Published in Cancer Res on March 15, 2004
Prevention and treatment of colon cancer by peroral administration of HAMLET (human α-lactalbumin made lethal to tumour cells). Gut (2013) 1.45
EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathol (2013) 1.13
Changes in proteasome structure and function caused by HAMLET in tumor cells. PLoS One (2009) 0.95
Autophagy protein p62/SQSTM1 is involved in HAMLET-induced cell death by modulating apotosis in U87MG cells. Cell Death Dis (2013) 0.95
Interaction of antitumor alpha-lactalbumin-oleic acid complexes with artificial and natural membranes. J Bioenerg Biomembr (2009) 0.90
Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis. Oncogene (2011) 0.90
Clinical applications of bioactive milk components. Nutr Rev (2015) 0.83
The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents. PLoS One (2012) 0.83
Sensitization of Staphylococcus aureus to methicillin and other antibiotics in vitro and in vivo in the presence of HAMLET. PLoS One (2013) 0.82
A unifying mechanism for cancer cell death through ion channel activation by HAMLET. PLoS One (2013) 0.81
HAMLET binding to α-actinin facilitates tumor cell detachment. PLoS One (2011) 0.80
Molecular mechanisms of the cytotoxicity of human α-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes. J Biol Chem (2013) 0.79
Stability of HAMLET--a kinetically trapped alpha-lactalbumin oleic acid complex. Protein Sci (2005) 0.79
Low resolution solution structure of HAMLET and the importance of its alpha-domains in tumoricidal activity. PLoS One (2012) 0.78
Lipids as tumoricidal components of human α-lactalbumin made lethal to tumor cells (HAMLET): unique and shared effects on signaling and death. J Biol Chem (2013) 0.78
Targeting of nucleotide-binding proteins by HAMLET-a conserved tumor cell death mechanism. Oncogene (2015) 0.78
Apoptotic-like tumor cells and apoptotic neutrophils in mitochondrion-rich gastric adenocarcinomas: a comparative study with light and electron microscopy between these two forms of cell death. Rare Tumors (2013) 0.76
Protein-dependent Membrane Interaction of A Partially Disordered Protein Complex with Oleic Acid: Implications for Cancer Lipidomics. Sci Rep (2016) 0.75
Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res (2009) 4.58
Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci U S A (2011) 3.48
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer (2008) 3.46
Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins. Nat Med (2008) 3.40
Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid. N Engl J Med (2004) 2.38
Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays. J Bacteriol (2003) 2.36
Critical appraisal of the side population assay in stem cell and cancer stem cell research. Cell Stem Cell (2011) 2.13
Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: putting the research field on track - letter. Cancer Res (2010) 2.09
Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proc Natl Acad Sci U S A (2006) 1.96
Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens. Nat Biotechnol (2012) 1.90
Toll-like receptor 4 promoter polymorphisms: common TLR4 variants may protect against severe urinary tract infection. PLoS One (2010) 1.82
Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes. Acta Neuropathol (2010) 1.82
Protein disulfide isomerase expression is related to the invasive properties of malignant glioma. Cancer Res (2006) 1.75
HAMLET interacts with lipid membranes and perturbs their structure and integrity. PLoS One (2010) 1.58
Natural history of renal scarring in susceptible mIL-8Rh-/- mice. Kidney Int (2005) 1.56
Host imprints on bacterial genomes--rapid, divergent evolution in individual patients. PLoS Pathog (2010) 1.54
In vivo animal models for studying brain metastasis: value and limitations. Clin Exp Metastasis (2013) 1.52
Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa. Infect Immun (2004) 1.48
Prevention and treatment of colon cancer by peroral administration of HAMLET (human α-lactalbumin made lethal to tumour cells). Gut (2013) 1.45
Molecular characterization of the Escherichia coli asymptomatic bacteriuria strain 83972: the taming of a pathogen. Infect Immun (2006) 1.45
Molecular basis of commensalism in the urinary tract: low virulence or virulence attenuation? Infect Immun (2007) 1.39
Expression of extracellular matrix components in a highly infiltrative in vivo glioma model. Acta Neuropathol (2002) 1.35
A reproducible brain tumour model established from human glioblastoma biopsies. BMC Cancer (2009) 1.35
Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection. Eur J Immunol (2006) 1.32
DNA repair and cancer stem-like cells--potential partners in glioma drug resistance? Cancer Treat Rev (2008) 1.30
A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. FASEB J (2008) 1.29
A genetic basis of susceptibility to acute pyelonephritis. PLoS One (2007) 1.28
Reduced toll-like receptor 4 expression in children with asymptomatic bacteriuria. J Infect Dis (2007) 1.26
Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Res (2010) 1.24
Genetics of innate immunity and UTI susceptibility. Nat Rev Urol (2011) 1.22
Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence. PLoS Pathog (2010) 1.21
In vivo models of primary brain tumors: pitfalls and perspectives. Neuro Oncol (2012) 1.21
Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4. Cell Microbiol (2007) 1.19
NG2 proteoglycan promotes angiogenesis-dependent tumor growth in CNS by sequestering angiostatin. FASEB J (2002) 1.18
Therapeutic effect of blocking CXCR2 on neutrophil recruitment and dextran sodium sulfate-induced colitis. J Pharmacol Exp Ther (2009) 1.17
Cancer initiation and progression: involvement of stem cells and the microenvironment. Biochim Biophys Acta (2007) 1.16
Virulence properties of asymptomatic bacteriuria Escherichia coli. Int J Med Microbiol (2008) 1.15
Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection. J Infect Dis (2007) 1.15
Molecular mechanisms of temozolomide resistance in glioblastoma multiforme. Expert Rev Anticancer Ther (2012) 1.15
iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype. Mol Cell Proteomics (2009) 1.14
Hemodynamic effects of vacuum-assisted closure therapy in cardiac surgery: assessment using magnetic resonance imaging. J Thorac Cardiovasc Surg (2007) 1.14
EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathol (2013) 1.13
PapG-dependent adherence breaks mucosal inertia and triggers the innate host response. J Infect Dis (2004) 1.13
Comparison of asymptomatic bacteriuria Escherichia coli isolates from healthy individuals versus those from hospital patients shows that long-term bladder colonization selects for attenuated virulence phenotypes. Infect Immun (2011) 1.13
Escherichia coli, fimbriae, bacterial persistence and host response induction in the human urinary tract. Int J Med Microbiol (2005) 1.12
Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells. Brain (2013) 1.12
Mesenchymal stem cell signaling in cancer progression. Cancer Treat Rev (2012) 1.10
Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres. Nucleic Acids Res (2007) 1.10
Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection. PLoS Pathog (2010) 1.10
Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanisms. Expert Opin Ther Targets (2009) 1.09
PML-nuclear bodies accumulate DNA in response to polyomavirus BK and simian virus 40 replication. Exp Cell Res (2004) 1.08
Immunohistochemical expression of stem cell, endothelial cell, and chemosensitivity markers in primary glioma spheroids cultured in serum-containing and serum-free medium. Neurosurgery (2010) 1.06
HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects. Adv Cancer Res (2003) 1.05
Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma. PLoS One (2011) 1.05
Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas. Acta Neuropathol (2014) 1.04
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathol (2011) 1.03
Micro- and macromechanical effects on the wound bed of negative pressure wound therapy using gauze and foam. Ann Plast Surg (2010) 1.03
Apoptosis-like death in bacteria induced by HAMLET, a human milk lipid-protein complex. PLoS One (2011) 1.03
Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes. Acta Neuropathol (2013) 1.03
Do type 1 fimbriae promote inflammation in the human urinary tract? Cell Microbiol (2007) 1.02
Interstitial fluid: the overlooked component of the tumor microenvironment? Fibrogenesis Tissue Repair (2010) 1.02
HAMLET interacts with histones and chromatin in tumor cell nuclei. J Biol Chem (2003) 1.00
Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells). Int J Cancer (2007) 1.00
MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells. Endocr Relat Cancer (2011) 1.00
Promyelocytic leukemia nuclear bodies are predetermined processing sites for damaged DNA. J Cell Sci (2006) 0.99
Lipids as cofactors in protein folding: stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells). Protein Sci (2003) 0.98
HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death. Int J Cancer (2009) 0.97
Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire? Microb Pathog (2011) 0.97
Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors. BMC Cancer (2007) 0.97
Sternal stability at different negative pressures during vacuum-assisted closure therapy. Ann Thorac Surg (2006) 0.96
Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy. PLoS One (2009) 0.96
Changes in proteasome structure and function caused by HAMLET in tumor cells. PLoS One (2009) 0.95
Cellular host responses to gliomas. PLoS One (2012) 0.95
Preferential increase of extracellular dopamine in the rat nucleus accumbens shell as compared to that in the core during acquisition and maintenance of intravenous nicotine self-administration. Psychopharmacology (Berl) (2006) 0.95
Bacterial control of host gene expression through RNA polymerase II. J Clin Invest (2013) 0.95
Automated tracking of nanoparticle-labeled melanoma cells improves the predictive power of a brain metastasis model. Cancer Res (2013) 0.94
Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Angiogenesis (2012) 0.94
αB-crystallin is elevated in highly infiltrative apoptosis-resistant glioblastoma cells. Am J Pathol (2010) 0.94
Endostatin reduces vascularization, blood flow, and growth in a rat gliosarcoma. Neuro Oncol (2002) 0.94
A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1. PLoS One (2013) 0.93
Widespread dispersion of adeno-associated virus serotype 1 and adeno-associated virus serotype 6 vectors in the rat central nervous system and in human glioblastoma multiforme xenografts. Hum Gene Ther (2005) 0.93
Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells). Adv Exp Med Biol (2008) 0.92
Adeno-associated viral vectors penetrate human solid tumor tissue in vivo more effectively than adenoviral vectors. Hum Gene Ther (2002) 0.92
Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice. Kidney Int (2011) 0.92
Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. J Gene Med (2006) 0.91
Genetic control of the variable innate immune response to asymptomatic bacteriuria. PLoS One (2011) 0.91
Lymphangiogenesis in colorectal cancer--prognostic and therapeutic aspects. Int J Cancer (2007) 0.91