Published in J Exp Med on July 12, 2004
Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest (2006) 1.90
The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol (2012) 1.39
Crystal structure of the human TRPV2 channel ankyrin repeat domain. Protein Sci (2006) 1.32
A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1. Pain (2008) 1.31
TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J Neurosci (2011) 1.28
Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium. Am J Physiol Renal Physiol (2010) 1.27
Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes (2008) 1.08
Ca2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate. J Neurosci (2010) 1.07
The Role of TRP Proteins in Mast Cells. Front Immunol (2012) 1.02
Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea. J Invest Dermatol (2011) 1.02
TRP channels and analgesia. Life Sci (2012) 0.99
ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. Curr Neuropharmacol (2008) 0.93
Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics. Br J Pharmacol (2014) 0.91
What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? FEBS J (2013) 0.90
Structure-function analysis of TRPV channels. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.89
Functional Expression of TRPV4 Cation Channels in Human Mast Cell Line (HMC-1). Korean J Physiol Pharmacol (2010) 0.87
Bronchoconstriction induced by increasing airway temperature in ovalbumin-sensitized rats: role of tachykinins. J Appl Physiol (1985) (2013) 0.86
Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel. PLoS One (2012) 0.85
Trafficking of ThermoTRP Channels. Membranes (Basel) (2014) 0.83
Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance. Am J Physiol Heart Circ Physiol (2013) 0.83
TRP channel cannabinoid receptors in skin sensation, homeostasis, and inflammation. ACS Chem Neurosci (2014) 0.82
Research on effects of the thermal stimulation by moxibustion at different temperatures on cardiac function in rats and on mast cells in the local site of moxibustion. Evid Based Complement Alternat Med (2013) 0.81
Identification and functional characterization of ion channels in CD34(+) hematopoietic stem cells from human peripheral blood. Mol Cells (2011) 0.81
TRPV2 expression in rat oral mucosa. Histochem Cell Biol (2009) 0.81
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nat Commun (2015) 0.80
The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune responses. Front Immunol (2013) 0.80
Inhibition of TRPM7 channels reduces degranulation and release of cytokines in rat bone marrow-derived mast cells. Int J Mol Sci (2014) 0.79
Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3. Am J Physiol Cell Physiol (2010) 0.79
Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies. Pharmaceuticals (Basel) (2016) 0.78
Monitoring the Effects of Acupoint Antioxidant Intervention by Measuring Electrical Potential Difference along the Meridian. Evid Based Complement Alternat Med (2015) 0.76
Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells. PLoS One (2017) 0.75
Differential regulation of calcium signalling pathways by components of Piper methysticum ('Awa). Phytother Res (2015) 0.75
Involvement of thermosensitive TRP channels in energy metabolism. J Physiol Sci (2017) 0.75
The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 30.59
Molecular mechanisms of nociception. Nature (2001) 7.75
Analysis of molecular masses and oligomeric states of protein complexes by blue native electrophoresis and isolation of membrane protein complexes by two-dimensional native electrophoresis. Anal Biochem (1994) 7.30
Mast cells. Physiol Rev (1997) 6.51
A capsaicin-receptor homologue with a high threshold for noxious heat. Nature (1999) 5.85
LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature (2001) 5.52
Heat-evoked activation of the ion channel, TRPV4. J Neurosci (2002) 4.69
A heat-sensitive TRP channel expressed in keratinocytes. Science (2002) 3.85
TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature (2002) 3.55
TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature (2002) 3.23
AKAPs: from structure to function. Trends Cell Biol (1999) 3.15
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem (2002) 2.87
TREK-1 is a heat-activated background K(+) channel. EMBO J (2000) 2.82
TRP channel proteins and signal transduction. Physiol Rev (2002) 2.68
Analysis of the native quaternary structure of vanilloid receptor 1. J Biol Chem (2001) 2.55
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat Neurosci (2002) 2.43
Hypotonicity induces TRPV4-mediated nociception in rat. Neuron (2003) 2.43
Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat Cell Biol (1999) 2.25
Mast cells and basophils. Curr Opin Hematol (2000) 2.01
Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J (2003) 1.97
Monomeric and oligomeric complexes of the B cell antigen receptor. Immunity (2000) 1.77
Ion channels gated by heat. Proc Natl Acad Sci U S A (1999) 1.63
TRPV channels as temperature sensors. Cell Calcium (2003) 1.63
International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev (2003) 1.61
PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia. J Neurosci (2002) 1.60
Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. J Biol Chem (1997) 1.56
Peripheral and central mechanisms of NGF-induced hyperalgesia. Eur J Neurosci (1994) 1.54
The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase. J Neurochem (2001) 1.43
Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein. Mol Endocrinol (2001) 1.36
A novel mechanism of myocyte degeneration involving the Ca2+-permeable growth factor-regulated channel. J Cell Biol (2003) 1.34
The mast cell in wound healing. Vet Dermatol (2001) 1.25
Characterization of functional vanilloid receptors expressed by mast cells. Blood (1998) 1.21
Physical urticaria/angioedema: an experimental model of mast cell activation in humans. J Allergy Clin Immunol (1980) 1.19
The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC. J Cell Sci (2001) 1.15
Role and regulation of TRP channels in neutrophil granulocytes. Cell Calcium (2003) 1.14
Discrimination of intracellular calcium store subcompartments using TRPV1 (transient receptor potential channel, vanilloid subfamily member 1) release channel activity. Biochem J (2003) 1.12
In vivo release of inflammatory mediators by hyperosmolar solutions. Am Rev Respir Dis (1988) 1.08
A comparison of the osmotic activation of basophils and human lung mast cells. Am Rev Respir Dis (1987) 1.07
Subunit modification and association in VR1 ion channels. BMC Neurosci (2002) 1.06
Chronic idiopathic urticaria. Curr Opin Allergy Clin Immunol (2003) 1.05
Urticaria, angioedema, and mediator release in humans in response to physical environmental stimuli. Fed Proc (1977) 0.97
PAP7, a PBR/PKA-RIalpha-associated protein: a new element in the relay of the hormonal induction of steroidogenesis. J Steroid Biochem Mol Biol (2003) 0.92
From TRPs to SOCs, CCEs, and CRACs: consensus and controversies. Cell Calcium (2003) 0.87
Cold urticaria. J Investig Dermatol Symp Proc (2001) 0.86
Mast cells. Receptors, secretagogues, and signaling. Clin Rev Allergy Immunol (2002) 0.83
Pathomechanisms in physical urticaria. J Investig Dermatol Symp Proc (2001) 0.82
Localized heat urticaria. J Allergy Clin Immunol (1978) 0.80
The physical urticarias. Clin Exp Allergy (1991) 0.79
Mediator secretion from human skin mast cells provoked by immunological and non-immunological stimulation. Skin Pharmacol (1991) 0.79
Standard treatment: the role of antihistamines. J Investig Dermatol Symp Proc (2001) 0.79
Studies on histamine release from skin and from peritoneal mast cells of the rat induced by heat. Acta Derm Venereol (1970) 0.77
Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol (2006) 6.31
Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes. Diabetes (2008) 2.25
Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes. J Immunol (2009) 2.15
Differential roles of CB1 and CB2 cannabinoid receptors in mast cells. J Immunol (2003) 1.75
The RABIT: a rapid automated biodosimetry tool for radiological triage. Health Phys (2010) 1.69
Human HTm4 is a hematopoietic cell cycle regulator. J Clin Invest (2002) 1.15
Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Hum Genet (2005) 1.14
A randomized, double-blind comparison study of EMLA and ELA-Max for topical anesthesia in children undergoing intravenous insertion. Paediatr Anaesth (2004) 1.08
Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. J Allergy Clin Immunol (2002) 1.03
Including culturally diverse samples in health research: a case study of an urban trial of social support. Ethn Health (2003) 1.03
Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2. J Cell Biochem (2005) 1.03
TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. Cell Signal (2006) 1.01
Profiling of normal and malignant breast tissue show CD44high/CD24low phenotype as a predominant stem/progenitor marker when used in combination with Ep-CAM/CD49f markers. BMC Cancer (2013) 0.97
Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A. J Immunol (2008) 0.96
RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. J Cell Biochem (2004) 0.96
Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes? PLoS One (2012) 0.94
Transplant tourism outcome: a single center experience. Transplantation (2010) 0.94
Effluxing ABC transporters in human corneal epithelium. J Pharm Sci (2010) 0.93
Genetic diagnosis in consanguineous families with kidney disease by homozygosity mapping coupled with whole-exome sequencing. Am J Kidney Dis (2011) 0.91
Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues. J Cell Mol Med (2011) 0.90
Identification of granulocyte subtype-selective receptors and ion channels by using a high-density oligonucleotide probe array. J Allergy Clin Immunol (2004) 0.89
Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. J Biol Chem (2005) 0.89
Molecular profiling of conjunctival epithelial side-population stem cells: atypical cell surface markers and sources of a slow-cycling phenotype. Invest Ophthalmol Vis Sci (2009) 0.88
DUSP5 and DUSP6 modulate corneal epithelial cell proliferation. Mol Vis (2010) 0.88
Differential gene expression in the pig limbal side population: implications for stem cell cycling, replication, and survival. Invest Ophthalmol Vis Sci (2009) 0.86
Beyond apoptosis: the mechanism and function of phosphatidylserine asymmetry in the membrane of activating mast cells. Bioarchitecture (2014) 0.86
Assessment of acute and chronic pain symptoms in children with cystic fibrosis. Pediatr Pulmonol (2005) 0.84
Effects of chronic bhang (cannabis) administration on the reproductive system of male mice. Birth Defects Res B Dev Reprod Toxicol (2011) 0.84
Discovery of serum protein biomarkers for prostate cancer progression by proteomic analysis. Cancer Genomics Proteomics (2010) 0.84
Aryl hydrocarbon receptor ligand effects in RBL2H3 cells. J Immunotoxicol (2012) 0.83
Anti-inflammatory potential of CB1-mediated cAMP elevation in mast cells. Biochem J (2005) 0.82
Exposure to tobacco-derived materials induces overproduction of secreted proteinases in mast cells. Toxicol Appl Pharmacol (2005) 0.82
Evaluating parent support initiatives: lessons from two case studies. Health Soc Care Community (1998) 0.81
Fcepsilon RI control of Ras via inositol (1,4,5) trisphosphate 3-kinase and inositol tetrakisphosphate. Cell Signal (2005) 0.81
MRSA screening on a paediatric intensive care unit. Arch Dis Child (2010) 0.81
Cell cycle disruption and apoptotic activity of 3-aminothiazolo[3,2-a]benzimidazole-2-carbonitrile and its homologues. Eur J Med Chem (2010) 0.81
Insulin-containing lipogenic stimuli suppress mast cell degranulation potential and up-regulate lipid body biogenesis and eicosanoid secretion in a PPARγ-independent manner. J Leukoc Biol (2012) 0.80
Immunoactive effects of cannabinoids: considerations for the therapeutic use of cannabinoid receptor agonists and antagonists. Int Immunopharmacol (2010) 0.80
The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice. J Mol Histol (2005) 0.79
Pacific island 'Awa (Kava) extracts, but not isolated kavalactones, promote proinflammatory responses in model mast cells. Phytother Res (2012) 0.79
Demographic and clinical characteristics of adolescents in Hawaii with obsessive-compulsive disorder. Arch Pediatr Adolesc Med (2003) 0.78
A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours. Cancer Chemother Pharmacol (2013) 0.77
Correction: High Throughput Measurement of γH2AX DSB Repair Kinetics in a Healthy Human Population. PLoS One (2015) 0.76
A novel Phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer. Stat Med (2012) 0.76
Comparative analysis of lipotoxicity induced by endocrine, pharmacological, and innate immune stimuli in rat basophilic leukemia cells. J Immunotoxicol (2014) 0.76
A survey of dopamine agonist withdrawal policy in UK endocrinologists treating patients with prolactinomas. Clinical Endocrinology 58, 111. Clin Endocrinol (Oxf) (2003) 0.75
Dioxins: diagnostic and prognostic challenges arising from complex mechanisms. J Appl Toxicol (2012) 0.75
Pediatric patient-controlled analgesia by proxy. AACN Adv Crit Care (2007) 0.75