Published in Am J Respir Crit Care Med on July 28, 2004
Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev (2009) 5.64
Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med (2011) 3.28
Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir Res (2006) 2.40
Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol (2008) 2.18
Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 2.01
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema. Am J Respir Crit Care Med (2006) 1.72
Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med (2010) 1.67
Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells. AAPS J (2006) 1.52
Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet (2015) 1.52
Progress in chronic obstructive pulmonary disease genetics. Proc Am Thorac Soc (2006) 1.51
Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice. Respir Res (2008) 1.46
Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking. Am J Respir Crit Care Med (2010) 1.42
Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression. Am J Physiol Lung Cell Mol Physiol (2009) 1.40
Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am J Respir Crit Care Med (2009) 1.31
Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice. Am J Physiol Heart Circ Physiol (2010) 1.29
Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation. Respir Res (2010) 1.27
Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells. Am J Respir Cell Mol Biol (2008) 1.25
Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. J Clin Invest (2006) 1.22
Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice. J Clin Invest (2011) 1.17
Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown. Am J Physiol Lung Cell Mol Physiol (2010) 1.15
Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells. Am J Respir Cell Mol Biol (2006) 1.11
Recent advances in pre-clinical mouse models of COPD. Clin Sci (Lond) (2014) 1.10
Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling. Am J Physiol Lung Cell Mol Physiol (2009) 1.09
Long-term nose-only cigarette smoke exposure induces emphysema and mild skeletal muscle dysfunction in mice. Dis Model Mech (2012) 1.08
Autoimmunity in chronic obstructive pulmonary disease: clinical and experimental evidence. Expert Rev Clin Immunol (2012) 1.07
A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice. Am J Physiol Lung Cell Mol Physiol (2011) 1.06
CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. Am J Pathol (2008) 1.06
Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. FASEB J (2013) 1.02
Leptin receptor polymorphisms and lung function decline in COPD. Eur Respir J (2009) 1.00
FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. J Immunol (2011) 0.98
The role of toll-like receptors in acute and chronic lung inflammation. J Inflamm (Lond) (2010) 0.97
Autoreactive T Cells in Human Smokers is Predictive of Clinical Outcome. Front Immunol (2012) 0.96
The genetics of chronic obstructive pulmonary disease. Respir Res (2006) 0.95
An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 0.95
Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice. Respir Res (2012) 0.94
Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice. Am J Physiol Lung Cell Mol Physiol (2008) 0.93
Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med (2015) 0.92
Tobacco smoke induced COPD/emphysema in the animal model-are we all on the same page? Front Physiol (2013) 0.89
Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice. Respir Res (2007) 0.89
Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2011) 0.87
A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin. Am J Respir Crit Care Med (2016) 0.87
Smoke and mirrors: Mouse models as a reflection of human chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2004) 0.87
Alveolar fractal box dimension inversely correlates with mean linear intercept in mice with elastase-induced emphysema. Int J Chron Obstruct Pulmon Dis (2012) 0.86
Copy number variation in the mouse genome: implications for the mouse as a model organism for human disease. Cytogenet Genome Res (2009) 0.85
Blunted ventilatory response to hypoxia/hypercapnia in mice with cigarette smoke-induced emphysema. Respir Physiol Neurobiol (2007) 0.84
Respiratory mechanics do not always mirror pulmonary histological changes in emphysema. Clinics (Sao Paulo) (2011) 0.84
Sustained adenosine exposure causes lung endothelial apoptosis: a possible contributor to cigarette smoke-induced endothelial apoptosis and lung injury. Am J Physiol Lung Cell Mol Physiol (2013) 0.84
Second hand smoke and COPD: lessons from animal studies. Front Physiol (2013) 0.83
p38 mitogen-activated protein kinase determines the susceptibility to cigarette smoke-induced emphysema in mice. BMC Pulm Med (2014) 0.83
Sub-chronic exposure to second hand smoke induces airspace leukocyte infiltration and decreased lung elastance. Front Physiol (2012) 0.82
A murine model of elastase- and cigarette smoke-induced emphysema. J Bras Pneumol (2017) 0.82
Novosphingobium and its potential role in chronic obstructive pulmonary diseases: insights from microbiome studies. PLoS One (2014) 0.82
Lung inflammatory effects, tumorigenesis, and emphysema development in a long-term inhalation study with cigarette mainstream smoke in mice. Toxicol Sci (2012) 0.81
Automated measurement of pulmonary emphysema and small airway remodeling in cigarette smoke-exposed mice. J Vis Exp (2015) 0.81
Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2α. Microvasc Res (2014) 0.80
Transcriptomic Analysis of Lung Tissue from Cigarette Smoke Induced Emphysema Murine Models and Human COPD Show Shared and Distinct Pathways. Am J Respir Cell Mol Biol (2017) 0.80
A new experimental model of cigarette smoke-induced emphysema in Wistar rats. J Bras Pneumol (2014) 0.80
Variable Susceptibility to Cigarette Smoke-Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility. Am J Respir Cell Mol Biol (2017) 0.80
Angiotensin-converting enzyme I/D polymorphism in chronic obstructive pulmonary disease. Eur J Med Res (2009) 0.79
Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains. Inflamm Res (2015) 0.79
Monitoring in vivo changes in lung microstructure with ³He MRI in Sendai virus-infected mice. J Appl Physiol (1985) (2012) 0.79
Correlation of Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema in C3H and C57Bl/6 Mice. Toxicol Sci (2015) 0.79
Mmp1a and Mmp1b are not functional orthologs to human MMP1 in cigarette smoke induced lung disease. Exp Toxicol Pathol (2014) 0.78
Airway epithelial cell PPARγ modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice. Am J Physiol Lung Cell Mol Physiol (2015) 0.78
The lung inflammation and skeletal muscle wasting induced by subchronic cigarette smoke exposure are not altered by a high-fat diet in mice. PLoS One (2013) 0.78
Role of recently migrated monocytes in cigarette smoke-induced lung inflammation in different strain of mice. PLoS One (2013) 0.78
Thioredoxin-1 protects against neutrophilic inflammation and emphysema progression in a mouse model of chronic obstructive pulmonary disease exacerbation. PLoS One (2013) 0.77
Experimental progressive emphysema in BALB/cJ mice as a model for chronic alveolar destruction in humans. Am J Physiol Lung Cell Mol Physiol (2015) 0.76
Comparison of biological responses in rats under various cigarette smoke exposure conditions. J Toxicol Pathol (2013) 0.76
Sex-Related Differences in Pulmonary Function following 6 Months of Cigarette Exposure: Implications for Sexual Dimorphism in Mild COPD. PLoS One (2016) 0.76
Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions. Proteomes (2016) 0.75
Double-Hit Mouse Model of Cigarette Smoke Priming for Acute Lung Injury. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Increased circulating β2-adrenergic receptor autoantibodies are associated with smoking-related emphysema. Sci Rep (2017) 0.75
Alpha-1 Antitrypsin Investigations Using Animal Models of Emphysema. Ann Am Thorac Soc (2016) 0.75
Proteomic differences with and without ozone-exposure in a smoking-induced emphysema lung model. Korean J Intern Med (2014) 0.75
Cigarette Smoke and DNA Cleavage Promote Lung Inflammation and Emphysema. Trans Am Clin Climatol Assoc (2017) 0.75
Vulnerability and Genetic Susceptibility to Cigarette Smoke-Induced Emphysema in Mice. Am J Respir Cell Mol Biol (2017) 0.75
A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet (2008) 3.25
Lung cancer in patients with chronic obstructive pulmonary disease-- incidence and predicting factors. Am J Respir Crit Care Med (2011) 2.93
Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2005) 2.62
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat Cell Biol (2006) 2.57
Long-term outcomes of acute irritant-induced asthma. Am J Respir Crit Care Med (2009) 2.28
Role of TNFalpha in pulmonary pathophysiology. Respir Res (2006) 2.27
Impact of exacerbations on emphysema progression in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2011) 2.03
Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature (2007) 1.87
Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes. Nicotine Tob Res (2009) 1.84
Airway inflammation after cessation of exposure to agents causing occupational asthma. Am J Respir Crit Care Med (2003) 1.79
Risk and severity of COPD is associated with the group-specific component of serum globulin 1F allele. Chest (2004) 1.77
NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells. Am J Physiol Cell Physiol (2003) 1.73
Implication of receptor for advanced glycation end product (RAGE) in pulmonary health and pathophysiology. Respir Physiol Neurobiol (2008) 1.68
Reference values of pulmonary function tests for Canadian Caucasians. Can Respir J (2004) 1.58
CT scan findings of emphysema predict mortality in COPD. Chest (2010) 1.57
An NAD(P)H oxidase regulates growth and transcription in melanoma cells. Am J Physiol Cell Physiol (2002) 1.55
Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction. J Allergy Clin Immunol (2009) 1.52
Immune activation in α1-antitrypsin-deficiency emphysema. Beyond the protease-antiprotease paradigm. Am J Respir Crit Care Med (2015) 1.52
Long-term outcomes in a prospective cohort of apprentices exposed to high-molecular-weight agents. Am J Respir Crit Care Med (2008) 1.51
Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2007) 1.49
Incidence of occupational rhinoconjunctivitis and risk factors in animal-health apprentices. J Allergy Clin Immunol (2003) 1.40
Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice. Immunity (2005) 1.39
Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium. Free Radic Biol Med (2011) 1.39
Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells. Dev Biol (2008) 1.36
Neutrophil-derived S100A12 in acute lung injury and respiratory distress syndrome. Crit Care Med (2007) 1.34
Relationship between pulmonary emphysema and osteoporosis assessed by CT in patients with COPD. Chest (2008) 1.28
Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res (2013) 1.25
Abnormal swallowing reflex and COPD exacerbations. Chest (2009) 1.22
Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands. Am J Physiol Cell Physiol (2010) 1.21
Receptors for advanced glycation end-products targeting protect against hyperoxia-induced lung injury in mice. Am J Respir Cell Mol Biol (2009) 1.16
Childhood predictors of smoking in adolescence: a follow-up study of Montreal schoolchildren. CMAJ (2005) 1.16
Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells. Am J Respir Cell Mol Biol (2006) 1.11
Alpha1-antitrypsin determines the pattern of emphysema and function in tobacco smoke-exposed mice: parallels with human disease. Am J Respir Crit Care Med (2002) 1.10
Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PLoS One (2012) 1.10
RAGE: developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol (2008) 1.07
Characterization of T lymphocytes in chronic obstructive pulmonary disease. PLoS Med (2004) 1.05
NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2002) 1.05
Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle. Biochim Biophys Acta (2012) 1.04
Inhibition of mammalian target of rapamycin augments lipopolysaccharide-induced lung injury and apoptosis. J Immunol (2012) 1.04
Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice. J Pharmacol Exp Ther (2008) 1.04
Future research directions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2002) 1.04
Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography. Respirology (2008) 1.04
The role of reactive oxygen species in TNFalpha-dependent expression of the receptor for advanced glycation end products in human umbilical vein endothelial cells. Biochim Biophys Acta (2005) 1.02
Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin. J Biol Chem (2005) 1.02
Emphysema distribution and annual changes in pulmonary function in male patients with chronic obstructive pulmonary disease. Respir Res (2012) 1.01
Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. PLoS One (2012) 0.98
High concentration of antioxidants N-acetylcysteine and mitoquinone-Q induces intercellular adhesion molecule 1 and oxidative stress by increasing intracellular glutathione. J Immunol (2007) 0.98
Thioredoxin 1 delivery as new therapeutics. Adv Drug Deliv Rev (2009) 0.97
Direct costs of occupational asthma in Quebec between 1988 and 2002. Can Respir J (2008) 0.95
Phosphatidylinositol 3-kinase-dependent suppression of the human inducible nitric-oxide synthase promoter is mediated by FKHRL1. J Biol Chem (2006) 0.95
Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development. J Biol Chem (2005) 0.94
Receptor for advanced glycation end-products signals through Ras during tobacco smoke-induced pulmonary inflammation. Am J Respir Cell Mol Biol (2010) 0.94
Expression of the atypical chemokine receptor D6 in human alveolar macrophages in COPD. Chest (2013) 0.93
Sarcoidosis with bilateral epididymal and testicular lesions. Intern Med (2003) 0.93
The NOX on pulmonary hypertension. Circ Res (2007) 0.92
Time course of onset of sensitization to common and occupational inhalants in apprentices. J Allergy Clin Immunol (2003) 0.91
Mast cell infiltration discriminates between histopathological phenotypes of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 0.91
Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment. Int Immunol (2005) 0.89
Impact of COPD exacerbations on osteoporosis assessed by chest CT scan. COPD (2012) 0.86
The association between serum ferritin and uric acid in humans. Free Radic Res (2005) 0.86
Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism. Curr Drug Metab (2006) 0.85
Does clinical trial subject selection restrict the ability to generalize use and cost of health services to "real life" subjects? Int J Technol Assess Health Care (2003) 0.85
Longitudinal study of spatially heterogeneous emphysema progression in current smokers with chronic obstructive pulmonary disease. PLoS One (2012) 0.84
Differential effect of estrogen receptor alpha and beta agonists on the receptor for advanced glycation end product expression in human microvascular endothelial cells. Biochim Biophys Acta (2005) 0.84
Cell-surface thioredoxin-1: possible involvement in thiol-mediated leukocyte-endothelial cell interaction through lipid rafts. Antioxid Redox Signal (2007) 0.84
Relationship between peripheral airway function and patient-reported outcomes in COPD: a cross-sectional study. BMC Pulm Med (2010) 0.84
Suppression of choroidal neovascularization by thioredoxin-1 via interaction with complement factor H. Invest Ophthalmol Vis Sci (2008) 0.84
Pathophysiology of the small airways. Semin Respir Crit Care Med (2003) 0.84
Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking. Antioxid Redox Signal (2006) 0.83
Sites of allergic airway smooth muscle remodeling and hyperresponsiveness are not associated in the rat. J Appl Physiol (1985) (2010) 0.83
Quality-of-life, psychological, and cost outcomes 2 years after diagnosis of occupational asthma. J Occup Environ Med (2011) 0.83
Recombinant human thioredoxin suppresses lipopolysaccharide-induced bronchoalveolar neutrophil infiltration in rat. Life Sci (2006) 0.83
Thioredoxin-binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice. Antioxid Redox Signal (2009) 0.83
Recovery of methacholine responsiveness after end of exposure in occupational asthma. Am J Respir Crit Care Med (2004) 0.82
Smoking, COPD, and 3-nitrotyrosine levels of plasma proteins. Environ Health Perspect (2011) 0.82
Characterization of proteins binding to E-box/Ku86 sites and function of Ku86 in transcriptional regulation of the human xanthine oxidoreductase gene. J Biol Chem (2004) 0.82
Identification of proteins binding to E-Box/Ku86 sites and function of the tumor suppressor SAFB1 in transcriptional regulation of the human xanthine oxidoreductase gene. J Biol Chem (2008) 0.82
CPG15, a new factor upregulated after ischemic brain injury, contributes to neuronal network re-establishment after glutamate-induced injury. J Neurotrauma (2007) 0.82
Orthopnea and tidal expiratory flow limitation in chronic heart failure. Chest (2006) 0.81
A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population. Respirology (2012) 0.81
Computed tomography assessment of pharmacological lung volume reduction induced by bronchodilators in COPD. COPD (2012) 0.80
Matrix metalloproteinase-9 increases in the sputum from allergic occupational asthma patients after specific inhalation challenge. Int Arch Allergy Immunol (2012) 0.80
Short dental implants in reduced alveolar bone height. Quintessence Int (2010) 0.80
Reproducibility of nasal lavage in the context of the inhalation challenge investigation of occupational rhinitis. Am J Rhinol (2008) 0.80
Iron regulates xanthine oxidase activity in the lung. Am J Physiol Lung Cell Mol Physiol (2002) 0.79
Human leukocyte elastase gene expression is regulated by PU.1 in conjunction with closely associated cytidine-rich and Myb binding sites. Biochim Biophys Acta (2004) 0.79
Retracted Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase. Am J Physiol Lung Cell Mol Physiol (2007) 0.79
Cough-reflex sensitivity to inhaled capsaicin in COPD associated with increased exacerbation frequency. Respirology (2009) 0.79
Identification of clinically significant psychological distress and psychiatric morbidity by examining quality of life in subjects with occupational asthma. Health Qual Life Outcomes (2011) 0.78
Development of an automated SNP analysis method using a paramagnetic beads handling robot. Biotechnol Bioeng (2007) 0.78
Looking at the acinus with function tests: can you believe it? Am J Respir Crit Care Med (2006) 0.78
Affinity selection of DNA-binding proteins from yeast genomic DNA libraries by improved lambda phage display vector. J Biochem (2002) 0.78
Recombinant human thioredoxin-1 becomes oxidized in circulation and suppresses bleomycin-induced neutrophil recruitment in the rat airway. Free Radic Res (2007) 0.78
Reproducibility of acoustic rhinometry in the investigation of occupational rhinitis. Am J Rhinol (2007) 0.78
Relationship between periodontitis-related antibody and frequent exacerbations in chronic obstructive pulmonary disease. PLoS One (2012) 0.78