Published in Trends Immunol on July 01, 2004
Complement: a key system for immune surveillance and homeostasis. Nat Immunol (2010) 10.37
C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition. J Immunol (2008) 1.59
The human IgM pentamer is a mushroom-shaped molecule with a flexural bias. Proc Natl Acad Sci U S A (2009) 1.55
Complement System Part I - Molecular Mechanisms of Activation and Regulation. Front Immunol (2015) 1.52
Complement is activated by IgG hexamers assembled at the cell surface. Science (2014) 1.52
Paths reunited: Initiation of the classical and lectin pathways of complement activation. Immunobiology (2009) 1.50
Complement System Part II: Role in Immunity. Front Immunol (2015) 1.31
Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2011) 1.30
Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation. Mol Immunol (2008) 1.21
Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations. J Biol Chem (2009) 1.15
Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement. J Biol Chem (2009) 1.13
Identification of residues in the Cmu4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). J Immunol (2008) 1.12
Complement activation in the injured central nervous system: another dual-edged sword? J Neuroinflammation (2012) 1.11
Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathway. Immunobiology (2006) 1.07
Analogous interactions in initiating complexes of the classical and lectin pathways of complement. J Immunol (2009) 1.06
Collagen Mimetic Peptides: Progress Towards Functional Applications. Soft Matter (2011) 1.04
Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway. J Biol Chem (2013) 1.04
The role of the complement system in metabolic organs and metabolic diseases. Semin Immunol (2013) 0.95
Antibodies against C1q in patients with systemic lupus erythematosus. Springer Semin Immunopathol (2005) 0.95
Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1. J Lipid Res (2009) 0.95
Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex. J Biol Chem (2010) 0.94
Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites. Proc Natl Acad Sci U S A (2013) 0.94
The human c1q globular domain: structure and recognition of non-immune self ligands. Front Immunol (2012) 0.91
Deciphering the fine details of c1 assembly and activation mechanisms: "mission impossible"? Front Immunol (2014) 0.90
Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes. Proc Natl Acad Sci U S A (2014) 0.90
Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r. J Biol Chem (2010) 0.90
C-reactive protein exists in an NaCl concentration-dependent pentamer-decamer equilibrium in physiological buffer. J Biol Chem (2009) 0.89
Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection. EBioMedicine (2017) 0.87
Analysis of human C1q by combined bottom-up and top-down mass spectrometry: detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites. Mol Cell Proteomics (2009) 0.87
Complement protein C1q forms a complex with cytotoxic prion protein oligomers. J Biol Chem (2010) 0.86
Trimeric reassembly of the globular domain of human C1q. Biochim Biophys Acta (2007) 0.85
Possible novel biomarkers of organ involvement in systemic lupus erythematosus. Clin Rheumatol (2014) 0.83
Heme interacts with c1q and inhibits the classical complement pathway. J Biol Chem (2011) 0.82
Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined. Proc Natl Acad Sci U S A (2016) 0.82
Clusterin and complement activation in exfoliation glaucoma. Invest Ophthalmol Vis Sci (2014) 0.81
Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion. Front Microbiol (2016) 0.80
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. PLoS Pathog (2016) 0.80
The importance of C4d in biopsies of kidney transplant recipients. Clin Dev Immunol (2013) 0.79
Complementing the inflammasome. Immunology (2016) 0.79
Initiating protease with modular domains interacts with β-glucan recognition protein to trigger innate immune response in insects. Proc Natl Acad Sci U S A (2015) 0.79
Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity. Clin Immunol (2016) 0.78
CUZD1 and anti-CUZD1 antibodies as markers of cancer and inflammatory bowel diseases. Clin Dev Immunol (2013) 0.77
Enzymatically modified low-density lipoprotein is recognized by c1q and activates the classical complement pathway. J Lipids (2011) 0.76
The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin. PLoS One (2013) 0.76
Full-length sequence of mouse acupuncture-induced 1-L (aig1l) gene including its transcriptional start site. Evid Based Complement Alternat Med (2011) 0.75
Complement in Lupus Nephritis: New Perspectives. Kidney Dis (Basel) (2015) 0.75
Fc microparticles can modulate the physical extent and magnitude of complement activity. Biomater Sci (2017) 0.75
An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation. Exp Mol Med (2017) 0.75
A tug-of-war between the host and the pathogen generates strategic hotspots for the development of novel therapeutic interventions against infectious diseases. Virulence (2015) 0.75
Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA. Science (2006) 2.88
Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products. J Biol Chem (2003) 2.88
Ni-Zn-[Fe4-S4] and Ni-Ni-[Fe4-S4] clusters in closed and open subunits of acetyl-CoA synthase/carbon monoxide dehydrogenase. Nat Struct Biol (2003) 2.75
The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties. J Biol Chem (2003) 2.02
Serendipitous discovery and X-ray structure of a human phosphate binding apolipoprotein. Structure (2006) 1.90
C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition. J Immunol (2008) 1.59
X-ray crystallographic and computational studies of the O2-tolerant [NiFe]-hydrogenase 1 from Escherichia coli. Proc Natl Acad Sci U S A (2012) 1.57
Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals. J Immunol Methods (2003) 1.54
Structural insights into the Slit-Robo complex. Proc Natl Acad Sci U S A (2007) 1.54
Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J (2007) 1.53
Structural differences between the ready and unready oxidized states of [NiFe] hydrogenases. J Biol Inorg Chem (2005) 1.47
Visible light-driven H(2) production by hydrogenases attached to dye-sensitized TiO(2) nanoparticles. J Am Chem Soc (2009) 1.41
(IscS-IscU)2 complex structures provide insights into Fe2S2 biogenesis and transfer. Angew Chem Int Ed Engl (2012) 1.37
Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization. Eur J Biochem (2002) 1.35
Electrochemical definitions of O2 sensitivity and oxidative inactivation in hydrogenases. J Am Chem Soc (2005) 1.33
X-ray structure of the [FeFe]-hydrogenase maturase HydE from Thermotoga maritima. J Biol Chem (2008) 1.33
Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition. J Biol Chem (2009) 1.29
The role of the maturase HydG in [FeFe]-hydrogenase active site synthesis and assembly. FEBS Lett (2009) 1.26
X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement. J Biol Chem (2003) 1.21
Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins. J Immunol (2005) 1.19
Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin. J Biol Chem (2009) 1.16
The difference a Se makes? Oxygen-tolerant hydrogen production by the [NiFeSe]-hydrogenase from Desulfomicrobium baculatum. J Am Chem Soc (2008) 1.15
Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation. Mol Immunol (2009) 1.14
Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement. J Biol Chem (2009) 1.13
Unexpected electron transfer mechanism upon AdoMet cleavage in radical SAM proteins. Proc Natl Acad Sci U S A (2009) 1.12
Molecular organization of human Ficolin-2. Mol Immunol (2006) 1.11
Interaction of C1q and mannan-binding lectin with viruses. Immunobiology (2002) 1.09
Modified low density lipoproteins differentially bind and activate the C1 complex of complement. Mol Immunol (2006) 1.08
Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J Biol Chem (2008) 1.08
Complement protein C1q induces maturation of human dendritic cells. Mol Immunol (2007) 1.06
Electrochemical kinetic investigations of the reactions of [FeFe]-hydrogenases with carbon monoxide and oxygen: comparing the importance of gas tunnels and active-site electronic/redox effects. J Am Chem Soc (2009) 1.05
Evidence that complement protein C1q interacts with C-reactive protein through its globular head region. J Immunol (2006) 1.05
Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch. J Biol Chem (2007) 1.04
X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism. PLoS One (2011) 1.02
Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system. J Immunol (2013) 1.01
Studies on the interactions between C-reactive protein and complement proteins. Immunology (2007) 1.01
Investigations on the C1q-calreticulin-phosphatidylserine interactions yield new insights into apoptotic cell recognition. J Mol Biol (2011) 1.00
The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases. J Immunol (2005) 1.00
Carbon monoxide dehydrogenase reaction mechanism: a likely case of abnormal CO2 insertion to a Ni-H(-) bond. Inorg Chem (2011) 1.00
Electronic states of the O2-tolerant [NiFe] hydrogenase proximal cluster. Proc Natl Acad Sci U S A (2013) 1.00
Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55. J Immunol (2007) 0.99
Principles of sustained enzymatic hydrogen oxidation in the presence of oxygen--the crucial influence of high potential Fe-S clusters in the electron relay of [NiFe]-hydrogenases. J Am Chem Soc (2013) 0.99
Crystal structure of tryptophan lyase (NosL): evidence for radical formation at the amino group of tryptophan. Angew Chem Int Ed Engl (2014) 0.99
A glycyl free radical as the precursor in the synthesis of carbon monoxide and cyanide by the [FeFe]-hydrogenase maturase HydG. FEBS Lett (2010) 0.99
Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2. J Immunol (2004) 0.98
Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism. Structure (2002) 0.98
Flexibility of thiamine diphosphate revealed by kinetic crystallographic studies of the reaction of pyruvate-ferredoxin oxidoreductase with pyruvate. Structure (2006) 0.98
The structural plasticity of the proximal [4Fe3S] cluster is responsible for the O2 tolerance of membrane-bound [NiFe] hydrogenases. Angew Chem Int Ed Engl (2013) 0.98
M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules. J Immunol (2011) 0.96
Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor. Mol Immunol (2007) 0.95
Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex. J Biol Chem (2010) 0.94
How light-harvesting semiconductors can alter the bias of reversible electrocatalysts in favor of H2 production and CO2 reduction. J Am Chem Soc (2013) 0.94
Cutting edge: C1q binds deoxyribose and heparan sulfate through neighboring sites of its recognition domain. J Immunol (2010) 0.94
Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites. Proc Natl Acad Sci U S A (2013) 0.94
The quest for a functional substrate access tunnel in FeFe hydrogenase. Faraday Discuss (2011) 0.94
Catalytic electrochemistry of a [NiFeSe]-hydrogenase on TiO2 and demonstration of its suitability for visible-light driven H2 production. Chem Commun (Camb) (2008) 0.94
Assembly of C1 and the MBL- and ficolin-MASP complexes: structural insights. Immunobiology (2006) 0.93
The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin. J Biol Chem (2004) 0.93
A QM/MM study of proton transport pathways in a [NiFe] hydrogenase. Proteins (2008) 0.93
Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. J Biol Chem (2013) 0.92
Structural insights into the recognition properties of human ficolins. J Innate Immun (2009) 0.92
Crystallographic evidence for a CO/CO(2) tunnel gating mechanism in the bifunctional carbon monoxide dehydrogenase/acetyl coenzyme A synthase from Moorella thermoacetica. J Biol Inorg Chem (2004) 0.92
Function of the tunnel in acetylcoenzyme A synthase/carbon monoxide dehydrogenase. J Biol Inorg Chem (2006) 0.92
The human c1q globular domain: structure and recognition of non-immune self ligands. Front Immunol (2012) 0.91
Structural biology of the C1 complex of complement unveils the mechanisms of its activation and proteolytic activity. Mol Immunol (2002) 0.91
Complement protein C1q recognizes a conformationally modified form of the prion protein. Biochemistry (2005) 0.91
Structural and functional characterization of the recombinant human mitochondrial trifunctional protein. Biochemistry (2010) 0.90
Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. J Immunol (2002) 0.89