Published in J Biol Chem on April 21, 2004
Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet (2010) 15.70
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature (2007) 8.33
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Nat Struct Mol Biol (2008) 3.33
Genome-wide analysis of mono-, di- and trimethylation of histone H3 lysine 4 in Arabidopsis thaliana. Genome Biol (2009) 2.86
Mammalian DNA methyltransferases: a structural perspective. Structure (2008) 2.72
Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol (2008) 2.67
Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A (2005) 2.56
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Res (2012) 2.55
Mammalian cytosine methylation at a glance. J Cell Sci (2009) 2.43
Regulation and function of DNA methylation in plants and animals. Cell Res (2011) 2.41
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res (2010) 2.39
Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet (2009) 2.11
DNA methylation and demethylation in mammals. J Biol Chem (2011) 1.89
A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Res (2010) 1.83
DNA methylation and its basic function. Neuropsychopharmacology (2012) 1.76
DNA methylation in development and human disease. Mutat Res (2008) 1.74
Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry (2010) 1.74
Breast cancer epigenetics: from DNA methylation to microRNAs. J Mammary Gland Biol Neoplasia (2010) 1.58
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic Acids Res (2006) 1.52
Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Res (2008) 1.46
ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation. Autoimmunity (2008) 1.43
Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair. Nucleic Acids Res (2006) 1.40
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells. Blood (2013) 1.38
Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues. Proc Natl Acad Sci U S A (2010) 1.37
DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm. Eur J Hum Genet (2009) 1.36
Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability. Nat Genet (2014) 1.34
A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line. Bioessays (2014) 1.33
Transgenerational epigenetic programming of the embryonic testis transcriptome. Genomics (2007) 1.30
The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. Proc Natl Acad Sci U S A (2009) 1.24
De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET. Development (2013) 1.23
Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation. J Biol Chem (2012) 1.23
DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta. J Biol Chem (2010) 1.15
Dynamic instability of genomic methylation patterns in pluripotent stem cells. Epigenetics Chromatin (2010) 1.15
Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation. Neoplasia (2007) 1.15
Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules: heterochromatic localization and role of Dnmt3L. J Biol Chem (2011) 1.14
The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L. J Biol Chem (2010) 1.14
Coordinate regulation of DNA methyltransferase expression during oogenesis. BMC Dev Biol (2007) 1.12
A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding. Mol Cancer Res (2009) 1.10
Role of DNMT3B in the regulation of early neural and neural crest specifiers. Epigenetics (2012) 1.09
Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives. Epigenetics (2011) 1.08
The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. J Biol Chem (2013) 1.08
The maternal to zygotic transition in mammals. Mol Aspects Med (2013) 1.05
Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants. Nucleic Acids Res (2011) 1.05
Transcriptome analysis during human trophectoderm specification suggests new roles of metabolic and epigenetic genes. PLoS One (2012) 1.03
Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis. Cancer Lett (2012) 1.02
Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs. Curr Med Chem (2010) 0.99
Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma. Mol Cell Endocrinol (2013) 0.99
Structural and functional coordination of DNA and histone methylation. Cold Spring Harb Perspect Biol (2014) 0.98
Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline. Cell Mol Life Sci (2013) 0.97
Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L. BMC Dev Biol (2007) 0.97
MiRNAs, epigenetics, and cancer. Mamm Genome (2008) 0.96
Epigenetic inheritance and the missing heritability. Hum Genomics (2015) 0.95
Chemical methods for decoding cytosine modifications in DNA. Chem Rev (2014) 0.95
Role of chromatin states in transcriptional memory. Biochim Biophys Acta (2009) 0.94
Non-CG Methylation in the Human Genome. Annu Rev Genomics Hum Genet (2015) 0.92
Epigenetics and phenotypic variability: some interesting insights from birds. Genet Sel Evol (2013) 0.91
Male germline control of transposable elements. Biol Reprod (2012) 0.90
DNA methyltransferase 3b preferentially associates with condensed chromatin. Nucleic Acids Res (2010) 0.90
Epigenetic mechanisms and genome stability. Clin Epigenetics (2011) 0.89
DNA methylation profile at the DNMT3L promoter: a potential biomarker for cervical cancer. Epigenetics (2006) 0.88
Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay. Anal Chem (2011) 0.87
Epigenetic control of the genome-lessons from genomic imprinting. Genes (Basel) (2014) 0.87
Repression of androgen receptor transcription through the E2F1/DNMT1 axis. PLoS One (2011) 0.86
Symmetrical Dose-Dependent DNA-Methylation Profiles in Children with Deletion or Duplication of 7q11.23. Am J Hum Genet (2015) 0.84
Human intelligence and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking. PLoS One (2010) 0.83
Inactive DNMT3B splice variants modulate de novo DNA methylation. PLoS One (2013) 0.83
Role of distinct surfaces of the G9a ankyrin repeat domain in histone and DNA methylation during embryonic stem cell self-renewal and differentiation. Epigenetics Chromatin (2014) 0.82
The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis. Cell Rep (2015) 0.82
DNA methylation markers in the postnatal developing rat brain. Brain Res (2013) 0.82
Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells. PLoS Genet (2012) 0.82
Cross-talk between DNA methylation and active histone modifications regulates aberrant expression of ZAP70 in CLL. J Cell Mol Med (2012) 0.82
Epigenetic mechanisms of genomic imprinting: common themes in the regulation of imprinted regions in mammals, plants, and insects. Genet Res Int (2012) 0.82
DNA methylation as a dynamic regulator of development and disease processes: spotlight on the prostate. Epigenomics (2015) 0.81
De novo DNA methyltransferase DNMT3b interacts with NEDD8-modified proteins. J Biol Chem (2010) 0.81
A concise review on epigenetic regulation: insight into molecular mechanisms. Int J Mol Sci (2011) 0.81
DNA methyltransferases and TETs in the regulation of differentiation and invasiveness of extra-villous trophoblasts. Front Genet (2013) 0.79
Domains rearranged methyltransferase3 controls DNA methylation and regulates RNA polymerase V transcript abundance in Arabidopsis. Proc Natl Acad Sci U S A (2015) 0.79
Characterization and rescue of telomeric abnormalities in ICF syndrome type I fibroblasts. Front Oncol (2013) 0.79
Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives. Br J Cancer (2014) 0.79
Distinct DNA methylation dynamics of spermatogenic cell-specific intronless genes is associated with CpG content. PLoS One (2012) 0.79
Current Perspectives on Epigenetic Modifications by Dietary Chemopreventive and Herbal Phytochemicals. Curr Pharmacol Rep (2015) 0.78
Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. J Biol Chem (2014) 0.78
The carboxy-terminal domain of ROS1 is essential for 5-methylcytosine DNA glycosylase activity. J Mol Biol (2014) 0.78
Nutritional Influence on Epigenetic Marks and Effect on Livestock Production. Front Genet (2016) 0.78
Epigenetic Mechanisms of Serotonin Signaling. ACS Chem Neurosci (2015) 0.77
Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression. Hum Mol Genet (2016) 0.77
Experimental approaches to the study of epigenomic dysregulation in ageing. Exp Gerontol (2010) 0.77
Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm. Nucleic Acids Res (2016) 0.76
DNA Methylation: a New Player in Multiple Sclerosis. Mol Neurobiol (2016) 0.76
Epigenetic dysregulation in the developing Down syndrome cortex. Epigenetics (2016) 0.75
Comparative Analysis of DNA Methyltransferase Gene Family in Fungi: A Focus on Basidiomycota. Front Plant Sci (2016) 0.75
No evidence for mutations of CTCFL/BORIS in Silver-Russell syndrome patients with IGF2/H19 imprinting control region 1 hypomethylation. PLoS One (2009) 0.75
DNA methyltransferase 3A promoter polymorphism is associated with the risk of human spontaneous abortion after assisted reproduction techniques and natural conception. J Assist Reprod Genet (2016) 0.75
Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in Disease. Front Genet (2016) 0.75
Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment. Clin Epigenetics (2016) 0.75
DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders. Front Oncol (2016) 0.75
Regulation of CpG methylation by Dnmt and Tet in pluripotent stem cells. J Reprod Dev (2016) 0.75
rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. PLoS Genet (2017) 0.75
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature (2007) 8.17
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev (2008) 2.99
Processive methylation of hemimethylated CpG sites by mouse Dnmt1 DNA methyltransferase. J Biol Chem (2004) 1.77
Co-expression of de novo DNA methyltransferases Dnmt3a2 and Dnmt3L in gonocytes of mouse embryos. Gene Expr Patterns (2004) 1.59
Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc Natl Acad Sci U S A (2011) 1.52
Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis. Mech Dev (2002) 1.43
Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment. Hippocampus (2011) 1.20
Three novel DNMT3B mutations in Japanese patients with ICF syndrome. Am J Med Genet (2002) 1.18
Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1. J Cell Biochem (2003) 1.17
Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1. Biochem Biophys Res Commun (2008) 1.16
Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing. Biochem Biophys Res Commun (2006) 1.14
Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA. J Biochem (2006) 1.07
Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice. Synapse (2010) 1.07
The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated (SRA) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA. J Biol Chem (2013) 1.05
PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA. Genes Cells (2002) 1.04
The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon. Biochem J (2010) 1.03
Mouse Dnmt3a preferentially methylates linker DNA and is inhibited by histone H1. J Mol Biol (2008) 1.01
Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain. Brain (2013) 1.01
Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b. J Biochem (2003) 1.00
Evaluation of pH-responsive liposomes containing amino acid-based zwitterionic lipids for improving intracellular drug delivery in vitro and in vivo. J Control Release (2009) 1.00
miR-29 represses the activities of DNA methyltransferases and DNA demethylases. Int J Mol Sci (2013) 1.00
Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects. Biol Reprod (2009) 0.99
Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4. J Biol Chem (2013) 0.99
Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. Gastric Cancer (2014) 0.95
Isolation and characterization of l-rhamnose-binding lectin, which binds to microsporidian Glugea plecoglossi, from ayu (Plecoglossus altivelis) eggs. Dev Comp Immunol (2007) 0.95
Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells. PLoS One (2013) 0.94
Genome-wide analysis of DNA methylation and expression of microRNAs in breast cancer cells. Int J Mol Sci (2012) 0.92
Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation. Cancer Lett (2012) 0.91
Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. Cancer Lett (2012) 0.91
Development of a novel output value for quantitative assessment in methylated DNA immunoprecipitation-CpG island microarray analysis. DNA Res (2009) 0.91
Stimulation effect of Dnmt3L on the DNA methylation activity of Dnmt3a2. J Biochem (2006) 0.90
The amino-terminus of mouse DNA methyltransferase 1 forms an independent domain and binds to DNA with the sequence involving PCNA binding motif. J Biochem (2006) 0.89
Expression of Dnmt3b in mouse hematopoietic progenitor cells and spermatogonia at specific stages. Gene Expr Patterns (2004) 0.89
Recombinant mammalian DNA methyltransferase activity on model transcriptional gene silencing short RNA-DNA heteroduplex substrates. Biochem J (2010) 0.88
Hinge and chromoshadow of HP1α participate in recognition of K9 methylated histone H3 in nucleosomes. J Mol Biol (2012) 0.88
Xenopus MBD3 plays a crucial role in an early stage of development. Dev Biol (2004) 0.86
Hippocampal epigenetic modification at the doublecortin gene is involved in the impairment of neurogenesis with aging. Synapse (2010) 0.83
Recombinant Tol2 transposase with activity in Xenopus embryos. FEBS Lett (2007) 0.83
Expression, purification and characterization of methyl DNA binding protein from Bombyx mori. J Insect Sci (2005) 0.83
Characterization of DNA-binding activity in the N-terminal domain of the DNA methyltransferase Dnmt3a. Biochem J (2011) 0.81
Monoclonal antibody against dnmt1 arrests the cell division of xenopus early-stage embryos. Exp Cell Res (2003) 0.81
Fabrication of wool keratin sponge scaffolds for long-term cell cultivation. J Biotechnol (2002) 0.79
Ars insulator identified in sea urchin possesses an activity to ensure the transgene expression in mouse cells. J Biochem (2006) 0.79
Cloning and characterization of a novel Ca2+/calmodulin-dependent protein kinase I homologue in Xenopus laevis. J Biochem (2004) 0.79
Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine. Addict Biol (2010) 0.79
Exogenous expression of mouse Dnmt3 induces apoptosis in Xenopus early embryos. J Biochem (2002) 0.78
The Dnmt3b splice variant is specifically expressed in in vitro-manipulated blastocysts and their derivative ES cells. J Reprod Dev (2011) 0.77
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Selective oxidation of 5-hydroxymethylcytosine with micelle incarcerated oxidants to determine it at single base resolution. Bioorg Med Chem Lett (2015) 0.75
Usefulness of low-dose methotrexate monotherapy for treating sarcoidosis. Intern Med (2013) 0.75