care needs of returning veterans with PTSD: their other burden. J Gen Intern Med (2010) 1.19
MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2. Mol Cell (2013) 1.18
A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility. Biophys J (2008) 1.18
Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode. DNA Repair (Amst) (2006) 1.18
Childhood anxiety in a diverse primary care population: parent-child reports, ethnicity and SCARED factor structure. J Am Acad Child Adolesc Psychiatry (2007) 1.18
Shared active site architecture between the large subunit of eukaryotic primase and DNA photolyase. PLoS One (2010) 1.17
Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex. J Mol Biol (2004) 1.14
The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity. J Biol Chem (2010) 1.14
The promiscuous primase. Trends Genet (2005) 1.13
Staying cool in difficult times: mitochondrial dynamics, quality control and the stress response. Biochim Biophys Acta (2012) 1.13
Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism. Bioessays (2010) 1.12
Mechanism for priming DNA synthesis by yeast DNA polymerase α. Elife (2013) 1.10
Extracellular chelation of zinc does not affect hippocampal excitability and seizure-induced cell death in rats. J Physiol (2006) 1.06
Cellular spelunking: exploring adipocyte caveolae. J Lipid Res (2007) 1.04
A novel cell-free mitochondrial fusion assay amenable for high-throughput screenings of fusion modulators. BMC Biol (2010) 1.04
Mitochondrial dynamics in the regulation of neuronal cell death. Apoptosis (2007) 1.04
Flexible tethering of primase and DNA Pol α in the eukaryotic primosome. Nucleic Acids Res (2011) 1.04
Mitochondrial vesicles: an ancient process providing new links to peroxisomes. Curr Opin Cell Biol (2009) 1.02
Structural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complex. Nucleic Acids Res (2011) 1.02
Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes. Front Physiol (2013) 1.02
The PARL family of mitochondrial rhomboid proteases. Semin Cell Dev Biol (2010) 1.01
Structures of human primase reveal design of nucleotide elongation site and mode of Pol α tethering. Proc Natl Acad Sci U S A (2013) 1.01
Using unsupervised analysis to constrain generalization bounds for support vector classifiers. IEEE Trans Neural Netw (2010) 1.00
Identification of surface-exposed components of MOMP of Chlamydia trachomatis serovar F. Protein Sci (2005) 0.99
End-resection at DNA double-strand breaks in the three domains of life. Biochem Soc Trans (2013) 0.98
A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome. J Biol Chem (2012) 0.98
Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy. Autophagy (2013) 0.97
ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics. Sci Signal (2014) 0.96
Quantum optimization for training support vector machines. Neural Netw (2003) 0.95
Tandem mass spectrometry for structural characterization of proline-rich proteins: application to salivary PRP-3. Anal Chem (2002) 0.94
Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking. Cell Signal (2010) 0.93
Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res (2006) 0.93
Amyloid precursor protein interacts with notch receptors. J Neurosci Res (2005) 0.93
Structural basis for inhibition of homologous recombination by the RecX protein. EMBO J (2008) 0.92
Peptide-conjugated PAMAM dendrimer as a universal DNA vaccine platform to target antigen-presenting cells. Cancer Res (2011) 0.91
Calcium regulation of mitochondria motility and morphology. Biochim Biophys Acta (2008) 0.91
Amphioxus SARM involved in neural development may function as a suppressor of TLR signaling. J Immunol (2010) 0.91
Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy. J Lipid Res (2005) 0.91
The dynamin GTPase OPA1: more than mitochondria? Biochim Biophys Acta (2012) 0.90
Cell type-specific action of seizure-induced intracellular zinc accumulation in the rat hippocampus. J Physiol (2005) 0.89
Insights into Fanconi Anaemia from the structure of human FANCE. Nucleic Acids Res (2007) 0.89
Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core. Neurosci Lett (2011) 0.89
Ontogeny of excitation-contraction coupling in the mammalian heart. Comp Biochem Physiol A Mol Integr Physiol (2002) 0.89
Structural features of covalently cross-linked hydroxylase and reductase proteins of soluble methane monooxygenase as revealed by mass spectrometric analysis. J Biol Chem (2003) 0.88
Children of parents with unipolar depression: a comparison of stably remitted, partially remitted, and nonremitted parents and nondepressed controls. Child Psychiatry Hum Dev (2002) 0.88
IL-6 activates STAT5 in T cells. Cytokine (2012) 0.87
The structural biology of growth factor receptor activation. Biophys Chem (2003) 0.87
Calcium/calmodulin-dependent phosphorylation of tumor protein D52 on serine residue 136 may be mediated by CAMK2delta6. Am J Physiol Gastrointest Liver Physiol (2008) 0.87
Tumor-initiating cells are enriched in CD44(hi) population in murine salivary gland tumor. PLoS One (2011) 0.87
Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly. Open Biol (2012) 0.87
Vesicular zinc regulates the Ca2+ sensitivity of a subpopulation of presynaptic vesicles at hippocampal mossy fiber terminals. J Neurosci (2011) 0.85
SR-BI undergoes cholesterol-stimulated transcytosis to the bile canaliculus in polarized WIF-B cells. J Biol Chem (2006) 0.84