Published in Nat Struct Mol Biol on February 08, 2004
Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev (2005) 4.43
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet (2011) 4.02
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs. Nucleic Acids Res (2007) 2.95
Sequence-specific binding of single-stranded RNA: is there a code for recognition? Nucleic Acids Res (2006) 2.89
MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T. RNA (2007) 2.58
The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA. Proc Natl Acad Sci U S A (2006) 2.12
The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis. Arthritis Res Ther (2004) 2.05
Structural basis for suppression of a host antiviral response by influenza A virus. Proc Natl Acad Sci U S A (2008) 2.02
Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Nat Struct Mol Biol (2008) 2.00
Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation. PLoS One (2008) 1.95
Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action. Biochim Biophys Acta (2013) 1.90
AREsite: a database for the comprehensive investigation of AU-rich elements. Nucleic Acids Res (2010) 1.58
Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency. Cell Metab (2008) 1.57
Structural basis for polyadenosine-RNA binding by Nab2 Zn fingers and its function in mRNA nuclear export. Structure (2012) 1.56
The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. EMBO J (2004) 1.55
Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice. BMC Genomics (2008) 1.55
SOMNUS, a CCCH-type zinc finger protein in Arabidopsis, negatively regulates light-dependent seed germination downstream of PIL5. Plant Cell (2008) 1.52
Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nat Immunol (2010) 1.49
RNA sequence- and shape-dependent recognition by proteins in the ribonucleoprotein particle. EMBO Rep (2005) 1.48
Quantitative approaches to monitor protein-nucleic acid interactions using fluorescent probes. RNA (2010) 1.40
The role of tristetraprolin in cancer and inflammation. Front Biosci (Landmark Ed) (2012) 1.33
The Arabidopsis tandem zinc finger protein AtTZF1 traffics between the nucleus and cytoplasmic foci and binds both DNA and RNA. Plant Physiol (2009) 1.27
The roles of TTP and BRF proteins in regulated mRNA decay. Wiley Interdiscip Rev RNA (2011) 1.24
TIS11 family proteins and their roles in posttranscriptional gene regulation. J Biomed Biotechnol (2009) 1.21
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). Nat Struct Mol Biol (2010) 1.19
Microarray analysis of iron deficiency chlorosis in near-isogenic soybean lines. BMC Genomics (2007) 1.18
Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle. Cell (2011) 1.17
Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing. Proc Natl Acad Sci U S A (2010) 1.15
Global target mRNA specification and regulation by the RNA-binding protein ZFP36. Genome Biol (2014) 1.15
The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans. Proc Natl Acad Sci U S A (2006) 1.15
A hairpin-like structure within an AU-rich mRNA-destabilizing element regulates trans-factor binding selectivity and mRNA decay kinetics. J Biol Chem (2005) 1.14
Structural basis for DNA binding by replication initiator Mcm10. Structure (2008) 1.14
Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response. Proc Natl Acad Sci U S A (2010) 1.14
U2AF1 mutations alter splice site recognition in hematological malignancies. Genome Res (2014) 1.13
Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications. Biochemistry (2004) 1.12
RNA target specificity of the embryonic cell fate determinant POS-1. RNA (2008) 1.12
ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors. Nature (2013) 1.08
Identification and stage-specific association with the translational apparatus of TbZFP3, a CCCH protein that promotes trypanosome life-cycle development. J Biol Chem (2006) 1.08
Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase. Nucleic Acids Res (2012) 1.07
Phosphorylation site analysis of the anti-inflammatory and mRNA-destabilizing protein tristetraprolin. Expert Rev Proteomics (2007) 1.06
Engineering RNA-binding proteins for biology. FEBS J (2013) 1.06
Understanding biomolecular motion, recognition, and allostery by use of conformational ensembles. Eur Biophys J (2011) 1.06
Post-transcriptional regulation of the trypanosome heat shock response by a zinc finger protein. PLoS Pathog (2013) 1.04
Comprehensive analysis of CCCH zinc finger family in poplar (Populus trichocarpa). BMC Genomics (2012) 1.03
Solution structure of the RNA binding domain in the human muscleblind-like protein 2. Protein Sci (2009) 1.01
Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein. Mol Microbiol (2005) 1.01
mRNA degradation plays a significant role in the program of gene expression regulated by phosphatidylinositol 3-kinase signaling. Mol Cell Biol (2010) 1.00
Regulation of ARE transcript 3' end processing by the yeast Cth2 mRNA decay factor. EMBO J (2008) 0.99
Global analysis reveals multiple pathways for unique regulation of mRNA decay in induced pluripotent stem cells. Genome Res (2012) 0.98
Large favorable enthalpy changes drive specific RNA recognition by RNA recognition motif proteins. Biochemistry (2011) 0.97
Genome-wide analysis of the CCCH zinc finger gene family in Medicago truncatula. Plant Cell Rep (2013) 0.97
CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin. PLoS One (2014) 0.97
Direct binding of specific AUF1 isoforms to tandem zinc finger domains of tristetraprolin (TTP) family proteins. J Biol Chem (2011) 0.97
The end of the message: multiple protein-RNA interactions define the mRNA polyadenylation site. Genes Dev (2015) 0.96
MBNL1-RNA recognition: contributions of MBNL1 sequence and RNA conformation. Chembiochem (2011) 0.96
Roles of intrinsic disorder in protein-nucleic acid interactions. Mol Biosyst (2011) 0.96
Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery. Mol Cell Biol (2014) 0.96
Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal. J Biol Chem (2008) 0.95
cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b. Mol Endocrinol (2009) 0.95
The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences. Proc Natl Acad Sci U S A (2009) 0.94
Allele-specific recognition of the 3' splice site of INS intron 1. Hum Genet (2010) 0.94
Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO J (2012) 0.94
Characterization of zfs1 as an mRNA-binding and -destabilizing protein in Schizosaccharomyces pombe. J Biol Chem (2007) 0.92
Phylogenetic distribution and evolution of the linked RNA-binding and NOT1-binding domains in the tristetraprolin family of tandem CCCH zinc finger proteins. J Interferon Cytokine Res (2014) 0.90
Post-transcriptional Regulation of Genes Encoding Anti-microbial Peptides in Drosophila. J Biol Chem (2009) 0.90
Early recruitment of AU-rich element-containing mRNAs determines their cytosolic fate during iron deficiency. Mol Cell Biol (2010) 0.89
Hsp70 is a novel posttranscriptional regulator of gene expression that binds and stabilizes selected mRNAs containing AU-rich elements. Mol Cell Biol (2012) 0.89
Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe. Mol Cell Biol (2012) 0.89
Substrate dependence of conformational changes in the RNA-binding domain of tristetraprolin assessed by fluorescence spectroscopy of tryptophan mutants. Biochemistry (2006) 0.89
Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation. EMBO J (2014) 0.89
Short, synthetic and selectively 13C-labeled RNA sequences for the NMR structure determination of protein-RNA complexes. Nucleic Acids Res (2006) 0.88
MCP-1-induced protein-1, an immune regulator. Protein Cell (2012) 0.87
Inhibition of tristetraprolin deadenylation by poly(A) binding protein. Am J Physiol Gastrointest Liver Physiol (2008) 0.87
Computational assessment of the cooperativity between RNA binding proteins and MicroRNAs in Transcript Decay. PLoS Comput Biol (2013) 0.86
Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae. Elife (2014) 0.86
Mutational and structural analysis of the tandem zinc finger domain of tristetraprolin. J Biol Chem (2013) 0.86
PPR proteins of green algae. RNA Biol (2013) 0.86
The Arabidopsis thaliana tandem zinc finger 1 (AtTZF1) protein in RNA binding and decay. Plant J (2014) 0.86
Structural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingers. Nucleic Acids Res (2013) 0.85
Crystal structure of zinc-finger domain of Nanos and its functional implications. EMBO Rep (2010) 0.85
2'-Methylseleno-modified oligoribonucleotides for X-ray crystallography synthesized by the ACE RNA solid-phase approach. Nucleic Acids Res (2007) 0.85
Secondary interactions involving zinc-bound ligands: roles in structural stabilization and macromolecular interactions. J Inorg Biochem (2011) 0.85
A computational study of RNA binding and specificity in the tandem zinc finger domain of TIS11d. Protein Sci (2010) 0.85
Rapid proteasomal degradation of posttranscriptional regulators of the TIS11/tristetraprolin family is induced by an intrinsically unstructured region independently of ubiquitination. Mol Cell Biol (2014) 0.84
The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1. Nucleic Acids Res (2010) 0.84
Structure and function of nematode RNA-binding proteins. Curr Opin Struct Biol (2010) 0.84
Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Genome Biol (2011) 0.84
A new pathway in the control of the initiation of puberty: the MKRN3 gene. J Mol Endocrinol (2015) 0.83
Insights into the structural basis of RNA recognition by STAR domain proteins. Adv Exp Med Biol (2010) 0.83
A novel 3' splice site recognition by the two zinc fingers in the U2AF small subunit. Genes Dev (2015) 0.82
Cell-free selection of RNA-binding proteins using in vitro compartmentalization. Nucleic Acids Res (2008) 0.82
Putative molecular mechanisms underlying tandem CCCH zinc finger protein mediated plant growth, stress, and gene expression responses. Plant Signal Behav (2011) 0.82
The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation. Nucleic Acids Res (2016) 0.82
The role of RNA conformation in RNA-protein recognition. RNA Biol (2015) 0.81
Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway. Oncotarget (2015) 0.81
Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Nat Struct Mol Biol (2015) 0.81
ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway. Nucleic Acids Res (2014) 0.81
Dissecting domains necessary for activation and repression of splicing by Muscleblind-like protein 1. BMC Mol Biol (2013) 0.81
EGF activates TTP expression by activation of ELK-1 and EGR-1 transcription factors. BMC Mol Biol (2012) 0.80
Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol (2005) 17.63
The dynamic energy landscape of dihydrofolate reductase catalysis. Science (2006) 7.55
The role of dynamic conformational ensembles in biomolecular recognition. Nat Chem Biol (2009) 7.36
Coupling of folding and binding for unstructured proteins. Curr Opin Struct Biol (2002) 6.53
Mechanism of coupled folding and binding of an intrinsically disordered protein. Nature (2007) 6.26
Linking folding and binding. Curr Opin Struct Biol (2009) 5.19
PRAK is essential for ras-induced senescence and tumor suppression. Cell (2007) 4.30
Structure, dynamics, and catalytic function of dihydrofolate reductase. Annu Rev Biophys Biomol Struct (2004) 3.42
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science (2011) 3.19
An NMR perspective on enzyme dynamics. Chem Rev (2006) 3.11
Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Proc Natl Acad Sci U S A (2002) 2.97
Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature (2002) 2.78
Unfolded proteins and protein folding studied by NMR. Chem Rev (2004) 2.71
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis. Proc Natl Acad Sci U S A (2005) 2.21
Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb. J Mol Biol (2004) 1.83
Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain. J Biol Chem (2002) 1.80
Structural basis for cooperative transcription factor binding to the CBP coactivator. J Mol Biol (2005) 1.75
Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones. J Mol Biol (2005) 1.74
Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. Biochemistry (2004) 1.72
Insights into the structure and dynamics of unfolded proteins from nuclear magnetic resonance. Adv Protein Chem (2002) 1.71
Modulation of allostery by protein intrinsic disorder. Nature (2013) 1.69
Structural characterization of unfolded states of apomyoglobin using residual dipolar couplings. J Mol Biol (2004) 1.68
Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators. J Biol Chem (2002) 1.61
Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53. J Mol Biol (2006) 1.61
Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase. Biochemistry (2004) 1.59
Biochemistry. How do proteins interact? Science (2008) 1.58
Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands. Proc Natl Acad Sci U S A (2010) 1.53
Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state. Biochemistry (2008) 1.51
Mapping long-range contacts in a highly unfolded protein. J Mol Biol (2002) 1.49
Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. Proc Natl Acad Sci U S A (2009) 1.48
Transfer of flexibility between ankyrin repeats in IkappaB* upon formation of the NF-kappaB complex. J Mol Biol (2008) 1.44
The role of hydrophobic interactions in initiation and propagation of protein folding. Proc Natl Acad Sci U S A (2006) 1.42
Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites. J Biol Chem (2003) 1.40
Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A (2010) 1.39
Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA. J Mol Biol (2007) 1.39
Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP. Biochemistry (2009) 1.35
Molecular hinges in protein folding: the urea-denatured state of apomyoglobin. Biochemistry (2002) 1.35
Automated identification of functional dynamic contact networks from X-ray crystallography. Nat Methods (2013) 1.35
Modeling transient collapsed states of an unfolded protein to provide insights into early folding events. Proc Natl Acad Sci U S A (2008) 1.33
Model-free analysis of protein dynamics: assessment of accuracy and model selection protocols based on molecular dynamics simulation. J Biomol NMR (2004) 1.32
Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. Proc Natl Acad Sci U S A (2009) 1.31
Identification of native and non-native structure in kinetic folding intermediates of apomyoglobin. J Mol Biol (2005) 1.31
Comparison of protein solution structures refined by molecular dynamics simulation in vacuum, with a generalized Born model, and with explicit water. J Biomol NMR (2002) 1.28
Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR. Proc Natl Acad Sci U S A (2014) 1.25
Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. J Mol Biol (2003) 1.24
Activation of the redox-regulated chaperone Hsp33 by domain unfolding. J Biol Chem (2004) 1.23
Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains. EMBO J (2009) 1.23
The apomyoglobin folding pathway revisited: structural heterogeneity in the kinetic burst phase intermediate. J Mol Biol (2002) 1.23
Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP. J Am Chem Soc (2012) 1.22
Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of CREB binding protein. Biochemistry (2010) 1.21
Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein. Protein Sci (2004) 1.20
Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes. Protein Sci (2003) 1.20
Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis. Biochemistry (2008) 1.19
Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso. Proc Natl Acad Sci U S A (2012) 1.18