Published in Nature on March 11, 2004
The nature of the globular- to fibrous-actin transition. Nature (2009) 4.33
Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly. Nature (2005) 3.54
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. Nat Biotechnol (2010) 3.16
High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis. Cell (2014) 2.71
Structural basis of interprotofilament interaction and lateral deformation of microtubules. Structure (2010) 2.44
Mechanochemical model of microtubule structure and self-assembly kinetics. Biophys J (2005) 2.31
EBs recognize a nucleotide-dependent structural cap at growing microtubule ends. Cell (2012) 2.24
Insights into the mechanism of microtubule stabilization by Taxol. Proc Natl Acad Sci U S A (2006) 1.96
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Posttranslational acetylation of α-tubulin constrains protofilament number in native microtubules. Curr Biol (2012) 1.72
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JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. J Cell Biol (2006) 1.69
A decade of user operation on the macromolecular crystallography MAD beamline ID14-4 at the ESRF. J Synchrotron Radiat (2009) 1.64
Systematic analysis of the transcriptional switch inducing migration of border cells. Dev Cell (2006) 1.63
Growth, fluctuation and switching at microtubule plus ends. Nat Rev Mol Cell Biol (2009) 1.62
Variations in the colchicine-binding domain provide insight into the structural switch of tubulin. Proc Natl Acad Sci U S A (2009) 1.59
Structure of bacterial tubulin BtubA/B: evidence for horizontal gene transfer. Proc Natl Acad Sci U S A (2005) 1.59
Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule lattice. Nat Struct Mol Biol (2008) 1.55
Microtubule dynamics as a target in oncology. Cancer Treat Rev (2008) 1.50
A TOG:αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase. Science (2012) 1.50
An overview of tubulin inhibitors that interact with the colchicine binding site. Pharm Res (2012) 1.49
Transformation of taxol-stabilized microtubules into inverted tubulin tubules triggered by a tubulin conformation switch. Nat Mater (2014) 1.48
Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions. J Proteome Res (2007) 1.48
Synergistic antimicrotubule therapy for prostate cancer. Biochem Pharmacol (2010) 1.44
The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity. Sci Transl Med (2016) 1.40
Energetics and geometry of FtsZ polymers: nucleated self-assembly of single protofilaments. Biophys J (2007) 1.40
Template-free 13-protofilament microtubule-MAP assembly visualized at 8 A resolution. J Cell Biol (2010) 1.38
The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs. Proc Natl Acad Sci U S A (2004) 1.37
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Mol Cancer Ther (2006) 1.36
Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin. J Exp Med (2011) 1.36
Structural insight into the inhibition of tubulin by vinca domain peptide ligands. EMBO Rep (2008) 1.32
Control of microtubule organization and dynamics: two ends in the limelight. Nat Rev Mol Cell Biol (2015) 1.31
Structure of a kinesin-tubulin complex and implications for kinesin motility. Nat Struct Mol Biol (2013) 1.31
Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin. Nat Struct Mol Biol (2011) 1.27
Dual roles of Gln137 of actin revealed by recombinant human cardiac muscle alpha-actin mutants. J Biol Chem (2008) 1.26
Allosteric models for cooperative polymerization of linear polymers. Biophys J (2008) 1.22
Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. J Med Chem (2010) 1.21
Structural basis of tubulin tyrosination by tubulin tyrosine ligase. J Cell Biol (2013) 1.21
Cytoskeletal dynamics and spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 1.19
Interactions of halichondrin B and eribulin with tubulin. J Chem Inf Model (2011) 1.19
Regulation of microtubule dynamic instability in vitro by differentially phosphorylated stathmin. J Biol Chem (2009) 1.18
Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity. Bioorg Med Chem (2007) 1.18
A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end. Proc Natl Acad Sci U S A (2012) 1.16
Distinct roles of doublecortin modulating the microtubule cytoskeleton. EMBO J (2006) 1.16
Stathmin and interfacial microtubule inhibitors recognize a naturally curved conformation of tubulin dimers. J Biol Chem (2010) 1.15
Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring. J Med Chem (2015) 1.14
New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies. J Med Chem (2009) 1.14
Highly potent triazole-based tubulin polymerization inhibitors. J Med Chem (2007) 1.13
Identifying compound-target associations by combining bioactivity profile similarity search and public databases mining. J Chem Inf Model (2011) 1.12
The contribution of αβ-tubulin curvature to microtubule dynamics. J Cell Biol (2014) 1.11
MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol (2011) 1.09
Targeting microtubules by natural agents for cancer therapy. Mol Cancer Ther (2014) 1.08
Structure of the kinesin13-microtubule ring complex. Structure (2008) 1.06
The PN2-3 domain of centrosomal P4.1-associated protein implements a novel mechanism for tubulin sequestration. J Biol Chem (2009) 1.06
Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues. J Med Chem (2010) 1.06
Building complexity: insights into self-organized assembly of microtubule-based architectures. Dev Cell (2012) 1.06
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proc Natl Acad Sci U S A (2015) 1.05
Comparison of small molecule inhibitors of the bacterial cell division protein FtsZ and identification of a reliable cross-species inhibitor. ACS Chem Biol (2012) 1.04
Mechanical properties of a complete microtubule revealed through molecular dynamics simulation. Biophys J (2010) 1.03
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors. J Med Chem (2012) 1.03
A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation. Mol Biol Cell (2010) 1.02
An extended γ-tubulin ring functions as a stable platform in microtubule nucleation. J Cell Biol (2012) 1.02
Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance. J Med Chem (2010) 1.02
Novel tubulin polymerization inhibitors overcome multidrug resistance and reduce melanoma lung metastasis. Pharm Res (2012) 1.02
Structural studies of ciliary components. J Mol Biol (2012) 1.02
Conformational changes of FtsZ reported by tryptophan mutants. Biochemistry (2011) 1.01
Expanding the spectrum of TUBA1A-related cortical dysgenesis to Polymicrogyria. Eur J Hum Genet (2012) 1.00
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc Natl Acad Sci U S A (2014) 1.00
Human mutations that confer paclitaxel resistance. Mol Cancer Ther (2010) 1.00
Intrinsic bending and structural rearrangement of tubulin dimer: molecular dynamics simulations and coarse-grained analysis. Biophys J (2008) 1.00
Structural mass spectrometry of the alpha beta-tubulin dimer supports a revised model of microtubule assembly. Biochemistry (2009) 1.00
Ring closure activates yeast γTuRC for species-specific microtubule nucleation. Nat Struct Mol Biol (2015) 0.99
Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy. J Cell Biol (2012) 0.98
A tethered delivery mechanism explains the catalytic action of a microtubule polymerase. Elife (2014) 0.98
The roles of beta-tubulin mutations and isotype expression in acquired drug resistance. Cancer Inform (2007) 0.98
Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem (2011) 0.98
A new model for binding of kinesin 13 to curved microtubule protofilaments. J Cell Biol (2009) 0.98
Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity. J Med Chem (2011) 0.97
Mechanism for the catastrophe-promoting activity of the microtubule destabilizer Op18/stathmin. Proc Natl Acad Sci U S A (2013) 0.97
Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis. J Med Chem (2011) 0.96
Expression and phosphorylation of stathmin correlate with cell migration in esophageal squamous cell carcinoma. Oncol Rep (2012) 0.95
S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton. PLoS One (2009) 0.95
Pyrrole-Based Antitubulin Agents: Two Distinct Binding Modalities are Predicted for C-2 Analogs in the Colchicine Site. ACS Med Chem Lett (2011) 0.94
Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site. Mol Pharmacol (2011) 0.93
Tubulin dimers oligomerize before their incorporation into microtubules. PLoS One (2008) 0.93
N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin. Eur J Med Chem (2013) 0.93
Visualisation of a kinesin-13 motor on microtubule end mimics. J Mol Biol (2008) 0.93
Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity. Cancer Res (2009) 0.93
Bacterial tubulin TubZ-Bt transitions between a two-stranded intermediate and a four-stranded filament upon GTP hydrolysis. Proc Natl Acad Sci U S A (2014) 0.93
The Chlamydia effector chlamydial outer protein N (CopN) sequesters tubulin and prevents microtubule assembly. J Biol Chem (2011) 0.92
Mapping flexibility and the assembly switch of cell division protein FtsZ by computational and mutational approaches. J Biol Chem (2010) 0.92
A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization. J Biol Chem (2010) 0.92
Motor regulation results in distal forces that bend partially disintegrated Chlamydomonas axonemes into circular arcs. Biophys J (2014) 0.92
Anti-angiogenic and vascular disrupting effects of C9, a new microtubule-depolymerizing agent. Br J Pharmacol (2009) 0.92
Molecular basis for class V beta-tubulin effects on microtubule assembly and paclitaxel resistance. J Biol Chem (2009) 0.92
Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents. J Med Chem (2011) 0.92
Heterotrimeric G-proteins interact directly with cytoskeletal components to modify microtubule-dependent cellular processes. Neurosignals (2009) 0.92
Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives. Mol Cancer (2010) 0.91
Microtubule stability studied by three-dimensional molecular theory of solvation. Biophys J (2006) 0.91
Structural basis for the regulation of tubulin by vinblastine. Nature (2005) 3.10
The beta-thymosin/WH2 domain; structural basis for the switch from inhibition to promotion of actin assembly. Cell (2004) 2.35
Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell (2012) 2.14
Photoluminescent diamond nanoparticles for cell labeling: study of the uptake mechanism in mammalian cells. ACS Nano (2009) 2.08
Structural properties of POPC monolayers under lateral compression: computer simulations analysis. Langmuir (2014) 1.98
Variations in the colchicine-binding domain provide insight into the structural switch of tubulin. Proc Natl Acad Sci U S A (2009) 1.59
Fluorescence and spin properties of defects in single digit nanodiamonds. ACS Nano (2009) 1.47
Crystal structure of vesicular stomatitis virus matrix protein. EMBO J (2002) 1.34
Structural insight into the inhibition of tubulin by vinca domain peptide ligands. EMBO Rep (2008) 1.32
Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants. Proc Natl Acad Sci U S A (2004) 1.31
Structure of a kinesin-tubulin complex and implications for kinesin motility. Nat Struct Mol Biol (2013) 1.31
The determinants that govern microtubule assembly from the atomic structure of GTP-tubulin. J Mol Biol (2011) 1.27
The microtubule network and neuronal morphogenesis: Dynamic and coordinated orchestration through multiple players. Mol Cell Neurosci (2009) 1.23
Role of microtubules in stress granule assembly: microtubule dynamical instability favors the formation of micrometric stress granules in cells. J Biol Chem (2009) 1.17
A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end. Proc Natl Acad Sci U S A (2012) 1.16
Stathmin and interfacial microtubule inhibitors recognize a naturally curved conformation of tubulin dimers. J Biol Chem (2010) 1.15
Detection of single photoluminescent diamond nanoparticles in cells and study of the internalization pathway. Small (2008) 1.15
Inhibition of autophagy by TAB2 and TAB3. EMBO J (2011) 1.15
Major phosphorylation of SF1 on adjacent Ser-Pro motifs enhances interaction with U2AF65. FEBS J (2006) 1.13
High yield fabrication of fluorescent nanodiamonds. Nanotechnology (2009) 1.06
The PN2-3 domain of centrosomal P4.1-associated protein implements a novel mechanism for tubulin sequestration. J Biol Chem (2009) 1.06
Drosophila stathmin: a microtubule-destabilizing factor involved in nervous system formation. Mol Biol Cell (2002) 1.05
The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neurons, unlike SCG10. Mol Cell Neurosci (2006) 1.03
Structural plasticity of tubulin assembly probed by vinca-domain ligands. Acta Crystallogr D Biol Crystallogr (2012) 1.02
Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice. Dis Model Mech (2012) 1.01
Both lipid environment and pH are critical for determining physiological solution structure of 3-D-conserved epitopes of the HIV-1 gp41-MPER peptide P1. FASEB J (2008) 0.99
Phosphorylation of the tubulin-binding protein, stathmin, by Cdk5 and MAP kinases in the brain. J Neurochem (2006) 0.98
Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells. FEBS Lett (2004) 0.98
YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubules. BMC Biochem (2008) 0.97
Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB-1 and PABP. FEBS Lett (2008) 0.97
Heterogeneity and regulation of cellular prion protein glycoforms in neuronal cell lines. Eur J Neurosci (2003) 0.93
Mica surface promotes the assembly of cytoskeletal proteins. Langmuir (2009) 0.92
SCLIP is crucial for the formation and development of the Purkinje cell dendritic arbor. J Neurosci (2008) 0.91
Phosphorylation controls the interaction of the connexin43 C-terminal domain with tubulin and microtubules. Biochemistry (2012) 0.91
Functional analysis of a fungal endophyte stress-activated MAP kinase. Curr Genet (2008) 0.91
Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases. Mol Biol Cell (2011) 0.90
Direct molecular interactions between Beclin 1 and the canonical NFκB activation pathway. Autophagy (2012) 0.90
Insight into the GTPase activity of tubulin from complexes with stathmin-like domains. Biochemistry (2007) 0.90
Macromolecular crowding regulates assembly of mRNA stress granules after osmotic stress: new role for compatible osmolytes. J Biol Chem (2011) 0.89
Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons. J Neurosci Res (2002) 0.89
N-terminal acetylation of ectopic recombinant proteins in Escherichia coli. FEBS Lett (2002) 0.88
Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP. Genomics (2003) 0.88
Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human. Brain Res Mol Brain Res (2003) 0.87
Studying drug-tubulin interactions by X-ray crystallography. Methods Mol Med (2007) 0.87
Structure, function, and evolution of the beta-thymosin/WH2 (WASP-Homology2) actin-binding module. Ann N Y Acad Sci (2007) 0.87
A synergistic relationship between three regions of stathmin family proteins is required for the formation of a stable complex with tubulin. Biochem J (2004) 0.86
Systematic identification of tubulin-interacting fragments of the microtubule-associated protein Tau leads to a highly efficient promoter of microtubule assembly. J Biol Chem (2011) 0.86
Design and characterization of modular scaffolds for tubulin assembly. J Biol Chem (2012) 0.86
Different requirements of the kinase and UHM domains of KIS for its nuclear localization and binding to splicing factors. J Mol Biol (2008) 0.86
Palmitoylation of stathmin family proteins domain A controls Golgi versus mitochondrial subcellular targeting. Biol Cell (2008) 0.86
Nodes of ranvier and paranodes in chronic acquired neuropathies. PLoS One (2011) 0.86
Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy. Autophagy (2012) 0.85
Drosophila stathmins bind tubulin heterodimers with high and variable stoichiometries. J Biol Chem (2010) 0.85
Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization. J Biol Chem (2012) 0.85
The dynamin-related protein Vps1 regulates vacuole fission, fusion and tubulation in the fission yeast, Schizosaccharomyces pombe. Fungal Genet Biol (2009) 0.85
A central role for polyamines in microtubule assembly in cells. Biochem J (2010) 0.84
N-terminal stathmin-like peptides bind tubulin and impede microtubule assembly. Biochemistry (2005) 0.84
Specific DNA-protein interactions on mica investigated by atomic force microscopy. Langmuir (2010) 0.83
Polyamine sharing between tubulin dimers favours microtubule nucleation and elongation via facilitated diffusion. PLoS Comput Biol (2009) 0.83
Two separate motifs cooperate to target stathmin-related proteins to the Golgi complex. J Cell Sci (2005) 0.83
NMR characterization and molecular modeling of fucoidan showing the importance of oligosaccharide branching in its anticomplementary activity. Glycobiology (2010) 0.83
The C terminus of tubulin, a versatile partner for cationic molecules: binding of Tau, polyamines, and calcium. J Biol Chem (2010) 0.82
Effect of the multifunctional proteins RPA, YB-1, and XPC repair factor on AP site cleavage by DNA glycosylase NEIL1. J Mol Recognit (2012) 0.82
High-resolution imaging of microtubules and cytoskeleton structures by atomic force microscopy. Methods Cell Biol (2010) 0.82
Rapid assembly and collective behavior of microtubule bundles in the presence of polyamines. Biophys J (2011) 0.81
Mechanism of Tau-promoted microtubule assembly as probed by NMR spectroscopy. J Am Chem Soc (2014) 0.81
The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to postmitotic neurons during adult hippocampal neurogenesis. Dev Neurobiol (2014) 0.80
Mapping the conformational stability of maltose binding protein at the residue scale using nuclear magnetic resonance hydrogen exchange experiments. Biochemistry (2012) 0.80
Benomyl and colchicine synergistically inhibit cell proliferation and mitosis: evidence of distinct binding sites for these agents in tubulin. Biochemistry (2008) 0.80