Published in J Biol Chem on April 09, 2003
The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. PLoS One (2008) 1.76
USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol (2011) 1.61
Role of transforming growth factor Beta in corneal function, biology and pathology. Curr Mol Med (2010) 1.39
Structural determinants of Smad function in TGF-β signaling. Trends Biochem Sci (2015) 1.18
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Genome-wide mechanisms of Smad binding. Oncogene (2012) 1.02
Zinc depletion causes multiple defects in ovarian function during the periovulatory period in mice. Endocrinology (2011) 0.92
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Strategies for exploring TGF-β signaling in Drosophila. Methods (2014) 0.83
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Computational design of binding proteins to EGFR domain II. PLoS One (2014) 0.79
Identification of Smad Response Elements in the Promoter of Goldfish FSHβ Gene and Evidence for Their Mediation of Activin and GnRH Stimulation of FSHβ Expression. Front Endocrinol (Lausanne) (2012) 0.78
The structures that underlie normal reproductive function. Mol Cell Endocrinol (2006) 0.78
Structural basis for the Smad5 MH1 domain to recognize different DNA sequences. Nucleic Acids Res (2015) 0.76
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Solution NMR structure of VF0530 from Vibrio fischeri reveals a nucleic acid-binding function. Proteins (2011) 0.75
Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94
Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85
Cancer metastasis: building a framework. Cell (2006) 19.67
A multigenic program mediating breast cancer metastasis to bone. Cancer Cell (2003) 16.86
Endogenous human microRNAs that suppress breast cancer metastasis. Nature (2008) 14.37
Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer (2003) 8.35
Genes that mediate breast cancer metastasis to the brain. Nature (2009) 8.23
Molecular basis of metastasis. N Engl J Med (2008) 8.19
TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell (2008) 7.60
Epithelial-mesenchymal transitions: twist in development and metastasis. Cell (2004) 7.14
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature (2007) 7.05
Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol (2004) 6.76
Tumor self-seeding by circulating cancer cells. Cell (2009) 6.66
Genetic determinants of cancer metastasis. Nat Rev Genet (2007) 6.38
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell (2004) 6.35
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science (2002) 6.32
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest (2005) 6.10
Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures. Nature (2008) 5.85
Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol Cell (2003) 5.31
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell (2006) 5.28
Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature (2002) 5.25
Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell (2009) 5.24
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem (2007) 5.21
China's research culture. Science (2010) 5.08
A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell (2012) 4.89
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell (2009) 4.81
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell (2005) 4.46
Roles of TGFbeta in metastasis. Cell Res (2009) 4.35
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med (2011) 4.25
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci U S A (2005) 4.20
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Nature (2005) 4.08
Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell (2003) 4.07
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. Mol Cell (2007) 3.97
Lung metastasis genes couple breast tumor size and metastatic spread. Proc Natl Acad Sci U S A (2007) 3.92
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell (2002) 3.87
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science (2002) 3.86
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell (2009) 3.76
Structural basis for sequence-specific recognition of DNA by TAL effectors. Science (2012) 3.64
Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res (2007) 3.63
Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci U S A (2003) 3.61
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell (2003) 3.57
Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell (2013) 3.33
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell (2006) 3.31
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell (2011) 3.23
Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol Cell (2007) 3.23
Is cancer a disease of self-seeding? Nat Med (2006) 3.19
Structure of the protein phosphatase 2A holoenzyme. Cell (2006) 3.07
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol (2006) 3.00
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature (2012) 2.97
Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature (2007) 2.97
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat Med (2012) 2.95
Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. Cancer Cell (2012) 2.94
Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol (2009) 2.94
C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell (2006) 2.87
ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc Natl Acad Sci U S A (2007) 2.85
mTOR kinase structure, mechanism and regulation. Nature (2013) 2.80
Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 2.75
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell (2005) 2.75
Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature (2012) 2.64
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell (2011) 2.64
Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature (2005) 2.63
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Nat Struct Biol (2002) 2.60
A FoxO-Smad synexpression group in human keratinocytes. Proc Natl Acad Sci U S A (2006) 2.60
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev (2009) 2.59
Origins of metastatic traits. Cancer Cell (2013) 2.49
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell (2008) 2.47
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell (2009) 2.45
Structure and mechanism of an amino acid antiporter. Science (2009) 2.40
Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science (2002) 2.36
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol Cell (2004) 2.31
Structure of a fucose transporter in an outward-open conformation. Nature (2010) 2.28
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev (2002) 2.26
Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54. Nat Struct Mol Biol (2005) 2.25
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature (2009) 2.25
Sorting out breast-cancer gene signatures. N Engl J Med (2007) 2.22
tRNA binds to cytochrome c and inhibits caspase activation. Mol Cell (2010) 2.14
Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature (2005) 2.08
Structure of a site-2 protease family intramembrane metalloprotease. Science (2007) 2.08
Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature (2009) 2.07
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell (2002) 2.05
Nucleocytoplasmic shuttling of signal transducers. Nat Rev Mol Cell Biol (2004) 2.04
Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat Struct Mol Biol (2004) 2.03
Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene. J Biol Chem (2001) 1.99
The structural basis for activation of plant immunity by bacterial effector protein AvrPto. Nature (2007) 1.95
Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. Mol Cell (2008) 1.93
Mechanism of substrate recognition and transport by an amino acid antiporter. Nature (2010) 1.92