Published in J Mol Biol on July 23, 2004
Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation. Protein Sci (2006) 3.73
Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Proc Natl Acad Sci U S A (2005) 3.48
Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase. Structure (2010) 2.33
Statistical coil model of the unfolded state: resolving the reconciliation problem. Proc Natl Acad Sci U S A (2005) 2.32
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14
Biophysical characterization of intrinsically disordered proteins. Curr Opin Struct Biol (2009) 1.98
An experimental study of GFP-based FRET, with application to intrinsically unstructured proteins. Protein Sci (2007) 1.82
Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol (2009) 1.61
Residual structure, backbone dynamics, and interactions within the synuclein family. J Mol Biol (2007) 1.43
Structural reorganization of alpha-synuclein at low pH observed by NMR and REMD simulations. J Mol Biol (2009) 1.39
Modeling transient collapsed states of an unfolded protein to provide insights into early folding events. Proc Natl Acad Sci U S A (2008) 1.33
Shaping up the protein folding funnel by local interaction: lesson from a structure prediction study. Proc Natl Acad Sci U S A (2006) 1.22
Toward an accurate theoretical framework for describing ensembles for proteins under strongly denaturing conditions. Biophys J (2006) 1.21
Unfolded-state dynamics and structure of protein L characterized by simulation and experiment. J Am Chem Soc (2010) 1.18
Structural characterization of alpha-synuclein in an aggregation prone state. Protein Sci (2009) 1.18
Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH. Protein Sci (2009) 1.12
Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta. Proc Natl Acad Sci U S A (2006) 1.08
Kinetic barriers and the role of topology in protein and RNA folding. Protein Sci (2008) 1.07
E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein. J Mol Biol (2009) 1.05
Folding very short peptides using molecular dynamics. PLoS Comput Biol (2006) 1.04
Electrostatic interactions in the denatured state ensemble: their effect upon protein folding and protein stability. Arch Biochem Biophys (2007) 1.01
Urea denatured state ensembles contain extensive secondary structure that is increased in hydrophobic proteins. Protein Sci (2010) 1.01
Further evidence for the absence of polyproline II stretch in the XAO peptide. Biophys J (2007) 1.00
Sequence-specific solvent accessibilities of protein residues in unfolded protein ensembles. Biophys J (2006) 1.00
Experiments and simulations show how long-range contacts can form in expanded unfolded proteins with negligible secondary structure. Proc Natl Acad Sci U S A (2013) 0.96
Motional properties of unfolded ubiquitin: a model for a random coil protein. J Biomol NMR (2006) 0.95
The effect of a DeltaK280 mutation on the unfolded state of a microtubule-binding repeat in Tau. PLoS Comput Biol (2008) 0.93
Structural signature of the MYPT1-PP1 interaction. J Am Chem Soc (2010) 0.91
A statistical analysis of the PPII propensity of amino acid guests in proline-rich peptides. Biophys J (2011) 0.90
NMR contributions to structural dynamics studies of intrinsically disordered proteins. J Magn Reson (2014) 0.89
A self-consistent description of the conformational behavior of chemically denatured proteins from NMR and small angle scattering. Biophys J (2009) 0.89
The extremely slow-exchanging core and acid-denatured state of green fluorescent protein. HFSP J (2008) 0.86
A hypothesis to reconcile the physical and chemical unfolding of proteins. Proc Natl Acad Sci U S A (2015) 0.86
p15PAF is an intrinsically disordered protein with nonrandom structural preferences at sites of interaction with other proteins. Biophys J (2014) 0.85
The cold denatured state of the C-terminal domain of protein L9 is compact and contains both native and non-native structure. J Am Chem Soc (2010) 0.85
Structure and dynamics of the MKK7-JNK signaling complex. Proc Natl Acad Sci U S A (2015) 0.82
Domain cooperativity in multidomain proteins: what can we learn from molecular alignment in anisotropic media? J Biomol NMR (2011) 0.82
Investigation of the Polymeric Properties of α-Synuclein and Comparison with NMR Experiments: A Replica Exchange Molecular Dynamics Study. J Chem Theory Comput (2012) 0.82
Prediction of charge-induced molecular alignment: residual dipolar couplings at pH 3 and alignment in surfactant liquid crystalline phases. Eur Biophys J (2005) 0.82
Theoretical framework for NMR residual dipolar couplings in unfolded proteins. J Biomol NMR (2007) 0.81
Mechanisms of amyloid formation revealed by solution NMR. Prog Nucl Magn Reson Spectrosc (2015) 0.80
Estimating the accuracy of protein structures using residual dipolar couplings. J Biomol NMR (2005) 0.79
Local structural preferences and dynamics restrictions in the urea-denatured state of SUMO-1: NMR characterization. Biophys J (2006) 0.79
NMR characterization of the near native and unfolded states of the PTB domain of Dok1: alternate conformations and residual clusters. PLoS One (2014) 0.78
Maximum entropy reconstruction of joint phi, psi-distribution with a coil-library prior: the backbone conformation of the peptide hormone motilin in aqueous solution from phi and psi-dependent J-couplings. J Biomol NMR (2007) 0.78
How Does Your Protein Fold? Elucidating the Apomyoglobin Folding Pathway. Acc Chem Res (2016) 0.77
Apoglobin Stability Is the Major Factor Governing both Cell-free and in Vivo Expression of Holomyoglobin. J Biol Chem (2015) 0.77
The interplay between transient α-helix formation and side chain rotamer distributions in disordered proteins probed by methyl chemical shifts. Protein Sci (2011) 0.77
Electrostatic screening and backbone preferences of amino acid residues in urea-denatured ubiquitin. Protein Sci (2007) 0.77
A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein. Biochemistry (2014) 0.76
Protein alignment using cellulose nanocrystals: practical considerations and range of application. J Biomol NMR (2010) 0.76
Probing the urea dependence of residual structure in denatured human alpha-lactalbumin. J Biomol NMR (2009) 0.76
Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation. PLoS One (2015) 0.75
Molecular Simulations Find Stable Structures in Fragments of Protein G. Acta Chim Slov (2008) 0.75
Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol (2005) 17.63
The dynamic energy landscape of dihydrofolate reductase catalysis. Science (2006) 7.55
The role of dynamic conformational ensembles in biomolecular recognition. Nat Chem Biol (2009) 7.36
Coupling of folding and binding for unstructured proteins. Curr Opin Struct Biol (2002) 6.53
Mechanism of coupled folding and binding of an intrinsically disordered protein. Nature (2007) 6.26
Linking folding and binding. Curr Opin Struct Biol (2009) 5.19
PRAK is essential for ras-induced senescence and tumor suppression. Cell (2007) 4.30
Structure, dynamics, and catalytic function of dihydrofolate reductase. Annu Rev Biophys Biomol Struct (2004) 3.42
Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. Nat Struct Mol Biol (2004) 3.39
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science (2011) 3.19
An NMR perspective on enzyme dynamics. Chem Rev (2006) 3.11
Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Proc Natl Acad Sci U S A (2002) 2.97
Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature (2002) 2.78
Unfolded proteins and protein folding studied by NMR. Chem Rev (2004) 2.71
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis. Proc Natl Acad Sci U S A (2005) 2.21
Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb. J Mol Biol (2004) 1.83
Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain. J Biol Chem (2002) 1.80
Structural basis for cooperative transcription factor binding to the CBP coactivator. J Mol Biol (2005) 1.75
Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones. J Mol Biol (2005) 1.74
Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. Biochemistry (2004) 1.72
Insights into the structure and dynamics of unfolded proteins from nuclear magnetic resonance. Adv Protein Chem (2002) 1.71
Modulation of allostery by protein intrinsic disorder. Nature (2013) 1.69
Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53. J Mol Biol (2006) 1.61
Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators. J Biol Chem (2002) 1.61
Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase. Biochemistry (2004) 1.59
Biochemistry. How do proteins interact? Science (2008) 1.58
Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands. Proc Natl Acad Sci U S A (2010) 1.53
Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state. Biochemistry (2008) 1.51
Mapping long-range contacts in a highly unfolded protein. J Mol Biol (2002) 1.49
Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. Proc Natl Acad Sci U S A (2009) 1.48
Transfer of flexibility between ankyrin repeats in IkappaB* upon formation of the NF-kappaB complex. J Mol Biol (2008) 1.44
The role of hydrophobic interactions in initiation and propagation of protein folding. Proc Natl Acad Sci U S A (2006) 1.42
Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites. J Biol Chem (2003) 1.40
Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A (2010) 1.39
Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA. J Mol Biol (2007) 1.39
Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP. Biochemistry (2009) 1.35
Molecular hinges in protein folding: the urea-denatured state of apomyoglobin. Biochemistry (2002) 1.35
Automated identification of functional dynamic contact networks from X-ray crystallography. Nat Methods (2013) 1.35
Modeling transient collapsed states of an unfolded protein to provide insights into early folding events. Proc Natl Acad Sci U S A (2008) 1.33
Model-free analysis of protein dynamics: assessment of accuracy and model selection protocols based on molecular dynamics simulation. J Biomol NMR (2004) 1.32
Identification of native and non-native structure in kinetic folding intermediates of apomyoglobin. J Mol Biol (2005) 1.31
Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. Proc Natl Acad Sci U S A (2009) 1.31
Comparison of protein solution structures refined by molecular dynamics simulation in vacuum, with a generalized Born model, and with explicit water. J Biomol NMR (2002) 1.28
Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR. Proc Natl Acad Sci U S A (2014) 1.25
Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. J Mol Biol (2003) 1.24
Activation of the redox-regulated chaperone Hsp33 by domain unfolding. J Biol Chem (2004) 1.23
Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains. EMBO J (2009) 1.23
The apomyoglobin folding pathway revisited: structural heterogeneity in the kinetic burst phase intermediate. J Mol Biol (2002) 1.23
Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP. J Am Chem Soc (2012) 1.22
Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of CREB binding protein. Biochemistry (2010) 1.21
Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein. Protein Sci (2004) 1.20
Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes. Protein Sci (2003) 1.20
Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis. Biochemistry (2008) 1.19
Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso. Proc Natl Acad Sci U S A (2012) 1.18
Enhanced picture of protein-folding intermediates using organic solvents in H/D exchange and quench-flow experiments. Proc Natl Acad Sci U S A (2005) 1.18
Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast H/D exchange coupled with 2D NMR. Proc Natl Acad Sci U S A (2008) 1.17
CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding. Biochemistry (2005) 1.16
Measurement of protein unfolding/refolding kinetics and structural characterization of hidden intermediates by NMR relaxation dispersion. Proc Natl Acad Sci U S A (2011) 1.15