Published in J Cell Biol on October 25, 2010
EBs recognize a nucleotide-dependent structural cap at growing microtubule ends. Cell (2012) 2.24
Doublecortin recognizes the 13-protofilament microtubule cooperatively and tracks microtubule ends. Dev Cell (2012) 1.85
Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations. Curr Opin Genet Dev (2011) 1.84
Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell (2014) 1.79
Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules. Mol Biol Cell (2011) 1.31
Control of microtubule organization and dynamics: two ends in the limelight. Nat Rev Mol Cell Biol (2015) 1.31
+TIPs: SxIPping along microtubule ends. Trends Cell Biol (2012) 1.28
A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end. Proc Natl Acad Sci U S A (2012) 1.16
Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. PLoS Biol (2013) 1.15
New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum. Brain (2013) 1.14
The contribution of αβ-tubulin curvature to microtubule dynamics. J Cell Biol (2014) 1.11
Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins. Mol Cell (2012) 1.08
Structural studies of ciliary components. J Mol Biol (2012) 1.02
Expanding the spectrum of TUBA1A-related cortical dysgenesis to Polymicrogyria. Eur J Hum Genet (2012) 1.00
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc Natl Acad Sci U S A (2014) 1.00
Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy. J Cell Biol (2012) 0.98
Taccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity. Cancer Res (2013) 0.98
Dynamic instability 30 years later: complexities in microtubule growth and catastrophe. Mol Biol Cell (2015) 0.98
Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes. Hum Mol Genet (2015) 0.91
Design and characterization of modular scaffolds for tubulin assembly. J Biol Chem (2012) 0.86
Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment. Trends Cell Biol (2015) 0.85
LIS1 and DCX: Implications for Brain Development and Human Disease in Relation to Microtubules. Scientifica (Cairo) (2013) 0.85
The doublecortin-related gene zyg-8 is a microtubule organizer in Caenorhabditis elegans neurons. J Cell Sci (2012) 0.84
Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization. Cell Cycle (2012) 0.84
Visualizing microtubule structural transitions and interactions with associated proteins. Curr Opin Struct Biol (2016) 0.83
Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites. EMBO J (2016) 0.82
Doublecortin Is Excluded from Growing Microtubule Ends and Recognizes the GDP-Microtubule Lattice. Curr Biol (2016) 0.81
Bacterial kinesin light chain (Bklc) links the Btub cytoskeleton to membranes. Sci Rep (2017) 0.78
Organelle and cellular abnormalities associated with hippocampal heterotopia in neonatal doublecortin knockout mice. PLoS One (2013) 0.77
Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads. Nat Prod Rep (2014) 0.77
Designing and Testing of Novel Taxanes to Probe the Highly Complex Mechanisms by Which Taxanes Bind to Microtubules and Cause Cytotoxicity to Cancer Cells. PLoS One (2015) 0.75
Loss of a doublecortin (DCX) domain protein causes structural defects in a tubulin-based organelle of Toxoplasma gondii and impairs host-cell invasion. Mol Biol Cell (2016) 0.75
Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies. J Biol Chem (2016) 0.75
Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility. Front Mol Neurosci (2017) 0.75
Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus. Sci Rep (2017) 0.75
Non-equilibrium assembly of microtubules: from molecules to autonomous chemical robots. Chem Soc Rev (2017) 0.75
Four-stranded mini microtubules formed by Prosthecobacter BtubAB show dynamic instability. Proc Natl Acad Sci U S A (2017) 0.75
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol (1993) 64.61
Microtubule polymerization dynamics. Annu Rev Cell Dev Biol (1997) 12.39
Structure of the alpha beta tubulin dimer by electron crystallography. Nature (1998) 11.07
Refined structure of alpha beta-tubulin at 3.5 A resolution. J Mol Biol (2001) 7.08
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature (2004) 6.77
FREALIGN: high-resolution refinement of single particle structures. J Struct Biol (2006) 5.85
Microtubules: evidence for 13 protofilaments. J Cell Biol (1973) 4.91
Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. Cell (1998) 4.44
Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell (2010) 4.37
Microtubule structure at 8 A resolution. Structure (2002) 3.41
Protein structure fitting and refinement guided by cryo-EM density. Structure (2008) 3.12
A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome. Cell (1998) 3.09
Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell (2007) 3.06
Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet (2009) 3.01
The Schizosaccharomyces pombe EB1 homolog Mal3p binds and stabilizes the microtubule lattice seam. Cell (2006) 2.91
Ab initio resolution measurement for single particle structures. J Struct Biol (2006) 2.53
Structural changes accompanying GTP hydrolysis in microtubules: information from a slowly hydrolyzable analogue guanylyl-(alpha,beta)-methylene-diphosphonate. J Cell Biol (1995) 2.47
Structural basis of interprotofilament interaction and lateral deformation of microtubules. Structure (2010) 2.44
Lattice defects in microtubules: protofilament numbers vary within individual microtubules. J Cell Biol (1992) 2.28
Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A). Hum Mutat (2007) 2.24
The DCX-domain tandems of doublecortin and doublecortin-like kinase. Nat Struct Biol (2003) 2.22
The beginning of kinesin's force-generating cycle visualized at 9-A resolution. J Cell Biol (2007) 1.97
An atomic-level mechanism for activation of the kinesin molecular motors. Proc Natl Acad Sci U S A (2010) 1.93
Microtubule nucleating gamma-TuSC assembles structures with 13-fold microtubule-like symmetry. Nature (2010) 1.86
Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons. Neuron (2004) 1.75
Structural and functional diversity in the neuronal microtubules of Caenorhabditis elegans. J Cell Biol (1982) 1.70
Axon extension occurs independently of centrosomal microtubule nucleation. Science (2010) 1.63
Straight GDP-tubulin protofilaments form in the presence of taxol. Curr Biol (2007) 1.59
Variations in the colchicine-binding domain provide insight into the structural switch of tubulin. Proc Natl Acad Sci U S A (2009) 1.59
Tubulin GTP hydrolysis influences the structure, mechanical properties, and kinesin-driven transport of microtubules. J Biol Chem (1994) 1.56
Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wrist. Cell (2007) 1.56
Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule lattice. Nat Struct Mol Biol (2008) 1.55
Mechanism of microtubule stabilization by doublecortin. Mol Cell (2004) 1.52
PHOELIX: a package for semi-automated helical reconstruction. Ultramicroscopy (1995) 1.51
Direct visualization of the microtubule lattice seam both in vitro and in vivo. J Cell Biol (1994) 1.38
Gamma-tubulin distribution in the neuron: implications for the origins of neuritic microtubules. J Cell Biol (1992) 1.34
The evolving doublecortin (DCX) superfamily. BMC Genomics (2006) 1.29
9-Angström structure of a microtubule-bound mitotic motor. J Mol Biol (2009) 1.19
Distinct roles of doublecortin modulating the microtubule cytoskeleton. EMBO J (2006) 1.16
Lattice structure of cytoplasmic microtubules in a cultured Mammalian cell. J Mol Biol (2009) 0.95
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Cell (2008) 5.87
A structural state of the myosin V motor without bound nucleotide. Nature (2003) 3.63
Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J (2002) 3.53
Three myosin V structures delineate essential features of chemo-mechanical transduction. EMBO J (2004) 3.21
Structural and functional insights into the Myosin motor mechanism. Annu Rev Biophys (2010) 2.55
Genetics and pathophysiology of mental retardation. Eur J Hum Genet (2006) 2.52
The structure of the myosin VI motor reveals the mechanism of directionality reversal. Nature (2005) 2.50
ARX, a novel Prd-class-homeobox gene highly expressed in the telencephalon, is mutated in X-linked mental retardation. Hum Mol Genet (2002) 2.30
EBs recognize a nucleotide-dependent structural cap at growing microtubule ends. Cell (2012) 2.24
Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A). Hum Mutat (2007) 2.24
The structure of the rigor complex and its implications for the power stroke. Philos Trans R Soc Lond B Biol Sci (2004) 2.17
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. Nat Genet (2013) 2.06
Structural basis for the interaction of Asf1 with histone H3 and its functional implications. Proc Natl Acad Sci U S A (2005) 1.98
Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes. Nat Struct Mol Biol (2006) 1.94
Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1). J Clin Invest (2003) 1.93
What can myosin VI do in cells? Curr Opin Cell Biol (2006) 1.77
Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc Natl Acad Sci U S A (2013) 1.75
Comparative aspects of cerebral cortical development. Eur J Neurosci (2006) 1.68
The kinesin-1 motor protein is regulated by a direct interaction of its head and tail. Proc Natl Acad Sci U S A (2008) 1.63
The structural basis for the large powerstroke of myosin VI. Cell (2007) 1.56
The motor mechanism of myosin V: insights for muscle contraction. Philos Trans R Soc Lond B Biol Sci (2004) 1.53
Mechanism of microtubule stabilization by doublecortin. Mol Cell (2004) 1.52
Topologies of a substrate protein bound to the chaperonin GroEL. Mol Cell (2007) 1.52
Structural and functional analysis of SGT1 reveals that its interaction with HSP90 is required for the accumulation of Rx, an R protein involved in plant immunity. Plant Cell (2007) 1.51
Structural basis for recruitment of Rab6-interacting protein 1 to Golgi via a RUN domain. Structure (2009) 1.50
Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections. J Struct Biol (2007) 1.45
Branching and nucleokinesis defects in migrating interneurons derived from doublecortin knockout mice. Hum Mol Genet (2006) 1.44
Myosin VI rewrites the rules for myosin motors. Cell (2010) 1.43
Myosin VI dimerization triggers an unfolding of a three-helix bundle in order to extend its reach. Mol Cell (2009) 1.42
Magnesium regulates ADP dissociation from myosin V. J Biol Chem (2004) 1.42
The unique insert in myosin VI is a structural calcium-calmodulin binding site. Proc Natl Acad Sci U S A (2004) 1.38
Doublecortin functions at the extremities of growing neuronal processes. Cereb Cortex (2003) 1.38
Motor mechanism for protein threading through Hsp104. Mol Cell (2009) 1.33
The unique insert at the end of the myosin VI motor is the sole determinant of directionality. Proc Natl Acad Sci U S A (2007) 1.30
Neuropathological phenotype of a distinct form of lissencephaly associated with mutations in TUBA1A. Brain (2008) 1.26
Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. EMBO J (2007) 1.24
Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability. Hum Mol Genet (2013) 1.23
ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement. Cell (2009) 1.22
Cre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles. Nucleic Acids Res (2003) 1.21
Insight into the molecular mechanism of the multitasking kinesin-8 motor. EMBO J (2010) 1.19
9-Angström structure of a microtubule-bound mitotic motor. J Mol Biol (2009) 1.19
Neuroanatomical distribution of ARX in brain and its localisation in GABAergic neurons. Brain Res Mol Brain Res (2004) 1.19
RNA channelling by the eukaryotic exosome. EMBO Rep (2010) 1.16
Distinct roles of doublecortin modulating the microtubule cytoskeleton. EMBO J (2006) 1.16
Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids. Hum Mol Genet (2010) 1.14
An atomic model for actin binding by the CH domains and spectrin-repeat modules of utrophin and dystrophin. J Mol Biol (2003) 1.14
New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum. Brain (2013) 1.14
Structure and allostery of the chaperonin GroEL. J Mol Biol (2012) 1.11
Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. PLoS One (2008) 1.09
Chlamydiae assemble a pathogen synapse to hijack the host endoplasmic reticulum. Traffic (2012) 1.09
The association of patient characteristics and surgical variables on symptoms of pain and function over 5 years following primary hip-replacement surgery: a prospective cohort study. BMJ Open (2013) 1.09
Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins. Mol Cell (2012) 1.08
The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4. EMBO J (2009) 1.07
Novel septin 9 repeat motifs altered in neuralgic amyotrophy bind and bundle microtubules. J Cell Biol (2013) 1.06
The structural basis of force generation by the mitotic motor kinesin-5. J Biol Chem (2012) 1.06
Disease-associated mutations in TUBA1A result in a spectrum of defects in the tubulin folding and heterodimer assembly pathway. Hum Mol Genet (2010) 1.06
Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients. Blood (2002) 1.03
A Geographically Diverse Collection of Schizosaccharomyces pombe Isolates Shows Limited Phenotypic Variation but Extensive Karyotypic Diversity. G3 (Bethesda) (2011) 1.03
Magnetic resonance imaging and histological studies of corpus callosal and hippocampal abnormalities linked to doublecortin deficiency. J Comp Neurol (2007) 1.02
Folding with and without encapsulation by cis- and trans-only GroEL-GroES complexes. EMBO J (2003) 1.01
Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family. Proc Natl Acad Sci U S A (2014) 1.00
Expanding the spectrum of TUBA1A-related cortical dysgenesis to Polymicrogyria. Eur J Hum Genet (2012) 1.00
An overview and online registry of microvillus inclusion disease patients and their MYO5B mutations. Hum Mutat (2013) 0.99
A new model for binding of kinesin 13 to curved microtubule protofilaments. J Cell Biol (2009) 0.98
The post-rigor structure of myosin VI and implications for the recovery stroke. EMBO J (2007) 0.98
Doublecortin interacts with the ubiquitin protease DFFRX, which associates with microtubules in neuronal processes. Mol Cell Neurosci (2005) 0.97
Epilepsy in Dcx knockout mice associated with discrete lamination defects and enhanced excitability in the hippocampus. PLoS One (2008) 0.96
Biochemical and structural characterization of the gem GTPase. J Biol Chem (2006) 0.93
Cholinergic influences on cortical development and adult neurogenesis. Behav Brain Res (2011) 0.93
Who wants to be a surgeon? A study of 300 first year medical students. BMC Med Educ (2007) 0.92
Rapid motif-based prediction of circular permutations in multi-domain proteins. Bioinformatics (2005) 0.92
The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells. Nucleic Acids Res (2013) 0.91
Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling. J Cell Biol (2012) 0.91
MAPping out distribution routes for kinesin couriers. Biol Cell (2013) 0.90
Analysis of adult neurogenesis: evidence for a prominent "non-neurogenic" DCX-protein pool in rodent brain. PLoS One (2013) 0.90
Electrospray ionization mass spectrometry studies of noncovalent myosin VI complexes reveal a new specific calmodulin binding site. J Am Soc Mass Spectrom (2005) 0.89
The location of DCX mutations predicts malformation severity in X-linked lissencephaly. Neurogenetics (2008) 0.89
Structural aspects of Rab6-effector complexes. Biochem Soc Trans (2009) 0.87
Beta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdown. Hum Mol Genet (2013) 0.87
Role of insert-1 of myosin VI in modulating nucleotide affinity. J Biol Chem (2011) 0.87
Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study. J Biol Chem (2013) 0.86
Isolation and characterization of an aggresome determinant in the NF2 tumor suppressor. J Biol Chem (2002) 0.84
Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice. Dev Neurosci (2008) 0.84
Drosophila melanogaster myosin-18 represents a highly divergent motor with actin tethering properties. J Biol Chem (2011) 0.84
A vertebrate myosin-I structure reveals unique insights into myosin mechanochemical tuning. Proc Natl Acad Sci U S A (2014) 0.84
Biochemical characterization of RAR1 cysteine- and histidine-rich domains (CHORDs): a novel class of zinc-dependent protein-protein interaction modules. Biochemistry (2007) 0.83
Doublecortin knockout mice show normal hippocampal-dependent memory despite CA3 lamination defects. PLoS One (2013) 0.83
Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (2014) 0.82
Cellular anatomy, physiology and epileptiform activity in the CA3 region of Dcx knockout mice: a neuronal lamination defect and its consequences. Eur J Neurosci (2012) 0.79