Published in Cancer Res on February 17, 2009
An overview of tubulin inhibitors that interact with the colchicine binding site. Pharm Res (2012) 1.49
IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. Oncogene (2011) 1.15
Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities. Br J Pharmacol (2013) 0.80
A Novel Nitrobenzoate Microtubule Inhibitor that Overcomes Multidrug Resistance Exhibits Antitumor Activity. Sci Rep (2016) 0.77
Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules. Oncotarget (2017) 0.75
Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach. Int J Med Chem (2014) 0.75
Albendazole as a promising molecule for tumor control. Redox Biol (2016) 0.75
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles. Tetrahedron (2013) 0.75
Microtubules as a target for anticancer drugs. Nat Rev Cancer (2004) 13.93
The NCI60 human tumour cell line anticancer drug screen. Nat Rev Cancer (2006) 11.49
Refined structure of alpha beta-tubulin at 3.5 A resolution. J Mol Biol (2001) 7.08
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature (2004) 6.77
The spindle: a dynamic assembly of microtubules and motors. Nat Cell Biol (2001) 3.74
Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res (1996) 3.00
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4. Experientia (1989) 2.90
Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death. J Clin Oncol (1999) 2.43
Functional organization of mitotic microtubules. Physical chemistry of the in vivo equilibrium system. Biophys J (1975) 2.18
Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships. J Med Chem (1998) 2.09
Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol Med (1995) 1.65
Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP. Bioessays (1998) 1.58
Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administration. Neurotoxicology (2000) 1.25
Highly potent triazole-based tubulin polymerization inhibitors. J Med Chem (2007) 1.13
Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines. J Med Chem (2005) 1.10
Chemotherapeutic neuropathy. Curr Opin Neurol (1999) 1.03
Microtubulin binding sites as target for developing anticancer agents. Mini Rev Med Chem (2004) 1.02
Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am J Pathol (1993) 0.99
The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death. Am J Pathol (2004) 0.95
Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug. Anticancer Drug Des (1998) 0.91
Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol Res Pract (1993) 0.85
Antineoplastic agents. 410. Asymmetric hydroxylation of trans-combretastatin A-4. J Med Chem (1999) 0.82
A preliminary risk-benefit assessment of paclitaxel. Drug Saf (1995) 0.81
Tubulin-targeting agents. Cancer Chemother Biol Response Modif (2005) 0.79
Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol (2014) 5.80
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell (2007) 5.49
Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell (2008) 5.04
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science (2013) 4.94
Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature (2011) 3.19
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol (2012) 3.18
Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer. J Clin Oncol (2012) 3.04
The use and interpretation of competing risks regression models. Clin Cancer Res (2012) 3.01
The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles. Nat Nanotechnol (2011) 2.98
Lifestyle change and mobility in obese adults with type 2 diabetes. N Engl J Med (2012) 2.90
Gold nanocages covered by smart polymers for controlled release with near-infrared light. Nat Mater (2009) 2.85
Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta. J Immunol (2007) 2.69
Groundwater arsenic contamination throughout China. Science (2013) 2.64
Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. Nat Med (2004) 2.64
The HIV epidemic in Yunnan Province, China, 1989-2007. J Acquir Immune Defic Syndr (2010) 2.61
Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes (2007) 2.59
Controlling the synthesis and assembly of silver nanostructures for plasmonic applications. Chem Rev (2011) 2.40
Prion detection by an amyloid seeding assay. Proc Natl Acad Sci U S A (2007) 2.34
In vivo molecular photoacoustic tomography of melanomas targeted by bioconjugated gold nanocages. ACS Nano (2010) 2.29
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J Immunol (2009) 2.19
Energy policy: A low-carbon road map for China. Nature (2013) 2.18
Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR). Environ Health Perspect (2004) 2.16
Patellar resurfacing versus nonresurfacing in total knee arthroplasty: a meta-analysis of randomised controlled trials. Int Orthop (2013) 2.13
Corneal immunity is mediated by heterogeneous population of antigen-presenting cells. J Leukoc Biol (2003) 2.08
The corneal stroma is endowed with a significant number of resident dendritic cells. Invest Ophthalmol Vis Sci (2003) 2.05
Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res (2010) 2.04
Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial. Lancet Oncol (2011) 2.03
Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature (2010) 2.02
The extended distally based sural neurocutaneous flap for foot and ankle reconstruction: a retrospective review of 10 years of experience. Ann Plast Surg (2014) 2.00
Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma. Prog Retin Eye Res (2003) 1.98
Gold nanocages as photothermal transducers for cancer treatment. Small (2010) 1.92
De novo assembly and characterisation of the transcriptome during seed development, and generation of genic-SSR markers in peanut (Arachis hypogaea L.). BMC Genomics (2012) 1.90
Phase II trial of neoadjuvant/adjuvant imatinib mesylate for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumors: long-term follow-up results of Radiation Therapy Oncology Group 0132. Ann Surg Oncol (2011) 1.86
Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (2008) 1.86
Bisphenol A and its analogues activate human pregnane X receptor. Environ Health Perspect (2012) 1.81
Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells. Invest Ophthalmol Vis Sci (2002) 1.80
Gold nanocages: from synthesis to theranostic applications. Acc Chem Res (2011) 1.80
Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts. J Exp Med (2002) 1.79
Long-term follow-up of the RTOG 9501/intergroup phase III trial: postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys (2012) 1.77
Reduction of transient signal oscillations in true-FISP using a linear flip angle series magnetization preparation. Magn Reson Med (2003) 1.73
Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information. J Comput Aided Mol Des (2011) 1.68
China's international trade and air pollution in the United States. Proc Natl Acad Sci U S A (2014) 1.66
ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol (2009) 1.63
Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. Int J Cancer (2008) 1.63
St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis. Toxicol Appl Pharmacol (2006) 1.60
Versatile synthesis strategy for carboxylic acid-functionalized upconverting nanophosphors as biological labels. J Am Chem Soc (2008) 1.56
Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP. Structure (2003) 1.54
In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. Int J Pharm (2012) 1.54
CFTR Expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis. Biochemistry (2006) 1.54
Automated rectilinear self-gated cardiac cine imaging. Magn Reson Med (2004) 1.52
Genetic evolution of swine influenza A (H3N2) viruses in China from 1970 to 2006. J Clin Microbiol (2008) 1.52
Satellite-Based Spatiotemporal Trends in PM2.5 Concentrations: China, 2004-2013. Environ Health Perspect (2015) 1.51
Projections of global mercury emissions in 2050. Environ Sci Technol (2009) 1.51
The effects of size, shape, and surface functional group of gold nanostructures on their adsorption and internalization by cells. Small (2010) 1.50
Gaussian mixture clustering and imputation of microarray data. Bioinformatics (2004) 1.49
Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress. Environ Health Perspect (2010) 1.47
Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem (2011) 1.43
Alterations in corneal stromal dendritic cell phenotype and distribution in inflammation. Arch Ophthalmol (2003) 1.43
Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators. Invest Ophthalmol Vis Sci (2009) 1.42
Shape signatures: a new approach to computer-aided ligand- and receptor-based drug design. J Med Chem (2003) 1.39
Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites. Mol Pharmacol (2007) 1.39
Comparison of KRAS and EGFR gene status between primary non-small cell lung cancer and local lymph node metastases: implications for clinical practice. J Exp Clin Cancer Res (2011) 1.38
Introducing the external link model for studying spine fixation and misalignment: part 1--need, rationale, and applications. J Manipulative Physiol Ther (2007) 1.38
Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals. J Control Release (2009) 1.38
The toll-like receptor pathway: a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells. Prostate (2008) 1.38
Schiff base transition metal complexes as novel inhibitors of xanthine oxidase. Eur J Med Chem (2007) 1.36
Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype. Breast Cancer Res (2008) 1.35
Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK. J Immunol (2008) 1.34
A three-dimensional carbon nanotube/graphene sandwich and its application as electrode in supercapacitors. Adv Mater (2010) 1.31
Modeling regional/urban ozone and particulate matter in Beijing, China. J Air Waste Manag Assoc (2009) 1.29
Superlubricity in centimetres-long double-walled carbon nanotubes under ambient conditions. Nat Nanotechnol (2013) 1.28
Novel expression of vascular endothelial growth factor receptor (VEGFR)-3 and VEGF-C on corneal dendritic cells. Am J Pathol (2003) 1.28
Analysis of flavivirus NS5 methyltransferase cap binding. J Mol Biol (2008) 1.27
Detecting hidden sequence propensity for amyloid fibril formation. Protein Sci (2004) 1.25
Artifact and noise suppression in GRAPPA imaging using improved k-space coil calibration and variable density sampling. Magn Reson Med (2005) 1.25
The utility and validity of the modified brief pain inventory in a multiple-dose postoperative analgesic trial. Clin J Pain (2004) 1.24
Enhanced intracellular delivery and improved antitumor efficacy of doxorubicin by sterically stabilized liposomes modified with a synthetic RGD mimetic. J Control Release (2005) 1.24
A modeling study of coarse particulate matter pollution in Beijing: regional source contributions and control implications for the 2008 Summer Olympics. J Air Waste Manag Assoc (2008) 1.24
DNA microarray data imputation and significance analysis of differential expression. Bioinformatics (2005) 1.24
Partially ordered mixed hidden Markov model for the disablement process of older adults. J Am Stat Assoc (2013) 1.24
Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands. Am J Pathol (2009) 1.23
Novel expression and characterization of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1) by conjunctival cells. Invest Ophthalmol Vis Sci (2005) 1.22
Effects of narcotic analgesic drugs on human Oddi's sphincter motility. World J Gastroenterol (2004) 1.22
In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases. J Ethnopharmacol (2005) 1.21
Experimental measurement-device-independent quantum key distribution. Phys Rev Lett (2013) 1.21
A deterministic map of Waddington's epigenetic landscape for cell fate specification. BMC Syst Biol (2011) 1.21
Characterization of effector T cells in dry eye disease. Invest Ophthalmol Vis Sci (2009) 1.21
New predictive models for blood-brain barrier permeability of drug-like molecules. Pharm Res (2008) 1.20
Super-stretchable, transparent carbon nanotube-based capacitive strain sensors for human motion detection. Sci Rep (2013) 1.19
Isolation and genetic analysis of human origin H1N1 and H3N2 influenza viruses from pigs in China. Biochem Biophys Res Commun (2007) 1.19
Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase. Am J Physiol Heart Circ Physiol (2003) 1.19
Evidence of corneal lymphangiogenesis in dry eye disease: a potential link to adaptive immunity? Arch Ophthalmol (2010) 1.18
Integrating epidermal growth factor receptor assay with clinical parameters improves risk classification for relapse and survival in head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys (2010) 1.16
Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo. Glia (2007) 1.16
The chemokine receptor CCR7 mediates corneal antigen-presenting cell trafficking. Mol Vis (2007) 1.16
Amelioration of murine dry eye disease by topical antagonist to chemokine receptor 2. Arch Ophthalmol (2009) 1.16
Chronic ocular hypertension induces dendrite pathology in the lateral geniculate nucleus of the brain. Exp Eye Res (2006) 1.16
Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages. Toxicol Appl Pharmacol (2009) 1.15
A comparison study of the catalytic properties of Au-based nanocages, nanoboxes, and nanoparticles. Nano Lett (2010) 1.15
Annotated ESTs from various tissues of the brown planthopper Nilaparvata lugens: a genomic resource for studying agricultural pests. BMC Genomics (2008) 1.15