Published in Cancer Res on July 14, 2010
Concise review: Dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth? Stem Cells (2011) 2.74
Autologous mesenchymal stromal cells and kidney transplantation: a pilot study of safety and clinical feasibility. Clin J Am Soc Nephrol (2010) 1.87
Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc (2011) 1.66
Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks. Aging (Albany NY) (2011) 1.58
DNA fingerprinting of glioma cell lines and considerations on similarity measurements. Neuro Oncol (2012) 1.44
Expression analysis of all protease genes reveals cathepsin K to be overexpressed in glioblastoma. PLoS One (2014) 1.41
Risk factors in the development of stem cell therapy. J Transl Med (2011) 1.38
Natural history of mesenchymal stem cells, from vessel walls to culture vessels. Cell Mol Life Sci (2013) 1.31
Safety of mesenchymal stem cells for clinical application. Stem Cells Int (2012) 1.20
Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy. Cell Death Dis (2013) 1.16
Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial. Int J Colorectal Dis (2012) 1.15
Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy. Curr Pharm Des (2013) 1.13
From cytogenomic to epigenomic profiles: monitoring the biologic behavior of in vitro cultured human bone marrow mesenchymal stem cells. Stem Cell Res Ther (2012) 1.12
Guidelines for the use of cell lines in biomedical research. Br J Cancer (2014) 1.11
Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington's disease. Mol Neurobiol (2011) 1.11
Production of mesenchymal stromal/stem cells according to good manufacturing practices: a review. Stem Cell Res Ther (2013) 1.10
Modeling sarcomagenesis using multipotent mesenchymal stem cells. Cell Res (2011) 1.09
Stem cells and regenerative medicine in lung biology and diseases. Mol Ther (2012) 1.08
Translating research into clinical scale manufacturing of mesenchymal stromal cells. Stem Cells Int (2011) 1.07
Mesenchymal stem cells derived from adipose tissue vs bone marrow: in vitro comparison of their tropism towards gliomas. PLoS One (2013) 1.03
The role of mesenchymal stem cells in cancer development. Front Genet (2013) 1.02
Culture and Use of Mesenchymal Stromal Cells in Phase I and II Clinical Trials. Stem Cells Int (2010) 0.99
Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation. Cell Death Dis (2013) 0.99
Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion. Cancer Res (2015) 0.98
Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment. Endocr Relat Cancer (2013) 0.96
Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol (2011) 0.96
Mesenchymal stem cell transformation and sarcoma genesis. Clin Sarcoma Res (2013) 0.95
What is the oncologic risk of stem cell treatment for heart disease? Circ Res (2011) 0.94
Age-associated changes in the ecological niche: implications for mesenchymal stem cell aging. Stem Cell Res Ther (2013) 0.93
Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: lessons learned from first clinical trials. Transplantation (2013) 0.93
Immunomodulation by mesenchymal stem cells in veterinary species. Comp Med (2013) 0.93
Defining essential stem cell characteristics in adipose-derived stromal cells extracted from distinct anatomical sites. Cell Tissue Res (2012) 0.92
Cell therapy in joint disorders. Sports Health (2015) 0.92
Human umbilical cord-derived mesenchymal stem cells do not undergo malignant transformation during long-term culturing in serum-free medium. PLoS One (2014) 0.90
DNA Methylation Changes during In Vitro Propagation of Human Mesenchymal Stem Cells: Implications for Their Genomic Stability? Stem Cells Int (2013) 0.90
Recent advances in bone regeneration using adult stem cells. World J Stem Cells (2015) 0.86
Brain tumor cell line authentication, an efficient alternative to capillary electrophoresis by using a microfluidics-based system. Neuro Oncol (2013) 0.86
Mesenchymal stem cells in tissue growth and repair. Acta Naturae (2011) 0.85
Human umbilical cord matrix stem cells maintain multilineage differentiation abilities and do not transform during long-term culture. PLoS One (2013) 0.85
Microenvironmental stiffness enhances glioma cell proliferation by stimulating epidermal growth factor receptor signaling. PLoS One (2014) 0.85
Transmembrane protein CD9 is glioblastoma biomarker, relevant for maintenance of glioblastoma stem cells. Oncotarget (2016) 0.84
Passage-dependent cancerous transformation of human mesenchymal stem cells under carcinogenic hypoxia. FASEB J (2013) 0.84
Editorial: The imperative to authenticate cell lines. Clin Orthop Relat Res (2010) 0.84
Human adipose tissue-derived stem cells cultured in xeno-free culture condition enhance c-MYC expression increasing proliferation but bypassing spontaneous cell transformation. Stem Cell Res Ther (2015) 0.84
Implications of long-term culture for mesenchymal stem cells: genetic defects or epigenetic regulation? Stem Cell Res Ther (2012) 0.83
An exploratory clinical trial for idiopathic osteonecrosis of femoral head by cultured autologous multipotent mesenchymal stromal cells augmented with vascularized bone grafts. Tissue Eng Part B Rev (2014) 0.83
Chromosomal stability of mesenchymal stromal cells during in vitro culture. Cytotherapy (2016) 0.82
Epigenetic Classification of Human Mesenchymal Stromal Cells. Stem Cell Reports (2016) 0.82
Spontaneous transformation of stem cells in vitro and the issue of cross-contamination. Int J Biol Sci (2012) 0.81
Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review. BMC Musculoskelet Disord (2016) 0.80
Frequent occurrence of non-malignant genetic alterations in clinical grade mesenchymal stromal cells expanded for cell therapy protocols. Haematologica (2014) 0.80
Heterogeneous glioblastoma cell cross-talk promotes phenotype alterations and enhanced drug resistance. Oncotarget (2015) 0.79
Mesenchymal stem cells in cardiac regeneration: a detailed progress report of the last 6 years (2010-2015). Stem Cell Res Ther (2016) 0.79
A shorter telomere is the key factor in preventing cultured human mesenchymal stem cells from senescence escape. Histochem Cell Biol (2014) 0.78
The uncertain role of unmodified mesenchymal stem cells in tumor progression: what master switch? Stem Cell Res Ther (2013) 0.78
Ultra-sensitive detection of tumorigenic cellular impurities in human cell-processed therapeutic products by digital analysis of soft agar colony formation. Sci Rep (2015) 0.77
Analgesia for neuropathic pain by dorsal root ganglion transplantation of genetically engineered mesenchymal stem cells: initial results. Mol Pain (2015) 0.77
Stem Cells and Their Mediators - Next Generation Therapy for Bronchopulmonary Dysplasia. Front Med (Lausanne) (2015) 0.77
Mesenchymal stromal cell therapy in liver disease: opportunities and lessons to be learnt? Am J Physiol Gastrointest Liver Physiol (2015) 0.77
Mesenchymal stem cells in regenerative rehabilitation. J Phys Ther Sci (2016) 0.77
Human adipose stromal cells (ASC) for the regeneration of injured cartilage display genetic stability after in vitro culture expansion. PLoS One (2013) 0.77
Role of mesenchymal stem cells in leukaemia: Dr. Jekyll or Mr. Hyde? Clin Exp Med (2013) 0.77
Rationale for the potential use of mesenchymal stromal cells in liver transplantation. World J Gastroenterol (2014) 0.77
A composite hydrogel platform for the dissection of tumor cell migration at tissue interfaces. Biomaterials (2014) 0.77
Comment on: 'guidelines for the use of cell lines in biomedical research': human-to-human cancer transmission as a laboratory safety concern. Br J Cancer (2015) 0.77
Resistance to neoplastic transformation of ex-vivo expanded human mesenchymal stromal cells after exposure to supramaximal physical and chemical stress. Oncotarget (2016) 0.75
Mesenchymal Stromal Cells as a Therapeutic Strategy to Support Islet Transplantation in Type 1 Diabetes Mellitus. Cell Med (2011) 0.75
Asymmetric aneuploidy in mesenchymal stromal cells detected by in situ karyotyping and fluorescence in situ hybridization: suggestions for reference values for stem cells. Stem Cells Dev (2015) 0.75
The role of mesenchymal stem/progenitor cells in sarcoma: update and dispute. Stem Cell Investig (2014) 0.75
Therapeutic potential of human adipose-derived stem cells (ADSCs) from cancer patients: a pilot study. PLoS One (2014) 0.75
Identity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow. Oncotarget (2016) 0.75
Mesenchymal stromal cells of osteosarcoma patients do not show evidence of neoplastic changes during long-term culture. Clin Sarcoma Res (2015) 0.75
Current Biosafety Considerations in Stem Cell Therapy. Cell J (2016) 0.75
Evaluation of Three Devices for the Isolation of the Stromal Vascular Fraction from Adipose Tissue and for ASC Culture: A Comparative Study. Stem Cells Int (2017) 0.75
Double-edged sword of mesenchymal stem cells: cancer-promoting VS therapeutic potentials. Cancer Sci (2017) 0.75
Therapeutic Development of Mesenchymal Stem Cells or Their Extracellular Vesicles to Inhibit Autoimmune-Mediated Inflammatory Processes in Systemic Lupus Erythematosus. Front Immunol (2017) 0.75
Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential. Stem Cells Int (2017) 0.75
Signatures of mutational processes in human cancer. Nature (2013) 21.63
Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res (2009) 4.58
Real-time imaging reveals the single steps of brain metastasis formation. Nat Med (2009) 3.95
Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci U S A (2011) 3.48
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer (2008) 3.46
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proc Natl Acad Sci U S A (2009) 3.29
Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma. J Clin Oncol (2010) 3.05
Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study. J Clin Oncol (2002) 2.87
Genome-wide association study identifies three new melanoma susceptibility loci. Nat Genet (2011) 2.29
Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nat Genet (2005) 2.22
Critical appraisal of the side population assay in stem cell and cancer stem cell research. Cell Stem Cell (2011) 2.13
Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy. Diabetes (2004) 2.10
Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome. Clin Cancer Res (2010) 2.01
Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res (2004) 2.01
Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proc Natl Acad Sci U S A (2006) 1.96
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proc Natl Acad Sci U S A (2009) 1.93
Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nat Genet (2013) 1.91
TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer. Clin Cancer Res (2003) 1.89
Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas. BMC Cancer (2008) 1.82
Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells. Cell Stem Cell (2012) 1.76
FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. Diabetes (2011) 1.75
Protein disulfide isomerase expression is related to the invasive properties of malignant glioma. Cancer Res (2006) 1.75
MiR-182 and miR-203 induce mesenchymal to epithelial transition and self-sufficiency of growth signals via repressing SNAI2 in prostate cells. Int J Cancer (2013) 1.72
BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. J Invest Dermatol (2005) 1.66
Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer. Mol Cancer Ther (2006) 1.64
Cancer stem cells as mediators of treatment resistance in brain tumors: status and controversies. Neoplasia (2007) 1.62
Genomics-based prognosis and therapeutic prediction in breast cancer. J Natl Compr Canc Netw (2005) 1.59
In vivo animal models for studying brain metastasis: value and limitations. Clin Exp Metastasis (2013) 1.52
Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial. J Neurooncol (2007) 1.51
Distal phalangeal creases--a distinctive dysmorphic feature in disorders of the RAS signalling pathway? Eur J Med Genet (2007) 1.45
Implantable microenvironments to attract hematopoietic stem/cancer cells. Proc Natl Acad Sci U S A (2012) 1.44
Clinical effect of temozolomide-based chemotherapy in poorly differentiated endocrine carcinoma after progression on first-line chemotherapy. Cancer (2011) 1.43
Iron particles enhance visualization of experimental gliomas with high-resolution sonography. AJNR Am J Neuroradiol (2005) 1.43
Alternative splicing and mutation status of CHEK2 in stage III breast cancer. Oncogene (2004) 1.42
Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines. J Neurooncol (2007) 1.42
Biochemical and functional characterization of germ line KRAS mutations. Mol Cell Biol (2007) 1.41
Endotracheal Tube Electrodes to Assess Vocal Cord Motor Function During Surgery in the Cerebellopontine Angle. Neurosurgery (2015) 1.40
DC-NK cell cross talk as a novel CD4+ T-cell-independent pathway for antitumor CTL induction. Blood (2005) 1.39
Giant multilevel thoracic hemangioma with spinal cord compression in a patient with Klippel-Weber-Trenaunay syndrome: case report. Spine (Phila Pa 1976) (2009) 1.38
Expression of extracellular matrix components in a highly infiltrative in vivo glioma model. Acta Neuropathol (2002) 1.35
A reproducible brain tumour model established from human glioblastoma biopsies. BMC Cancer (2009) 1.35
Disruption of a long distance regulatory region upstream of SOX9 in isolated disorders of sex development. J Med Genet (2011) 1.34
Vascular endothelial growth factor A contributes to glioma-induced migration of human marrow stromal cells (hMSC). Exp Neurol (2006) 1.32
Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation. Int J Cancer (2006) 1.32
DNA repair and cancer stem-like cells--potential partners in glioma drug resistance? Cancer Treat Rev (2008) 1.30
Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations. Arthritis Res Ther (2008) 1.29
A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. FASEB J (2008) 1.29
Diagnosis of pseudoprogression in patients with glioblastoma using O-(2-[18F]fluoroethyl)-L-tyrosine PET. Eur J Nucl Med Mol Imaging (2014) 1.26
Human mesenchymal stem cells and their use in cell-based therapies. Cancer (2010) 1.24
Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Res (2010) 1.24
In vivo models of primary brain tumors: pitfalls and perspectives. Neuro Oncol (2012) 1.21
CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer. PLoS One (2008) 1.20
From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation. Diabetes (2006) 1.20
NG2 proteoglycan promotes angiogenesis-dependent tumor growth in CNS by sequestering angiostatin. FASEB J (2002) 1.18
A variant in FTO shows association with melanoma risk not due to BMI. Nat Genet (2013) 1.17
Pattern of recurrence following local chemotherapy with biodegradable carmustine (BCNU) implants in patients with glioblastoma. J Neurooncol (2004) 1.17
Cancer initiation and progression: involvement of stem cells and the microenvironment. Biochim Biophys Acta (2007) 1.16
Intraoperative computed tomography with integrated navigation system in spinal stabilizations. Spine (Phila Pa 1976) (2009) 1.15
Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway. Diabetes (2003) 1.15
Molecular mechanisms of temozolomide resistance in glioblastoma multiforme. Expert Rev Anticancer Ther (2012) 1.15
iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype. Mol Cell Proteomics (2009) 1.14
EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis. Acta Neuropathol (2013) 1.13
Aromatase inhibition: translation into a successful therapeutic approach. Clin Cancer Res (2005) 1.13
IDH1 mutations in grade II astrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival. Cancer (2011) 1.12
Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells. Brain (2013) 1.12
Mesenchymal stem cell signaling in cancer progression. Cancer Treat Rev (2012) 1.10
The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas. Cancer Epidemiol Biomarkers Prev (2002) 1.10
Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome. J Biol Chem (2011) 1.10
MDM2 SNP309 and risk of endometrial cancer. Pol J Pathol (2013) 1.10
Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres. Nucleic Acids Res (2007) 1.10
Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase. Diabetes (2007) 1.09
Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanisms. Expert Opin Ther Targets (2009) 1.09
Intraoperative computed tomography with integrated navigation system in a multidisciplinary operating suite. Neurosurgery (2009) 1.09
Presence of pluripotent CD133+ cells correlates with malignancy of gliomas. Mol Cell Neurosci (2008) 1.08
PML-nuclear bodies accumulate DNA in response to polyomavirus BK and simian virus 40 replication. Exp Cell Res (2004) 1.08