Published in Genomics on May 01, 2003
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science (2008) 5.36
Aneuploidy: cells losing their balance. Genetics (2008) 3.48
Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome. Genome Res (2004) 2.29
Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes. Am J Hum Genet (2007) 2.06
Retracted Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun (2008) 1.91
Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21. Eur J Hum Genet (2008) 1.90
Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance. Am J Hum Genet (2007) 1.86
Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome. Genome Res (2004) 1.75
Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells. Cancer Res (2004) 1.74
Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart. Genome Biol (2005) 1.64
Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Proc Natl Acad Sci U S A (2006) 1.63
The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends Genet (2011) 1.60
Retracted Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. J Biol Chem (2009) 1.53
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. Proc Natl Acad Sci U S A (2012) 1.46
Understanding the basis for Down syndrome phenotypes. PLoS Genet (2006) 1.41
New insights into the troubles of aneuploidy. Annu Rev Cell Dev Biol (2012) 1.36
Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy. BMC Genomics (2007) 1.24
A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Hum Mol Genet (2009) 1.20
Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21. BMC Med Genet (2006) 1.19
Massive-scale RNA-Seq analysis of non ribosomal transcriptome in human trisomy 21. PLoS One (2011) 1.15
Comparison of array-based comparative genomic hybridization with gene expression-based regional expression biases to identify genetic abnormalities in hepatocellular carcinoma. BMC Genomics (2005) 1.14
DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1. Mol Biol Cell (2005) 1.10
Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression. Proc Natl Acad Sci U S A (2004) 1.09
Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes. Proc Natl Acad Sci U S A (2005) 1.08
Profiling expression changes caused by a segmental aneuploid in maize. BMC Genomics (2008) 1.08
The power of comparative and developmental studies for mouse models of Down syndrome. Mamm Genome (2007) 1.07
The genomically mosaic brain: aneuploidy and more in neural diversity and disease. Semin Cell Dev Biol (2013) 1.05
Gene expression variation in Down's syndrome mice allows prioritization of candidate genes. Genome Biol (2007) 1.04
Positional gene enrichment analysis of gene sets for high-resolution identification of overrepresented chromosomal regions. Nucleic Acids Res (2008) 1.03
Genetic basis for dosage sensitivity in Arabidopsis thaliana. PLoS Genet (2007) 1.01
Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes. BMC Genomics (2011) 1.00
Impairment of circulating endothelial progenitors in Down syndrome. BMC Med Genomics (2010) 0.99
The consequences of chromosomal aneuploidy on the transcriptome of cancer cells. Biochim Biophys Acta (2012) 0.97
Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development. BMC Genomics (2009) 0.97
Small regulatory RNAs in neurodevelopmental disorders. Hum Mol Genet (2009) 0.96
Global DNA hypermethylation in down syndrome placenta. PLoS Genet (2013) 0.95
Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks. BMC Genomics (2014) 0.93
Gene expression variation increase in trisomy 21 tissues. Mamm Genome (2008) 0.92
Application of serial analysis of gene expression to the study of human genetic disease. Hum Genet (2009) 0.91
Gene-dosage effects in Down syndrome and trisomic mouse models. Genome Biol (2004) 0.89
Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol Cell Biol (2004) 0.89
A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells. Dev Neurosci (2009) 0.89
Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos. Cancer Metastasis Rev (2013) 0.87
Noncoding RNAs in mental retardation. Clin Genet (2009) 0.86
Aneuploidy causes tissue-specific qualitative changes in global gene expression patterns in maize. Plant Physiol (2009) 0.86
Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1. BMC Mol Biol (2008) 0.86
Matrix factorisation methods applied in microarray data analysis. Int J Data Min Bioinform (2010) 0.85
From the genome to the proteome--biomarkers in colorectal cancer. Langenbecks Arch Surg (2007) 0.84
Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress. Proc Natl Acad Sci U S A (2014) 0.84
The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome. Am J Med Genet A (2015) 0.83
Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome. BMC Med Genomics (2013) 0.81
Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease. Stem Cells Transl Med (2013) 0.80
The cognitive phenotype of Down syndrome: insights from intracellular network analysis. NeuroRx (2006) 0.80
Gene expression analysis of induced pluripotent stem cells from aneuploid chromosomal syndromes. BMC Genomics (2013) 0.80
Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron (2016) 0.80
An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome. Sci Rep (2016) 0.79
Segmental trisomy of mouse chromosome 17: introducing an alternative model of Down's syndrome. Comp Funct Genomics (2003) 0.77
A Review of Biomarkers for Alzheimer's Disease in Down Syndrome. Neurol Ther (2017) 0.76
Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus. Chromosoma (2016) 0.75
Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma. Elife (2017) 0.75
Placental transcriptomes in the common aneuploidies reveal critical regions on the trisomic chromosomes and genome-wide effects. Prenat Diagn (2016) 0.75
Dissecting Gene Expression Changes Accompanying a Ploidy-Based Phenotypic Switch. G3 (Bethesda) (2016) 0.75
Transcriptome bioinformatic analysis identifies potential therapeutic mechanism of pentylenetetrazole in down syndrome. BioData Min (2010) 0.75
Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis. J Cell Physiol (2015) 0.75
Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB. PLoS One (2011) 0.75
The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance. Genes Dev (2016) 0.75
Trans-acting epigenetic effects of chromosomal aneuploidies: lessons from Down syndrome and mouse models. Epigenomics (2016) 0.75
Genome-wide gene expression analysis in the placenta from fetus with trisomy 21. BMC Genomics (2017) 0.75
Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits. Mol Genet Genomic Med (2017) 0.75
Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74
HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell (2007) 4.81
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell (2003) 4.55
Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene. PLoS Genet (2010) 4.29
Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med (2013) 4.26
An astrocytic basis of epilepsy. Nat Med (2005) 3.50
DNA methylation signatures within the human brain. Am J Hum Genet (2007) 3.50
SNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis. Bioinformatics (2002) 2.69
Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev (2004) 2.30
Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A (2008) 2.29
Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. J Lipid Res (2007) 1.82
Hidden Markov models for the assessment of chromosomal alterations using high-throughput SNP arrays. Ann Appl Stat (2008) 1.75
Progress in the use of microarray technology to study the neurobiology of disease. Nat Neurosci (2004) 1.72
Astrocytic control of glutamatergic activity: astrocytes as stars of the show. Trends Neurosci (2004) 1.69
Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart. Genome Biol (2005) 1.64
MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. J Mol Neurosci (2003) 1.54
Analysis and visualization of chromosomal abnormalities in SNP data with SNPscan. BMC Bioinformatics (2006) 1.50
Receptor-mediated glutamate release from volume sensitive channels in astrocytes. Proc Natl Acad Sci U S A (2005) 1.44
Inference of relationships in population data using identity-by-descent and identity-by-state. PLoS Genet (2011) 1.43
DRAGON View: information visualization for annotated microarray data. Bioinformatics (2002) 1.43
Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus. J Virol (2002) 1.41
FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice. Hum Mol Genet (2007) 1.39
Local mean normalization of microarray element signal intensities across an array surface: quality control and correction of spatially systematic artifacts. Biotechniques (2002) 1.31
Estimating genome-wide copy number using allele-specific mixture models. J Comput Biol (2008) 1.23
Visualization of shared genomic regions and meiotic recombination in high-density SNP data. PLoS One (2009) 1.23
Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissue. Pediatr Res (2003) 1.21
Expression of MeCP2 in olfactory receptor neurons is developmentally regulated and occurs before synaptogenesis. Mol Cell Neurosci (2003) 1.20
Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain. J Neurochem (2005) 1.14
Viral Bcl-2 homologs and their role in virus replication and associated diseases. Biochim Biophys Acta (2004) 1.14
Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression. Proc Natl Acad Sci U S A (2004) 1.09
Visualization of uniparental inheritance, Mendelian inconsistencies, deletions, and parent of origin effects in single nucleotide polymorphism trio data with SNPtrio. Hum Mutat (2007) 1.07
A transcriptional progression model for head and neck cancer. Clin Cancer Res (2003) 1.06
Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy. J Biol Chem (2002) 1.05
Effect of fluorocitrate on cerebral oxidation of lactate and glucose in freely moving rats. J Neurochem (2007) 1.04
Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: utility and limitation of the surrogate tissues in research for brain disorders. Neurosci Res (2013) 1.04
Molecular (SNP) analyses of overlapping hemizygous deletions of 10q25.3 to 10qter in four patients: evidence for HMX2 and HMX3 as candidate genes in hearing and vestibular function. Am J Med Genet A (2009) 1.03
Vascular endothelial growth factor in the cerebrospinal fluid of infants who died of sudden infant death syndrome: evidence for antecedent hypoxia. Pediatrics (2003) 1.00
Genomic analysis of partial 21q monosomies with variable phenotypes. Eur J Hum Genet (2010) 0.97
Direct measurement of oxidative metabolism in the living brain by microdialysis: a review. J Neurochem (2009) 0.97
Efficient array-based identification of novel cardiac genes through differentiation of mouse ESCs. PLoS One (2008) 0.95
SNPchip: R classes and methods for SNP array data. Bioinformatics (2007) 0.93
Sudden unexpected death in epilepsy: Evaluation of forensic autopsy cases. Forensic Sci Int (2012) 0.93
mVps24p functions in EGF receptor sorting/trafficking from the early endosome. Exp Cell Res (2004) 0.90
A novel variant in GABRB2 associated with intellectual disability and epilepsy. Am J Med Genet A (2014) 0.90
Trends and pattern of drug abuse deaths in Maryland teenagers. J Forensic Sci (2011) 0.90
Clinical variability in Rett syndrome. J Child Neurol (2003) 0.89
Oxidation of (14)C-labeled compounds perfused by microdialysis in the brains of free-moving rats. J Neurosci Res (2007) 0.88
Performance assessment of copy number microarray platforms using a spike-in experiment. Bioinformatics (2011) 0.88
Locations and patterns of meiotic recombination in two-generation pedigrees. BMC Med Genet (2009) 0.87
Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative diseases. Prog Brain Res (2004) 0.86
Unexpected relationships and inbreeding in HapMap phase III populations. PLoS One (2012) 0.86
Large neutral amino acids auto exchange when infused by microdialysis into the rat brain: implication for maple syrup urine disease and phenylketonuria. Neurochem Int (2002) 0.86
Chromosomal variation in lymphoblastoid cell lines. Hum Mutat (2012) 0.86
Sensitive and specific detection of mosaic chromosomal abnormalities using the Parent-of-Origin-based Detection (POD) method. BMC Genomics (2013) 0.84
Sudden unexpected death due to inflammatory myofibroblastic tumor of the heart: a case report and review of the literature. Int J Legal Med (2010) 0.82
DRAGON and DRAGON view: information annotation and visualization tools for large-scale expression data. Curr Protoc Bioinformatics (2003) 0.80
Consanguinity in Centre d'Étude du Polymorphisme Humain (CEPH) pedigrees. Eur J Hum Genet (2012) 0.79
Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription. J Neurosci (2009) 0.78
Hormonal modulation of amino acid neurotransmitter metabolism in the arcuate nucleus of the adult female rat: a novel action of estradiol. Endocrinology (2009) 0.78
Concentration of carbon monoxide (CO) in postmortem human tissues: effect of environmental CO exposure. J Forensic Sci (2006) 0.77
Glutamate decarboxylase protects neurons against excitotoxic injury. J Neurosci Res (2007) 0.77
Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate. Brain Res (2005) 0.76
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science (2017) 0.76
Removal of cerumen from ear canal using lighted curettes. Am Fam Physician (2007) 0.75
A needle in a haystack: Sturge-Weber syndrome gene discovery. Pediatr Neurol (2013) 0.75
Failure to detect elevated levels of carboxyhemoglobin in infants dying from SIDS. J Forensic Sci (2002) 0.75
The use of genomic microarrays to study chromosomal abnormalities in mental retardation. Ment Retard Dev Disabil Res Rev (2005) 0.75
Comprehensive cellular-resolution atlas of the adult human brain. J Comp Neurol (2017) 0.75