Catecholamine binding to the beta-adrenergic receptor.

Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. Proc Natl Acad Sci U S A (1980) 1.65

Agonist-induced increase in apparent beta-adrenergic receptor size. Proc Natl Acad Sci U S A (1978) 1.27

Regulation of human leukocyte beta receptors by endogenous catecholamines: relationship of leukocyte beta receptor density to the cardiac sensitivity to isoproterenol. J Clin Invest (1981) 1.23

Impaired beta adrenergic receptor binding and function in cystic fibrosis neutrophils. J Clin Invest (1981) 1.01

(-)-S-[3H]CGP-12177 and its use to determine the rate constants of unlabeled beta-adrenergic antagonists. Proc Natl Acad Sci U S A (1985) 0.97

Differential effects of fluoride on adenylate cyclase activity and guanine nucleotide regulation of agonist high-affinity receptor binding. Biochem J (1988) 0.92

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature (2016) 0.92

Thermodynamics and docking of agonists to the β(2)-adrenoceptor determined using [(3)H](R,R')-4-methoxyfenoterol as the marker ligand. Mol Pharmacol (2012) 0.86

Beta receptor occupancy. Assessment in the intact animal. J Clin Invest (1980) 0.86

Unmasking of magnesium-dependent high-affinity binding sites for [dAla2, dLeu5]enkephalin after pretreatment of brain membranes with guanine nucleotides. Proc Natl Acad Sci U S A (1983) 0.83

Hormone-receptor interactions are noncooperative: application to the beta-adrenergic receptor. Proc Natl Acad Sci U S A (1980) 0.83

Guanine nucleotide regulation of [3H]vasopressin binding to liver plasma membranes and solubilized receptors. Evidence for the involvement of a guanine nucleotide regulatory protein. Biochem J (1986) 0.82

Inhibition of [3H]-dihydroalprenolol binding to rat cardiac membranes of various beta-blocking agents. Br J Pharmacol (1978) 0.77

N-Aralkyl substitution increases the affinity of adrenergic drugs for the alpha-adrenoceptor in rat liver. Br J Pharmacol (1979) 0.77

Attempts to obtain anti(D2 dopamine receptor) antibodies via the anti-idiotypic route. Biochem J (1986) 0.75

Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91

The beta-adrenergic receptor and adenylate cyclase. Biochim Biophys Acta (1976) 2.02

Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol. J Biol Chem (1975) 1.99

Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. Proc Natl Acad Sci U S A (1975) 1.87

Beta adrenergic receptor binding in membrane preparations from mammalian brain. Mol Pharmacol (1976) 1.72

Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro. J Biol Chem (1975) 1.72

Binding of (125I)iodohydroxybenzylpindolol to putative beta-adrenergic receptors of rat glioma cells and other cell clones. J Biol Chem (1976) 1.69

The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon. J Biol Chem (1971) 1.68

Beta-adrenergic receptor: stereospecific interaction of iodinated beta-blocking agent with high affinity site. Science (1974) 1.68

Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase. Proc Natl Acad Sci U S A (1975) 1.60

An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor. Mol Pharmacol (1976) 1.59

Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes. J Biol Chem (1976) 1.52

Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides. J Biol Chem (1976) 1.45

Binding of (3H)prostaglandin E1 to putative receptors linked to adenylate cyclase of cultured cell clones. J Biol Chem (1976) 1.44

The binding characteristics and number of beta-adrenergic receptors on the turkey erythrocyte. Proc Natl Acad Sci U S A (1974) 1.41

Hormone action at the membrane level. II. The binding of epinephrine and glucagon to the rat liver plasma membrane. Biochim Biophys Acta (1970) 1.41

Noradrenaline binding and the search for catecholamine receptors. Nature (1974) 1.40

Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. Biochem Biophys Res Commun (1974) 1.30

Dopamine receptor binding in the corpus striatum of mammalian brain. Proc Natl Acad Sci U S A (1975) 1.29

A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor. Proc Natl Acad Sci U S A (1971) 1.17

Epinephrine binding to the catecholamine receptor and activation of the adenylate cyclase in erythrocyte membranes (hormone receptor- -adrenergic receptor-cyclic AMP-turkey). Proc Natl Acad Sci U S A (1972) 1.16

Binding of iodinated beta adrenergic antagonists to proteins derived from rat heart. Mol Pharmacol (1976) 1.13

Stereospecific binding of propranolol and catecholamines to the beta-adrenergic receptor. Proc Natl Acad Sci U S A (1974) 1.09

Specific binding of -adrenergic catecholamines to a subcellular fraction from cardiac muscle. J Biol Chem (1973) 1.09

Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides. Proc Natl Acad Sci U S A (1976) 1.09

Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines. Endocrinology (1976) 1.09

A beta-adrenergic receptor of the turkey erythrocyte. II. Characterization and solubilization of the receptor. J Biol Chem (1973) 1.05

Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies. Mol Pharmacol (1976) 1.05

Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro. Mol Pharmacol (1976) 1.04

Beta-Adrenergic receptor interactions. Characterization of iodohydroxybenzylpindolol as a specific ligand. J Biol Chem (1976) 1.01

Circadian cycles in binding of 3H-alprenolol to beta-adrenergic receptor sites in rat pineal. Nature (1975) 0.98

Pineal beta adrenergic receptor: correlation of binding of 3H-l-alprenolol with stimulation of adenylate cyclase. J Pharmacol Exp Ther (1976) 0.98

The beta-adrenergic receptor. Life Sci (1976) 0.88

Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. Biochem Pharmacol (1975) 0.78

Selective identification of "true" beta-adrenergic receptors in the plasma membranes of rat adipocytes. FEBS Lett (1975) 0.78

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science (1999) 7.57

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science (1992) 7.49

Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature (1986) 7.06

Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J Exp Med (1999) 6.09

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. J Biol Chem (1980) 6.06

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci U S A (1998) 5.94

Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (1977) 5.87

Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem (1991) 5.70

G protein-coupled receptor kinases. Annu Rev Biochem (1998) 5.53

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature (1997) 5.31

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science (2000) 5.20

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell (1992) 5.09

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science (2001) 5.05

Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor. Cell (1989) 4.86

PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell (1990) 4.85

Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science (1994) 4.84

cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor. Cell (1991) 4.76

Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res (1993) 4.67

Cloning of the cDNA for the human beta 1-adrenergic receptor. Proc Natl Acad Sci U S A (1987) 4.66

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci U S A (1987) 4.61

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proc Natl Acad Sci U S A (2001) 4.56

beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science (1990) 4.53

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature (1998) 4.52

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem (1993) 4.52

Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science (1989) 4.21

Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science (1997) 4.19

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science (1995) 4.18

Signalling by receptor tyrosine kinases. Annu Rev Biochem (1993) 4.11

Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J (1990) 4.05

Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science (1999) 4.04

Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor. Science (1989) 3.83

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol Cell Biol (1996) 3.82

Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization. J Clin Invest (1988) 3.76

Regulation of transmembrane signaling by receptor phosphorylation. Cell (1987) 3.74

Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-coupled adenylate cyclase system as a model. Nature (1985) 3.74

Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science (1988) 3.60

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol Cell Biol (1997) 3.52

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science (1987) 3.47

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. Science (1992) 3.45

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science (1995) 3.42

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature (2000) 3.42

The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature (1998) 3.41

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A (1986) 3.38

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature (1987) 3.33

International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev (1994) 3.26

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. Mol Pharmacol (1982) 3.23

Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature (1994) 3.21

A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine. Mol Cell Biol (1991) 3.20

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. Proc Natl Acad Sci U S A (1988) 3.18

The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Science (1994) 3.07

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci U S A (1993) 3.01

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J Biol Chem (1992) 2.97

Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. J Biol Chem (1989) 2.95

A family of receptors coupled to guanine nucleotide regulatory proteins. Biochemistry (1987) 2.91

Binding of G protein beta gamma-subunits to pleckstrin homology domains. J Biol Chem (1994) 2.91

Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc Natl Acad Sci U S A (1992) 2.89

Molecular basis for interactions of G protein betagamma subunits with effectors. Science (1998) 2.88

beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A (2001) 2.86

Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol (1999) 2.86

An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Science (1994) 2.80

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. Proc Natl Acad Sci U S A (1988) 2.78

Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors. Proc Natl Acad Sci U S A (2001) 2.77

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci U S A (1998) 2.76

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta. Nature (1994) 2.71

Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex. Mol Cell Biol (1990) 2.71

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF. Cell (1985) 2.69

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat Cell Biol (2001) 2.69

A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proc Natl Acad Sci U S A (1998) 2.68

Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription. Proc Natl Acad Sci U S A (1998) 2.66

Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature (1995) 2.64

Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science (1998) 2.64

The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol Cell Biol (1991) 2.63

Platelet-derived growth factor receptors form a high affinity state in membrane preparations. Kinetics and affinity cross-linking studies. J Biol Chem (1984) 2.61

Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding. J Clin Invest (1976) 2.58

Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5. Proc Natl Acad Sci U S A (1995) 2.58

International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. Pharmacol Rev (1995) 2.53

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. J Biol Chem (1994) 2.53

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci U S A (2001) 2.52

Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3. Proc Natl Acad Sci U S A (1991) 2.48

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis. Nature (1992) 2.46

Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J Biol Chem (1998) 2.45

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J Biol Chem (2000) 2.44

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. J Biol Chem (1990) 2.42

Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization. Annu Rev Biochem (1983) 2.40

Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. J Biol Chem (1996) 2.39

Beta-adrenergic receptors: biochemical mechanisms of physiological regulation. Physiol Rev (1984) 2.38

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. Circ Res (1999) 2.37

Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors. Nat Rev Neurosci (2001) 2.36

Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. J Biol Chem (1991) 2.35

Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. J Biol Chem (1995) 2.35

Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype. J Biol Chem (1990) 2.35

Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. J Biol Chem (1997) 2.34

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development (1992) 2.34

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. J Biol Chem (1993) 2.33

Diverse forms of a receptor for acidic and basic fibroblast growth factors. Mol Cell Biol (1990) 2.33

Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine. J Biol Chem (1984) 2.33

Desensitization of G protein-coupled receptors. Recent Prog Horm Res (1996) 2.32

Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci U S A (1993) 2.32