Published in Proteome Sci on February 12, 2008
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis. J Cell Mol Med (2011) 2.21
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. Matrix Biol (2015) 1.91
Diverse cell signaling events modulated by perlecan. Biochemistry (2008) 1.49
A central function for perlecan in skeletal muscle and cardiovascular development. J Cell Biol (2008) 1.22
A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis. Am J Pathol (2009) 1.07
Decoding the Matrix: Instructive Roles of Proteoglycan Receptors. Biochemistry (2015) 0.90
Proteomic analysis of regenerating mouse liver following 50% partial hepatectomy. Proteome Sci (2009) 0.84
Protein expression profiling in the African clawed frog Xenopus laevis tadpoles exposed to the polychlorinated biphenyl mixture aroclor 1254. Mol Cell Proteomics (2008) 0.84
Venous and arterial endothelial proteomics: mining for markers and mechanisms of endothelial diversity. Expert Rev Proteomics (2010) 0.78
The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy. Connect Tissue Res (2015) 0.77
Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. PLoS One (2014) 0.76
Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis. J Biol Chem (2017) 0.75
Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ Res (2005) 5.08
Endothelial cell migration during angiogenesis. Circ Res (2007) 4.67
Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol (1999) 2.94
Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene. EMBO J (1987) 2.79
beta-Actin messenger RNA localization and protein synthesis augment cell motility. J Cell Biol (1997) 2.43
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells. EMBO J (1999) 2.36
Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins. Proc Natl Acad Sci U S A (1997) 2.32
Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc Natl Acad Sci U S A (2003) 2.28
Basement membrane proteoglycans: from cellar to ceiling. Nat Rev Mol Cell Biol (2005) 2.28
Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (2002) 2.28
Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. Cell (1994) 2.23
Perlecan is essential for cartilage and cephalic development. Nat Genet (1999) 2.21
Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion. Nature (1997) 2.21
Beta actin and its mRNA are localized at the plasma membrane and the regions of moving cytoplasm during the cellular response to injury. J Cell Biol (1991) 2.19
Protein disulfide isomerase. A multifunctional protein resident in the lumen of the endoplasmic reticulum. J Biol Chem (1992) 2.18
Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena. J Clin Invest (2001) 2.18
Focal adhesion assembly. Trends Cell Biol (1997) 2.10
Intermediate filaments mediate cytoskeletal crosstalk. Nat Rev Mol Cell Biol (2004) 2.02
Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res (2002) 1.96
A single polypeptide acts both as the beta subunit of prolyl 4-hydroxylase and as a protein disulfide-isomerase. J Biol Chem (1987) 1.92
Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis. Cell Death Differ (2001) 1.87
The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. Am J Pathol (2002) 1.75
Prolyl 4-hydroxylases and their protein disulfide isomerase subunit. Matrix Biol (1998) 1.70
Chaperone-like activity of protein disulfide isomerase in the refolding of a protein with no disulfide bonds. J Biol Chem (1994) 1.68
Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. J Biol Chem (2002) 1.67
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. J Cell Biol (2004) 1.61
Heparan sulfate: a complex polymer charged with biological activity. Chem Rev (2005) 1.57
Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth. J Exp Med (1998) 1.57
Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo. J Clin Invest (1998) 1.46
Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. J Biol Chem (2000) 1.46
Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration. J Cell Sci (2003) 1.39
Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice. Cancer Res (2004) 1.36
Angiogenesis in collagen I requires alpha2beta1 ligation of a GFP*GER sequence and possibly p38 MAPK activation and focal adhesion disassembly. J Biol Chem (2003) 1.36
Structure and function of a vimentin-associated matrix adhesion in endothelial cells. Mol Biol Cell (2001) 1.33
Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. J Biol Chem (2003) 1.31
BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. J Biol Chem (2004) 1.31
Combined and individual mitochondrial HSP60 and HSP10 expression in cardiac myocytes protects mitochondrial function and prevents apoptotic cell deaths induced by simulated ischemia-reoxygenation. Circulation (2001) 1.31
A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth. J Biol Chem (2003) 1.30
Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. J Biol Chem (2001) 1.29
Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation (2002) 1.29
Mitochondrial chaperones in cancer: from molecular biology to clinical diagnostics. Cancer Biol Ther (2006) 1.26
Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia. Proc Natl Acad Sci U S A (2000) 1.25
Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth. Blood (1999) 1.25
The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin. J Biol Chem (2002) 1.23
Inducible interaction of integrin alpha 2 beta 1 with calreticulin. Dependence on the activation state of the integrin. J Biol Chem (1995) 1.22
Cell-free synthesis and assembly of prolyl 4-hydroxylase: the role of the beta-subunit (PDI) in preventing misfolding and aggregation of the alpha-subunit. EMBO J (1993) 1.19
Perlecan--a multifunctional extracellular proteoglycan scaffold. Glycobiology (2007) 1.19
Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism. J Natl Cancer Inst (2006) 1.17
Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha2beta1 integrin. J Cell Sci (2006) 1.17
Endostatin regulates endothelial cell adhesion and cytoskeletal organization. Cancer Res (2002) 1.15
Perlecan heparan sulfate proteoglycan: a novel receptor that mediates a distinct pathway for ligand catabolism. J Biol Chem (2000) 1.13
Protein disulfide isomerase is both an enzyme and a chaperone. FASEB J (1993) 1.13
Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. J Biol Chem (2006) 1.11
Perlecan: how does one molecule do so many things? Cell Mol Life Sci (2006) 1.10
Calreticulin. Int J Biochem Cell Biol (1998) 1.09
Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res (2002) 1.08
Angiogenesis inhibitors target the endothelial cell cytoskeleton through altered regulation of heat shock protein 27 and cofilin. Cancer Res (2003) 1.07
Perlecan knockdown in metastatic prostate cancer cells reduces heparin-binding growth factor responses in vitro and tumor growth in vivo. Clin Exp Metastasis (2005) 1.05
A role for perlecan in the suppression of growth and invasion in fibrosarcoma cells. Cancer Res (1997) 1.05
The intermediate filament protein vimentin binds specifically to a recombinant integrin alpha2/beta1 cytoplasmic tail complex and co-localizes with native alpha2/beta1 in endothelial cell focal adhesions. Exp Cell Res (2005) 1.04
Calreticulin modulates cell adhesiveness via regulation of vinculin expression. J Cell Biol (1996) 1.04
Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity. J Biol Chem (2007) 1.03
Suppression of autocrine and paracrine functions of basic fibroblast growth factor by stable expression of perlecan antisense cDNA. Mol Cell Biol (1997) 1.01
Physical and functional interaction between cell-surface calreticulin and the collagen receptors integrin alpha2beta1 and glycoprotein VI in human platelets. Thromb Haemost (2002) 0.96
Calreticulin couples calcium release and calcium influx in integrin-mediated calcium signaling. Mol Biol Cell (2000) 0.96
Role of perlecan in skeletal development and diseases. Glycoconj J (2003) 0.96
Calreticulin affects focal contact-dependent but not close contact-dependent cell-substratum adhesion. J Biol Chem (1999) 0.96
Ligand-specific, transient interaction between integrins and calreticulin during cell adhesion to extracellular matrix proteins is dependent upon phosphorylation/dephosphorylation events. Biochem J (1999) 0.89
Endostatin-induced modulation of plasminogen activation with concomitant loss of focal adhesions and actin stress fibers in cultured human endothelial cells. Cancer Res (2001) 0.89
Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells. Blood (2003) 0.88
Antiangiogenic antithrombin induces global changes in the gene expression profile of endothelial cells. Cancer Res (2006) 0.88
Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. Thromb Haemost (2005) 0.83
Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development. J Cell Biochem (2006) 2.71
Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction. J Biol Chem (2008) 2.53
The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J (2003) 2.13
The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood (2011) 1.89
Extracellular matrix proteoglycans control the fate of bone marrow stromal cells. J Biol Chem (2005) 1.82
Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan. J Biol Chem (2009) 1.79
Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol (2009) 1.76
FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney. Development (2013) 1.71
Influence of decorin and biglycan on mechanical properties of multiple tendons in knockout mice. J Biomech Eng (2005) 1.71
Decorin prevents metastatic spreading of breast cancer. Oncogene (2005) 1.69
Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. J Biol Chem (2002) 1.67
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. J Cell Biol (2004) 1.61
Decorin, a novel player in the insulin-like growth factor system. J Biol Chem (2005) 1.59
Heparan sulfate: a complex polymer charged with biological activity. Chem Rev (2005) 1.57
Decorin suppresses tumor cell-mediated angiogenesis. Oncogene (2002) 1.57
Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation. J Biol Chem (2006) 1.55
Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope. J Biol Chem (2002) 1.53
Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Am J Pathol (2002) 1.52
Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis. Cell Cycle (2011) 1.52
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int J Cancer (2008) 1.51
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21. Sci Signal (2011) 1.50
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis. J Biol Chem (2005) 1.50
Diverse cell signaling events modulated by perlecan. Biochemistry (2008) 1.49
Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts. Cancer Biol Ther (2011) 1.48
Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex. Cancer Res (2006) 1.46
Decorin: a guardian from the matrix. Am J Pathol (2012) 1.46
Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin. Oncogene (2002) 1.42
Biologically active decorin is a monomer in solution. J Biol Chem (2003) 1.40
Decorin expression is important for age-related changes in tendon structure and mechanical properties. Matrix Biol (2012) 1.39
Effect of altered matrix proteins on quasilinear viscoelastic properties in transgenic mouse tail tendons. Ann Biomed Eng (2003) 1.38
Angiogenesis in collagen I requires alpha2beta1 ligation of a GFP*GER sequence and possibly p38 MAPK activation and focal adhesion disassembly. J Biol Chem (2003) 1.36
An antimetastatic role for decorin in breast cancer. Am J Pathol (2008) 1.34
A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen (2006) 1.33
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels. J Biol Chem (2010) 1.32
Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. J Biol Chem (2003) 1.31
BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. J Biol Chem (2004) 1.31
The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis. FEBS J (2007) 1.31
A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth. J Biol Chem (2003) 1.30
Decorin deficiency leads to impaired angiogenesis in injured mouse cornea. J Vasc Res (2004) 1.29
Protective niche for Borrelia burgdorferi to evade humoral immunity. Am J Pathol (2004) 1.29
Matrix revolutions: "tails" of basement-membrane components with angiostatic functions. Trends Cell Biol (2005) 1.28
Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Carcinogenesis (2008) 1.28
Decorin causes autophagy in endothelial cells via Peg3. Proc Natl Acad Sci U S A (2013) 1.22
A central function for perlecan in skeletal muscle and cardiovascular development. J Cell Biol (2008) 1.22
Biological interplay between proteoglycans and their innate immune receptors in inflammation. FEBS J (2013) 1.22
Strain-rate sensitive mechanical properties of tendon fascicles from mice with genetically engineered alterations in collagen and decorin. J Biomech Eng (2004) 1.22
Decorin deficiency enhances progressive nephropathy in diabetic mice. Am J Pathol (2007) 1.22
In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer. FASEB J (2003) 1.22
Influence of decorin on the mechanical, compositional, and structural properties of the mouse patellar tendon. J Biomech Eng (2012) 1.20
Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin. Am J Pathol (2007) 1.20
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3. J Biol Chem (2011) 1.20
Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism. J Natl Cancer Inst (2006) 1.17
Effect of age and proteoglycan deficiency on collagen fiber re-alignment and mechanical properties in mouse supraspinatus tendon. J Biomech Eng (2013) 1.13
The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin. Am J Pathol (2010) 1.13
Investigating tendon fascicle structure-function relationships in a transgenic-age mouse model using multiple regression models. Ann Biomed Eng (2004) 1.13
Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. J Biol Chem (2006) 1.11
Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF-beta signaling pathway. Circ Res (2008) 1.11
Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation. Curr Opin Genet Dev (2012) 1.11
Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation. Cell Cycle (2012) 1.11
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice. Carcinogenesis (2011) 1.10
Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model. PLoS One (2012) 1.09
Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A. J Biol Chem (2012) 1.09
Decorin-TGFβ axis in hepatic fibrosis and cirrhosis. J Histochem Cytochem (2012) 1.08
Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth. Am J Pathol (2009) 1.08
A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis. Am J Pathol (2009) 1.07
A role for decorin in the remodeling of myocardial infarction. Matrix Biol (2005) 1.07
Novel interactions of perlecan: unraveling perlecan's role in angiogenesis. Microsc Res Tech (2008) 1.06
Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis. J Biol Chem (2008) 1.05
Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan. Biochemistry (2010) 1.04
Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism. J Biol Chem (2011) 1.04
The biology of small leucine-rich proteoglycans in bone pathophysiology. J Biol Chem (2012) 1.04
Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity. J Biol Chem (2007) 1.03
Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury. Am J Pathol (2004) 1.03
Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the alpha2beta1-integrin receptor. Blood (2006) 1.02
Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice. Lab Invest (2010) 1.02
Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis. Matrix Biol (2009) 1.01
Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Blood (2009) 1.01
Alcoholic pancreatitis in rats: injury from nonoxidative metabolites of ethanol. Am J Physiol Gastrointest Liver Physiol (2002) 1.00
Proepithelin is an autocrine growth factor for bladder cancer. Carcinogenesis (2009) 0.97
Dichotomy of decorin activity on the insulin-like growth factor-I system. FEBS J (2013) 0.96
The role of proteomics in the assessment of premature rupture of fetal membranes. Clin Chim Acta (2005) 0.95
Stimulation of human colonic epithelial cells by leukemia inhibitory factor is dependent on collagen-embedded fibroblasts in organotypic culture. FASEB J (2003) 0.94
Genetic evidence for key roles of decorin and biglycan in dentin mineralization. Matrix Biol (2009) 0.94
The role for decorin in delayed-type hypersensitivity. J Immunol (2011) 0.94
A central role for decorin during vertebrate convergent extension. J Biol Chem (2009) 0.93
Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation. J Biol Chem (2005) 0.92
Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing. J Biol Chem (2012) 0.92
Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer. FEBS J (2014) 0.92
Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan. Matrix Biol (2009) 0.91
Alterations in lung mechanics in decorin-deficient mice. Am J Physiol Lung Cell Mol Physiol (2004) 0.91
Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis. Carcinogenesis (2008) 0.90
Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development. Histochem Cell Biol (2009) 0.89
Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis. FEBS J (2013) 0.89
Thrombospondins in physiology and disease: new tricks for old dogs. Matrix Biol (2012) 0.89
Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin. J Biol Chem (2014) 0.89
Targeting heparanase for cancer therapy at the tumor-matrix interface. Matrix Biol (2012) 0.89
The tendon injury response is influenced by decorin and biglycan. Ann Biomed Eng (2013) 0.88