Published in Aging Cell on July 12, 2012
Age-dependent dysregulation of innate immunity. Nat Rev Immunol (2013) 2.44
Human T cell aging and the impact of persistent viral infections. Front Immunol (2013) 1.39
Understanding how we age: insights into inflammaging. Longev Healthspan (2013) 1.22
T-cell aging in rheumatoid arthritis. Curr Opin Rheumatol (2014) 1.04
Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. Biomed Res Int (2014) 1.01
Immune aging, dysmetabolism, and inflammation in neurological diseases. Front Neurosci (2015) 0.92
Impact of aging on antigen presentation cell function of dendritic cells. Curr Opin Immunol (2013) 0.88
Cytomegalovirus (CMV) seropositivity decreases B cell responses to the influenza vaccine. Vaccine (2015) 0.87
Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer's disease. PLoS One (2014) 0.85
CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study. Aging Cell (2015) 0.81
Aging of the human innate immune system in HIV infection. Curr Opin Immunol (2014) 0.81
Chronic CMV infection in older women: longitudinal comparisons of CMV DNA in peripheral monocytes, anti-CMV IgG titers, serum IL-6 levels, and CMV pp65 (NLV)-specific CD8(+) T-cell frequencies with twelve year follow-up. Exp Gerontol (2014) 0.81
HSC Aging and Senescent Immune Remodeling. Trends Immunol (2015) 0.80
Decreased proportion of cytomegalovirus specific CD8 T-cells but no signs of general immunosenescence in Alzheimer's disease. PLoS One (2013) 0.79
Physical function impairment of older, HIV-infected adults is associated with cytomegalovirus immunoglobulin response. AIDS Res Hum Retroviruses (2015) 0.79
Respiratory syncytial virus (RSV) infection in elderly mice results in altered antiviral gene expression and enhanced pathology. PLoS One (2014) 0.79
Sex differences and the role of IL-10 in ischemic stroke recovery. Biol Sex Differ (2015) 0.79
The role of gender and labour status in immunosenescence of 65+ Polish population. Biogerontology (2017) 0.78
Better immunity in later life: a position paper. Age (Dordr) (2014) 0.77
Circulating muramyl dipeptide is negatively associated with interleukin-10 in the frail elderly. Inflammation (2015) 0.77
Biochemical alterations during the obese-aging process in female and male monosodium glutamate (MSG)-treated mice. Int J Mol Sci (2014) 0.76
Cytomegalovirus infection is associated with an increase in systolic blood pressure in older individuals. QJM (2016) 0.76
Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism. Aging Cell (2017) 0.75
Increased basal and alum-induced interleukin-6 levels in geriatric patients are associated with cardiovascular morbidity. PLoS One (2013) 0.75
The individual and combined effects of obesity- and ageing-induced systemic inflammation on human skeletal muscle properties. Int J Obes (Lond) (2016) 0.75
Meeting report: British Society for Research on Ageing (BSRA) annual scientific meeting 2012, Aston University, Birmingham, 3rd to 4th July 2012. Longev Healthspan (2013) 0.75
Cytomegalovirus serostatus, inflammation, and antibody response to influenza vaccination in older adults: The moderating effect of beta blockade. Brain Behav Immun (2016) 0.75
A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α. Eur J Med Res (2017) 0.75
Prevalence and correlation of cytokine-specific autoantibodies with epidemiological factors and C-reactive protein in 8,972 healthy individuals: Results from the Danish Blood Donor Study. PLoS One (2017) 0.75
C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions. Front Immunol (2017) 0.75
Telomere Shortening, Inflammatory Cytokines, and Anti-Cytomegalovirus Antibody Follow Distinct Age-Associated Trajectories in Humans. Front Immunol (2017) 0.75
Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells. Front Immunol (2017) 0.75
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Effect of in utero and early-life conditions on adult health and disease. N Engl J Med (2008) 14.46
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Birth weight and risk of type 2 diabetes: a systematic review. JAMA (2008) 6.73
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Osteoporosis. Lancet (2006) 5.40
Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial. Ann Rheum Dis (2012) 4.81
Using natural experiments to evaluate population health interventions: new Medical Research Council guidance. J Epidemiol Community Health (2012) 4.26
Cohort profile: The Southampton Women's Survey. Int J Epidemiol (2005) 4.11
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Reanalysis of two studies with contrasting results on the association between statin use and fracture risk: the General Practice Research Database. Int J Epidemiol (2006) 3.36
Grip strength, body composition, and mortality. Int J Epidemiol (2006) 3.36
A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing (2011) 3.27
Prevalence and impact of musculoskeletal disorders of the upper limb in the general population. Arthritis Rheum (2004) 3.24
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes (2011) 3.18
Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res Ther (2005) 3.17
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Objective measures of physical capability and subsequent health: a systematic review. Age Ageing (2010) 2.78
The cost-effectiveness of alendronate in the management of osteoporosis. Bone (2007) 2.75
Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res (2015) 2.74
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73
Intelligence in childhood and chronic widespread pain in middle age: the National Child Development Survey. Pain (2012) 2.71
Does sarcopenia originate in early life? Findings from the Hertfordshire cohort study. J Gerontol A Biol Sci Med Sci (2004) 2.64
Epidemiology of hip fracture: Worldwide geographic variation. Indian J Orthop (2011) 2.60
Women's compliance with nutrition and lifestyle recommendations before pregnancy: general population cohort study. BMJ (2009) 2.54
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Aging of the innate immune system. Curr Opin Immunol (2010) 2.43
Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML). Blood (2012) 2.39
Vitamin D: some perspective please. BMJ (2012) 2.35
Developmental origins of midlife physical performance: evidence from a British birth cohort. Am J Epidemiol (2006) 2.35
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet (2011) 2.34
Osteoporosis: impact on health and economics. Nat Rev Rheumatol (2010) 2.25
Is grip strength a useful single marker of frailty? Age Ageing (2003) 2.22
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes (2011) 2.21
Osteoporosis: burden, health care provision and opportunities in the EU: a report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos (2011) 2.14
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med (2011) 2.07
Predictors of outcomes of total knee replacement surgery. Rheumatology (Oxford) (2012) 2.05
Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg? Diabetes Care (2005) 2.03
Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol (2009) 2.00
Epidemiology and burden of osteoarthritis. Br Med Bull (2013) 1.97
Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med (2011) 1.95
Prediction of childhood obesity by infancy weight gain: an individual-level meta-analysis. Paediatr Perinat Epidemiol (2011) 1.93
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90
Risk of hip/femur fracture after stroke: a population-based case-control study. Stroke (2009) 1.88
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL. Blood (2005) 1.81
Monthly oral ibandronate therapy in postmenopausal osteoporosis: 1-year results from the MOBILE study. J Bone Miner Res (2005) 1.81
Low maternal vitamin D status and fetal bone development: cohort study. J Bone Miner Res (2010) 1.80
Effect of co-morbidities on fracture risk: findings from the Global Longitudinal Study of Osteoporosis in Women (GLOW). Bone (2012) 1.79
Women's dietary patterns change little from before to during pregnancy. J Nutr (2009) 1.79
Developmental origins of midlife grip strength: findings from a birth cohort study. J Gerontol A Biol Sci Med Sci (2006) 1.77
Dietary patterns in infancy: the importance of maternal and family influences on feeding practice. Br J Nutr (2007) 1.76
Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood (2013) 1.73
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance. Ann Rheum Dis (2010) 1.70
Immunodeficiency and immunotherapy in multiple myeloma. Br J Haematol (2007) 1.69
Birth weight, weight at 1 y of age, and body composition in older men: findings from the Hertfordshire Cohort Study. Am J Clin Nutr (2004) 1.68
Process evaluation in complex public health intervention studies: the need for guidance. J Epidemiol Community Health (2013) 1.68
Weight gain in pregnancy and childhood body composition: findings from the Southampton Women's Survey. Am J Clin Nutr (2010) 1.67
Epidemiological differences between back pain of sudden and gradual onset. J Rheumatol (2005) 1.67
Birth weight, childhood size, and muscle strength in adult life: evidence from a birth cohort study. Am J Epidemiol (2002) 1.66
Epidemiology of osteoporosis. Best Pract Res Clin Endocrinol Metab (2008) 1.65
Do women change their health behaviours in pregnancy? Findings from the Southampton Women's Survey. Paediatr Perinat Epidemiol (2009) 1.64
Prenatal and childhood influences on osteoporosis. Best Pract Res Clin Endocrinol Metab (2002) 1.64
Fracture risk with intermittent high-dose oral glucocorticoid therapy. Arthritis Rheum (2007) 1.63
New horizons in the pathogenesis, diagnosis and management of sarcopenia. Age Ageing (2013) 1.63
Impact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in women. Mayo Clin Proc (2010) 1.62
Risk factors for treatment failure with antiosteoporosis medication: the global longitudinal study of osteoporosis in women (GLOW). J Bone Miner Res (2014) 1.62
Prevalence of sarcopenia in community-dwelling older people in the UK using the European Working Group on Sarcopenia in Older People (EWGSOP) definition: findings from the Hertfordshire Cohort Study (HCS). Age Ageing (2013) 1.62
Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire Cohort Study. J Bone Miner Res (2013) 1.60
Relationship between changes in bone mineral density and vertebral fracture risk associated with risedronate: greater increases in bone mineral density do not relate to greater decreases in fracture risk. J Clin Densitom (2004) 1.59
Donor KIR genotype has a major influence on the rate of cytomegalovirus reactivation following T-cell replete stem cell transplantation. Blood (2005) 1.58
Is grip strength associated with health-related quality of life? Findings from the Hertfordshire Cohort Study. Age Ageing (2006) 1.56
Educating nursing home staff on fracture prevention: a cluster randomised trial. Age Ageing (2007) 1.54
Predictors of fracture while on treatment with oral bisphosphonates: a population-based cohort study. J Bone Miner Res (2014) 1.52
Birth weight and weight at 1 year are independent determinants of bone mass in the seventh decade: the Hertfordshire cohort study. Pediatr Res (2005) 1.52
Prevalence and correlates of frailty among community-dwelling older men and women: findings from the Hertfordshire Cohort Study. Age Ageing (2009) 1.52
Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D(3) and/or calcium (RECORD trial). J Clin Endocrinol Metab (2011) 1.52
Epidemiology of osteoporosis. Rheum Dis Clin North Am (2006) 1.52
Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate. J Immunol (2006) 1.51
Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: the Global Burden of Disease Study 2015. Lancet HIV (2016) 1.51
Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis. Calcif Tissue Int (2011) 1.50
Osteoporosis risk assessment. BMJ (2012) 1.49
Birthweight, vitamin D receptor gene polymorphism, and risk of lumbar spine osteoarthritis. J Rheumatol (2005) 1.49
An investigation into the relationship between age and physiological function in highly active older adults. J Physiol (2015) 1.47
Processed meat consumption and lung function: modification by antioxidants and smoking. Eur Respir J (2013) 1.47