Published in Blood on July 06, 2004
Peculiarities of cell death mechanisms in neutrophils. Cell Death Differ (2011) 1.64
Ceramide-rich platforms in transmembrane signaling. FEBS Lett (2010) 1.46
Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum. Clin Microbiol Rev (2011) 1.44
Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions. PLoS One (2015) 1.41
Role of neutrophils in innate immunity: a systems biology-level approach. Wiley Interdiscip Rev Syst Biol Med (2010) 1.37
Temporal analysis of equine bone marrow aspirate during establishment of putative mesenchymal progenitor cell populations. Stem Cells Dev (2010) 1.20
Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis. PLoS One (2009) 1.18
Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1. PLoS One (2007) 1.13
Molecular events involved in cellular invasion by Ehrlichia chaffeensis and Anaplasma phagocytophilum. Vet Parasitol (2009) 1.04
Role of Nox2 in elimination of microorganisms. Semin Immunopathol (2008) 1.01
SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes. Proc Natl Acad Sci U S A (2006) 0.94
Mechanisms regulating neutrophil survival and cell death. Semin Immunopathol (2013) 0.94
Molecular mechanisms underlying delayed apoptosis in neutrophils from multiple trauma patients with and without sepsis. Mol Med (2012) 0.94
The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow. J Exp Med (2013) 0.93
Febrile-range hyperthermia accelerates caspase-dependent apoptosis in human neutrophils. J Immunol (2008) 0.93
Ceramide signaling in mammalian epidermis. Biochim Biophys Acta (2013) 0.92
Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis. Blood (2016) 0.89
Infection of neutrophil granulocytes with Leishmania major activates ERK 1/2 and modulates multiple apoptotic pathways to inhibit apoptosis. Med Microbiol Immunol (2012) 0.89
Oxidative stress-induced changes in pyridine nucleotides and chemoattractant 5-lipoxygenase products in aging neutrophils. Free Radic Biol Med (2009) 0.88
Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis. PLoS One (2012) 0.88
Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid. Rheumatology (Oxford) (2008) 0.88
Mechanisms of neutrophil death in human immunodeficiency virus-infected patients: role of reactive oxygen species, caspases and map kinase pathways. Clin Exp Immunol (2007) 0.87
Severe exercise and exercise training exert opposite effects on human neutrophil apoptosis via altering the redox status. PLoS One (2011) 0.86
Oxidative stress triggers Ca-dependent lysosome trafficking and activation of acid sphingomyelinase. Cell Physiol Biochem (2012) 0.85
Recent advances in the immunobiology of ceramide. Exp Mol Pathol (2006) 0.83
Adiponectin inhibits neutrophil apoptosis via activation of AMP kinase, PKB and ERK 1/2 MAP kinase. Apoptosis (2013) 0.83
Gestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring. Mediators Inflamm (2013) 0.82
Secondary necrotic neutrophils release interleukin-16C and macrophage migration inhibitory factor from stores in the cytosol. Cell Death Discov (2015) 0.80
Virus-infected alveolar epithelial cells direct neutrophil chemotaxis and inhibit their apoptosis. Am J Respir Cell Mol Biol (2012) 0.79
Ubiquitin-proteasome-rich cytoplasmic structures in neutrophils of patients with Shwachman-Diamond syndrome. Haematologica (2012) 0.79
Nitric oxide-mediated apoptosis of neutrophils through caspase-8 and caspase-3-dependent mechanism. Cell Death Dis (2016) 0.78
Leukocytes apoptosis and adipocytokines in children with beta thalassemia major. Clin Exp Med (2015) 0.77
Vitamin E prevents the age-dependent and palmitate-induced disturbances of sphingolipid turnover in liver cells. Age (Dordr) (2011) 0.76
Sphingolipids are involved in N-methyl-N'-nitro-N-nitrosoguanidine-induced epidermal growth factor receptor clustering. Biochem Biophys Res Commun (2005) 0.75
Increased leucocyte apoptosis in transfused β-thalassaemia patients. Br J Haematol (2012) 0.75
Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects. Antioxid Redox Signal (2016) 0.75
Formation of Neutrophil Extracellular Traps under Low Oxygen Level. Front Immunol (2016) 0.75
The influence of uremic high cystatin C concentration on neutrophil apoptosis and selected neutrophil functions isolated from healthy subjects. Med Sci Monit (2012) 0.75
Glycolysis regulates the expansion of myeloid-derived suppressor cells in tumor-bearing hosts through prevention of ROS-mediated apoptosis. Cell Death Dis (2017) 0.75
ABCG2 and NCF4 polymorphisms are associated with clinical outcomes in diffuse large B-cell lymphoma patients treated with R-CHOP. Oncotarget (2017) 0.75
CD47 overexpression is associated with decreased neutrophil apoptosis/phagocytosis and poor prognosis in non-small-cell lung cancer patients. Br J Cancer (2017) 0.75
Bayesian variable selection in multinomial probit models to identify molecular signatures of disease stage. Biometrics (2004) 4.71
Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med (2008) 3.41
Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res Ther (2005) 3.17
Inhibition of fibrocyte differentiation by serum amyloid P. J Immunol (2003) 2.67
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat Med (2004) 2.66
Lipid raft clustering and redox signaling platform formation in coronary arterial endothelial cells. Hypertension (2005) 2.62
Aging of the innate immune system. Curr Opin Immunol (2010) 2.43
Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells. J Immunol (2006) 2.29
Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis. J Rheumatol (2005) 2.28
Ceramide-enriched membrane domains. Biochim Biophys Acta (2005) 2.25
Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells. Eur J Immunol (2002) 2.18
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. Nat Med (2007) 2.14
Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol (2009) 2.00
Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis. Ann Rheum Dis (2011) 1.96
Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PLoS One (2011) 1.86
Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion. J Immunol (2005) 1.85
Identification of a phenotypically and functionally distinct population of long-lived neutrophils in a model of reverse endothelial migration. J Leukoc Biol (2005) 1.74
Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood (2013) 1.73
Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. J Exp Med (2004) 1.71
Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO. J Immunol (2010) 1.66
Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity. J Immunol (2009) 1.66
Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements. Hum Genet (2013) 1.63
Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis. Invest Ophthalmol Vis Sci (2005) 1.61
Follicular helper T cell signature in type 1 diabetes. J Clin Invest (2014) 1.61
Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue. Arthritis Rheum (2003) 1.56
Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns. Thromb Haemost (2003) 1.55
Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene (2003) 1.53
Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate. J Immunol (2006) 1.51
CD95 rapidly clusters in cells of diverse origins. Cancer Biol Ther (2003) 1.50
Ceramide-enriched membrane domains--structure and function. Biochim Biophys Acta (2008) 1.49
Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation. Thromb Haemost (2014) 1.48
Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing. J Med Genet (2013) 1.47
An investigation into the relationship between age and physiological function in highly active older adults. J Physiol (2015) 1.47
The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo. J Clin Invest (2008) 1.46
Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis. J Exp Med (2004) 1.43
A chemokine-dependent stromal induction mechanism for aberrant lymphocyte accumulation and compromised lymphatic return in rheumatoid arthritis. J Immunol (2005) 1.41
Biological aspects of ceramide-enriched membrane domains. Prog Lipid Res (2007) 1.40
The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation. J Immunol (2007) 1.38
Treating very early rheumatoid arthritis. Best Pract Res Clin Rheumatol (2006) 1.34
Next-generation sequencing-based molecular diagnosis of a Chinese patient cohort with autosomal recessive retinitis pigmentosa. Invest Ophthalmol Vis Sci (2013) 1.32
Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless. Genome Res (2006) 1.32
Cell volume regulatory ion channels in cell proliferation and cell death. Methods Enzymol (2007) 1.31
Suicidal erythrocyte death in sepsis. J Mol Med (Berl) (2006) 1.30
Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cell Physiol Biochem (2010) 1.29
PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood (2005) 1.29
The cerebral microvasculature in schizophrenia: a laser capture microdissection study. PLoS One (2008) 1.29
Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J Exp Med (2009) 1.29
Inhibition of neutrophil apoptosis by type 1 IFN depends on cross-talk between phosphoinositol 3-kinase, protein kinase C-delta, and NF-kappa B signaling pathways. J Immunol (2003) 1.29
Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells. Antioxid Redox Signal (2007) 1.28
Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms. J Biol Chem (2005) 1.28
A novel potassium channel in lymphocyte mitochondria. J Biol Chem (2005) 1.26
The peripheral generation of CD4+ CD25+ regulatory T cells. Immunology (2003) 1.25
Raised cortisol:DHEAS ratios in the elderly after injury: potential impact upon neutrophil function and immunity. Aging Cell (2005) 1.25
Ceramide-rich membrane rafts mediate CD40 clustering. J Immunol (2002) 1.24
The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection. Aging Cell (2012) 1.24
Immune interactions in hepatic fibrosis. Clin Liver Dis (2008) 1.23
Cystic fibrosis and innate immunity: how chloride channel mutations provoke lung disease. Cell Microbiol (2008) 1.22
Will telomere erosion lead to a loss of T-cell memory? Nat Rev Immunol (2004) 1.21
Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils. Arthritis Rheum (2006) 1.20
Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes. Proc Natl Acad Sci U S A (2008) 1.20
Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling. J Immunol (2004) 1.17
Alterations in ceramide concentration and pH determine the release of reactive oxygen species by Cftr-deficient macrophages on infection. J Immunol (2010) 1.17
Sphingolipids in the lungs. Am J Respir Crit Care Med (2008) 1.17
Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis. Arthritis Res Ther (2006) 1.16
CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. FEBS Lett (2007) 1.16
Stress responses and innate immunity: aging as a contributory factor. Aging Cell (2004) 1.14
Ceramide: physiological and pathophysiological aspects. Arch Biochem Biophys (2007) 1.14
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. J Med Chem (2007) 1.13
Epstein-Barr virus-specific CD8(+) T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential. Blood (2002) 1.13
Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis. Am J Respir Cell Mol Biol (2009) 1.13
Alveolar inflammation in cystic fibrosis. J Cyst Fibros (2010) 1.11
Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha. Arthritis Res Ther (2008) 1.10
Next-generation sequencing-based molecular diagnosis of 82 retinitis pigmentosa probands from Northern Ireland. Hum Genet (2014) 1.10
Eryptosis, a window to systemic disease. Cell Physiol Biochem (2008) 1.10
Dehydroepiandrosterone as a regulator of immune cell function. J Steroid Biochem Mol Biol (2010) 1.10
The role of chemokines and their receptors in ocular disease. Prog Retin Eye Res (2004) 1.08
Ceramide-induced cell death in malignant cells. Cancer Lett (2008) 1.07
Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells. Cancer Res (2007) 1.07
Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms. Biochem Biophys Res Commun (2003) 1.07
Suicide for survival--death of infected erythrocytes as a host mechanism to survive malaria. Cell Physiol Biochem (2009) 1.05
Ion channels and cell volume in regulation of cell proliferation and apoptotic cell death. Contrib Nephrol (2006) 1.04
Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment. Environ Microbiol (2014) 1.04
The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-delta dependent manner. Cancer Immunol Immunother (2008) 1.04
Membrane rafts in host-pathogen interactions. Biochim Biophys Acta (2006) 1.04
Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid joint. Arthritis Rheum (2007) 1.04
Contribution of voltage-gated potassium channels to the regulation of apoptosis. FEBS Lett (2010) 1.03
Ingenol mebutate: induced cell death patterns in normal and cancer epithelial cells. J Drugs Dermatol (2012) 1.03
Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways. Arthritis Rheum (2009) 1.02
Clustering of CD40 ligand is required to form a functional contact with CD40. J Biol Chem (2002) 1.02
Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency. Cell Physiol Biochem (2009) 1.02