Published in Biochemistry on October 22, 2002
Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments. Proc Natl Acad Sci U S A (2003) 1.93
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Measurement of 15N relaxation in the detergent-solubilized tetrameric KcsA potassium channel. J Biomol NMR (2006) 1.23
Fibril growth kinetics reveal a region of beta2-microglobulin important for nucleation and elongation of aggregation. J Mol Biol (2008) 1.23
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Detailed structural characterization of unbound protein phosphatase 1 inhibitors. Biochemistry (2008) 1.14
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Effects of denaturants and substitutions of hydrophobic residues on backbone dynamics of denatured staphylococcal nuclease. Protein Sci (2003) 0.89
Structural characterization of partially folded intermediates of apomyoglobin H64F. Protein Sci (2008) 0.89
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Characterization of the unfolded state of bovine alpha-lactalbumin and comparison with unfolded states of homologous proteins. Protein Sci (2006) 0.89
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Backbone dynamics of the monomeric lambda repressor denatured state ensemble under nondenaturing conditions. Biochemistry (2007) 0.85
Model-independent interpretation of NMR relaxation data for unfolded proteins: the acid-denatured state of ACBP. J Biomol NMR (2008) 0.84
Characterisation of a mobile protein-binding epitope in the translocation domain of colicin E9. J Biomol NMR (2004) 0.83
Propensities of aromatic amino acids versus leucine and proline to induce residual structure in the denatured-state ensemble of iso-1-cytochrome c. J Mol Biol (2010) 0.82
Structural characterization of apomyoglobin self-associated species in aqueous buffer and urea solution. Biophys J (2005) 0.80
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Consequences of stabilizing the natively disordered f helix for the folding pathway of apomyoglobin. J Mol Biol (2011) 0.80
Non-native hydrophobic interactions detected in unfolded apoflavodoxin by paramagnetic relaxation enhancement. Eur Biophys J (2009) 0.80
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NMR characterization of the near native and unfolded states of the PTB domain of Dok1: alternate conformations and residual clusters. PLoS One (2014) 0.78
Conformational dynamics is more important than helical propensity for the folding of the all α-helical protein Im7. Protein Sci (2013) 0.78
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Electrostatic screening and backbone preferences of amino acid residues in urea-denatured ubiquitin. Protein Sci (2007) 0.77
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Atomic-level structure characterization of an ultrafast folding mini-protein denatured state. PLoS One (2012) 0.76
NMR insights into folding and self-association of Plasmodium falciparum P2. PLoS One (2012) 0.76
Probing the urea dependence of residual structure in denatured human alpha-lactalbumin. J Biomol NMR (2009) 0.76
Evidence for a Shared Mechanism in the Formation of Urea-Induced Kinetic and Equilibrium Intermediates of Horse Apomyoglobin from Ultrarapid Mixing Experiments. PLoS One (2015) 0.75
Residue-Specific Interactions of an Intrinsically Disordered Protein with Silica Nanoparticles and their Quantitative Prediction. J Phys Chem C Nanomater Interfaces (2016) 0.75
Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol (2005) 17.63
The dynamic energy landscape of dihydrofolate reductase catalysis. Science (2006) 7.55
The role of dynamic conformational ensembles in biomolecular recognition. Nat Chem Biol (2009) 7.36
Coupling of folding and binding for unstructured proteins. Curr Opin Struct Biol (2002) 6.53
Mechanism of coupled folding and binding of an intrinsically disordered protein. Nature (2007) 6.26
Linking folding and binding. Curr Opin Struct Biol (2009) 5.19
PRAK is essential for ras-induced senescence and tumor suppression. Cell (2007) 4.30
Structure, dynamics, and catalytic function of dihydrofolate reductase. Annu Rev Biophys Biomol Struct (2004) 3.42
Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. Nat Struct Mol Biol (2004) 3.39
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science (2011) 3.19
An NMR perspective on enzyme dynamics. Chem Rev (2006) 3.11
Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Proc Natl Acad Sci U S A (2002) 2.97
Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature (2002) 2.78
Unfolded proteins and protein folding studied by NMR. Chem Rev (2004) 2.71
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis. Proc Natl Acad Sci U S A (2005) 2.21
Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb. J Mol Biol (2004) 1.83
Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain. J Biol Chem (2002) 1.80
Structural basis for cooperative transcription factor binding to the CBP coactivator. J Mol Biol (2005) 1.75
Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones. J Mol Biol (2005) 1.74
Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. Biochemistry (2004) 1.72
Insights into the structure and dynamics of unfolded proteins from nuclear magnetic resonance. Adv Protein Chem (2002) 1.71
Modulation of allostery by protein intrinsic disorder. Nature (2013) 1.69
Structural characterization of unfolded states of apomyoglobin using residual dipolar couplings. J Mol Biol (2004) 1.68
Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators. J Biol Chem (2002) 1.61
Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53. J Mol Biol (2006) 1.61
Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase. Biochemistry (2004) 1.59
Biochemistry. How do proteins interact? Science (2008) 1.58
Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands. Proc Natl Acad Sci U S A (2010) 1.53
Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state. Biochemistry (2008) 1.51
Mapping long-range contacts in a highly unfolded protein. J Mol Biol (2002) 1.49
Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. Proc Natl Acad Sci U S A (2009) 1.48
Transfer of flexibility between ankyrin repeats in IkappaB* upon formation of the NF-kappaB complex. J Mol Biol (2008) 1.44
The role of hydrophobic interactions in initiation and propagation of protein folding. Proc Natl Acad Sci U S A (2006) 1.42
Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites. J Biol Chem (2003) 1.40
Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A (2010) 1.39
Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA. J Mol Biol (2007) 1.39
Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP. Biochemistry (2009) 1.35
Automated identification of functional dynamic contact networks from X-ray crystallography. Nat Methods (2013) 1.35
Modeling transient collapsed states of an unfolded protein to provide insights into early folding events. Proc Natl Acad Sci U S A (2008) 1.33
Model-free analysis of protein dynamics: assessment of accuracy and model selection protocols based on molecular dynamics simulation. J Biomol NMR (2004) 1.32
Identification of native and non-native structure in kinetic folding intermediates of apomyoglobin. J Mol Biol (2005) 1.31
Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. Proc Natl Acad Sci U S A (2009) 1.31
Comparison of protein solution structures refined by molecular dynamics simulation in vacuum, with a generalized Born model, and with explicit water. J Biomol NMR (2002) 1.28
Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR. Proc Natl Acad Sci U S A (2014) 1.25
Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. J Mol Biol (2003) 1.24
Activation of the redox-regulated chaperone Hsp33 by domain unfolding. J Biol Chem (2004) 1.23
Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains. EMBO J (2009) 1.23
The apomyoglobin folding pathway revisited: structural heterogeneity in the kinetic burst phase intermediate. J Mol Biol (2002) 1.23
Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP. J Am Chem Soc (2012) 1.22
Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of CREB binding protein. Biochemistry (2010) 1.21
Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein. Protein Sci (2004) 1.20
Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes. Protein Sci (2003) 1.20
Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis. Biochemistry (2008) 1.19
Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso. Proc Natl Acad Sci U S A (2012) 1.18
Enhanced picture of protein-folding intermediates using organic solvents in H/D exchange and quench-flow experiments. Proc Natl Acad Sci U S A (2005) 1.18
Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast H/D exchange coupled with 2D NMR. Proc Natl Acad Sci U S A (2008) 1.17
CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding. Biochemistry (2005) 1.16
Measurement of protein unfolding/refolding kinetics and structural characterization of hidden intermediates by NMR relaxation dispersion. Proc Natl Acad Sci U S A (2011) 1.15
Functional dynamics of the folded ankyrin repeats of I kappa B alpha revealed by nuclear magnetic resonance. Biochemistry (2009) 1.14
pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins. Nucleic Acids Res (2013) 1.13