Published in J Biol Chem on March 26, 2009
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An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets. Sci Rep (2016) 0.75
No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis. J Neuroimmunol (2010) 0.75
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A rare coding allele in IFIH1 is protective for psoriatic arthritis. Ann Rheum Dis (2017) 0.75
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Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature (2007) 8.87
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A (2006) 8.27
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Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol Cell (2008) 5.20
Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity (2008) 2.81
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. J Biol Chem (2009) 1.78
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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65
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Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol (2005) 9.11
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A (2006) 5.70
Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci U S A (2005) 5.64
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol Cell (2008) 5.35
Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol Cell (2008) 5.20
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci U S A (2006) 4.84
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature (2002) 4.81
RNA recognition and signal transduction by RIG-I-like receptors. Immunol Rev (2009) 4.41
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nat Biotechnol (2006) 3.46
Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev (2004) 3.33
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci U S A (2010) 2.90
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proc Natl Acad Sci U S A (2007) 2.88
Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nat Immunol (2006) 2.85
Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity (2008) 2.81
NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I. Am J Respir Cell Mol Biol (2006) 2.78
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Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells. J Immunol (2007) 2.73
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem (2003) 2.61
RIG-I-like receptors: cytoplasmic sensors for non-self RNA. Immunol Rev (2011) 2.48
Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J Biol Chem (2003) 2.45
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Control of IRF-3 activation by phosphorylation. J Interferon Cytokine Res (2002) 2.39
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease. Arthritis Rheum (2009) 2.37
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Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet (2002) 1.83
Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. PLoS Pathog (2010) 1.82
Green light drives leaf photosynthesis more efficiently than red light in strong white light: revisiting the enigmatic question of why leaves are green. Plant Cell Physiol (2009) 1.75
Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. J Virol (2005) 1.72
A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. Int Immunol (2002) 1.70
Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors. J Biol Chem (2009) 1.68
Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1. PLoS Pathog (2010) 1.66
A20 is a negative regulator of IFN regulatory factor 3 signaling. J Immunol (2005) 1.63
Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency. Dev Dyn (2007) 1.56
Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity. PLoS One (2012) 1.55
NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. J Immunol (2006) 1.54
Effect of warm ischemia on renal function during partial nephrectomy: assessment with new 99mTc-mercaptoacetyltriglycine scintigraphy parameter. Urology (2011) 1.54
The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metabolism (2008) 1.50
Prediction of partial nephrectomy outcomes by using the diameter-axis-polar nephrometry score. Int J Urol (2013) 1.42
Triggering antiviral response by RIG-I-related RNA helicases. Biochimie (2007) 1.37
Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex. J Biol Chem (2002) 1.32
Cytoplasmic nucleic acid sensors in antiviral immunity. Trends Mol Med (2009) 1.15
Intra-leaf gradients of photoinhibition induced by different color lights: implications for the dual mechanisms of photoinhibition and for the application of conventional chlorophyll fluorometers. New Phytol (2011) 1.15
Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses. J Virol (2013) 1.13
RIG-I activation inhibits ebolavirus replication. Virology (2009) 1.12
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Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3. Mol Ther (2011) 1.09
Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development. Dev Biol (2006) 1.08
Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. J Biol Chem (2003) 1.07
Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity. Hepatology (2013) 1.03
Akt regulates skeletal development through GSK3, mTOR, and FoxOs. Dev Biol (2009) 1.03
5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication. Virol J (2010) 1.02
HxlR, a member of the DUF24 protein family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis. Mol Microbiol (2005) 1.02
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Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. J Bone Miner Res (2006) 1.01
Role of the alpha/beta interferon response in the acquisition of susceptibility to poliovirus by kidney cells in culture. J Virol (2006) 0.99
IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC. J Immunol (2003) 0.99
Complete nucleotide sequence and construction of an infectious clone of Chinese yam necrotic mosaic virus suggest that macluraviruses have the smallest genome among members of the family Potyviridae. Arch Virol (2012) 0.99
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High incidence of sudden cardiac death with conduction disturbances and atrial cardiomyopathy caused by a nonsense mutation in the STA gene. Circulation (2005) 0.98
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