Published in Anal Biochem on August 15, 2004
Mass spectrometry-based metabolomics. Mass Spectrom Rev (2006) 5.23
The Cinderella story of metabolic profiling: does metabolomics get to go to the functional genomics ball? Philos Trans R Soc Lond B Biol Sci (2006) 1.63
TargetSearch--a Bioconductor package for the efficient preprocessing of GC-MS metabolite profiling data. BMC Bioinformatics (2009) 1.40
Soluble carbohydrates regulate auxin biosynthesis via PIF proteins in Arabidopsis. Plant Cell (2012) 1.39
Extending the breadth of metabolite profiling by gas chromatography coupled to mass spectrometry. Trends Analyt Chem (2008) 1.31
Metabolic networks: how to identify key components in the regulation of metabolism and growth. Plant Physiol (2009) 1.27
Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana. BMC Syst Biol (2007) 1.25
High quality metabolomic data for Chlamydomonas reinhardtii. Plant Methods (2008) 1.23
The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue. Genome Biol (2011) 1.22
Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives. Metabolomics (2010) 1.21
An integrated functional genomic study of acute phenobarbital exposure in the rat. BMC Genomics (2010) 1.19
Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse. Mol Syst Biol (2009) 1.18
Relative quantification of carboxylic acid metabolites by liquid chromatography-mass spectrometry using isotopic variants of cholamine. Anal Chem (2007) 1.18
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet (2010) 1.13
Arabidopsis roots and shoots show distinct temporal adaptation patterns toward nitrogen starvation. Plant Physiol (2011) 1.13
Metabolic phenotyping of a model of adipocyte differentiation. Physiol Genomics (2009) 1.10
Improper excess light energy dissipation in Arabidopsis results in a metabolic reprogramming. BMC Plant Biol (2009) 1.03
Alkylation or Silylation for Analysis of Amino and Non-Amino Organic Acids by GC-MS? Metabolites (2011) 1.01
Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse. Genome Med (2009) 0.94
Statistical methods for handling unwanted variation in metabolomics data. Anal Chem (2015) 0.94
Collection and chemical composition of phloem sap from Citrus sinensis L. Osbeck (sweet orange). PLoS One (2014) 0.94
Evaluation of normalization methods to pave the way towards large-scale LC-MS-based metabolomics profiling experiments. OMICS (2013) 0.91
UHPLC-ESI/TOFMS determination of salicylate-like phenolic gycosides in Populus tremula leaves. J Chem Ecol (2011) 0.91
A metabolomic approach to study major metabolite changes during acclimation to limiting CO2 in Chlamydomonas reinhardtii. Plant Physiol (2010) 0.89
Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line. PLoS One (2015) 0.88
Root metabolic response of rice (Oryza sativa L.) genotypes with contrasting tolerance to zinc deficiency and bicarbonate excess. Planta (2012) 0.87
Development of a model system to identify differences in spring and winter oat. PLoS One (2012) 0.83
Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circ Res (2016) 0.82
Chemometric profile of root extracts of Rhodiola imbricata Edgew. with hyphenated gas chromatography mass spectrometric technique. PLoS One (2013) 0.82
Design-of-experiment optimization of exhaled breath condensate analysis using a miniature differential mobility spectrometer (DMS). Anal Chim Acta (2008) 0.81
Forestry alters foraging efficiency and crop contents of aphid-tending red wood ants, Formica aquilonia. PLoS One (2012) 0.81
Mass spectrometry-based metabolomics, analysis of metabolite-protein interactions, and imaging. Biotechniques (2010) 0.81
Rationales and approaches for studying metabolism in eukaryotic microalgae. Metabolites (2014) 0.80
Metabolomic analysis of akt1-mediated muscle hypertrophy in models of diet-induced obesity and age-related fat accumulation. J Proteome Res (2014) 0.80
A metabolomics based test of independent action and concentration addition using the earthworm Lumbricus rubellus. Ecotoxicology (2012) 0.79
Chemical composition and biological activities of trans-Himalayan alga Spirogyra porticalis (Muell.) Cleve. PLoS One (2015) 0.79
Pair-wise multicomparison and OPLS analyses of cold-acclimation phases in Siberian spruce. Metabolomics (2011) 0.79
Proposal for field sampling of plants and processing in the lab for environmental metabolic fingerprinting. Plant Methods (2010) 0.79
Metabolomic evaluation of pulsed electric field-induced stress on potato tissue. Planta (2009) 0.78
Metabolomics reveals differences of metal toxicity in cultures of Pseudomonas pseudoalcaligenes KF707 grown on different carbon sources. Front Microbiol (2015) 0.78
Metabolomics of aerobic metabolism in mice selected for increased maximal metabolic rate. Comp Biochem Physiol Part D Genomics Proteomics (2011) 0.78
Metabolomics Suggests That Soil Inoculation with Arbuscular Mycorrhizal Fungi Decreased Free Amino Acid Content in Roots of Durum Wheat Grown under N-Limited, P-Rich Field Conditions. PLoS One (2015) 0.77
Metabolomic and Lipidomic Analysis of the Heart of Peroxisome Proliferator-Activated Receptor-γ Coactivator 1-β Knock Out Mice on a High Fat Diet. Metabolites (2012) 0.77
Mass spectrometry as a quantitative tool in plant metabolomics. Philos Trans A Math Phys Eng Sci (2016) 0.77
Metabolite Signature during Short-Day Induced Growth Cessation in Populus. Front Plant Sci (2011) 0.77
Reduced mitochondrial malate dehydrogenase activity has a strong effect on photorespiratory metabolism as revealed by 13C labelling. J Exp Bot (2016) 0.76
A modified data normalization method for GC-MS-based metabolomics to minimize batch variation. Springerplus (2014) 0.76
Interactions among Glomus irregulare, arbuscular mycorrhizal spore-associated bacteria, and plant pathogens under in vitro conditions. Mycorrhiza (2011) 0.76
Increased sucrose levels mediate selective mRNA translation in Arabidopsis. BMC Plant Biol (2014) 0.76
Cell-type specific metabolic profiling of Arabidopsis thaliana protoplasts as a tool for plant systems biology. Metabolomics (2015) 0.76
Dissecting the Metabolic Role of Mitochondria during Developmental Leaf Senescence. Plant Physiol (2016) 0.76
Zuogui Wan rescues the high-glucose-induced damaging effects on early embryo development. BMC Complement Altern Med (2016) 0.75
Integrated analysis of gene expression from carbon metabolism, proteome and metabolome, reveals altered primary metabolism in Eucalyptus grandis bark, in response to seasonal variation. BMC Plant Biol (2016) 0.75
Seasonal Variation of Carbon Metabolism in the Cambial Zone of Eucalyptus grandis. Front Plant Sci (2016) 0.75
Expanding the biomass resource: sustainable oil production via fast pyrolysis of low input high diversity biomass and the potential integration of thermochemical and biological conversion routes. Appl Energy (2016) 0.75
Transcriptome response signatures associated with the overexpression of a mitochondrial uncoupling protein (AtUCP1) in tobacco. PLoS One (2015) 0.75
Metabolites in Blood for Prediction of Bacteremic Sepsis in the Emergency Room. PLoS One (2016) 0.75
Unbiased profiling of volatile organic compounds in the headspace of Allium plants using an in-tube extraction device. BMC Res Notes (2016) 0.75
Functional metabolomics as a tool to analyze Mediator function and structure in plants. PLoS One (2017) 0.75
Metabolome Dynamics of Smutted Sugarcane Reveals Mechanisms Involved in Disease Progression and Whip Emission. Front Plant Sci (2017) 0.75
From chromatogram to analyte to metabolite. How to pick horses for courses from the massive web-resources for mass spectral plant metabolomics. Gigascience (2017) 0.75
Nitrogen uptake and assimilation in proliferating embryogenic cultures of Norway spruce-Investigating the specific role of glutamine. PLoS One (2017) 0.75
International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc (2003) 47.83
Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med (2008) 25.70
Sex-specific, male-line transgenerational responses in humans. Eur J Hum Genet (2006) 5.72
Integration of plant responses to environmentally activated phytohormonal signals. Science (2006) 5.46
The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity. Public Health Nutr (2006) 5.17
Physical activity and inactivity in an adult population assessed by accelerometry. Med Sci Sports Exerc (2007) 5.15
Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal Chem (2007) 4.04
The lack of a systematic validation of reference genes: a serious pitfall undervalued in reverse transcription-polymerase chain reaction (RT-PCR) analysis in plants. Plant Biotechnol J (2008) 3.81
Neighborhood environments and physical activity among adults in 11 countries. Am J Prev Med (2009) 3.65
Association between muscular strength and mortality in men: prospective cohort study. BMJ (2008) 3.33
GC-MS libraries for the rapid identification of metabolites in complex biological samples. FEBS Lett (2005) 3.29
Radial artery grafts vs saphenous vein grafts in coronary artery bypass surgery: a randomized trial. JAMA (2011) 3.03
Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: results from a Department of Veterans Affairs Cooperative Study. J Am Coll Cardiol (2004) 2.99
An auxin gradient and maximum in the Arabidopsis root apex shown by high-resolution cell-specific analysis of IAA distribution and synthesis. Plant Cell (2009) 2.97
Percutaneous coronary intervention versus coronary bypass surgery in United States veterans with diabetes. J Am Coll Cardiol (2013) 2.79
The descriptive epidemiology of sitting. A 20-country comparison using the International Physical Activity Questionnaire (IPAQ). Am J Prev Med (2011) 2.51
High-throughput data analysis for detecting and identifying differences between samples in GC/MS-based metabolomic analyses. Anal Chem (2005) 2.38
Levels and patterns of objectively assessed physical activity--a comparison between Sweden and the United States. Am J Epidemiol (2010) 2.35
Transgenerational response to nutrition, early life circumstances and longevity. Eur J Hum Genet (2007) 2.27
Extraction and GC/MS analysis of the human blood plasma metabolome. Anal Chem (2005) 2.13
Clathrate nanostructures for mass spectrometry. Nature (2007) 2.10
Sterol-dependent endocytosis mediates post-cytokinetic acquisition of PIN2 auxin efflux carrier polarity. Nat Cell Biol (2008) 2.09
From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics. J Proteome Res (2007) 2.08
Physical activity but not energy expenditure is reduced in obese adolescents: a case-control study. Am J Clin Nutr (2002) 1.81
A strategy for identifying differences in large series of metabolomic samples analyzed by GC/MS. Anal Chem (2004) 1.80
GA4 is the active gibberellin in the regulation of LEAFY transcription and Arabidopsis floral initiation. Plant Cell (2006) 1.77
The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes. Proc Natl Acad Sci U S A (2007) 1.74
Recommended levels of physical activity to avoid an excess of body fat in European adolescents: the HELENA Study. Am J Prev Med (2010) 1.72
Relations of total physical activity and intensity to fitness and fatness in children: the European Youth Heart Study. Am J Clin Nutr (2006) 1.67
Are muscular and cardiovascular fitness partially programmed at birth? Role of body composition. J Pediatr (2008) 1.65
Data integration in plant biology: the O2PLS method for combined modeling of transcript and metabolite data. Plant J (2007) 1.58
[Physically active adolescents are more likely to have a healthier cardiovascular fitness level independently of their adiposity status. The European youth heart study]. Rev Esp Cardiol (2008) 1.56
Relationship of physical activity, fitness, and fatness with clustered metabolic risk in children and adolescents: the European youth heart study. J Pediatr (2007) 1.56
Assessment of environmental correlates of physical activity: development of a European questionnaire. Int J Behav Nutr Phys Act (2009) 1.53
Objectively measured physical activity and sedentary time in European adolescents: the HELENA study. Am J Epidemiol (2011) 1.53
AtGA3ox2, a key gene responsible for bioactive gibberellin biosynthesis, is regulated during embryogenesis by LEAFY COTYLEDON2 and FUSCA3 in Arabidopsis. Plant Physiol (2004) 1.52
Serum free light chain analysis and urine immunofixation electrophoresis in patients with multiple myeloma. Clin Cancer Res (2005) 1.49
Participation in organized weekly physical exercise in obese adolescents reduced daily physical activity. Acta Paediatr (2008) 1.49
Measuring physical activity-related environmental factors: reliability and predictive validity of the European environmental questionnaire ALPHA. Int J Behav Nutr Phys Act (2010) 1.46
Docetaxel and gemcitabine in the treatment of soft tissue sarcoma - a single-center experience. Onkologie (2008) 1.45
Environmental and hormonal regulation of the activity-dormancy cycle in the cambial meristem involves stage-specific modulation of transcriptional and metabolic networks. Plant J (2007) 1.41
Objectively measured physical activity and sedentary time during childhood, adolescence and young adulthood: a cohort study. PLoS One (2013) 1.40
Molecular characterization of type III secretion signals via analysis of synthetic N-terminal amino acid sequences. Mol Microbiol (2002) 1.40
The human visceral fat depot has a unique inflammatory profile. Obesity (Silver Spring) (2010) 1.39
Arabidopsis REGULATOR OF AXILLARY MERISTEMS1 controls a leaf axil stem cell niche and modulates vegetative development. Plant Cell (2006) 1.37
Independent activation of cold acclimation by low temperature and short photoperiod in hybrid aspen. Plant Physiol (2002) 1.37
Attenuation of the effect of the FTO rs9939609 polymorphism on total and central body fat by physical activity in adolescents: the HELENA study. Arch Pediatr Adolesc Med (2010) 1.35
Adherence to physical activity recommendations and the influence of socio-demographic correlates - a population-based cross-sectional study. BMC Public Health (2008) 1.32
Body movement and physical activity energy expenditure in children and adolescents: how to adjust for differences in body size and age. Am J Clin Nutr (2004) 1.32
Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol. PLoS One (2010) 1.28
Cross-talk between gibberellin and auxin in development of Populus wood: gibberellin stimulates polar auxin transport and has a common transcriptome with auxin. Plant J (2007) 1.28
Inflammatory proteins are related to total and abdominal adiposity in a healthy adolescent population: the AVENA Study. Am J Clin Nutr (2006) 1.25
Veterans Affairs diabetes trial--corrections. N Engl J Med (2009) 1.25
Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana. BMC Syst Biol (2007) 1.25
Compensation for systematic cross-contribution improves normalization of mass spectrometry based metabolomics data. Anal Chem (2009) 1.25
Field-based fitness assessment in young people: the ALPHA health-related fitness test battery for children and adolescents. Br J Sports Med (2010) 1.24
Application of a metabolomic method combining one-dimensional and two-dimensional gas chromatography-time-of-flight/mass spectrometry to metabolic phenotyping of natural variants in rice. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 1.23
Predictive metabolite profiling applying hierarchical multivariate curve resolution to GC-MS data--a potential tool for multi-parametric diagnosis. J Proteome Res (2006) 1.21
High cardiovascular fitness is associated with low metabolic risk score in children: the European Youth Heart Study. Pediatr Res (2007) 1.20
Progress and pitfalls in the use of the International Physical Activity Questionnaire (IPAQ) for adult physical activity surveillance. J Phys Act Health (2009) 1.19
The roles of ethylene, auxin, abscisic acid, and gibberellin in the hyponastic growth of submerged Rumex palustris petioles. Plant Physiol (2004) 1.19
Physical activity, overweight and central adiposity in Swedish children and adolescents: the European Youth Heart Study. Int J Behav Nutr Phys Act (2007) 1.18
Sedentary patterns and media availability in European adolescents: The HELENA study. Prev Med (2010) 1.18
A multivariate screening strategy for investigating metabolic effects of strenuous physical exercise in human serum. J Proteome Res (2007) 1.18
Validity of self-reported total physical activity questionnaire among older women. Eur J Epidemiol (2008) 1.16
Transitions in the functioning of the shoot apical meristem in birch (Betula pendula) involve ethylene. Plant J (2006) 1.13
Hand span influences optimal grip span in male and female teenagers. J Hand Surg Am (2006) 1.13
Tissue-specific localization of gibberellins and expression of gibberellin-biosynthetic and signaling genes in wood-forming tissues in aspen. Plant J (2005) 1.13
Perceived neighborhood environment and physical activity in 11 countries: do associations differ by country? Int J Behav Nutr Phys Act (2013) 1.13
The sucrose-regulated Arabidopsis transcription factor bZIP11 reprograms metabolism and regulates trehalose metabolism. New Phytol (2011) 1.12
Cardiorespiratory fitness relates more strongly than physical activity to cardiovascular disease risk factors in healthy children and adolescents: the European Youth Heart Study. Eur J Cardiovasc Prev Rehabil (2007) 1.11
Decreased mitochondrial activities of malate dehydrogenase and fumarase in tomato lead to altered root growth and architecture via diverse mechanisms. Plant Physiol (2008) 1.10
The repeatability and validity of questionnaires assessing occupational physical activity--a systematic review. Scand J Work Environ Health (2010) 1.10
Diagnostic properties of metabolic perturbations in rheumatoid arthritis. Arthritis Res Ther (2011) 1.09
A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny. Stem Cells (2013) 1.09
Asymmetric expression of a poplar ACC oxidase controls ethylene production during gravitational induction of tension wood. Plant J (2003) 1.09
Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets. Analyst (2005) 1.09
Orthogonal projections to latent structures as a strategy for microarray data normalization. BMC Bioinformatics (2007) 1.09
Derivatization for LC-electrospray ionization-MS: a tool for improving reversed-phase separation and ESI responses of bases, ribosides, and intact nucleotides. Anal Chem (2004) 1.09
Food and drink intake during television viewing in adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study. Public Health Nutr (2011) 1.09
Gibberellin mediates daylength-controlled differentiation of vegetative meristems in strawberry (Fragaria x ananassa Duch). BMC Plant Biol (2009) 1.09
Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients. Clin Immunol (2007) 1.08
Associations between physical activity, fitness, and academic achievement. J Pediatr (2009) 1.08
Reliability and intermethod agreement for body fat assessment among two field and two laboratory methods in adolescents. Obesity (Silver Spring) (2011) 1.07
Regulation of flowering in the long-day grass Lolium temulentum by gibberellins and the FLOWERING LOCUS T gene. Plant Physiol (2006) 1.07
Immune parameters in multiple myeloma patients: influence of treatment and correlation with opportunistic infections. Leuk Lymphoma (2006) 1.06
Assessing muscular strength in youth: usefulness of standing long jump as a general index of muscular fitness. J Strength Cond Res (2010) 1.06
Predictive metabolomics evaluation of nutrition-modulated metabolic stress responses in human blood serum during the early recovery phase of strenuous physical exercise. J Proteome Res (2009) 1.05
Nutritional knowledge in European adolescents: results from the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study. Public Health Nutr (2011) 1.05
Patterns of neighborhood environment attributes related to physical activity across 11 countries: a latent class analysis. Int J Behav Nutr Phys Act (2013) 1.04