Published in Nat Genet on February 22, 2004
A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin) (2012) 20.08
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell (2008) 4.90
MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A (2005) 3.78
Phenotypic robustness conferred by apparently redundant transcriptional enhancers. Nature (2010) 3.72
The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. Genetics (2004) 3.71
The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource. Genetics (2007) 3.08
Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell (2010) 2.96
The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature (2012) 2.94
MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nat Methods (2011) 2.76
The role of Drosophila Piezo in mechanical nociception. Nature (2012) 2.72
Genetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron (2011) 2.54
The ribosomal protein genes and Minute loci of Drosophila melanogaster. Genome Biol (2007) 2.40
Maturation of active zone assembly by Drosophila Bruchpilot. J Cell Biol (2009) 2.34
Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions. Genetics (2013) 2.22
Drosophila as a model for the identification of genes causing adult human heart disease. Proc Natl Acad Sci U S A (2006) 2.22
Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift. Front Genet (2012) 2.21
Sugar receptors in Drosophila. Curr Biol (2007) 2.18
Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies. Nat Genet (2011) 2.10
The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning. EMBO J (2007) 2.06
Contact chemoreceptors mediate male-male repulsion and male-female attraction during Drosophila courtship. Cell (2012) 1.96
Tachykinin-expressing neurons control male-specific aggressive arousal in Drosophila. Cell (2014) 1.89
Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development. Curr Biol (2007) 1.83
The molecular basis for water taste in Drosophila. Nature (2010) 1.81
Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol (2012) 1.80
Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. Mol Cell (2011) 1.79
Genetics and genomics of Drosophila mating behavior. Proc Natl Acad Sci U S A (2005) 1.74
Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol (2010) 1.73
Modeling spinal muscular atrophy in Drosophila. PLoS One (2008) 1.71
Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase. Toxicol Sci (2008) 1.66
Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. J Cell Biol (2007) 1.64
Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting. Nat Neurosci (2013) 1.63
The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome. Genome Biol (2012) 1.60
Plant insecticide L-canavanine repels Drosophila via the insect orphan GPCR DmX. PLoS Biol (2009) 1.60
Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron (2012) 1.58
Site-specific genomic targeting in Drosophila. Proc Natl Acad Sci U S A (2005) 1.58
The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol (2014) 1.52
A universal method for automated gene mapping. Genome Biol (2005) 1.50
Zasp is required for the assembly of functional integrin adhesion sites. J Cell Biol (2007) 1.46
The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression. Dev Cell (2013) 1.43
Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins. Dev Cell (2015) 1.42
Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities. Proc Natl Acad Sci U S A (2009) 1.41
Massively parallel resequencing of the isogenic Drosophila melanogaster strain w(1118); iso-2; iso-3 identifies hotspots for mutations in sensory perception genes. Fly (Austin) (2009) 1.41
Integrating evolutionary and molecular genetics of aging. Biochim Biophys Acta (2009) 1.40
An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Drosophila melanogaster. Proc Natl Acad Sci U S A (2008) 1.38
Control of Dpp morphogen signalling by a secreted feedback regulator. Nat Cell Biol (2010) 1.38
Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. J Cell Biol (2007) 1.37
Pumilio facilitates miRNA regulation of the E2F3 oncogene. Genes Dev (2012) 1.36
The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Mol Cell Biol (2006) 1.35
Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45. Mol Biol Cell (2008) 1.34
Epigenetic blocking of an enhancer region controls irradiation-induced proapoptotic gene expression in Drosophila embryos. Dev Cell (2008) 1.33
A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila. J Cell Biol (2010) 1.33
Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila. PLoS Biol (2008) 1.33
High-throughput multiplex sequencing to discover copy number variants in Drosophila. Genetics (2009) 1.31
Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives. Genome Biol (2007) 1.29
A single basis for developmental buffering of Drosophila wing shape. PLoS One (2006) 1.27
Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila. PLoS Genet (2011) 1.26
Quantitative trait loci for locomotor behavior in Drosophila melanogaster. Genetics (2006) 1.26
The Drosophila fragile X mental retardation gene regulates sleep need. J Neurosci (2009) 1.25
Mutations in NSUN2 cause autosomal-recessive intellectual disability. Am J Hum Genet (2012) 1.24
Intrakinetochore localization and essential functional domains of Drosophila Spc105. EMBO J (2009) 1.24
Organelle positioning in muscles requires cooperation between two KASH proteins and microtubules. J Cell Biol (2012) 1.23
Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells. Genetics (2008) 1.21
Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo. J Neurosci (2007) 1.20
straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. J Cell Biol (2008) 1.20
Targeted gene deletion and phenotypic analysis of the Drosophila melanogaster seminal fluid protease inhibitor Acp62F. Genetics (2008) 1.20
Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector. Genetics (2007) 1.19
Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. Hum Mol Genet (2012) 1.18
Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1. Proc Natl Acad Sci U S A (2007) 1.17
A molecularly defined duplication set for the X chromosome of Drosophila melanogaster. Genetics (2010) 1.17
A new Drosophila POU gene, pdm3, acts in odor receptor expression and axon targeting of olfactory neurons. J Neurosci (2008) 1.16
A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Proc Natl Acad Sci U S A (2005) 1.16
Similar levels of X-linked and autosomal nucleotide variation in African and non-African populations of Drosophila melanogaster. BMC Evol Biol (2007) 1.15
The 4.1 protein coracle mediates subunit-selective anchoring of Drosophila glutamate receptors to the postsynaptic actin cytoskeleton. J Neurosci (2005) 1.15
Precision of hunchback expression in the Drosophila embryo. Curr Biol (2012) 1.14
The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturation. J Cell Biol (2010) 1.13
Corona is required for higher-order assembly of transverse filaments into full-length synaptonemal complex in Drosophila oocytes. PLoS Genet (2008) 1.12
Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis. Development (2009) 1.12
Large-scale mutagenesis of the yeast genome using a Tn7-derived multipurpose transposon. Genome Res (2004) 1.11
Onset of the DNA replication checkpoint in the early Drosophila embryo. Genetics (2006) 1.11
Drosophila Ten-m and filamin affect motor neuron growth cone guidance. PLoS One (2011) 1.10
Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors. Nature (2011) 1.10
Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues. PLoS Biol (2010) 1.10
Direct evidence that genetic variation in glycerol-3-phosphate and malate dehydrogenase genes (Gpdh and Mdh1) affects adult ethanol tolerance in Drosophila melanogaster. Genetics (2008) 1.09
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model. Dis Model Mech (2009) 1.09
A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. Genetics (2005) 1.09
The conditional nature of genetic interactions: the consequences of wild-type backgrounds on mutational interactions in a genome-wide modifier screen. PLoS Genet (2013) 1.08
Quantitative trait loci for aggressive behavior in Drosophila melanogaster. Genetics (2009) 1.08
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. J Cell Biol (2012) 1.07
Mutations in the chromosomal passenger complex and the condensin complex differentially affect synaptonemal complex disassembly and metaphase I configuration in Drosophila female meiosis. Genetics (2008) 1.07
Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes. Neuron (2014) 1.07
Negative regulation of notch signaling by xylose. PLoS Genet (2013) 1.07
magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis. Dev Biol (2011) 1.05
The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G. J Biol Chem (2009) 1.05
The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc Natl Acad Sci U S A (2007) 1.03
Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning. J Neurosci (2008) 1.03
Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. Neuron (2009) 1.02
A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK. PLoS One (2009) 1.02
Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. Genes Dev (2010) 1.01
Modeling tumor invasion and metastasis in Drosophila. Dis Model Mech (2011) 1.00
The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. J Cell Biol (2013) 1.00
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature (2010) 15.63
Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39
The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Nat Genet (2004) 8.55
The knockout mouse project. Nat Genet (2004) 7.80
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis. Nature (2006) 5.52
Evolution of protein kinase signaling from yeast to man. Trends Biochem Sci (2002) 5.28
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Clin Cancer Res (2009) 4.81
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell (2002) 4.37
Dynamic transcriptome of Schizosaccharomyces pombe shown by RNA-DNA hybrid mapping. Nat Genet (2008) 4.03
Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. Cancer Res (2009) 3.72
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature (2002) 3.63
A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell (2010) 3.34
Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell (2011) 3.32
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models. Clin Cancer Res (2010) 3.20
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models. Nat Biotechnol (2010) 3.15
A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol (2010) 3.09
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci U S A (2009) 2.77
Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors. Cell (2006) 2.66
The transcriptional diversity of 25 Drosophila cell lines. Genome Res (2010) 2.47
Diversity and dynamics of the Drosophila transcriptome. Nature (2014) 2.47
The ribosomal protein genes and Minute loci of Drosophila melanogaster. Genome Biol (2007) 2.40
Genome-wide analysis of promoter architecture in Drosophila melanogaster. Genome Res (2010) 2.29
Hox genes and the evolution of the arthropod body plan. Evol Dev (2002) 2.27
A serpin mutant links Toll activation to melanization in the host defence of Drosophila. EMBO J (2002) 2.22
Dual activation of the Drosophila toll pathway by two pattern recognition receptors. Science (2003) 2.11
Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circ Res (2006) 2.09
Oncogenic ERBB3 mutations in human cancers. Cancer Cell (2013) 2.06
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. Proc Natl Acad Sci U S A (2011) 2.01
Presenilin diversifies its portfolio. Trends Genet (2007) 1.81
GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Mol Cancer Ther (2011) 1.76
Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab. Clin Cancer Res (2009) 1.70
P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma. J Natl Cancer Inst (2013) 1.68
Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical maps. Genetics (2008) 1.67
The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity (2002) 1.66
A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse. Genetics (2002) 1.61
The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome. Genome Biol (2012) 1.60
Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res (2011) 1.56
ERK inhibition overcomes acquired resistance to MEK inhibitors. Mol Cancer Ther (2012) 1.55
Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells. Cancer Res (2009) 1.54
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature (2013) 1.52
MicroRNAs and colon and rectal cancer: differential expression by tumor location and subtype. Genes Chromosomes Cancer (2010) 1.51
Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors. Cancer Res (2010) 1.49
Lifetime proteomic profiling of an A30P alpha-synuclein Drosophila model of Parkinson's disease. J Proteome Res (2007) 1.48
Insect appendages and comparative ontogenetics. Dev Biol (2005) 1.47
p21-activated kinase 1: PAK'ed with potential. Oncotarget (2011) 1.44
Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival. PLoS One (2007) 1.44
The centrosome is a dynamic structure that ejects PCM flares. J Cell Sci (2002) 1.37
Research resources for Drosophila: the expanding universe. Nat Rev Genet (2005) 1.34
Forkhead proteins control the outcome of transcription factor binding by antiactivation. EMBO J (2007) 1.33
EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation. Clin Cancer Res (2008) 1.30
Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene. J Biol Chem (2008) 1.28
An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer. Cancer Res (2012) 1.23
hunchback is required for suppression of abdominal identity, and for proper germband growth and segmentation in the intermediate germband insect Oncopeltus fasciatus. Development (2004) 1.20
Functional analyses in the hemipteran Oncopeltus fasciatus reveal conserved and derived aspects of appendage patterning in insects. Dev Biol (2004) 1.18
Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clin Cancer Res (2013) 1.18
A molecularly defined duplication set for the X chromosome of Drosophila melanogaster. Genetics (2010) 1.17
even-skipped is not a pair-rule gene but has segmental and gap-like functions in Oncopeltus fasciatus, an intermediate germband insect. Development (2005) 1.14
Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability. J Biol Chem (2007) 1.14
Exploring the myriapod body plan: expression patterns of the ten Hox genes in a centipede. Development (2002) 1.14
Health and safety practices in the nanomaterials workplace: results from an international survey. Environ Sci Technol (2008) 1.12
Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. Blood (2009) 1.11
Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension. Am J Ophthalmol (2011) 1.11
Mapping the proteome of Drosophila melanogaster: analysis of embryos and adult heads by LC-IMS-MS methods. J Proteome Res (2005) 1.10
Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel phosphatidylinositol 3-kinase inhibitor GDC-0941. Drug Metab Dispos (2010) 1.10
Nuclear phospho-Akt increase predicts synergy of PI3K inhibition and doxorubicin in breast and ovarian cancer. Sci Transl Med (2010) 1.10
A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J Exp Med (2009) 1.10
Functional analyses in the milkweed bug Oncopeltus fasciatus (Hemiptera) support a role for Wnt signaling in body segmentation but not appendage development. Dev Biol (2005) 1.09
Short and long germ segmentation: unanswered questions in the evolution of a developmental mode. Evol Dev (2005) 1.09
Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth. Dev Biol (2006) 1.09
Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. J Med Chem (2011) 1.08
Gene expression signatures in the newt irises during lens regeneration. FEBS Lett (2007) 1.07
GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death in vitro and in vivo. Clin Cancer Res (2012) 1.07
Oncopeltus fasciatus zen is essential for serosal tissue function in katatrepsis. Dev Biol (2006) 1.05
A potent combination of the novel PI3K Inhibitor, GDC-0941, with imatinib in gastrointestinal stromal tumor xenografts: long-lasting responses after treatment withdrawal. Clin Cancer Res (2012) 1.05
Hox gene function and interaction in the milkweed bug Oncopeltus fasciatus (Hemiptera). Dev Biol (2005) 1.05
Slow degeneration of zebrafish Rohon-Beard neurons during programmed cell death. Dev Dyn (2004) 1.04