Published in Chem Biol on April 01, 2004
Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes. J Mol Cell Cardiol (2008) 1.50
Quantitative imaging for discovery and assembly of the metabo-regulome. New Phytol (2008) 1.03
Design strategies of fluorescent biosensors based on biological macromolecular receptors. Sensors (Basel) (2010) 0.88
Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol (2006) 3.66
Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2006) 3.47
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell (2002) 3.36
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med (2008) 2.77
Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell (2011) 2.62
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev (2006) 2.62
Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity (2011) 2.60
TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J (2006) 2.28
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J (2006) 2.21
TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A (2009) 2.20
Transient receptor potential channels in cardiovascular function and disease. Circ Res (2006) 2.20
Upregulation of TRPC1 in the development of cardiac hypertrophy. J Mol Cell Cardiol (2006) 2.17
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A (2009) 2.08
Mutations in EFHC1 cause juvenile myoclonic epilepsy. Nat Genet (2004) 1.98
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat Neurosci (2007) 1.95
Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol (2004) 1.91
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nat Neurosci (2009) 1.75
Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes. J Exp Med (2002) 1.73
TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal (2009) 1.71
STIM protein coupling in the activation of Orai channels. Proc Natl Acad Sci U S A (2009) 1.70
FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Blood (2009) 1.59
Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Channels (Austin) (2008) 1.59
Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells. J Pharmacol Sci (2004) 1.56
Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. Proc Natl Acad Sci U S A (2006) 1.55
The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. J Mol Biol (2006) 1.54
Long-term low-dose spironolactone therapy is safe in oligoanuric hemodialysis patients. Cardiology (2009) 1.49
TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol (2011) 1.47
Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Sci Signal (2010) 1.44
Vpx is critical for reverse transcription of the human immunodeficiency virus type 2 genome in macrophages. J Virol (2008) 1.42
Nucleotide excision repair and homologous recombination systems commit differentially to the repair of DNA-protein crosslinks. Mol Cell (2007) 1.39
TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci U S A (2007) 1.37
Ethanol production from xylose by recombinant Saccharomyces cerevisiae expressing protein-engineered NADH-preferring xylose reductase from Pichia stipitis. Microbiology (2007) 1.33
Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. J Immunol (2008) 1.32
TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun (2013) 1.32
A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci (2006) 1.31
Synthesis and characterization of a practically better DEPMPO-type spin trap, 5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO). Free Radic Res (2006) 1.31
Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells. J Biol Chem (2009) 1.29
Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes (2010) 1.29
Roles of TRPM2 in oxidative stress. Cell Calcium (2011) 1.26
Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells. Nat Methods (2013) 1.25
Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles. Pharm Res (2009) 1.23
Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways. Circ Res (2009) 1.23
Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc Natl Acad Sci U S A (2004) 1.22
Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domain. J Biol Chem (2009) 1.21
Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation. J Biol Chem (2007) 1.21
Ca2+-dependent induction of TRPM2 currents in hippocampal neurons. J Physiol (2009) 1.19
Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6. J Physiol (2008) 1.19
Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice. J Neurosci (2002) 1.17
Expression of protein engineered NADP+-dependent xylitol dehydrogenase increases ethanol production from xylose in recombinant Saccharomyces cerevisiae. Appl Microbiol Biotechnol (2008) 1.16
DNA-protein cross-link formation mediated by oxanine. A novel genotoxic mechanism of nitric oxide-induced DNA damage. J Biol Chem (2003) 1.16
Three-dimensional reconstruction using transmission electron microscopy reveals a swollen, bell-shaped structure of transient receptor potential melastatin type 2 cation channel. J Biol Chem (2007) 1.16
Complete reversal of coenzyme specificity of xylitol dehydrogenase and increase of thermostability by the introduction of structural zinc. J Biol Chem (2004) 1.15
A novel method for synthesis of silica nanoparticles. J Colloid Interface Sci (2005) 1.14
TRPM1: a vertebrate TRP channel responsible for retinal ON bipolar function. Cell Calcium (2010) 1.13
Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy. Circ Res (2002) 1.13
Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart. Circ Res (2010) 1.12
Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes. EMBO J (2003) 1.11
Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. J Biol Chem (2003) 1.11
Oligo-Asp tag/Zn(II) complex probe as a new pair for labeling and fluorescence imaging of proteins. J Am Chem Soc (2006) 1.08
Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes. Physiol Genomics (2005) 1.08
FPL 64176 modification of Ca(V)1.2 L-type calcium channels: dissociation of effects on ionic current and gating current. Biophys J (2004) 1.08
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells. Free Radic Biol Med (2003) 1.07
Targeted disruption of the voltage-dependent calcium channel alpha2/delta-1-subunit. Am J Physiol Heart Circ Physiol (2009) 1.07
Eukaryotic and bacterial gene clusters related to an alternative pathway of nonphosphorylated L-rhamnose metabolism. J Biol Chem (2008) 1.06
Ethanol production from xylose by recombinant Saccharomyces cerevisiae expressing protein engineered NADP+-dependent xylitol dehydrogenase. J Biotechnol (2007) 1.06
Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress. Nucleic Acids Res (2005) 1.06
Do pluripotent stem cells exist in adult mice as very small embryonic stem cells? Stem Cell Reports (2013) 1.06
alpha-ketoglutaric semialdehyde dehydrogenase isozymes involved in metabolic pathways of D-glucarate, D-galactarate, and hydroxy-L-proline. Molecular and metabolic convergent evolution. J Biol Chem (2007) 1.06
Cloning, expression, and characterization of bacterial L-arabinose 1-dehydrogenase involved in an alternative pathway of L-arabinose metabolism. J Biol Chem (2005) 1.05
Novel repair activities of AlkA (3-methyladenine DNA glycosylase II) and endonuclease VIII for xanthine and oxanine, guanine lesions induced by nitric oxide and nitrous acid. Nucleic Acids Res (2002) 1.05
A novel alpha-ketoglutaric semialdehyde dehydrogenase: evolutionary insight into an alternative pathway of bacterial L-arabinose metabolism. J Biol Chem (2006) 1.05
Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release. FASEB J (2011) 1.04
Multifaceted activity of HIV Vpr/Vpx proteins: the current view of their virological functions. Rev Med Virol (2010) 1.04
Bioethanol production from xylose by recombinant Saccharomyces cerevisiae expressing xylose reductase, NADP(+)-dependent xylitol dehydrogenase, and xylulokinase. J Biosci Bioeng (2008) 1.03
Changes in temperature preferences and energy homeostasis in dystroglycan mutants. Science (2009) 1.03
The non-selective cation-permeable channel TRPC3 is a tetrahedron with a cap on the large cytoplasmic end. Biochem Biophys Res Commun (2005) 1.03
Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity. Gastroenterology (2011) 1.02
The role of canonical transient receptor potential 7 in B-cell receptor-activated channels. J Biol Chem (2005) 1.02
Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells. Mol Cell Neurosci (2006) 1.02
Rim2alpha determines docking and priming states in insulin granule exocytosis. Cell Metab (2010) 1.02
Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions. Proc Natl Acad Sci U S A (2012) 1.00
TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice. J Neurosci (2012) 1.00
Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts. J Biol Chem (2005) 1.00
Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. J Physiol (2005) 0.99
Characterization of a tobacco TPK-type K+ channel as a novel tonoplast K+ channel using yeast tonoplasts. J Biol Chem (2007) 0.99
Redox regulation of transient receptor potential channels. Antioxid Redox Signal (2013) 0.99
Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism. J Biol Chem (2006) 0.99