Published in Nucleic Acids Res on March 04, 2011
Repurposing the CRISPR-Cas9 system for targeted DNA methylation. Nucleic Acids Res (2016) 1.27
Understanding the relationship between DNA methylation and histone lysine methylation. Biochim Biophys Acta (2014) 1.23
Genomic insights into cancer-associated aberrant CpG island hypermethylation. Brief Funct Genomics (2013) 1.11
Integrated Analysis Reveals hsa-miR-142 as a Representative of a Lymphocyte-Specific Gene Expression and Methylation Signature. Cancer Inform (2012) 1.00
High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia. PLoS One (2012) 0.99
Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation. J Biol Chem (2011) 0.99
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis. Blood (2013) 0.97
Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia. Leukemia (2013) 0.96
Epigenetics and phenotypic variability: some interesting insights from birds. Genet Sel Evol (2013) 0.91
Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma. Cancer Res (2012) 0.88
P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis. Genome Biol (2015) 0.87
DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67-positive neurons in the GAD67-GFP mouse brain. J Comp Neurol (2012) 0.86
Inactive DNMT3B splice variants modulate de novo DNA methylation. PLoS One (2013) 0.83
∆ DNMT3B4-del Contributes to Aberrant DNA Methylation Patterns in Lung Tumorigenesis. EBioMedicine (2015) 0.82
Manipulating the epigenome for the treatment of urological malignancies. Pharmacol Ther (2013) 0.81
Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for Diseases. Biology (Basel) (2014) 0.79
Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B. Leukemia (2014) 0.78
There is a world beyond protein mutations: the role of non-coding RNAs in melanomagenesis. Exp Dermatol (2013) 0.77
DNA Methylation: a New Player in Multiple Sclerosis. Mol Neurobiol (2016) 0.76
Connecting the dots: chromatin and alternative splicing in EMT. Biochem Cell Biol (2015) 0.75
Hypomethylation of serum blood clot DNA, but not plasma EDTA-blood cell pellet DNA, from vitamin B12-deficient subjects. PLoS One (2013) 0.75
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell (1999) 25.75
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature (2007) 8.33
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature (2004) 7.57
Epigenetics in cancer. Carcinogenesis (2009) 7.49
Dnmt3L and the establishment of maternal genomic imprints. Science (2001) 7.42
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature (2004) 7.42
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res (1999) 4.74
DNA methylation analysis by pyrosequencing. Nat Protoc (2007) 4.65
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res (2003) 4.36
QUMA: quantification tool for methylation analysis. Nucleic Acids Res (2008) 3.73
DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction. J Biol Chem (2004) 3.25
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. J Biol Chem (2010) 3.03
Mammalian cytosine methylation at a glance. J Cell Sci (2009) 2.43
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev (2007) 2.34
The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol Cell Biol (2004) 2.30
Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L. J Biol Chem (2005) 2.28
Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family. J Cell Biochem (2005) 2.27
The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nat Struct Biol (2002) 2.24
Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol (2007) 2.15
Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L. J Biol Chem (2006) 2.13
Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases. J Biol Chem (2002) 1.85
Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem (2005) 1.84
DNA methylation in development and human disease. Mutat Res (2008) 1.74
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc Natl Acad Sci U S A (2002) 1.73
Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins. Oncogene (2007) 1.70
Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Mol Cancer Res (2004) 1.68
DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. Hum Mol Genet (2007) 1.65
Escape from gene silencing in ICF syndrome: evidence for advanced replication time as a major determinant. Hum Mol Genet (2000) 1.61
DNMT3B mutations and DNA methylation defect define two types of ICF syndrome. Hum Mutat (2005) 1.59
DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res (2010) 1.49
Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Res (2008) 1.46
Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development (2006) 1.44
Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis. Mech Dev (2002) 1.43
DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. Hum Mol Genet (2009) 1.41
Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells. Dev Biol (2004) 1.41
DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo. PLoS Genet (2010) 1.41
A novel DNMT3B subfamily, DeltaDNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer. Int J Oncol (2006) 1.27
Interactions within the mammalian DNA methyltransferase family. BMC Mol Biol (2003) 1.23
Immunodeficiency, centromeric region instability, facial anomalies syndrome (ICF). Orphanet J Rare Dis (2006) 1.17
The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L. J Biol Chem (2010) 1.14
A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding. Mol Cancer Res (2009) 1.10
Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA. J Biochem (2006) 1.07
Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas. Lab Invest (2008) 1.06
Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Hum Mol Genet (2006) 1.05
Identification of a second DNA binding site in human DNA methyltransferase 3A by substrate inhibition and domain deletion. Arch Biochem Biophys (2010) 0.96
Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD). PLoS Genet (2009) 2.90
DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Mol Cell Biol (2007) 2.47
Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. Cancer Res (2006) 2.00
DNA methylation in development and human disease. Mutat Res (2008) 1.74
Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together? J Cell Biochem (2002) 1.67
Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors. J Clin Oncol (2004) 1.65
DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. Hum Mol Genet (2007) 1.65
Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern. J Biol Chem (2004) 1.64
DNA methyltransferases, DNA damage repair, and cancer. Adv Exp Med Biol (2013) 1.57
Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res (2004) 1.52
Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis (2006) 1.47
DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer (2011) 1.45
Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. Nucleic Acids Res (2004) 1.44
DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. Hum Mol Genet (2009) 1.41
Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells. Hum Mol Genet (2002) 1.32
Preferential methylation of unmethylated DNA by Mammalian de novo DNA methyltransferase Dnmt3a. J Biol Chem (2002) 1.30
Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells. Cell Rep (2012) 1.27
DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer. Cancer Res (2009) 1.26
Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression. Cancer Res (2006) 1.20
The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. Lab Invest (2007) 1.19
Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. Am J Physiol Gastrointest Liver Physiol (2012) 1.18
Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing. Nucleic Acids Res (2011) 1.15
DNMT1 knockout delivers a strong blow to genome stability and cell viability. Nat Genet (2007) 1.12
DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Biochem Biophys Res Commun (2004) 1.11
A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding. Mol Cancer Res (2009) 1.10
Stealth technology: how Epstein-Barr virus utilizes DNA methylation to cloak itself from immune detection. Clin Immunol (2003) 1.09
Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro. Biochem Biophys Res Commun (2004) 1.08
An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. Cancer Res (2006) 1.08
Comparative epigenomics of human and mouse mammary tumors. Genes Chromosomes Cancer (2009) 1.07
Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Lab Invest (2009) 1.07
Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas. Lab Invest (2008) 1.06
Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery. Hum Mol Genet (2010) 1.06
Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy. J Mol Med (Berl) (2007) 1.03
Doxorubicin inhibits DNMT1, resulting in conditional apoptosis. Mol Pharmacol (2004) 1.01
Histone deacetylase inhibitors for cancer therapy. Epigenetics (2006) 0.98
Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells. Genome Biol (2014) 0.93
Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor. Adv Protein Chem Struct Biol (2012) 0.91
Epigenetic mechanisms and genome stability. Clin Epigenetics (2011) 0.89
The transglutaminase 2 gene is aberrantly hypermethylated in glioma. J Neurooncol (2010) 0.87
DMB (DNMT-magnetic beads) assay: measuring DNA methyltransferase activity in vitro. Methods Mol Biol (2004) 0.87
Epigenetic control of tumor suppression. Crit Rev Eukaryot Gene Expr (2007) 0.86
Dimethyl sulfoxide stimulates the catalytic activity of de novo DNA methyltransferase 3a (Dnmt3a) in vitro. Bioorg Chem (2004) 0.80