Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema.

PubWeight™: 2.40‹?› | Rank: Top 2%

🔗 View Article (PMC 1501017)

Published in Respir Res on March 30, 2006

Authors

Ingel K Demedts1, Tine Demoor, Ken R Bracke, Guy F Joos, Guy G Brusselle

Author Affiliations

1: Department of Respiratory Diseases, Ghent University Hospital, Belgium. M.DemedtsIngelK@UGent.be

Articles citing this

Percent emphysema, airflow obstruction, and impaired left ventricular filling. N Engl J Med (2010) 5.70

Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. Am J Physiol Lung Cell Mol Physiol (2008) 2.30

Impaired flow-mediated dilation is associated with low pulmonary function and emphysema in ex-smokers: the Emphysema and Cancer Action Project (EMCAP) Study. Am J Respir Crit Care Med (2007) 1.90

Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms. Am J Respir Crit Care Med (2008) 1.50

Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation. Int J Chron Obstruct Pulmon Dis (2011) 1.34

Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease. Proc Am Thorac Soc (2006) 1.34

Emphysema and mechanical stress-induced lung remodeling. Physiology (Bethesda) (2013) 1.32

Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice. Am J Respir Cell Mol Biol (2008) 1.30

Genetic ablation of the aryl hydrocarbon receptor causes cigarette smoke-induced mitochondrial dysfunction and apoptosis. J Biol Chem (2011) 1.29

Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury. Am J Respir Cell Mol Biol (2010) 1.22

HIV and chronic obstructive pulmonary disease: is it worse and why? Proc Am Thorac Soc (2011) 1.18

Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema. Am J Respir Cell Mol Biol (2010) 1.15

Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences. Int J Chron Obstruct Pulmon Dis (2011) 1.14

Critical role of CFTR-dependent lipid rafts in cigarette smoke-induced lung epithelial injury. Am J Physiol Lung Cell Mol Physiol (2011) 1.09

Percent emphysema and right ventricular structure and function: the Multi-Ethnic Study of Atherosclerosis-Lung and Multi-Ethnic Study of Atherosclerosis-Right Ventricle Studies. Chest (2013) 1.08

Structure-function relations in an elastase-induced mouse model of emphysema. Am J Respir Cell Mol Biol (2010) 1.04

Lung injury and cancer: Mechanistic insights into ceramide and EGFR signaling under cigarette smoke. Am J Respir Cell Mol Biol (2010) 1.03

Chronic obstructive pulmonary disease. Indian J Med Res (2013) 1.02

Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokers. Am J Respir Cell Mol Biol (2008) 1.01

The impact of coexisting COPD on survival of patients with early-stage non-small cell lung cancer undergoing surgical resection. Chest (2014) 1.00

p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor. Am J Respir Cell Mol Biol (2010) 1.00

Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism. J Immunol (2009) 0.99

Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation. Part Fibre Toxicol (2012) 0.96

Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease. PLoS One (2011) 0.93

Deregulation of apoptosis mediators' p53 and bcl2 in lung tissue of COPD patients. Respir Res (2010) 0.91

Lung injury after cigarette smoking is particle related. Int J Chron Obstruct Pulmon Dis (2011) 0.91

Prevention of elastase-induced emphysema in placenta growth factor knock-out mice. Respir Res (2009) 0.89

Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor. Antioxid Redox Signal (2014) 0.89

Airway Exposure to E-Cigarette Vapors Impairs Autophagy and Induces Aggresome Formation. Antioxid Redox Signal (2015) 0.89

A cellular model to mimic exhaled cigarette smokeinduced lung microvascular endothelial cell injury and death. Int J Clin Exp Med (2010) 0.88

Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease. FASEB J (2013) 0.88

Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema. Thorax (2013) 0.87

Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin C. J Inflamm (Lond) (2008) 0.86

Altered gene expression in blood and sputum in COPD frequent exacerbators in the ECLIPSE cohort. PLoS One (2014) 0.86

Imbalance of apoptosis and cell proliferation contributes to the development and persistence of emphysema. Lung (2011) 0.86

Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling. J Immunol (2013) 0.86

Human CD56+ cytotoxic lung lymphocytes kill autologous lung cells in chronic obstructive pulmonary disease. PLoS One (2014) 0.85

Macrophage migration inhibitory factor is a novel determinant of cigarette smoke-induced lung damage. Am J Respir Cell Mol Biol (2014) 0.85

Longitudinal study of spatially heterogeneous emphysema progression in current smokers with chronic obstructive pulmonary disease. PLoS One (2012) 0.84

Lung inflammation changes and oxidative stress induced by cigarette smoke exposure in guinea pigs affected by Zataria multiflora and its constituent, carvacrol. BMC Complement Altern Med (2015) 0.84

Flavonoid Fraction of Orange and Bergamot Juices Protect Human Lung Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Stress. Evid Based Complement Alternat Med (2015) 0.84

Effect of cigarette smoke exposure and structural modifications on the α-1 Antitrypsin interaction with caspases. Mol Med (2012) 0.83

Resveratrol exerts an anti-apoptotic effect on human bronchial epithelial cells undergoing cigarette smoke exposure. Mol Med Rep (2014) 0.83

Effect of the Zataria multiflora on systemic inflammation of experimental animals model of COPD. Biomed Res Int (2014) 0.83

Molecular multitasking in the airspace: alpha1-antitrypsin takes on thrombin and plasmin. Am J Respir Cell Mol Biol (2007) 0.83

Changes in airway histone deacetylase2 in smokers and COPD with inhaled corticosteroids: a randomized controlled trial. PLoS One (2013) 0.82

Cigarette smoke targets glutaredoxin 1, increasing s-glutathionylation and epithelial cell death. Am J Respir Cell Mol Biol (2011) 0.81

Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding. Bioorg Med Chem (2009) 0.81

Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells. PLoS One (2012) 0.80

Ceramides: a potential therapeutic target in pulmonary emphysema. Respir Res (2013) 0.80

Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner. Respir Res (2010) 0.80

The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation. Semin Immunopathol (2016) 0.80

Increased ectodomain shedding of cell adhesion molecule 1 as a cause of type II alveolar epithelial cell apoptosis in patients with idiopathic interstitial pneumonia. Respir Res (2015) 0.79

Correlation of Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema in C3H and C57Bl/6 Mice. Toxicol Sci (2015) 0.79

Expression and methylation of mitochondrial transcription factor a in chronic obstructive pulmonary disease patients with lung cancer. PLoS One (2013) 0.78

Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner. Sci Rep (2016) 0.78

Inflammatory and cytotoxic effects of acrolein, nicotine, acetylaldehyde and cigarette smoke extract on human nasal epithelial cells. BMC Pulm Med (2014) 0.78

Mesenchymal cell fate and phenotypes in the pathogenesis of emphysema. COPD (2009) 0.78

Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice. PLoS One (2013) 0.78

Circulating hematopoietic progenitor cells are decreased in COPD. COPD (2013) 0.78

Phagocytic clearance of apoptotic cells: role in lung disease. Expert Rev Respir Med (2008) 0.78

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls. Int J Chron Obstruct Pulmon Dis (2016) 0.78

SCGB3A2 Inhibits Acrolein-Induced Apoptosis through Decreased p53 Phosphorylation. Acta Histochem Cytochem (2015) 0.77

Airway Surface Dehydration Aggravates Cigarette Smoke-Induced Hallmarks of COPD in Mice. PLoS One (2015) 0.77

Replacements of rare herbs and simplifications of traditional chinese medicine formulae based on attribute similarities and pathway enrichment analysis. Evid Based Complement Alternat Med (2013) 0.77

Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice. Lab Invest (2015) 0.77

Screening of long non-coding RNA and TUG1 inhibits proliferation with TGF-β induction in patients with COPD. Int J Chron Obstruct Pulmon Dis (2016) 0.76

Effect of cigarette smoke and dexamethasone on Hsp72 system of alveolar epithelial cells. Cell Stress Chaperones (2010) 0.76

Scale dependence of structure-function relationship in the emphysematous mouse lung. Front Physiol (2015) 0.76

Aeroallergen Der p 2 induces apoptosis of bronchial epithelial BEAS-2B cells via activation of both intrinsic and extrinsic pathway. Cell Biosci (2015) 0.76

Characterization of a Mouse Model of Emphysema Induced by Multiple Instillations of Low-Dose Elastase. Front Physiol (2016) 0.76

Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold. Eur J Med Chem (2010) 0.76

The effects of carbon nanotubes on lung and dermal cellular behaviors. Nanomedicine (Lond) (2014) 0.76

Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3. Bioorg Med Chem (2009) 0.75

iPSC-derived mesenchymal stem cells exert SCF-dependent recovery of cigarette smoke-induced apoptosis/proliferation imbalance in airway cells. J Cell Mol Med (2016) 0.75

Endothelial progenitor cells in chronic obstructive pulmonary disease and emphysema. PLoS One (2017) 0.75

Computational modeling helps uncover mechanisms related to the progression of emphysema. Drug Discov Today Dis Models (2014) 0.75

Neutrophil Elastase-Generated Fragment of Vascular Endothelial Growth Factor-A Stimulates Macrophage and Endothelial Progenitor Cell Migration. PLoS One (2015) 0.75

Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD. Can Respir J (2016) 0.75

Mouse Lung Fibroblast Resistance to Fas-Mediated Apoptosis Is Dependent on the Baculoviral Inhibitor of Apoptosis Protein 4 and the Cellular FLICE-Inhibitory Protein. Front Physiol (2017) 0.75

The role of cyclooxygenase-2 in the protection against apoptosis in vascular endothelial cells induced by cigarette smoking. J Thorac Dis (2017) 0.75

Intratracheal transplantation of endothelial progenitor cells attenuates smoking-induced COPD in mice. Int J Chron Obstruct Pulmon Dis (2017) 0.75

Dual function inhibitors of relevance to chronic obstructive pulmonary disease. Bioorg Med Chem Lett (2010) 0.75

The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis. Int J Chron Obstruct Pulmon Dis (2012) 0.75

Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis. Proc Natl Acad Sci U S A (2016) 0.75

Elevated plasma levels of pigment epithelium-derived factor correlated with inflammation and lung function in COPD patients. Int J Chron Obstruct Pulmon Dis (2015) 0.75

The Impact of Autophagy on the Cigarette Smoke Extract-Induced Apoptosis of Bronchial Epithelial Cells. Tuberc Respir Dis (Seoul) (2016) 0.75

Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions. Sci Rep (2017) 0.75

Increased serum TRAIL and DR5 levels correlated with lung function and inflammation in stable COPD patients. Int J Chron Obstruct Pulmon Dis (2015) 0.75

COPD immunopathology. Semin Immunopathol (2016) 0.75

Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase. Bioorg Med Chem (2010) 0.75

The Isosteroid Alkaloid Imperialine from Bulbs of Fritillaria cirrhosa Mitigates Pulmonary Functional and Structural Impairment and Suppresses Inflammatory Response in a COPD-Like Rat Model. Mediators Inflamm (2016) 0.75

Mechanistic understanding of nanoparticles' interactions with extracellular matrix: the cell and immune system. Part Fibre Toxicol (2017) 0.75

Macrophage Migration Inhibitory Factor: A Novel Inhibitor of Apoptosis Signal-Regulating Kinase 1-p38-Xanthine Oxidoreductase-Dependent Cigarette Smoke-Induced Apoptosis. Am J Respir Cell Mol Biol (2016) 0.75

Hydrogen Sulfide Inhibits Cigarette Smoke-Induced Endoplasmic Reticulum Stress and Apoptosis in Bronchial Epithelial Cells. Front Pharmacol (2017) 0.75

Characterisation of lung macrophage subpopulations in COPD patients and controls. Sci Rep (2017) 0.75

Leucine and its transporter provide protection against cigarette smoke-induced cell death: A potential therapy for emphysema. Toxicol Rep (2014) 0.75

Mitochondria in chronic obstructive pulmonary disease and lung cancer: where are we now? Biomark Med (2017) 0.75

Flavored little cigar smoke induces cytotoxicity and apoptosis in airway epithelia. Cell Death Discov (2017) 0.75

Articles cited by this

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med (2001) 27.83

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell (1996) 16.73

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell (1998) 16.08

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell (1998) 13.87

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell (1997) 12.83

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell (1996) 12.07

Two CD95 (APO-1/Fas) signaling pathways. EMBO J (1998) 10.42

Anoikis mechanisms. Curr Opin Cell Biol (2001) 6.36

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest (2004) 6.32

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24

Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J (2003) 6.23

Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet (2004) 6.17

Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med (1996) 5.53

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest (2000) 5.26

Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol (2001) 5.10

Matrix metalloproteinases: they're not just for matrix anymore! Curr Opin Cell Biol (2001) 4.99

Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med (2005) 4.31

An induced proximity model for caspase-8 activation. J Biol Chem (1998) 4.18

Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med (2001) 3.92

Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am J Respir Cell Mol Biol (2003) 3.83

CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1998) 3.69

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature (1995) 3.59

A decade of caspases. Oncogene (2003) 3.55

Cytotoxic T lymphocytes: all roads lead to death. Nat Rev Immunol (2002) 3.01

The development of emphysema in cigarette smoke-exposed mice is strain dependent. Am J Respir Crit Care Med (2004) 2.94

Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest (2000) 2.92

Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem (2001) 2.86

Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am J Respir Crit Care Med (1999) 2.61

Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol (2003) 2.59

CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1999) 2.52

The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr Biol (2000) 2.42

Peripheral muscle weakness in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1998) 2.29

Caspase-12 and ER-stress-mediated apoptosis: the story so far. Ann N Y Acad Sci (2003) 2.26

Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest (2002) 2.19

Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells. Immunol Cell Biol (2003) 2.16

Skeletal muscle apoptosis and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2002) 2.01

Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema. Chest (2004) 1.91

Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease. J Allergy Clin Immunol (1993) 1.91

Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J Exp Med (1998) 1.74

Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation. Eur Respir J (2005) 1.72

Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice. J Appl Physiol (1985) (2004) 1.72

Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema. Eur Respir J (2001) 1.68

Programmed cell death and apoptosis: origins of the theory. Nat Rev Mol Cell Biol (2001) 1.60

Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants. Eur Respir J (2005) 1.55

Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. J Immunol (2005) 1.53

Correlation of lung surface area to apoptosis and proliferation in human emphysema. Eur Respir J (2005) 1.51

Local and systemic inflammation in chronic obstructive pulmonary disease. Proc Am Thorac Soc (2005) 1.47

Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol (2005) 1.38

Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema. J Clin Invest (2005) 1.37

Chronic obstructive pulmonary disease. 5: systemic effects of COPD. Thorax (2002) 1.37

Matrix metalloproteinases in asthma and COPD. Curr Opin Pharmacol (2005) 1.27

An increase of soluble Fas, an inhibitor of apoptosis, associated with progression of COPD. Respir Med (1998) 1.20

Increased production of TGF-beta and apoptosis of T lymphocytes isolated from peripheral blood in COPD. Am J Physiol Lung Cell Mol Physiol (2003) 1.20

Osteoporosis in chronic obstructive pulmonary disease. Eur Respir J Suppl (2003) 1.14

Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis. J Biol Chem (1998) 1.13

Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema. Respir Res (2005) 1.13

Perforin-independent CD8(+) T-cell-mediated cytotoxicity of alveolar epithelial cells is preferentially mediated by tumor necrosis factor-alpha: relative insensitivity to Fas ligand. Am J Respir Cell Mol Biol (1999) 1.05

Vascular endothelial growth factor and the risk of smoking-related COPD. Chest (2003) 1.05

Elevated oxidative stress and reciprocal reduction of vascular endothelial growth factor levels with severity of COPD. Chest (2005) 1.00

Apoptosis as a therapeutic target for the treatment of lung disease. Curr Opin Pharmacol (2005) 0.97

Cell-matrix and cell-cell interactions modulate apoptosis of bronchial epithelial cells. Am J Physiol (1997) 0.92

Survival factors, intracellular signal transduction, and the activation of endonucleases in apoptosis. Semin Cancer Biol (1995) 0.89

Circulating levels of soluble Fas ligand and soluble Fas in patients with chronic obstructive pulmonary disease. Respir Med (2000) 0.86

Articles by these authors

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56

Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med (2014) 3.50

Corticosteroids and the risk of atrial fibrillation. Arch Intern Med (2006) 3.28

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03

Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 2.26

New insights into the immunology of chronic obstructive pulmonary disease. Lancet (2011) 2.23

Activation of the WNT/β-catenin pathway attenuates experimental emphysema. Am J Respir Crit Care Med (2010) 1.94

Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax (2012) 1.88

House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection. Proc Natl Acad Sci U S A (2013) 1.88

Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly: the Rotterdam Study. Am J Respir Crit Care Med (2012) 1.87

Severe asthma in adults: what are the important questions? J Allergy Clin Immunol (2007) 1.85

Identification and characterization of human pulmonary dendritic cells. Am J Respir Cell Mol Biol (2004) 1.66

Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.63

Chronic obstructive pulmonary disease and cerebral microbleeds. The Rotterdam Study. Am J Respir Crit Care Med (2013) 1.57

Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice. J Immunol (2006) 1.55

Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases. Pulm Pharmacol Ther (2013) 1.54

Role of activin-A in cigarette smoke-induced inflammation and COPD. Eur Respir J (2013) 1.52

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet (2012) 1.52

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med (2012) 1.49

MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.42

Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms. Am J Respir Cell Mol Biol (2006) 1.30

Matrix metalloproteinases in asthma and COPD. Curr Opin Pharmacol (2005) 1.27

Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required? Respir Res (2005) 1.25

Prevalence, incidence, and lifetime risk for the development of COPD in the elderly: the Rotterdam study. Chest (2009) 1.21

Prolonged inhaled allergen exposure can induce persistent tolerance. Am J Respir Cell Mol Biol (2007) 1.20

Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation. J Immunol (2007) 1.17

Dendritic cells in chronic obstructive pulmonary disease: new players in an old game. Am J Respir Crit Care Med (2008) 1.15

Matrix metalloproteinases -8, -9 and -12 in smokers and patients with stage 0 COPD. Int J Chron Obstruct Pulmon Dis (2007) 1.15

Detection of exacerbations in asthma based on electronic diary data: results from the 1-year prospective BIOAIR study. Thorax (2013) 1.13

NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation. J Immunol (2011) 1.13

Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation. Int Arch Allergy Immunol (2006) 1.12

Short-term cigarette smoke exposure enhances allergic airway inflammation in mice. Am J Respir Crit Care Med (2005) 1.09

C-reactive protein levels, haplotypes, and the risk of incident chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 1.08

The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation. J Immunol (2011) 1.04

Statins, systemic inflammation and risk of death in COPD: the Rotterdam study. Pulm Pharmacol Ther (2012) 1.04

Extending the understanding of sensory neuropeptides. Eur J Pharmacol (2006) 1.03

Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice. J Immunol (2010) 1.03

Mouse models to unravel the role of inhaled pollutants on allergic sensitization and airway inflammation. Respir Res (2010) 1.03

Comparison of acute inflammatory and chronic structural asthma-like responses between C57BL/6 and BALB/c mice. Int Arch Allergy Immunol (2009) 1.02

Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD. Respir Res (2010) 1.01

Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice. Am J Respir Cell Mol Biol (2009) 1.00

Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure. Am J Respir Cell Mol Biol (2008) 1.00

Targeting interleukin-4 in asthma: lost in translation? Am J Respir Cell Mol Biol (2012) 0.99

Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma. Nat Med (2013) 0.97

Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells. J Immunol (2009) 0.95

Short cigarette smoke exposure facilitates sensitisation and asthma development in mice. Eur Respir J (2012) 0.94

Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance. Respir Res (2008) 0.93

Cigarette smoke exposure facilitates allergic sensitization in mice. Respir Res (2006) 0.91

CC-chemokine receptors in chronic obstructive pulmonary disease. Inflamm Allergy Drug Targets (2007) 0.90

β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination. J Control Release (2013) 0.90

Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way. J Immunol (2009) 0.89

Inflammasomes in respiratory disease: from bench to bedside. Chest (2014) 0.88

Activity of aclidinium bromide, a new long-acting muscarinic antagonist: a phase I study. Br J Clin Pharmacol (2010) 0.86

The role of dendritic cells in the pathogenesis of COPD: liaison officers in the front line. COPD (2009) 0.86

Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT. Lab Invest (2011) 0.85

Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation. Respir Res (2009) 0.85