Published in J Immunol on November 15, 2006
Signalling through C-type lectin receptors: shaping immune responses. Nat Rev Immunol (2009) 4.98
The role of saliva in tick feeding. Front Biosci (Landmark Ed) (2009) 2.73
A deep insight into the sialotranscriptome of the gulf coast tick, Amblyomma maculatum. PLoS One (2011) 1.49
Salivating for knowledge: potential pharmacological agents in tick saliva. PLoS Med (2008) 1.46
Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLoS Pathog (2008) 1.43
Tick salivary compounds: their role in modulation of host defences and pathogen transmission. Front Cell Infect Microbiol (2013) 1.31
Inhibition of neutrophil function by two tick salivary proteins. Infect Immun (2009) 1.16
Reviewing molecular adaptations of Lyme borreliosis spirochetes in the context of reproductive fitness in natural transmission cycles. Vet Res (2009) 1.14
Cutting edge: Immunity against a "silent" salivary antigen of the Lyme vector Ixodes scapularis impairs its ability to feed. J Immunol (2008) 1.13
The immunomodulatory action of sialostatin L on dendritic cells reveals its potential to interfere with autoimmunity. J Immunol (2009) 1.05
Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses. PLoS Pathog (2013) 1.00
Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva. J Infect Dis (2008) 1.00
The tick salivary protein Salp15 inhibits the killing of serum-sensitive Borrelia burgdorferi sensu lato isolates. Infect Immun (2008) 0.96
Langerhans cell deficiency impairs Ixodes scapularis suppression of Th1 responses in mice. Infect Immun (2009) 0.95
The crystal structures of two salivary cystatins from the tick Ixodes scapularis and the effect of these inhibitors on the establishment of Borrelia burgdorferi infection in a murine model. Mol Microbiol (2010) 0.93
Two immunoregulatory peptides with antioxidant activity from tick salivary glands. J Biol Chem (2010) 0.92
Antialarmin effect of tick saliva during the transmission of Lyme disease. Infect Immun (2010) 0.91
The tick salivary protein, Salp15, inhibits the development of experimental asthma. J Immunol (2007) 0.90
A novel sphingomyelinase-like enzyme in Ixodes scapularis tick saliva drives host CD4 T cells to express IL-4. Parasite Immunol (2009) 0.90
All For One and One For All on the Tick-Host Battlefield. Trends Parasitol (2016) 0.89
Ixodes scapularis saliva mitigates inflammatory cytokine secretion during Anaplasma phagocytophilum stimulation of immune cells. Parasit Vectors (2012) 0.88
Dermatologic changes induced by repeated Ixodes scapularis bites and implications for prevention of tick-borne infection. Vector Borne Zoonotic Dis (2009) 0.87
IrSPI, a tick serine protease inhibitor involved in tick feeding and Bartonella henselae infection. PLoS Negl Trop Dis (2014) 0.87
Novel Diagnosis of Lyme Disease: Potential for CAM Intervention. Evid Based Complement Alternat Med (2007) 0.85
Effects of Aedes aegypti salivary components on dendritic cell and lymphocyte biology. Parasit Vectors (2013) 0.82
Positive selection in tick saliva proteins of the Salp15 family. J Mol Evol (2009) 0.81
A Nod to disease vectors: mitigation of pathogen sensing by arthropod saliva. Front Microbiol (2013) 0.79
Suppression of cell proliferation and cytokine expression by HL-p36, a tick salivary gland-derived protein of Haemaphysalis longicornis. Immunology (2008) 0.79
Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation. Endocrinology (2010) 0.79
The tick saliva immunosuppressor, Salp15, contributes to Th17-induced pathology during Experimental Autoimmune Encephalomyelitis. Biochem Biophys Res Commun (2010) 0.78
Genetic diversity of Salp15 in the Ixodes ricinus complex (Acari: Ixodidae). PLoS One (2014) 0.78
The Ixodes scapularis salivary protein, salp15, prevents the association of HIV-1 gp120 and CD4. Biochem Biophys Res Commun (2007) 0.77
Phages and HIV-1: from display to interplay. Int J Mol Sci (2012) 0.76
Soluble cysteine-rich tick saliva proteins Salp15 and Iric-1 from E. coli. FEBS Open Bio (2014) 0.76
Immune and biochemical responses in skin differ between bovine hosts genetically susceptible and resistant to the cattle tick Rhipicephalus microplus. Parasit Vectors (2017) 0.76
Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases. Front Cell Infect Microbiol (2017) 0.75
An in vitro model to assess the immunosuppressive effect of tick saliva on the mobilization of inflammatory monocyte-derived cells. Vet Res (2015) 0.75
The immunosuppressive effect of the tick protein, Salp15, is long-lasting and persists in a murine model of hematopoietic transplant. Sci Rep (2017) 0.75
Lyme disease-a tick-borne spirochetosis? Science (1982) 27.50
Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. J Clin Microbiol (1994) 9.97
T-cell-antigen recognition and the immunological synapse. Nat Rev Immunol (2003) 3.38
Regulation of phosphoinositide-specific phospholipase C isozymes. J Biol Chem (1997) 3.34
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat Immunol (2004) 3.21
The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature (2005) 2.82
The role of lipid rafts in T cell antigen receptor (TCR) signalling. Semin Immunol (2000) 2.64
Tick modulation of host immunity: an important factor in pathogen transmission. Int J Parasitol (1999) 2.13
MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8. Nature (1992) 1.95
Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation. Immunity (2002) 1.75
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120. J Immunol (1988) 1.51
Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands. J Infect Dis (2001) 1.45
Saliva of the Lyme disease vector, Ixodes dammini, blocks cell activation by a nonprostaglandin E2-dependent mechanism. J Exp Med (1994) 1.39
Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH. J Biol Chem (2003) 1.34
Adaptation of Borrelia burgdorferi in the tick and the mammalian host. FEMS Microbiol Rev (2003) 1.19
Purification and characterization of prolixin S (nitrophorin 2), the salivary anticoagulant of the blood-sucking bug Rhodnius prolixus. Biochem J (1995) 1.16
Tick-host immunology: Significant advances and challenging opportunities. Parasitol Today (1997) 1.12
IL-16 inhibition of CD3-dependent lymphocyte activation and proliferation. J Immunol (1996) 1.10
Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase. Virology (1997) 1.06
Suppressive effect of Ixodes ricinus salivary gland extract on mechanisms of natural immunity in vitro. Parasite Immunol (1998) 1.05
Saliva of Rhipicephalus sanguineus tick impairs T cell proliferation and IFN-gamma-induced macrophage microbicidal activity. Vet Immunol Immunopathol (1998) 1.05
Ixodes scapularis: effects of repeated infestations with pathogen-free nymphs on macrophage and T lymphocyte cytokine responses of BALB/c and C3H/HeN mice. Exp Parasitol (1999) 0.97
Review of GCDFP-15. An apocrine marker protein. Ann N Y Acad Sci (1990) 0.97
Potent inhibition of CD4/TCR-mediated T cell apoptosis by a CD4-binding glycoprotein secreted from breast tumor and seminal vesicle cells. J Immunol (1999) 0.93
High-performance liquid chromatography analysis of spectrin oligomerization. Anal Biochem (2001) 0.81
gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes. Eur J Immunol (1997) 0.81
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med (2004) 7.49
RNA interference screen for human genes associated with West Nile virus infection. Nature (2008) 4.93
A structural state of the myosin V motor without bound nucleotide. Nature (2003) 3.63
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46
The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity (2012) 3.43
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest (2004) 3.38
Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J Exp Med (2004) 3.02
The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature (2005) 2.82
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet (2011) 2.70
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity (2009) 2.66
The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol (2002) 2.63
Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol (2010) 2.63
TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi. Cell (2004) 2.62
The structure of the myosin VI motor reveals the mechanism of directionality reversal. Nature (2005) 2.50
Molecular adaptation of Borrelia burgdorferi in the murine host. J Exp Med (2002) 2.49
Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes. J Virol (2006) 2.20
Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20
A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector. Cell Host Microbe (2007) 2.17
Rab 5 is required for the cellular entry of dengue and West Nile viruses. J Virol (2007) 2.12
Human Borrelia miyamotoi infection in the United States. N Engl J Med (2013) 2.11
IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. J Immunol (2003) 2.03
Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol (2009) 2.00
Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol (2008) 1.93
Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J Virol (2006) 1.84
Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments. Nat Cell Biol (2009) 1.83
Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses. Infect Immun (2004) 1.82
Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell (2009) 1.79
West Nile virus: a growing concern? J Clin Invest (2004) 1.77
Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation. Immunity (2002) 1.75
A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. Lancet (2013) 1.73
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine (2009) 1.72
Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus. J Virol (2005) 1.72
A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity. J Infect Dis (2007) 1.68
Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination. J Clin Microbiol (2003) 1.65
Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation. J Exp Med (2002) 1.61
Detection of human anti-flavivirus antibodies with a west nile virus recombinant antigen microsphere immunoassay. J Clin Microbiol (2004) 1.59
Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. J Clin Invest (2007) 1.57
Disruption of Ixodes scapularis anticoagulation by using RNA interference. Proc Natl Acad Sci U S A (2004) 1.56
IL-27 promotes T cell-dependent colitis through multiple mechanisms. J Exp Med (2010) 1.54
Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection. Infect Immun (2004) 1.52
Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation. J Immunol (2002) 1.52
Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity. Infect Immun (2006) 1.52
Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain. J Virol (2008) 1.49
The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med (2014) 1.49
Salivating for knowledge: potential pharmacological agents in tick saliva. PLoS Med (2008) 1.46
A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent. Cell Host Microbe (2011) 1.44
The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks. Mol Microbiol (2006) 1.44
Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLoS Pathog (2008) 1.43
Examination of the Borrelia burgdorferi transcriptome in Ixodes scapularis during feeding. J Bacteriol (2002) 1.43
Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo. Nature (2010) 1.42
IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J Exp Med (2010) 1.41
Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes Infect (2003) 1.41
Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry (2004) 1.40
Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell (2011) 1.39
West Nile Virus: biology, transmission, and human infection. Clin Microbiol Rev (2012) 1.38
Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J Infect Dis (2011) 1.38
c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. J Exp Med (2002) 1.38
A paradoxical role for neutrophils in the pathogenesis of West Nile virus. J Infect Dis (2010) 1.37
IL-10 signaling blockade controls murine West Nile virus infection. PLoS Pathog (2009) 1.35
Invasion and survival strategies of Anaplasma phagocytophilum. Cell Microbiol (2003) 1.35
Tick-host-pathogen interactions in Lyme borreliosis. Trends Parasitol (2007) 1.34
A recombinant envelope protein vaccine against West Nile virus. Vaccine (2005) 1.31
Association of linear plasmid 28-1 with an arthritic phenotype of Borrelia burgdorferi. Infect Immun (2005) 1.30
Protective niche for Borrelia burgdorferi to evade humoral immunity. Am J Pathol (2004) 1.29
Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis. J Exp Med (2007) 1.29
Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint. EMBO J (2006) 1.28
West Nile virus envelope protein inhibits dsRNA-induced innate immune responses. J Immunol (2007) 1.26
Borrelia burgdorferi transcriptome in the central nervous system of non-human primates. Proc Natl Acad Sci U S A (2003) 1.26
DNA microarray assessment of putative Borrelia burgdorferi lipoprotein genes. Infect Immun (2002) 1.25
Use of RNA interference to prevent lethal murine west nile virus infection. J Infect Dis (2005) 1.24
Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks. PLoS Pathog (2007) 1.24
A chromosomally encoded virulence factor protects the Lyme disease pathogen against host-adaptive immunity. PLoS Pathog (2009) 1.24
Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses. PLoS Pathog (2011) 1.22
Local production of IFN-gamma by invariant NKT cells modulates acute Lyme carditis. J Immunol (2009) 1.22
Notch signaling regulates mouse and human Th17 differentiation. J Immunol (2011) 1.21
Differential expression of the p44 gene family in the agent of human granulocytic ehrlichiosis. Infect Immun (2002) 1.21
Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling. J Biol Chem (2006) 1.21
Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display. PLoS One (2011) 1.21
Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold. J Clin Invest (2010) 1.21
CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis. Clin Diagn Lab Immunol (2004) 1.20
Adaptation of Borrelia burgdorferi in the tick and the mammalian host. FEMS Microbiol Rev (2003) 1.19
Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent. Cell Host Microbe (2009) 1.19
CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi. Proc Natl Acad Sci U S A (2012) 1.18
Structurally distinct requirements for binding of P-selectin glycoprotein ligand-1 and sialyl Lewis x to Anaplasma phagocytophilum and P-selectin. J Biol Chem (2003) 1.18
Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice. J Immunol (2006) 1.18