Published in Nature on February 20, 2005
T cell activation. Annu Rev Immunol (2009) 7.40
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity (2006) 6.93
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med (2005) 5.55
Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol (2005) 4.26
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature (2010) 3.96
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature (2010) 3.40
Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes. J Immunol (2006) 3.15
Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol (2010) 3.01
Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat Immunol (2011) 2.81
Naive T cell homeostasis: from awareness of space to a sense of place. Nat Rev Immunol (2009) 2.68
Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response. J Exp Med (2005) 2.57
The alphabeta T cell receptor is an anisotropic mechanosensor. J Biol Chem (2009) 2.41
An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol (2009) 2.38
Recognition of CD1d-restricted antigens by natural killer T cells. Nat Rev Immunol (2012) 2.32
Mechanisms for T cell receptor triggering. Nat Rev Immunol (2010) 2.30
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J Exp Med (2010) 2.20
T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nat Immunol (2009) 2.17
The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity (2008) 2.13
Display technologies: application for the discovery of drug and gene delivery agents. Adv Drug Deliv Rev (2006) 1.92
Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat Immunol (2014) 1.91
New insights into the T cell synapse from single molecule techniques. Nat Rev Immunol (2011) 1.90
Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol (2005) 1.85
T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity. Immunology (2009) 1.85
How the TCR balances sensitivity and specificity for the recognition of self and pathogens. Nat Immunol (2012) 1.80
An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells. Nat Immunol (2009) 1.78
Polyspecificity of T cell and B cell receptor recognition. Semin Immunol (2007) 1.68
A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells. Immunity (2013) 1.62
T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters. Proc Natl Acad Sci U S A (2011) 1.61
Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness. J Clin Invest (2012) 1.59
T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. Immunity (2013) 1.58
Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response. Proc Natl Acad Sci U S A (2006) 1.58
Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity. PLoS Biol (2008) 1.57
Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Mol Cell Biol (2006) 1.55
The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Immunity (2007) 1.52
Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper. Nat Rev Immunol (2009) 1.49
Receptor signaling clusters in the immune synapse. Annu Rev Biophys (2012) 1.48
Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. Proc Natl Acad Sci U S A (2005) 1.46
How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides? EMBO J (2007) 1.44
Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module. Proc Natl Acad Sci U S A (2007) 1.43
Insights into the initiation of TCR signaling. Nat Immunol (2014) 1.37
A constant affinity threshold for T cell tolerance. J Exp Med (2007) 1.36
Mechanisms and implications of adaptive immune responses after traumatic spinal cord injury. Neuroscience (2008) 1.30
Signaling in thymic selection. Curr Opin Immunol (2011) 1.29
The receptor deformation model of TCR triggering. FASEB J (2007) 1.27
Organization of proximal signal initiation at the TCR:CD3 complex. Immunol Rev (2009) 1.25
Pairing computation with experimentation: a powerful coupling for understanding T cell signalling. Nat Rev Immunol (2010) 1.25
Quantitative challenges in understanding ligand discrimination by alphabeta T cells. Mol Immunol (2007) 1.24
Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4. Proc Natl Acad Sci U S A (2012) 1.24
The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface. Proc Natl Acad Sci U S A (2006) 1.22
The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function. Immunol Rev (2012) 1.20
Clustering class I MHC modulates sensitivity of T cell recognition. J Immunol (2006) 1.19
The c-SMAC: sorting it all out (or in). J Cell Biol (2005) 1.16
Attenuated T cell responses to a high-potency ligand in vivo. PLoS Biol (2010) 1.15
T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy. Proc Natl Acad Sci U S A (2013) 1.14
Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse. J Virol (2009) 1.14
Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection. J Exp Med (2010) 1.12
A role for rebinding in rapid and reliable T cell responses to antigen. PLoS Comput Biol (2009) 1.11
Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation. Immunity (2008) 1.11
MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo. Proc Natl Acad Sci U S A (2007) 1.11
KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs. Mol Cell Biol (2009) 1.10
T-cell antigen receptor triggering and lipid rafts: a matter of space and time scales. Talking Point on the involvement of lipid rafts in T-cell activation. EMBO Rep (2008) 1.09
T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity. EMBO Rep (2006) 1.09
Recognition of self-peptide-MHC complexes by autoimmune T-cell receptors. Trends Biochem Sci (2007) 1.07
A role for "self" in T-cell activation. Semin Immunol (2007) 1.07
Solution mapping of T cell receptor docking footprints on peptide-MHC. Proc Natl Acad Sci U S A (2007) 1.06
T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J Exp Med (2007) 1.06
Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism. Proc Natl Acad Sci U S A (2013) 1.05
Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells. Elife (2013) 1.04
Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity? Curr Opin Immunol (2007) 1.03
Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition. J Biol Chem (2008) 1.03
NSOM/QD-based direct visualization of CD3-induced and CD28-enhanced nanospatial coclustering of TCR and coreceptor in nanodomains in T cell activation. PLoS One (2009) 1.01
Mediation of T-cell activation by actin meshworks. Cold Spring Harb Perspect Biol (2010) 1.00
TCR Signaling Emerges from the Sum of Many Parts. Front Immunol (2012) 0.99
Epitope density influences CD8+ memory T cell differentiation. PLoS One (2010) 0.98
Signaling microdomains in T cells. FEBS Lett (2010) 0.97
Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation. Biophys J (2006) 0.95
A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling. PLoS Biol (2009) 0.94
Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters. Biophys J (2008) 0.93
Engineering CAR-T cells: Design concepts. Trends Immunol (2015) 0.93
Barcoding T cell calcium response diversity with methods for automated and accurate analysis of cell signals (MAAACS). PLoS Comput Biol (2013) 0.92
Revisiting thymic positive selection and the mature T cell repertoire for antigen. Immunity (2014) 0.92
How the immune system talks to itself: the varied role of synapses. Immunol Rev (2013) 0.92
2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system. Eur J Immunol (2013) 0.92
Mechanical regulation of T-cell functions. Immunol Rev (2013) 0.91
Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells. J Immunol (2011) 0.90
T cell antigen recognition at the cell membrane. Mol Immunol (2012) 0.90
Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes. Immunol Res (2011) 0.89
Dynamic organization of lymphocyte plasma membrane: lessons from advanced imaging methods. Immunology (2010) 0.88
Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling. PLoS One (2012) 0.88
High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics. Mol Immunol (2010) 0.87
IL-12 enhances CTL synapse formation and induces self-reactivity. J Immunol (2009) 0.86
Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains. J Biol Chem (2010) 0.86
TCR Microclusters pre-exist and contain molecules necessary for TCR signal transduction. J Immunol (2014) 0.86
T cell activation is determined by the number of presented antigens. Nano Lett (2013) 0.86
The integration of signaling and the spatial organization of the T cell synapse. Front Immunol (2012) 0.86
Engineering improved T cell receptors using an alanine-scan guided T cell display selection system. J Immunol Methods (2013) 0.85
Systematic characterisation of cellular localisation and expression profiles of proteins containing MHC ligands. PLoS One (2009) 0.85
Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells. J Immunol (2015) 0.84
Bi-specific MHC heterodimers for characterization of cross-reactive T cells. J Biol Chem (2010) 0.83
Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC. J Exp Med (2013) 0.83
miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell (2007) 9.08
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity (2009) 7.69
Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. Immunity (2012) 5.26
Direct observation of ligand recognition by T cells. Nature (2002) 5.21
miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95
Cell type-specific gene expression differences in complex tissues. Nat Methods (2010) 4.75
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nat Immunol (2009) 4.22
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity (2008) 4.21
Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat Immunol (2003) 3.88
T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol (2004) 3.85
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity (2013) 3.72
Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton. Proc Natl Acad Sci U S A (2006) 3.60
Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry. Sci Transl Med (2013) 3.41
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature (2010) 3.40
T-cell-antigen recognition and the immunological synapse. Nat Rev Immunol (2003) 3.38
Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults. Immunity (2013) 3.38
Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat Immunol (2001) 3.24
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat Immunol (2004) 3.21
Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device. Proc Natl Acad Sci U S A (2009) 3.19
T cells use two directionally distinct pathways for cytokine secretion. Nat Immunol (2006) 3.01
"MIATA"-minimal information about T cell assays. Immunity (2009) 2.90
How T cells 'see' antigen. Nat Immunol (2005) 2.87
Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature (2012) 2.77
Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci Transl Med (2013) 2.71
Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol Cell (2003) 2.61
TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell (2012) 2.60
Retracted CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy. Sci Transl Med (2013) 2.51
Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature (2002) 2.45
An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol (2009) 2.38
Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells. Cell Stem Cell (2011) 2.35
Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts. Proc Natl Acad Sci U S A (2008) 2.25
The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. Development (2005) 2.23
A single class II myosin modulates T cell motility and stopping, but not synapse formation. Nat Immunol (2004) 2.20
In vivo imaging of lymphocyte trafficking. Annu Rev Cell Dev Biol (2005) 2.15
Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity (2007) 2.11
T cells as a self-referential, sensory organ. Annu Rev Immunol (2007) 2.07
High-throughput, high-fidelity HLA genotyping with deep sequencing. Proc Natl Acad Sci U S A (2012) 2.03
Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. Proc Natl Acad Sci U S A (2013) 2.00
Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. J Clin Invest (2011) 1.94
A human T cell-specific molecule is a member of a new gene family. 1988. J Immunol (2009) 1.93
Shouts, whispers and the kiss of death: directional secretion in T cells. Nat Immunol (2008) 1.92
Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. Blood (2011) 1.80
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol (2013) 1.79
Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr Opin Immunol (2002) 1.77
Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity (2002) 1.77
Apoptosis and other immune biomarkers predict influenza vaccine responsiveness. Mol Syst Biol (2013) 1.75
Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol (2013) 1.74
Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells. Nat Immunol (2009) 1.72
Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells. J Clin Invest (2003) 1.70
IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. J Exp Med (2013) 1.68
Simultaneous detection of many T-cell specificities using combinatorial tetramer staining. Nat Methods (2009) 1.67
Deconstructing the form and function of the TCR/CD3 complex. Immunity (2006) 1.64
A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells. Immunity (2013) 1.62
Detection and characterization of cellular immune responses using peptide-MHC microarrays. PLoS Biol (2003) 1.62
Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. J Immunol (2010) 1.60
Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization. J Immunol (2003) 1.58
Transcriptomic analysis of peripheral blood mononuclear cells in rapid progressors in early HIV infection identifies a signature closely correlated with disease progression. Clin Chem (2013) 1.54
Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires. J Immunol (2013) 1.51
Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection. Immunity (2002) 1.51
Pillars article: Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. 1994. J Immunol (2010) 1.51
Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice. Proc Natl Acad Sci U S A (2002) 1.49
Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling. Immunity (2007) 1.46
Dynamics of cell surface molecules during T cell recognition. Annu Rev Biochem (2003) 1.46
Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization. Nat Biotechnol (2013) 1.45
Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE). Proc Natl Acad Sci U S A (2013) 1.44
Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96. J Immunol (2011) 1.42
Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray. PLoS Med (2005) 1.42
A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells. Nat Immunol (2011) 1.39
Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease. Proc Natl Acad Sci U S A (2013) 1.36
Structural insight into pre-B cell receptor function. Science (2007) 1.29
CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery. Proc Natl Acad Sci U S A (2010) 1.28
Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells. J Cell Biol (2011) 1.26
Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol (2004) 1.24
Evidence for a functional sidedness to the alphabetaTCR. Proc Natl Acad Sci U S A (2010) 1.24
miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation. J Biol Chem (2014) 1.22
γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response. Immunity (2012) 1.22
Molecular and functional analysis using live cell microarrays. Curr Opin Chem Biol (2006) 1.22
T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells. Proc Natl Acad Sci U S A (2011) 1.21
CD4+ T-cell synapses involve multiple distinct stages. Proc Natl Acad Sci U S A (2011) 1.19
Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions. Proc Natl Acad Sci U S A (2006) 1.16
Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k). J Immunol (2011) 1.15
The safety on the TCR trigger. Cell (2008) 1.15
Linking molecular and cellular events in T-cell activation and synapse formation. Semin Immunol (2003) 1.13
Pillars article: The immunological synapse: a molecular machine controlling T cell activation. Science. 1999. 285: 221-227. J Immunol (2015) 1.13
Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation. Proc Natl Acad Sci U S A (2002) 1.13
Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection. J Exp Med (2010) 1.12
Distinct molecular mechanisms account for the specificity of two different T-cell receptors. Biochemistry (2003) 1.12