Published in J Cell Biol on July 05, 2004
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Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents. J Clin Invest (2011) 1.31
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A central function for perlecan in skeletal muscle and cardiovascular development. J Cell Biol (2008) 1.22
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Microvascular rarefaction: the decline and fall of blood vessels. Organogenesis (2010) 0.96
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Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior. Matrix Biol (2014) 0.94
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Novel collectin/C1q receptor mediates mast cell activation and innate immunity. Blood (2005) 0.93
The clinical potential of antiangiogenic fragments of extracellular matrix proteins. Br J Cancer (2005) 0.92
Oxygen-glucose deprivation and interleukin-1α trigger the release of perlecan LG3 by cells of neurovascular unit. J Neurochem (2011) 0.92
Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing. J Biol Chem (2012) 0.92
Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1. EMBO J (2009) 0.92
Decoding the Matrix: Instructive Roles of Proteoglycan Receptors. Biochemistry (2015) 0.90
Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products. Wiley Interdiscip Rev Syst Biol Med (2010) 0.88
Antagonism of VEGF-A-induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway. Blood (2012) 0.87
Proteomic profiling of endorepellin angiostatic activity on human endothelial cells. Proteome Sci (2008) 0.87
Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro. PLoS One (2013) 0.86
Vicrostatin - an anti-invasive multi-integrin targeting chimeric disintegrin with tumor anti-angiogenic and pro-apoptotic activities. PLoS One (2010) 0.86
Perlecan displays variable spatial and temporal immunolocalisation patterns in the articular and growth plate cartilages of the ovine stifle joint. Histochem Cell Biol (2005) 0.86
Urinary proteomic analysis of chronic allograft nephropathy. Proteomics Clin Appl (2008) 0.86
Endorepellin evokes autophagy in endothelial cells. J Biol Chem (2014) 0.86
Plasma proteome changes associated with refractory cytopenia with multilineage dysplasia. Proteome Sci (2011) 0.85
Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutin. J Proteome Res (2008) 0.85
Epithelial-mesenchymal status influences how cells deposit fibrillin microfibrils. J Cell Sci (2013) 0.84
Proteolytically Derived Endogenous Angioinhibitors Originating from the Extracellular Matrix. Pharmaceuticals (Basel) (2011) 0.84
Differential proteomic analysis of platelets suggested possible signal cascades network in platelets treated with salvianolic acid B. PLoS One (2011) 0.84
Perlecan and the blood-brain barrier: beneficial proteolysis? Front Pharmacol (2012) 0.84
Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness. J Biol Chem (2012) 0.83
Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress Chaperones (2009) 0.83
Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers. Adv Drug Deliv Rev (2015) 0.82
Extracellular matrix modulates angiogenesis in physiological and pathological conditions. Biomed Res Int (2014) 0.80
Perlecan domain V inhibits amyloid-β induced brain endothelial cell toxicity and restores angiogenic function. J Alzheimers Dis (2014) 0.79
Reversal of TNP-470-induced endothelial cell growth arrest by guanine and guanine nucleosides. J Pharmacol Exp Ther (2010) 0.79
The nature and biology of basement membranes. Matrix Biol (2016) 0.78
Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors. J Cancer Sci Ther (2013) 0.78
Exome sequencing identifies a rare HSPG2 variant associated with familial idiopathic scoliosis. G3 (Bethesda) (2014) 0.78
Proteoglycans in liver cancer. World J Gastroenterol (2016) 0.78
Vixapatin (VP12), a c-type lectin-protein from Vipera xantina palestinae venom: characterization as a novel anti-angiogenic compound. Toxins (Basel) (2012) 0.78
Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration. Biomed Res Int (2015) 0.77
A fragment of the LG3 peptide of endorepellin is present in the urine of physically active mining workers: a potential marker of physical activity. PLoS One (2012) 0.77
Acrolein: unwanted side product or contribution to antiangiogenic properties of metronomic cyclophosphamide therapy? J Cell Mol Med (2008) 0.77
The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy. Connect Tissue Res (2015) 0.77
DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion. Cell Cycle (2015) 0.77
Tensegrin in context: Dual role of α8 integrin in the migration of different cell types. Cell Adh Migr (2011) 0.76
Perlecan domain V is neuroprotective and affords functional improvement in a photothrombotic stroke model in young and aged mice. Transl Stroke Res (2013) 0.76
A current view of perlecan in physiology and pathology: A mosaic of functions. Matrix Biol (2016) 0.76
Proteoglycans in Normal and Healing Skin. Adv Wound Care (New Rochelle) (2015) 0.76
Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis. J Biol Chem (2017) 0.75
Extracellular Matrix, a Hard Player in Angiogenesis. Int J Mol Sci (2016) 0.75
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Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol (1999) 2.94
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Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins. EMBO J (1999) 2.31
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Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia. Proc Natl Acad Sci U S A (2000) 1.25
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Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling. Mol Biol Cell (2003) 0.88
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Endocarditis and biofilm-associated pili of Enterococcus faecalis. J Clin Invest (2006) 3.33
Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development. J Cell Biochem (2006) 2.71
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Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction. J Biol Chem (2008) 2.53
Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper. Nature (2003) 2.27
The molecular basis of fibronectin-mediated bacterial adherence to host cells. Mol Microbiol (2004) 2.20
The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J (2003) 2.13
The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis. Am J Pathol (2002) 2.09
A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A. EMBO J (2002) 2.06
Streptococcal Scl1 and Scl2 proteins form collagen-like triple helices. J Biol Chem (2002) 1.95
Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi. Mol Microbiol (2006) 1.93
Proprotein convertases: "master switches" in the regulation of tumor growth and progression. Mol Carcinog (2005) 1.89
The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood (2011) 1.89
Extracellular matrix proteoglycans control the fate of bone marrow stromal cells. J Biol Chem (2005) 1.82
Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan. J Biol Chem (2009) 1.79
A 'Collagen Hug' model for Staphylococcus aureus CNA binding to collagen. EMBO J (2005) 1.78
Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol (2009) 1.76
Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis. J Cell Biol (2004) 1.72
FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney. Development (2013) 1.71
Influence of decorin and biglycan on mechanical properties of multiple tendons in knockout mice. J Biomech Eng (2005) 1.71
Decorin prevents metastatic spreading of breast cancer. Oncogene (2005) 1.69
Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. J Biol Chem (2002) 1.67
The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses. J Clin Invest (2002) 1.63
A family of putative MSCRAMMs from Enterococcus faecalis. Microbiology (2004) 1.63
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Inhibition of complement activation by a secreted Staphylococcus aureus protein. J Infect Dis (2004) 1.62
Decorin, a novel player in the insulin-like growth factor system. J Biol Chem (2005) 1.59
Negative regulation of activated alpha-2 integrins during thrombopoiesis. Blood (2009) 1.59
Heparan sulfate: a complex polymer charged with biological activity. Chem Rev (2005) 1.57
Decorin suppresses tumor cell-mediated angiogenesis. Oncogene (2002) 1.57
Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation. J Biol Chem (2006) 1.55
The α₂β₁ integrin is a metastasis suppressor in mouse models and human cancer. J Clin Invest (2010) 1.55
Identification and characterization of the C3 binding domain of the Staphylococcus aureus extracellular fibrinogen-binding protein (Efb). J Biol Chem (2004) 1.55
A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics. PLoS Pathog (2008) 1.55
Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope. J Biol Chem (2002) 1.53
Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Am J Pathol (2002) 1.52
Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol (2004) 1.52
Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis. Cell Cycle (2011) 1.52
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int J Cancer (2008) 1.51
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21. Sci Signal (2011) 1.50
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis. J Biol Chem (2005) 1.50
Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development (2009) 1.50
Diverse cell signaling events modulated by perlecan. Biochemistry (2008) 1.49
Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts. Cancer Biol Ther (2011) 1.48
Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol (2006) 1.47
Identification and phenotypic characterization of a second collagen adhesin, Scm, and genome-based identification and analysis of 13 other predicted MSCRAMMs, including four distinct pilus loci, in Enterococcus faecium. Microbiology (2008) 1.47
Fibronectin-binding proteins of gram-positive cocci. Microbes Infect (2006) 1.47
GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood (2005) 1.47
Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex. Cancer Res (2006) 1.46
Decorin: a guardian from the matrix. Am J Pathol (2012) 1.46
Beta1 integrin mediates internalization of mammalian reovirus. J Virol (2006) 1.43
Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin. Oncogene (2002) 1.42
Biologically active decorin is a monomer in solution. J Biol Chem (2003) 1.40
Decorin expression is important for age-related changes in tendon structure and mechanical properties. Matrix Biol (2012) 1.39
Effect of altered matrix proteins on quasilinear viscoelastic properties in transgenic mouse tail tendons. Ann Biomed Eng (2003) 1.38
Identification and preliminary characterization of cell-wall-anchored proteins of Staphylococcus epidermidis. Microbiology (2005) 1.37
Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol (2009) 1.36
Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection. Infect Immun (2008) 1.36
Virulence potential of the staphylococcal adhesin CNA in experimental arthritis is determined by its affinity for collagen. J Infect Dis (2004) 1.36
Angiogenesis in collagen I requires alpha2beta1 ligation of a GFP*GER sequence and possibly p38 MAPK activation and focal adhesion disassembly. J Biol Chem (2003) 1.36
Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis. Mol Immunol (2007) 1.35
An antimetastatic role for decorin in breast cancer. Am J Pathol (2008) 1.34
A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen (2006) 1.33
The evolution and maintenance of virulence in Staphylococcus aureus: a role for host-to-host transmission? Nat Rev Microbiol (2006) 1.33
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Diabetes (2011) 1.33
The tandem beta-zipper model defines high affinity fibronectin-binding repeats within Staphylococcus aureus FnBPA. J Biol Chem (2007) 1.32
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels. J Biol Chem (2010) 1.32
Wound healing in the alpha2beta1 integrin-deficient mouse: altered keratinocyte biology and dysregulated matrix metalloproteinase expression. J Invest Dermatol (2006) 1.32
Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. J Biol Chem (2003) 1.31
BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. J Biol Chem (2004) 1.31
The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis. FEBS J (2007) 1.31
A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth. J Biol Chem (2003) 1.30
Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy. J Biol Chem (2009) 1.29
Decorin deficiency leads to impaired angiogenesis in injured mouse cornea. J Vasc Res (2004) 1.29
Protective niche for Borrelia burgdorferi to evade humoral immunity. Am J Pathol (2004) 1.29
Decorin-transforming growth factor- interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices. J Biol Chem (2007) 1.28
Matrix revolutions: "tails" of basement-membrane components with angiostatic functions. Trends Cell Biol (2005) 1.28
Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Carcinogenesis (2008) 1.28
A streptococcal collagen-like protein interacts with the alpha2beta1 integrin and induces intracellular signaling. J Biol Chem (2005) 1.27
Borrelia burgdorferi binds fibronectin through a tandem beta-zipper, a common mechanism of fibronectin binding in staphylococci, streptococci, and spirochetes. J Biol Chem (2005) 1.27
Assessment of prokaryotic collagen-like sequences derived from streptococcal Scl1 and Scl2 proteins as a source of recombinant GXY polymers. Appl Microbiol Biotechnol (2006) 1.26
Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM) ClfA and Fbl with fibrinogen. J Biol Chem (2009) 1.24
Fibrinogen-binding proteins of Gram-positive bacteria. Thromb Haemost (2007) 1.23
A central function for perlecan in skeletal muscle and cardiovascular development. J Cell Biol (2008) 1.22
Decorin causes autophagy in endothelial cells via Peg3. Proc Natl Acad Sci U S A (2013) 1.22