Published in Int J Mol Sci on July 26, 2017
Identification and importance of brown adipose tissue in adult humans. N Engl J Med (2009) 20.57
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun (1999) 14.25
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell (2012) 11.03
Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab (2007) 10.40
High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes (2009) 8.81
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature (2011) 8.45
Adipose tissue remodeling and obesity. J Clin Invest (2011) 6.12
Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature (1990) 5.20
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol (2008) 4.75
Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev (2009) 4.35
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A (2001) 4.30
Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med (2013) 3.86
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature (2016) 3.61
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology (2003) 3.59
A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci U S A (1997) 3.42
Racial differences in abdominal depot-specific adiposity in white and African American adults. Am J Clin Nutr (2009) 3.39
The adipose organ. Prostaglandins Leukot Essent Fatty Acids (2005) 3.34
Fat tissue, aging, and cellular senescence. Aging Cell (2010) 3.34
Visceral fat is an independent predictor of all-cause mortality in men. Obesity (Silver Spring) (2006) 3.29
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature (1996) 3.21
Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev (2004) 3.14
Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev (2009) 3.06
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A (2006) 3.04
Extending the lifespan of long-lived mice. Nature (2001) 2.98
Evidence for two types of brown adipose tissue in humans. Nat Med (2013) 2.97
Visceral fat, waist circumference, and BMI: impact of race/ethnicity. Obesity (Silver Spring) (2008) 2.92
Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J Clin Endocrinol Metab (2007) 2.81
Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care (2006) 2.77
The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. Nat Med (2014) 2.48
"USA-Fat": prevalence is related to ambient outdoor temperature-evaluation with 18F-FDG PET/CT. J Nucl Med (2003) 2.45
Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab (1997) 2.31
Pathogenesis of pituitary tumors. Nat Rev Endocrinol (2011) 2.30
Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia (2006) 2.27
Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes (1999) 2.25
Acromegaly pathogenesis and treatment. J Clin Invest (2009) 2.19
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2009) 2.08
Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications. Mol Aspects Med (2012) 2.07
Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol (2002) 2.06
Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source. Nat Cell Biol (2014) 2.02
Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab (2014) 2.01
Omentin plasma levels and gene expression are decreased in obesity. Diabetes (2007) 1.98
Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm IGF Res (2004) 1.96
Impact of reduced insulin-like growth factor-1/insulin signaling on aging in mammals: novel findings. Aging Cell (2008) 1.88
Visceral adipose tissue modulates mammalian longevity. Aging Cell (2008) 1.87
Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest (2004) 1.82
Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes (2002) 1.79
Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2011) 1.77
The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes. J Lipid Res (2012) 1.74
Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med (2015) 1.71
Adipose tissue collagen VI in obesity. J Clin Endocrinol Metab (2009) 1.70
Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance. J Clin Endocrinol Metab (2011) 1.65
Adipokines mediate inflammation and insulin resistance. Front Endocrinol (Lausanne) (2013) 1.62
Brown adipose tissue and seasonal variation in humans. Diabetes (2009) 1.61
A 3-year longitudinal study on body composition changes in the elderly: role of physical exercise. Clin Nutr (2005) 1.60
Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat Rev Endocrinol (2010) 1.56
Pituitary dwarfism with high serum levels of growth hormone. Isr J Med Sci (1969) 1.54
Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology (2003) 1.53
Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies. Eur J Endocrinol (2011) 1.52
The sexual dimorphism of obesity. Mol Cell Endocrinol (2015) 1.47
Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab (1993) 1.45
The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Obes Res (2001) 1.45
White, brown, beige/brite: different adipose cells for different functions? Endocrinology (2013) 1.42
Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: a preliminary report. Growth Horm IGF Res (2006) 1.41
Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1(+) Adipocytes. Cell Metab (2016) 1.41
Three years with adult human brown adipose tissue. Ann N Y Acad Sci (2010) 1.36
Two-year body composition analyses of long-lived GHR null mice. J Gerontol A Biol Sci Med Sci (2009) 1.35
Adipocytokines and lipid levels in Ames dwarf and calorie-restricted mice. J Gerontol A Biol Sci Med Sci (2006) 1.35
Lipodystrophy: pathophysiology and advances in treatment. Nat Rev Endocrinol (2010) 1.34
Growth hormone treatment reduces abdominal visceral fat in postmenopausal women with abdominal obesity: a 12-month placebo-controlled trial. J Clin Endocrinol Metab (2004) 1.33
Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32
Age-related changes in body composition of bovine growth hormone transgenic mice. Endocrinology (2008) 1.25
Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects. J Clin Endocrinol Metab (1995) 1.23
Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice. Endocrinology (2007) 1.23
Effects of GH in women with abdominal adiposity: a 6-month randomized, double-blind, placebo-controlled trial. Eur J Endocrinol (2012) 1.21
Effect of growth hormone on susceptibility to diet-induced obesity. Endocrinology (2006) 1.18
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging (Albany NY) (2014) 1.15
An endocrine role for brown adipose tissue? Am J Physiol Endocrinol Metab (2013) 1.15
Bovine growth hormone transgenic mice are resistant to diet-induced obesity but develop hyperphagia, dyslipidemia, and diabetes on a high-fat diet. Endocrinology (2004) 1.11
Growth hormone (GH) effects on bone and collagen turnover in healthy adults and its potential as a marker of GH abuse in sports: a double blind, placebo-controlled study. The GH-2000 Study Group. J Clin Endocrinol Metab (2000) 1.10
Glycine 119 of bovine growth hormone is critical for growth-promoting activity. Mol Endocrinol (1991) 1.10
The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations. Nat Rev Endocrinol (2013) 1.09
Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med (2015) 1.08
Lower visceral and subcutaneous but higher intermuscular adipose tissue depots in patients with growth hormone and insulin-like growth factor I excess due to acromegaly. J Clin Endocrinol Metab (2008) 1.07
Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression. J Biol Chem (2004) 1.07
Recruitment of brown adipose tissue as a therapy for obesity-associated diseases. Front Endocrinol (Lausanne) (2012) 1.07
Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice. Am J Physiol Endocrinol Metab (2005) 1.06
Risk of colorectal neoplasm in patients with acromegaly: a meta-analysis. World J Gastroenterol (2008) 1.04
Metabolic characteristics of long-lived mice. Front Genet (2012) 1.04
Is the Laron mouse an accurate model of Laron syndrome? Mol Genet Metab (1999) 1.04
American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Acromegaly--2011 update: executive summary. Endocr Pract (2011) 1.03
Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity). Clin Endocrinol (Oxf) (2006) 1.02
Effects of recombinant human growth hormone therapy in obesity in adults: a meta analysis. J Clin Endocrinol Metab (2008) 1.02
Obesity, growth hormone and weight loss. Mol Cell Endocrinol (2009) 1.01
Enlargement of interscapular brown adipose tissue in growth hormone antagonist transgenic and in growth hormone receptor gene-disrupted dwarf mice. Exp Biol Med (Maywood) (2003) 1.01
Long-living growth hormone receptor knockout mice: potential mechanisms of altered stress resistance. Exp Gerontol (2008) 1.00
Regional adipocity in man. J Endocrinol (1997) 1.00
Growth hormone and adipose tissue: beyond the adipocyte. Growth Horm IGF Res (2011) 1.00
Heterogeneity among white adipose tissue depots in male C57BL/6J mice. Obesity (Silver Spring) (2011) 1.00