Published in Infect Immun on May 01, 2004
The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism. Infect Immun (2006) 1.11
Interaction of Cryptosporidium hominis and Cryptosporidium parvum with primary human and bovine intestinal cells. Infect Immun (2006) 1.06
Actin depolymerization factor/cofilin activation regulates actin polymerization and tension development in canine tracheal smooth muscle. J Biol Chem (2008) 1.06
Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion. Proc Natl Acad Sci U S A (2005) 0.97
Evolution of apicomplexan secretory organelles. Int J Parasitol (2012) 0.90
Involvement of host cell integrin α2 in Cryptosporidium parvum infection. Infect Immun (2012) 0.87
Cryptosporidium parvum infects human cholangiocytes via sphingolipid-enriched membrane microdomains. Cell Microbiol (2006) 0.87
Survival of protozoan intracellular parasites in host cells. EMBO Rep (2004) 0.79
Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization. Infect Immun (2010) 0.76
SHP-2 Mediates Cryptosporidium parvum Infectivity in Human Intestinal Epithelial Cells. PLoS One (2015) 0.75
Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens. Pathogens (2017) 0.75
Rho GTPases and the actin cytoskeleton. Science (1998) 28.19
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell (1995) 24.99
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J (1999) 9.76
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell (1999) 8.07
Localized Rac activation dynamics visualized in living cells. Science (2000) 7.00
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem (1999) 5.80
S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell (1998) 5.27
Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. Cell (1996) 5.01
Cryptosporidium and cryptosporidiosis in man and animals. Int J Parasitol (1995) 4.24
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion. Nature (1999) 4.12
Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization. Biochemistry (1999) 3.77
Viability of Cryptosporidium parvum oocysts: correlation of in vitro excystation with inclusion or exclusion of fluorogenic vital dyes. Appl Environ Microbiol (1992) 3.74
Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. Nat Cell Biol (2001) 3.51
Cryptosporidiosis. N Engl J Med (2002) 3.24
Requirement of CDC42 for Salmonella-induced cytoskeletal and nuclear responses. Science (1996) 3.00
Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism. Hepatology (1998) 2.75
Microbial pathogenesis and cytoskeletal function. Nature (2003) 2.38
Regulation of intracellular pH by immortalized human intrahepatic biliary epithelial cell lines. Am J Physiol (1994) 2.36
Purification of recombinant Rho/Rac/G25K from Escherichia coli. Methods Enzymol (1995) 2.23
Chlamydia trachomatis induces remodeling of the actin cytoskeleton during attachment and entry into HeLa cells. Infect Immun (2002) 2.12
Direct nucleation and bundling of actin by the SipC protein of invasive Salmonella. EMBO J (1999) 1.96
Natural history and biology of Cryptosporidium parvum. Adv Parasitol (1998) 1.83
A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells. Mol Biol Cell (2003) 1.80
New insights into human cryptosporidiosis. Clin Microbiol Rev (1999) 1.72
In vitro cultivation of Cryptosporidium parvum and screening for anticryptosporidial drugs. Antimicrob Agents Chemother (1990) 1.57
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. Mol Cell Biol (2003) 1.44
Cryptosporidium parvum induces host cell actin accumulation at the host-parasite interface. Infect Immun (2000) 1.43
Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli. Cell Microbiol (2002) 1.34
Shigella deliver an effector protein to trigger host microtubule destabilization, which promotes Rac1 activity and efficient bacterial internalization. EMBO J (2002) 1.27
Mechanisms of attachment and internalization of Cryptosporidium parvum to biliary and intestinal epithelial cells. Gastroenterology (2000) 1.26
A role for host phosphoinositide 3-kinase and cytoskeletal remodeling during Cryptosporidium parvum infection. Infect Immun (1999) 1.24
Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src. Gastroenterology (2003) 1.21
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VII. Enteropathogenic Escherichia coli: physiological alterations from an extracellular position. Am J Physiol Gastrointest Liver Physiol (2001) 1.17
Inhibition of invasion and intraerythrocytic development of Plasmodium falciparum by kinase inhibitors. Experientia (1996) 1.15
Cryptosporidium parvum infection requires host cell actin polymerization. Infect Immun (2001) 1.12
Src tyrosine kinase activity down-regulates Rho-dependent responses during Shigella entry into epithelial cells and stress fibre formation. J Cell Sci (2000) 1.09
Concentration of amylase along its secretory pathway in the pancreatic acinar cell as revealed by high resolution immunocytochemistry. Histochem J (1984) 0.97
p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway. Oncogene (2000) 0.95
Effect of Rho and ADP-ribosylation factor GTPases on phospholipase D activity in intact human adenocarcinoma A549 cells. J Biol Chem (1999) 0.94
Ultrastructural study of asexual development of Cryptosporidium parvum in a human intestinal cell line. J Protozool (1992) 0.92
Immunodetection of the microvillous cytoskeleton molecules villin and ezrin in the parasitophorous vacuole wall of Cryptosporidium parvum (Protozoa: Apicomplexa). Eur J Cell Biol (1999) 0.89
Tyrosine phosphate hydrolysis of host proteins by Trypanosoma cruzi is linked to cell invasion. FEMS Microbiol Lett (1998) 0.78
Involvement of the actin cytoskeleton and p21rho-family GTPases in the pathogenesis of the human protozoan parasite Entamoeba histolytica. Braz J Med Biol Res (1998) 0.76
A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev Cell (2009) 4.89
The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol (2003) 4.56
Foot and mouth: podosomes, invadopodia and circular dorsal ruffles. Nat Rev Mol Cell Biol (2004) 4.35
Strategies for improving attendance at medical grand rounds at an academic medical center. Mayo Clin Proc (2003) 3.71
Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease. J Am Soc Nephrol (2010) 3.47
Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell (2009) 3.44
Cryptosporidiosis. N Engl J Med (2002) 3.24
Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity (2007) 3.14
A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem (2007) 2.89
Retromer-mediated endosomal protein sorting: all WASHed up! Trends Cell Biol (2013) 2.77
Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res (2005) 2.72
VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat Rev Immunol (2002) 2.57
Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res (2008) 2.56
Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia. Hum Mol Genet (2003) 2.55
Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Nat Cell Biol (2005) 2.50
Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. Gastroenterology (2006) 2.43
The large GTPase dynamin regulates actin comet formation and movement in living cells. Proc Natl Acad Sci U S A (2002) 2.25
Structure and control of the actin regulatory WAVE complex. Nature (2010) 2.25
MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. Hepatology (2009) 2.23
HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity (2006) 2.23
The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Curr Biol (2006) 2.20
Dynamin participates in focal extracellular matrix degradation by invasive cells. Mol Biol Cell (2003) 2.19
Dynamin-like protein 1 is involved in peroxisomal fission. J Biol Chem (2002) 2.18
Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol Cell Biol (2003) 2.15
Characterization of PKD protein-positive exosome-like vesicles. J Am Soc Nephrol (2009) 2.13
Perceived impact of duty hours limits on the fragmentation of patient care: results from an academic health center. Am J Med (2005) 2.10
Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Biochem Biophys Res Commun (2005) 2.08
A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization. Cancer Res (2006) 2.01
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell (2005) 2.01
Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis. Proc Natl Acad Sci U S A (2010) 1.95
Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Mol Cell Biol (2003) 1.92
Dynamin 2 binds gamma-tubulin and participates in centrosome cohesion. Nat Cell Biol (2004) 1.91
Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nat Immunol (2005) 1.90
A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell (2005) 1.89
Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB. J Immunol (2005) 1.88
Dynamin at the actin-membrane interface. Curr Opin Cell Biol (2003) 1.88
Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia. Am J Physiol Gastrointest Liver Physiol (2010) 1.85
Motoring around the Golgi. Nat Cell Biol (2002) 1.84
Defects in cholangiocyte fibrocystin expression and ciliary structure in the PCK rat. Gastroenterology (2003) 1.80
A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells. Mol Biol Cell (2003) 1.80
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Nat Immunol (2006) 1.78
MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes. J Immunol (2009) 1.76
Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc Natl Acad Sci U S A (2007) 1.72
WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Proc Natl Acad Sci U S A (2010) 1.71
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem (2008) 1.70
Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. Curr Biol (2003) 1.66
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem (2004) 1.64
T cell activation and the cytoskeleton: you can't have one without the other. Adv Immunol (2008) 1.62
Dynamin as a mover and pincher during cell migration and invasion. J Cell Sci (2006) 1.61
Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation. Clin Cancer Res (2006) 1.61
Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex. J Cell Biol (2012) 1.59
The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD). Hepatology (2009) 1.58
SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J Immunol (2003) 1.58
Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors. Am J Physiol Gastrointest Liver Physiol (2008) 1.56
Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors. Hepatology (2014) 1.55
Get off my back! Rapid receptor internalization through circular dorsal ruffles. Cancer Res (2006) 1.55
Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. J Immunol (2005) 1.54
Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell (2010) 1.51
Targeting GSK-3: a promising approach for cancer therapy? Future Oncol (2006) 1.50
The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis. Curr Biol (2002) 1.50
Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease. Am J Pathol (2004) 1.49
Research productivity of graduates from 3 physician-scientist training programs. Am J Med (2008) 1.44
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. Mol Cell Biol (2003) 1.44
The antiviral dynamin family member, MxA, tubulates lipids and localizes to the smooth endoplasmic reticulum. J Biol Chem (2002) 1.42
Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. J Biol Chem (2004) 1.40
Dynamin 2 mediates fluid-phase micropinocytosis in epithelial cells. J Cell Sci (2007) 1.40
Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma. Hepatology (2006) 1.40
Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion. Infect Immun (2004) 1.40
NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection. J Biol Chem (2009) 1.40
Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2. Clin Cancer Res (2008) 1.39
SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin. Mol Cell Biol (2009) 1.39
Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis. Hepatology (2012) 1.38
Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. Mol Biol Cell (2012) 1.38
Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling. FASEB J (2005) 1.37
Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Mol Biol Cell (2012) 1.36
Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells. J Biol Chem (2005) 1.35
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. Am J Pathol (2008) 1.34
Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell (2013) 1.32