Published in FASEB J on April 06, 2010
Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization. Nucleic Acids Res (2012) 1.05
Analysis of TP53 mutation spectra reveals the fingerprint of the potent environmental carcinogen, aristolochic acid. Mutat Res (2013) 1.02
TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts. Mutat Res (2015) 0.89
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Comparative study and meta-analysis of meta-analysis studies for the correlation of genomic markers with early cancer detection. Hum Genomics (2013) 0.81
Unambiguous detection of multiple TP53 gene mutations in AAN-associated urothelial cancer in Belgium using laser capture microdissection. PLoS One (2014) 0.80
TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts. DNA Repair (Amst) (2015) 0.80
A novel p53 mutant found in iatrogenic urothelial cancers is dysfunctional and can be rescued by a second-site global suppressor mutation. J Biol Chem (2013) 0.79
Unveiling the methylation status of CpG dinucleotides in the substituted segment of the human p53 knock-in (Hupki) mouse genome. Mol Carcinog (2010) 0.78
Evolution of p53 transactivation specificity through the lens of a yeast-based functional assay. PLoS One (2015) 0.76
Benzo[a]pyrene, aflatoxine B₁ and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiology. PLoS One (2012) 0.75
Evaluation of in vivo mutagenesis for assessing the health risk of air pollutants. Genes Environ (2017) 0.75
A suggested vital function for eIF-5A and dhs genes during murine malaria blood-stage infection. FEBS Open Bio (2016) 0.75
The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02
An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36
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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02
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Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27
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Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc Natl Acad Sci U S A (2003) 4.06
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Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci U S A (2007) 2.52
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TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours. Int J Cancer (2009) 1.52
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Second-hand smoke and human lung cancer. Lancet Oncol (2008) 1.17
Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene. Proc Natl Acad Sci U S A (2004) 1.16
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The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice. Carcinogenesis (1997) 1.11
Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis. Carcinogenesis (2005) 1.11
Dissociation of the recombination control and the sequence-specific transactivation function of P53. Oncogene (1999) 1.07
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MEF immortalization to investigate the ins and outs of mutagenesis. Carcinogenesis (2006) 1.04
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Aristolochic acid binds covalently to the exocyclic amino group of purine nucleotides in DNA. Carcinogenesis (1990) 1.02
p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors. Cancer Res (2005) 1.01
Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage. Oncogene (2004) 1.00
DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy. Am J Kidney Dis (2004) 0.99
3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence. Mutagenesis (2005) 0.98
Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence. J Biol Chem (2010) 0.97
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The carcinogenic air pollutant 3-nitrobenzanthrone induces GC to TA transversion mutations in human p53 sequences. Mutagenesis (2008) 0.93
Mutagenicity of aristolochic acid in the lambda/lacZ transgenic mouse (MutaMouse). Mutat Res (2002) 0.92
UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin. Cancer Res (2001) 0.91
DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3-nitrobenzanthrone in Muta Mouse. Environ Mol Mutagen (2004) 0.90
Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice. Int J Cancer (2006) 0.89
Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences. Mutat Res (2006) 0.88
Human p53 knock-in (hupki) mice do not differ in liver tumor response from their counterparts with murine p53. Carcinogenesis (2005) 0.84
p53 designer genes for the modern mouse. Cell Cycle (2004) 0.84
Sunlight ultraviolet irradiation and BRAF V600 mutagenesis in human melanoma. Hum Mutat (2008) 0.84
The yeast p53 functional assay: a new tool for molecular epidemiology. Hopes and facts. Mutat Res (2000) 0.82
Mutations in the lungs of gpt delta transgenic mice following inhalation of diesel exhaust. Environ Mol Mutagen (2007) 0.82
Mutagenic specificity of N-acetoxy-3-aminobenzanthrone, a major metabolically activated form of 3-nitrobenzanthrone, in shuttle vector plasmids propagated in human cells. Mutat Res (2008) 0.80
Functional analysis of p53 tumor suppressor in yeast. Differentiation (2005) 0.78
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature (2011) 6.73
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A (2011) 5.45
Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine. Nucleic Acids Res (2010) 4.79
A human B cell methylome at 100-base pair resolution. Proc Natl Acad Sci U S A (2009) 4.72
MIRA-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identifies frequent methylation of homeodomain-containing genes in lung cancer cells. Cancer Res (2006) 3.66
Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay. Proc Natl Acad Sci U S A (2007) 2.91
Genomic mapping of 5-hydroxymethylcytosine in the human brain. Nucleic Acids Res (2011) 2.53
The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochim Biophys Acta (2009) 2.50
5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res (2011) 2.36
GADD45A does not promote DNA demethylation. PLoS Genet (2008) 2.36
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell (2008) 2.28
Methylated-CpG island recovery assay: a new technique for the rapid detection of methylated-CpG islands in cancer. Lab Invest (2005) 2.23
Repair of methylation damage in DNA and RNA by mammalian AlkB homologues. J Biol Chem (2005) 2.19
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis. Cell Rep (2013) 2.10
High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer. Proc Natl Acad Sci U S A (2007) 2.10
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells. J Biol Chem (2006) 2.10
Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res (2008) 2.08
Tumor susceptibility of Rassf1a knockout mice. Cancer Res (2005) 2.03
Insulin gene expression is regulated by DNA methylation. PLoS One (2009) 1.97
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene (2002) 1.96
RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network. Curr Biol (2007) 1.91
Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells. Mol Ther (2005) 1.67
The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. Mol Cell (2005) 1.58
CpG island hypermethylation in human astrocytomas. Cancer Res (2010) 1.57
Control of microtubule stability by the RASSF1A tumor suppressor. Oncogene (2003) 1.54
Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks. PLoS One (2011) 1.50
Weak yet distinct mutagenicity of acrylamide in mammalian cells. J Natl Cancer Inst (2003) 1.48
Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma. Cancer Res (2003) 1.48
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis. Adv Genet (2010) 1.44
Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma. Mol Carcinog (2007) 1.44
Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer. Breast Cancer Res (2009) 1.43
In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure. Gastroenterology (2009) 1.43
MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex. J Biol Chem (2004) 1.41
The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein. Cell Cycle (2005) 1.37
The MIRA method for DNA methylation analysis. Methods Mol Biol (2009) 1.35
DNA methylation biomarkers for lung cancer. Tumour Biol (2011) 1.35
Epigenetic control of female puberty. Nat Neurosci (2013) 1.34
DNA methylation profiling using the methylated-CpG island recovery assay (MIRA). Methods (2010) 1.30
Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming. Genome Biol (2015) 1.30
RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene (2002) 1.29
Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma. Oncogene (2003) 1.27
Frequent hypermethylation of the RASSF1A gene in prostate cancer. Oncogene (2002) 1.23
Microcephalin encodes a centrosomal protein. Cell Cycle (2006) 1.21
Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG-->TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells. Nucleic Acids Res (2002) 1.21
The role of DNA polymerase eta in UV mutational spectra. DNA Repair (Amst) (2005) 1.20
Second-hand smoke and human lung cancer. Lancet Oncol (2008) 1.17
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma. Oncogene (2003) 1.15
DNA lesions induced by UV A1 and B radiation in human cells: comparative analyses in the overall genome and in the p53 tumor suppressor gene. Proc Natl Acad Sci U S A (2005) 1.15
Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma. Cancer Res (2002) 1.15
Aging and DNA methylation. BMC Biol (2015) 1.15
Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair. Nucleic Acids Res (2003) 1.14
A genome-wide screen identifies frequently methylated genes in haematological and epithelial cancers. Mol Cancer (2010) 1.14
Tet-mediated formation of 5-hydroxymethylcytosine in RNA. J Am Chem Soc (2014) 1.14
The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J Biol Chem (2004) 1.13
Human RIF1 encodes an anti-apoptotic factor required for DNA repair. Carcinogenesis (2009) 1.12
Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis. Carcinogenesis (2005) 1.11
Chromosome-wide analysis of parental allele-specific chromatin and DNA methylation. Mol Cell Biol (2011) 1.11
Protein phosphatase PP4 is overexpressed in human breast and lung tumors. Cell Res (2008) 1.10
A review of mechanisms of acrylamide carcinogenicity. Carcinogenesis (2007) 1.10
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2. J Biol Chem (2011) 1.09
Translesion synthesis of 7,8-dihydro-8-oxo-2'-deoxyguanosine by DNA polymerase eta in vivo. Mutat Res (2008) 1.09
Involvement of the RASSF1A tumor suppressor gene in controlling cell migration. Cancer Res (2005) 1.09
Epigenetic changes of DNA repair genes in cancer. J Mol Cell Biol (2011) 1.08
Deamination of 5-methylcytosines within cyclobutane pyrimidine dimers is an important component of UVB mutagenesis. J Biol Chem (2003) 1.08
CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia. PLoS Genet (2010) 1.07
Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene. Oncogene (2004) 1.07
Identification of 5 novel genes methylated in breast and other epithelial cancers. Mol Cancer (2010) 1.07
53BP1 is a positive regulator of the BRCA1 promoter. Cell Cycle (2005) 1.06
Genome-wide DNA methylation maps in follicular lymphoma cells determined by methylation-enriched bisulfite sequencing. PLoS One (2010) 1.06
G-to-T transversions and small tandem base deletions are the hallmark of mutations induced by ultraviolet a radiation in mammalian cells. Biochemistry (2004) 1.05
A methylation profile of in vitro immortalized human cell lines. Int J Oncol (2005) 1.04
MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor. Genomics (2002) 1.04
Inactivation of RAS association domain family 1A gene in cervical carcinomas and the role of human papillomavirus infection. Cancer Res (2003) 1.04
Fine tuning of globin gene expression by DNA methylation. PLoS One (2006) 1.04
The role of DNA polymerase iota in UV mutational spectra. Mutat Res (2006) 0.99
Methods for genome-wide analysis of DNA methylation in intestinal tumors. Mutat Res (2009) 0.99
Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases. Cancer Res (2006) 0.99
Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer. Cell Res (2011) 0.98
Transcription-dependent cytosine deamination is a novel mechanism in ultraviolet light-induced mutagenesis. Curr Biol (2009) 0.98
DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells. Cancer Res (2004) 0.98
Parent-of-origin-specific binding of nuclear hormone receptor complexes in the H19-Igf2 imprinting control region. Mol Cell Biol (2004) 0.98
Simulated sunlight and benzo[a]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay: lack of correspondence to tumor mutation spectra. Carcinogenesis (2003) 0.96
Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues. Biochemistry (2005) 0.96
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression. Nat Commun (2012) 0.95
MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. J Biol Chem (2005) 0.95
Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by vitamin C. Proc Natl Acad Sci U S A (2007) 0.94
Effects of endocrine disruptors on imprinted gene expression in the mouse embryo. Epigenetics (2011) 0.93
The mysterious presence of a 5-methylcytosine oxidase in the Drosophila genome: possible explanations. Cell Cycle (2013) 0.93
Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy. Circulation (2009) 0.92
Rapid repair of UVA-induced oxidized purines and persistence of UVB-induced dipyrimidine lesions determine the mutagenicity of sunlight in mouse cells. FASEB J (2008) 0.91
Lack of mutagenicity of acrolein-induced DNA adducts in mouse and human cells. Cancer Res (2007) 0.90
Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse. Dev Dyn (2008) 0.90
CDK5RAP2 is required for spindle checkpoint function. Cell Cycle (2009) 0.88
In vivo assays for transcription-coupled repair. Methods Enzymol (2006) 0.88
Similar mutagenicity of photoactivated porphyrins and ultraviolet A radiation in mouse embryonic fibroblasts: involvement of oxidative DNA lesions in mutagenesis. Biochemistry (2004) 0.88
Genotoxicity of acrylamide and glycidamide. J Natl Cancer Inst (2004) 0.87
Peroxyl radical mediated oxidative DNA base damage: implications for lipid peroxidation induced mutagenesis. Biochemistry (2004) 0.87
The retinitis pigmentosa-mutated RP2 protein exhibits exonuclease activity and translocates to the nucleus in response to DNA damage. Exp Cell Res (2006) 0.86