DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

PubWeight™: 1.44‹?› | Rank: Top 5%

🔗 View Article (PMC 549614)

Published in EMBO J on January 27, 2005

Authors

Ana-Maria Dragoi1, Xiaoying Fu, Stanimir Ivanov, Ping Zhang, Linbo Sheng, Dianqing Wu, Gloria C Li, Wen-Ming Chu

Author Affiliations

1: Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

Articles citing this

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood (2007) 3.09

The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity (2006) 2.04

High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. J Exp Med (2007) 1.63

CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion. J Cell Biol (2006) 1.49

TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes. J Immunol (2009) 1.37

CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Immunol Lett (2007) 1.29

Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation. J Leukoc Biol (2013) 1.10

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment. Transl Cancer Res (2012) 1.08

In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis. J Biol Chem (2008) 1.04

Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation. J Biol Chem (2013) 0.98

Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner. PLoS One (2012) 0.95

Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs. Cancer Lett (2008) 0.89

TCR-induced Akt serine 473 phosphorylation is regulated by protein kinase C-alpha. Biochem Biophys Res Commun (2010) 0.88

Extreme-longevity mutations orchestrate silencing of multiple signaling pathways. Biochim Biophys Acta (2009) 0.87

IFN-α production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and -independent pathways. Cell Mol Immunol (2011) 0.87

KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms. Oncotarget (2016) 0.87

Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation. Sci Rep (2016) 0.85

DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival. Mol Cancer (2013) 0.85

Contribution of interferon-beta to the immune activation induced by double-stranded DNA. Immunology (2006) 0.85

RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. Proc Natl Acad Sci U S A (2014) 0.83

Differential effects of the CpG-Toll-like receptor 9 axis on pregnancy outcome in nonobese diabetic mice and wild-type controls. Fertil Steril (2013) 0.83

G(i)α proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells. Cell Commun Signal (2014) 0.83

Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants. Front Genet (2013) 0.83

TRAIL is involved in CpG ODN-mediated anti-apoptotic signals. Oncol Rep (2011) 0.81

DNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulation. PLoS One (2013) 0.79

Involvement of DNA-PKcs in the IL-6 and IL-12 response to CpG-ODN is mediated by its interaction with TRAF6 in dendritic cells. PLoS One (2013) 0.78

Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages. PLoS One (2011) 0.78

Stimulation of Proliferation and Migration of Mouse Macrophages by Type B CpG-ODNs Is F-Spondin and IL-1Ra Dependent. PLoS One (2015) 0.77

Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value. Br J Cancer (2013) 0.77

FANCI is a negative regulator of Akt activation. Cell Cycle (2016) 0.75

Involvement of DNA-PKcs in the type I IFN response to CpG-ODNs in conventional dendritic cells in TLR9-dependent or -independent manners. PLoS One (2015) 0.75

DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes. PLoS One (2017) 0.75

Radiosensitizing activity of a novel Benzoxazine through the promotion of apoptosis and inhibition of DNA repair. Invest New Drugs (2014) 0.75

Articles cited by this

A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34

Missing pieces in the NF-kappaB puzzle. Cell (2002) 17.83

Cellular survival: a play in three Akts. Genes Dev (1999) 17.05

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science (1997) 8.81

Role of translocation in the activation and function of protein kinase B. J Biol Chem (1997) 7.29

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (1998) 6.79

The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28

The DNA-dependent protein kinase. Genes Dev (1999) 5.80

Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett (2003) 5.27

Structure, regulation and function of PKB/AKT--a major therapeutic target. Biochim Biophys Acta (2004) 4.11

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem (2004) 4.01

Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol (2001) 3.64

PKB binding proteins. Getting in on the Akt. Cell (2002) 3.34

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol (2001) 3.34

PKB/AKT: functional insights from genetic models. Nat Rev Mol Cell Biol (2001) 3.15

A DNA-activated protein kinase from HeLa cell nuclei. Mol Cell Biol (1990) 2.95

High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J Biol Chem (1997) 2.88

Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J Immunol (2003) 2.87

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc Natl Acad Sci U S A (1996) 2.77

JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity (1999) 2.74

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo. J Exp Med (1997) 2.71

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta. J Biol Chem (1997) 2.70

Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis. Proc Natl Acad Sci U S A (1999) 2.58

Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell (2002) 2.48

Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc Natl Acad Sci U S A (2000) 2.48

DNA damage-induced apoptosis. Oncogene (2004) 2.32

The immunobiology of the TLR9 subfamily. Trends Immunol (2004) 2.11

The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential. Oncogene (1993) 2.05

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol (1996) 2.02

The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell (2000) 1.96

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1. Curr Biol (2002) 1.56

Therapeutics targeting the innate immune system. Nat Rev Immunol (2004) 1.54

Retracted DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell (2000) 1.49

CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry. J Immunol (1998) 1.34

Cutting Edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3'-OH kinase pathway. J Immunol (2002) 1.31

Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B. J Biol Chem (1998) 1.18

Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells. J Immunol (2003) 1.18

Differential subcellular localization of DNA-dependent protein kinase components Ku and DNA-PKcs during mitosis. J Cell Sci (1999) 1.15

ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage. Mol Cell Biol (2004) 1.13

DNA-dependent protein kinase complex: a multifunctional protein in DNA repair and damage checkpoint. Mol Cells (2002) 1.00

Bacterial DNA activates human neutrophils by a CpG-independent pathway. Eur J Immunol (2003) 1.00

Novel localization of the DNA-PK complex in lipid rafts: a putative role in the signal transduction pathway of the ionizing radiation response. J Biol Chem (2003) 0.95

DNA-Dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards. Blood (1998) 0.94

CpG DNA rescues B cells from apoptosis by activating NFkappaB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway. Int Immunol (1999) 0.90

Cell cycle-dependent regulation of the DNA-dependent protein kinase. Cell Prolif (1999) 0.89

Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin. Cancer Res (1998) 0.82

Immunostimulatory DNA and applications to allergic disease. J Allergy Clin Immunol (1999) 0.82

The activity of the DNA-dependent protein kinase (DNA-PK) complex is determinant in the cellular response to nitrogen mustards. Biochimie (2000) 0.82

Involvement of DNA-dependent protein kinase in regulation of the mitochondrial heat shock proteins. Leuk Res (2003) 0.81

Articles by these authors

(truncated to the top 100)

High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med (2002) 11.28

The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet (2008) 9.03

The cost-effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance. Ann Intern Med (2005) 6.63

Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell (2003) 5.95

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem (2005) 5.33

Regulation of PTEN by Rho small GTPases. Nat Cell Biol (2005) 4.51

Costs associated with the primary prevention of type 2 diabetes mellitus in the diabetes prevention program. Diabetes Care (2003) 4.22

Socioeconomic status and trends in disparities in 4 major risk factors for cardiovascular disease among US adults, 1971-2002. Arch Intern Med (2006) 4.17

Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell (2003) 3.66

Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials. Circulation (2005) 3.61

Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol (2007) 3.54

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nat Med (2008) 3.33

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood (2007) 3.09

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell (2003) 3.06

Differential targeting of Gbetagamma-subunit signaling with small molecules. Science (2006) 2.96

The economic burden of major adult visual disorders in the United States. Arch Ophthalmol (2006) 2.92

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity. Nat Med (2011) 2.82

Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 2.75

Induction of pluripotency in human endothelial cells resets epigenetic profile on genome scale. Cell Cycle (2010) 2.64

Cost-effectiveness of interventions to prevent and control diabetes mellitus: a systematic review. Diabetes Care (2010) 2.49

Cost-effectiveness of screening for pre-diabetes among overweight and obese U.S. adults. Diabetes Care (2007) 2.20

Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction. Hypertension (2007) 2.20

Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet (2005) 2.10

Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol (2010) 2.09

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J Exp Med (2008) 2.04

Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system. Proc Natl Acad Sci U S A (2002) 2.04

Mouse taste buds use serotonin as a neurotransmitter. J Neurosci (2005) 1.98

The feasibility of using high frequency ultrasound to assess nerve ending neuropathy in patients with diabetic foot. Eur J Radiol (2012) 1.98

Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS. Infect Immun (2006) 1.93

Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. Mol Cell (2008) 1.93

Sites of regulated phosphorylation that control K-Cl cotransporter activity. Cell (2009) 1.93

Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol (2003) 1.86

Cost-of-illness studies in diabetes mellitus. Pharmacoeconomics (2004) 1.84

Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science (2008) 1.81

Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol (2012) 1.78

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell (2009) 1.78

Computer modeling of diabetes and its complications: a report on the Fifth Mount Hood challenge meeting. Value Health (2013) 1.77

Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev (2004) 1.77

The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol Cell Biol (2004) 1.77

Activation of peroxisome proliferator-activated receptor-γ coactivator 1α ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury. Kidney Int (2012) 1.75

Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer. Mol Endocrinol (2003) 1.74

Cytochrome P450 family member CYP704B2 catalyzes the {omega}-hydroxylation of fatty acids and is required for anther cutin biosynthesis and pollen exine formation in rice. Plant Cell (2010) 1.74

The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor. J Biol Chem (2005) 1.73

P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr Biol (2005) 1.70

How should developing countries manage diabetes? CMAJ (2006) 1.69

PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.67

High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. J Exp Med (2007) 1.63

Focal atrial tachycardia originating from the left atrial appendage: electrocardiographic and electrophysiologic characterization and long-term outcomes of radiofrequency ablation. J Cardiovasc Electrophysiol (2007) 1.62

Interferon action and the double-stranded RNA-dependent enzymes ADAR1 adenosine deaminase and PKR protein kinase. Prog Nucleic Acid Res Mol Biol (2006) 1.62

Heavy metal concentrations in roadside soils and correlation with urban traffic in Beijing, China. J Hazard Mater (2010) 1.61

Mechanism of substrate unfolding and translocation by the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 1.61

Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis. Proc Natl Acad Sci U S A (2002) 1.60

Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J Biol Chem (2002) 1.60

V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice. Am J Physiol Cell Physiol (2005) 1.59

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem (2001) 1.57

Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (2011) 1.56

Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum. J Neurosci (2005) 1.56

Oxidative stress regulates left ventricular PDE5 expression in the failing heart. Circulation (2010) 1.54

Genetic algorithm with logistic regression for prediction of progression to Alzheimer's disease. BMC Bioinformatics (2014) 1.53

PKA: lessons learned after twenty years. Biochim Biophys Acta (2013) 1.52

An evaluation of cost sharing to finance a diet and physical activity intervention to prevent diabetes. Diabetes Care (2006) 1.51

Re-induction of hsp70 synthesis: an assay for thermotolerance. 1988. Int J Hyperthermia (2009) 1.50

Predictors of rapid cognitive decline in Alzheimer's disease: results from the Australian imaging, biomarkers and lifestyle (AIBL) study of ageing. Int Psychogeriatr (2011) 1.49

The cost-effectiveness of Welcome to Medicare visual acuity screening and a possible alternative welcome to medicare eye evaluation among persons without diagnosed diabetes mellitus. Arch Ophthalmol (2012) 1.49

PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxid Redox Signal (2010) 1.48

Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction. Mol Cell Biol (2006) 1.48

Notch and BCR signaling synergistically promote the proliferation of Raji B-lymphoma cells. Leuk Res (2008) 1.47

Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. J Clin Invest (2003) 1.47

NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states. Carcinogenesis (2007) 1.47

Suppression of the stem cell antigen-1 response and granulocyte lineage expansion by alcohol during septicemia. Crit Care Med (2011) 1.46

A nationwide community-based lifestyle program could delay or prevent type 2 diabetes cases and save $5.7 billion in 25 years. Health Aff (Millwood) (2012) 1.44

PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A (2004) 1.42

IMU-based online kinematic calibration of robot manipulator. ScientificWorldJournal (2013) 1.42

Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx. Dev Biol (2006) 1.42

Autologous and allogeneic marrow stromal cells are safe and effective for the treatment of acute kidney injury. Stem Cells Dev (2009) 1.41

The effect of chronic binge ethanol consumption on the primary stage of SIV infection in rhesus macaques. Alcohol Clin Exp Res (2003) 1.41

High-risk individuals' willingness to pay for diabetes risk-reduction programs. Diabetes Care (2006) 1.41

Reuse of infected cardiac rhythm management devices in the same patients: a single-center experience. Pacing Clin Electrophysiol (2014) 1.40

Chronic binge ethanol consumption accelerates progression of simian immunodeficiency virus disease. Alcohol Clin Exp Res (2006) 1.40

The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1. J Biol Chem (2003) 1.38

Fecal transmission of AA amyloidosis in the cheetah contributes to high incidence of disease. Proc Natl Acad Sci U S A (2008) 1.36

Bioluminescence imaging to monitor the in vivo distribution of administered mesenchymal stem cells in acute kidney injury. Am J Physiol Renal Physiol (2008) 1.36

Knee-loading modality drives molecular transport in mouse femur. Ann Biomed Eng (2006) 1.36

Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting. J Mater Sci Mater Med (2008) 1.36

Immobilization of homing peptide on magnetite nanoparticles and its specificity in vitro. J Biomed Mater Res A (2008) 1.35

Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem (2008) 1.35

Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses. Atherosclerosis (2006) 1.34

Lifetime direct medical costs of treating type 2 diabetes and diabetic complications. Am J Prev Med (2013) 1.34

Interferon-γ-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway. Immunobiology (2011) 1.34

CoMn(2)O(4) spinel hierarchical microspheres assembled with porous nanosheets as stable anodes for lithium-ion batteries. Sci Rep (2012) 1.32

Stochasticity, succession, and environmental perturbations in a fluidic ecosystem. Proc Natl Acad Sci U S A (2014) 1.31

Characterization and application of a new optical probe for membrane lipid domains. Biophys J (2006) 1.31

The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol (2008) 1.31

Structural factors and mechanisms underlying the improved photodynamic cell killing with silicon phthalocyanine photosensitizers directed to lysosomes versus mitochondria. Photochem Photobiol (2009) 1.31

Endothelial differentiation of adipose-derived stem cells: effects of endothelial cell growth supplement and shear force. J Surg Res (2008) 1.28

Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway. J Biol Chem (2004) 1.27

Alcohol-induced suppression of lung chemokine production and the host defense response to Streptococcus pneumoniae. Alcohol Clin Exp Res (2003) 1.27

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radic Biol Med (2008) 1.27

The lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery. Fundam Clin Pharmacol (2008) 1.26

Cost-effectiveness of bariatric surgery for severely obese adults with diabetes. Diabetes Care (2010) 1.25