PubRank

Peter Kuhn

Author PubWeight™ 210.21‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 2007 20.32
2 Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science 2010 10.30
3 Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines. J Synchrotron Radiat 2002 9.48
4 A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure 2008 6.01
5 Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A 2002 6.00
6 A rare-cell detector for cancer. Proc Natl Acad Sci U S A 2004 3.95
7 Crystal structure of a lipid G protein-coupled receptor. Science 2012 3.78
8 Characterization of circulating endothelial cells in acute myocardial infarction. Sci Transl Med 2012 2.91
9 New paradigm for macromolecular crystallography experiments at SSRL: automated crystal screening and remote data collection. Acta Crystallogr D Biol Crystallogr 2008 2.79
10 Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type. Arch Pathol Lab Med 2009 2.73
11 Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam. J R Soc Interface 2009 2.69
12 Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3. Structure 2005 2.55
13 High speed detection of circulating tumor cells. Biosens Bioelectron 2006 2.29
14 Case study of the morphologic variation of circulating tumor cells. Hum Pathol 2006 2.28
15 Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein. Structure 2003 2.21
16 Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers. Phys Biol 2012 2.21
17 Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Chem Biol 2003 2.05
18 Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors. Phys Biol 2012 2.02
19 Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. Structure 2006 1.97
20 Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome. Acta Crystallogr D Biol Crystallogr 2003 1.92
21 Cytomorphology of circulating colorectal tumor cells:a small case series. J Oncol 2010 1.66
22 Mechanistic studies of a flavin-dependent thymidylate synthase. Biochemistry 2004 1.55
23 Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient. Front Oncol 2012 1.54
24 Enthalpy arrays. Proc Natl Acad Sci U S A 2004 1.52
25 Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins 2006 1.51
26 The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov 2012 1.50
27 Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine 2009 1.49
28 Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology. Phys Biol 2012 1.45
29 Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. Angew Chem Int Ed Engl 2006 1.45
30 Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1. J Mol Biol 2006 1.42
31 In situ data collection and structure refinement from microcapillary protein crystallization. J Appl Crystallogr 2005 1.42
32 Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proc Natl Acad Sci U S A 2007 1.40
33 Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. J Biol Chem 2006 1.40
34 A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells. Proc Natl Acad Sci U S A 2009 1.39
35 Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. J Neurochem 2004 1.38
36 High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis. Phys Biol 2012 1.37
37 Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans. Am J Hum Genet 2009 1.37
38 Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy. J Virol 2006 1.34
39 A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep 2013 1.33
40 In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels. Acta Crystallogr D Biol Crystallogr 2008 1.32
41 Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3. J Virol 2008 1.27
42 Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient. Front Oncol 2012 1.26
43 Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs. J Virol 2006 1.24
44 Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. J Mol Biol 2002 1.21
45 Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers. J Virol 2005 1.19
46 Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein. J Virol 2007 1.18
47 Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution. Proteins 2004 1.17
48 Alcohol exposure during the developmental period induces beta-endorphin neuronal death and causes alteration in the opioid control of stress axis function. Endocrinology 2007 1.12
49 Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR. Proc Natl Acad Sci U S A 2012 1.11
50 Improved absorption and bioactivity of active compounds from an anti-diabetic extract of Artemisia dracunculus L. Int J Pharm 2008 1.09
51 Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution. Proteins 2004 1.09
52 Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch. J Virol 2007 1.08
53 Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models. J Virol 2007 1.08
54 Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus. J Virol 2007 1.07
55 Efficient sorption of polyphenols to soybean flour enables natural fortification of foods. Food Chem 2012 1.07
56 Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J Mol Biol 2008 1.05
57 Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line. Phys Biol 2012 1.05
58 Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7. J Virol 2005 1.04
59 Enthalpy array analysis of enzymatic and binding reactions. Anal Biochem 2008 1.03
60 Cyclic adenosine monophosphate differentiated beta-endorphin neurons promote immune function and prevent prostate cancer growth. Proc Natl Acad Sci U S A 2008 1.03
61 Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution. Proteins 2006 1.03
62 Quality of life 15 years after sex reassignment surgery for transsexualism. Fertil Steril 2008 1.03
63 Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression. Protein Expr Purif 2007 1.01
64 Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus. J Neurochem 2006 1.00
65 Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution. Proteins 2004 1.00
66 Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 A resolution reveals a new fold. Proteins 2005 0.99
67 Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members. Proc Natl Acad Sci U S A 2010 0.98
68 In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix. Food Chem 2012 0.98
69 Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition. J Biol Chem 2007 0.98
70 Painful love-"hispareunia" after sling erosion of the female partner. J Sex Med 2011 0.98
71 Ethanol induces apoptotic death of developing beta-endorphin neurons via suppression of cyclic adenosine monophosphate production and activation of transforming growth factor-beta1-linked apoptotic signaling. Mol Pharmacol 2005 0.97
72 Protein crystallization in restricted geometry: advancing old ideas for modern times in structural proteomics. Methods Mol Biol 2008 0.96
73 Nuclear Receptor Cofactors in PPARgamma-Mediated Adipogenesis and Adipocyte Energy Metabolism. PPAR Res 2007 0.96
74 Alaskan wild berry resources and human health under the cloud of climate change. J Agric Food Chem 2010 0.96
75 Unifying metastasis--integrating intravasation, circulation and end-organ colonization. Nat Rev Cancer 2012 0.96
76 Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family. J Virol 2009 0.94
77 Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice. Pharmacol Res 2012 0.93
78 A stochastic Markov chain model to describe lung cancer growth and metastasis. PLoS One 2012 0.93
79 Spreaders and sponges define metastasis in lung cancer: a Markov chain Monte Carlo mathematical model. Cancer Res 2013 0.93
80 Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 A resolution. Proteins 2004 0.92
81 Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 A resolution. Proteins 2004 0.92
82 Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor. Proteins 2005 0.91
83 Mindfulness-based interventions in multiple sclerosis: beneficial effects of Tai Chi on balance, coordination, fatigue and depression. BMC Neurol 2014 0.91
84 Fetal ethanol exposure disrupts the daily rhythms of splenic granzyme B, IFN-gamma, and NK cell cytotoxicity in adulthood. Alcohol Clin Exp Res 2006 0.91
85 A structural analysis of M protein in coronavirus assembly and morphology. J Struct Biol 2010 0.90
86 Biochemical analysis and in vivo hypoglycemic activity of a grape polyphenol-soybean flour complex. J Agric Food Chem 2012 0.90
87 Unilateral aplasia cutis congenita on the leg. Pediatr Dermatol 2004 0.89
88 How should bladder wall thickness be measured? A comparison of vaginal, perineal and abdominal ultrasound. Neurourol Urodyn 2010 0.89
89 Nuclear magnetic resonance structure of the nucleic acid-binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3. J Virol 2009 0.89
90 Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution. Proteins 2004 0.89
91 Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 A resolution. Proteins 2004 0.89
92 Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 A resolution. Proteins 2006 0.89
93 Role for the molecular chaperones Zuo1 and Ssz1 in quorum sensing via activation of the transcription factor Pdr1. Proc Natl Acad Sci U S A 2011 0.88
94 Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold. J Virol 2008 0.88
95 Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 A resolution. Proteins 2004 0.88
96 An observational study of circulating tumor cells and (18)F-FDG PET uptake in patients with treatment-naive non-small cell lung cancer. PLoS One 2013 0.88
97 Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 A resolution reveals a new fold. Proteins 2006 0.88
98 Physical biology in cancer. 2. The physical biology of circulating tumor cells. Am J Physiol Cell Physiol 2013 0.87
99 Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution. Proteins 2004 0.87
100 Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 A resolution. Proteins 2004 0.87
101 Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p. Proteins 2006 0.87
102 Dietary phenethylisothiocyanate attenuates bowel inflammation in mice. BMC Chem Biol 2010 0.87
103 Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer. J Thorac Oncol 2014 0.86
104 Structural insights into the catalytic mechanism of bacterial guanosine-diphospho-D-mannose pyrophosphorylase and its regulation by divalent ions. J Biol Chem 2010 0.86
105 Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 A resolution reveals a new fold. Proteins 2005 0.86
106 Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling. J Virol 2009 0.86
107 Remedial strategies in structural proteomics: expression, purification, and crystallization of the Vav1/Rac1 complex. Protein Expr Purif 2006 0.86
108 Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 A resolution. Proteins 2005 0.85
109 X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source. J Struct Funct Genomics 2010 0.85
110 Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution. Proteins 2004 0.85
111 Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold. Proteins 2005 0.85
112 Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2.85 A resolution. Proteins 2003 0.84
113 Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution. Proteins 2005 0.84
114 Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution. Proteins 2004 0.84
115 Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 A resolution reveals a new fold. Proteins 2006 0.84
116 Male and female sexual function after surgical repair of female organ prolapse. J Sex Med 2009 0.83
117 Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution. Proteins 2004 0.83
118 Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution. Proteins 2005 0.83
119 A fluid biopsy as investigating technology for the fluid phase of solid tumors. Phys Biol 2012 0.83
120 Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 A resolution reveals a new fold with a novel active site. Proteins 2006 0.82
121 Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 A resolution. Proteins 2004 0.82
122 Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 A resolution. Proteins 2006 0.82
123 Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution. Proteins 2006 0.82
124 Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 A resolution. Proteins 2004 0.82
125 Concord grape pomace polyphenols complexed to soy protein isolate are stable and hypoglycemic in diabetic mice. J Agric Food Chem 2013 0.81
126 Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1.7 A resolution. Proteins 2004 0.81
127 Gynaecological operations: do they improve sexual life? Eur J Obstet Gynecol Reprod Biol 2006 0.80
128 Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold. Proteins 2005 0.80
129 Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 A resolution. Proteins 2006 0.80
130 Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution. Proteins 2006 0.79
131 Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution. Proteins 2003 0.79
132 Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77-A resolution. Proteins 2004 0.78
133 Adrenal metastases in lung cancer: clinical implications of a mathematical model. J Thorac Oncol 2014 0.78
134 Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction. Phys Biol 2014 0.77
135 Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. Phys Biol 2015 0.77
136 Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold. Proteins 2005 0.77
137 Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution. Proteins 2004 0.77
138 Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution. Proteins 2004 0.77
139 Circulating tumor cells in non-small cell lung carcinoma. J Thorac Dis 2012 0.77
140 Fluid biopsy for solid tumors: a patient's companion for lifelong characterization of their disease. Future Oncol 2012 0.76
141 International research networks in viral structural proteomics: again, lessons from SARS. Antiviral Res 2007 0.76
142 Advancing cancer patient care by integrating circulating tumor cell technology to understand the spatial and temporal dynamics of cancer. Drug Dev Res 2014 0.75
143 C-ME: a 3D community-based, real-time collaboration tool for scientific research and training. PLoS One 2008 0.75
144 Circulating tumour cells in early breast cancer. Lancet Oncol 2012 0.75
145 Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold. Proteins 2005 0.75
146 The correlation of urethral resistance pressure with maximum urethral closure pressure and stress incontinence. Eur J Obstet Gynecol Reprod Biol 2007 0.75
147 Validity of a patient-derived system of tissue-specific human endothelial cells: interleukin-6 as a surrogate marker in the coronary system. Am J Physiol Heart Circ Physiol 2007 0.75
148 New tools to battle emerging viruses. Curr Opin Microbiol 2008 0.75
149 The net which made her wet: two unusual cases of stress incontinence. BMJ Case Rep 2009 0.75
150 Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution. Proteins 2008 0.75
151 Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold. Proteins 2004 0.75
152 Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 A resolution. Proteins 2004 0.75
153 Does bladder wall thickness decrease when obstruction is resolved? Int Urogynecol J 2012 0.75
154 Do women with urinary incontinence really know where all the toilets are? The toilet paper. Eur J Obstet Gynecol Reprod Biol 2005 0.75