Published in Hum Mol Genet on July 28, 2004
Intracellular iron transport and storage: from molecular mechanisms to health implications. Antioxid Redox Signal (2008) 1.73
Frataxin and mitochondrial FeS cluster biogenesis. J Biol Chem (2010) 1.49
Characterization of mitochondrial ferritin in Drosophila. Proc Natl Acad Sci U S A (2006) 1.41
Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia. Hum Mol Genet (2008) 1.30
Friedreich ataxia: molecular mechanisms, redox considerations, and therapeutic opportunities. Antioxid Redox Signal (2010) 1.27
Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. PLoS One (2009) 1.25
Mitochondrial ferritin expression in adult mouse tissues. J Histochem Cytochem (2007) 1.17
Iron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia. Mol Cell Neurosci (2012) 1.08
The emerging role of iron dyshomeostasis in the mitochondrial decay of aging. Mech Ageing Dev (2010) 1.00
Friedreich's ataxia: the vicious circle hypothesis revisited. BMC Med (2011) 1.00
Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury. J Biol Chem (2011) 1.00
Mitochondrial ferritin in the substantia nigra in restless legs syndrome. J Neuropathol Exp Neurol (2009) 0.97
Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities. Antioxid Redox Signal (2013) 0.94
Frataxin, a conserved mitochondrial protein, in the hydrogenosome of Trichomonas vaginalis. Eukaryot Cell (2007) 0.94
Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation. Front Pharmacol (2014) 0.91
Assembly of the iron-binding protein frataxin in Saccharomyces cerevisiae responds to dynamic changes in mitochondrial iron influx and stress level. J Biol Chem (2008) 0.91
Role of intracellular labile iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide. Free Radic Biol Med (2013) 0.91
Frataxin depletion in yeast triggers up-regulation of iron transport systems before affecting iron-sulfur enzyme activities. J Biol Chem (2010) 0.89
Leucine biosynthesis regulates cytoplasmic iron-sulfur enzyme biogenesis in an Atm1p-independent manner. J Biol Chem (2011) 0.86
Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation. Haematologica (2011) 0.84
Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity. J Mol Med (Berl) (2014) 0.84
Fixing frataxin: 'ironing out' the metabolic defect in Friedreich's ataxia. Br J Pharmacol (2014) 0.83
Characterization of mitochondrial ferritin-deficient mice. Am J Hematol (2010) 0.83
Oxidative stress in inherited mitochondrial diseases. Free Radic Biol Med (2015) 0.81
Human mitochondrial ferritin improves respiratory function in yeast mutants deficient in iron-sulfur cluster biogenesis, but is not a functional homologue of yeast frataxin. Microbiologyopen (2012) 0.79
Oxidative stress and the homeodynamics of iron metabolism. Biomolecules (2015) 0.79
Iron binding activity is essential for the function of IscA in iron-sulphur cluster biogenesis. Dalton Trans (2012) 0.77
What can Drosophila teach us about iron-accumulation neurodegenerative disorders? J Neural Transm (Vienna) (2010) 0.76
Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects. Oxid Med Cell Longev (2016) 0.76
Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control. Sci Rep (2016) 0.75
Soybean Ferritin Expression in Saccharomyces cerevisiae Modulates Iron Accumulation and Resistance to Elevated Iron Concentrations. Appl Environ Microbiol (2016) 0.75
Nitric oxide prevents Aft1 activation and metabolic remodeling in frataxin-deficient yeast. Redox Biol (2017) 0.75
Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity. Int J Mol Sci (2017) 0.75
Mitochondrial processing peptidases. Biochim Biophys Acta (2002) 2.53
Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity. Science (2004) 2.29
Ferritin, iron homeostasis, and oxidative damage. Free Radic Biol Med (2002) 2.26
The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload. Blood (2007) 2.16
Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury. J Clin Invest (2013) 1.73
Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity. Hum Mol Genet (2005) 1.69
Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin. Blood (2009) 1.66
Differential regulation of iron homeostasis during human macrophage polarized activation. Eur J Immunol (2010) 1.64
The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proc Natl Acad Sci U S A (2004) 1.59
Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich ataxia. Hum Mol Genet (2002) 1.54
Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia. Blood (2002) 1.49
Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial beta-oxidation of unsaturated fatty acids. J Biol Chem (2005) 1.44
Yeast frataxin sequentially chaperones and stores iron by coupling protein assembly with iron oxidation. J Biol Chem (2003) 1.39
Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage. Biochim Biophys Acta (2010) 1.39
High-throughput immunoassay for the biochemical diagnosis of Friedreich ataxia in dried blood spots and whole blood. Clin Chem (2013) 1.39
RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload. Blood (2006) 1.38
Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis. Blood (2007) 1.36
Assembly of human frataxin is a mechanism for detoxifying redox-active iron. Biochemistry (2005) 1.34
Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3). Br J Haematol (2002) 1.32
The structures of frataxin oligomers reveal the mechanism for the delivery and detoxification of iron. Structure (2006) 1.31
Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia. Hum Mol Genet (2008) 1.30
Mitochondrial ferritin: a new player in iron metabolism. Blood Cells Mol Dis (2003) 1.29
The dentate nucleus in Friedreich's ataxia: the role of iron-responsive proteins. Acta Neuropathol (2007) 1.27
Multiple pathways for mineral core formation in mammalian apoferritin. The role of hydrogen peroxide. Biochemistry (2003) 1.26
Reversible redox-dependent modulation of mitochondrial aconitase and proteolytic activity during in vivo cardiac ischemia/reperfusion. Proc Natl Acad Sci U S A (2005) 1.24
Reduction in frataxin causes progressive accumulation of mitochondrial damage. Hum Mol Genet (2003) 1.24
Normal and Friedreich ataxia cells express different isoforms of frataxin with complementary roles in iron-sulfur cluster assembly. J Biol Chem (2010) 1.23
Physical evidence that yeast frataxin is an iron storage protein. Biochemistry (2002) 1.23
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation. J Am Chem Soc (2014) 1.22
Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism. J Biol Chem (2002) 1.22
Mitochondrial ferritin. Int J Biochem Cell Biol (2004) 1.21
New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. J Autoimmun (2008) 1.21
Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo. Blood (2010) 1.20
Analysis of the biologic functions of H- and L-ferritins in HeLa cells by transfection with siRNAs and cDNAs: evidence for a proliferative role of L-ferritin. Blood (2003) 1.20
Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin. J Mol Biol (2005) 1.20
Chelatases: distort to select? Trends Biochem Sci (2006) 1.18
Mitochondrial ferritin expression in adult mouse tissues. J Histochem Cytochem (2007) 1.17
Polymorphisms in mitochondrial genes and prostate cancer risk. Cancer Epidemiol Biomarkers Prev (2008) 1.17
Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells. Hepatology (2009) 1.15
Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload. Clin Chem (2003) 1.15
Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala. J Mol Biol (2004) 1.15
Oligomeric yeast frataxin drives assembly of core machinery for mitochondrial iron-sulfur cluster synthesis. J Biol Chem (2009) 1.13
Lateral-flow immunoassay for the frataxin protein in Friedreich's ataxia patients and carriers. Mol Genet Metab (2008) 1.12
Ferrous ion binding to recombinant human H-chain ferritin. An isothermal titration calorimetry study. Biochemistry (2002) 1.12
mu-1,2-Peroxobridged di-iron(III) dimer formation in human H-chain ferritin. Biochem J (2002) 1.11
Neuroferritinopathy: a neurodegenerative disorder associated with L-ferritin mutation. Best Pract Res Clin Haematol (2005) 1.11
Water-dispersible sugar-coated iron oxide nanoparticles. An evaluation of their relaxometric and magnetic hyperthermia properties. J Am Chem Soc (2011) 1.09
Supramolecular assemblies of human frataxin are formed via subunit-subunit interactions mediated by a non-conserved amino-terminal region. J Mol Biol (2005) 1.08
Iron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia. Mol Cell Neurosci (2012) 1.08
Biofortification for combating 'hidden hunger' for iron. Trends Plant Sci (2011) 1.07
Design of water-based ferrofluids as contrast agents for magnetic resonance imaging. J Colloid Interface Sci (2011) 1.06
Relative contribution of iron genes, dysmetabolism and hepatitis C virus (HCV) in the pathogenesis of altered iron regulation in HCV chronic hepatitis. Haematologica (2007) 1.06
Leucine-zipper-mediated homo- and hetero-dimerization of GIT family p95-ARF GTPase-activating protein, PIX-, paxillin-interacting proteins 1 and 2. Biochem J (2003) 1.04
Advancements in the pathophysiology of Friedreich's Ataxia and new prospects for treatments. Mol Genet Metab (2007) 1.04
Ferritin ferroxidase activity: a potent inhibitor of osteogenesis. J Bone Miner Res (2010) 1.03
Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo. Blood (2014) 1.03
Ferritin as an important player in neurodegeneration. Parkinsonism Relat Disord (2011) 1.03
Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis. J Neurosci (2009) 1.03
Cryptic proteolytic activity of dihydrolipoamide dehydrogenase. Proc Natl Acad Sci U S A (2007) 1.01
The ferroxidase activity of yeast frataxin. J Biol Chem (2002) 1.01
The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin. Biochim Biophys Acta (2007) 0.99
Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. Cell Biochem Biophys (2012) 0.99
Origin of the unusual kinetics of iron deposition in human H-chain ferritin. J Am Chem Soc (2005) 0.99
Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells. Blood (2002) 0.99
Association of increased levels of heavy-chain ferritin with increased CD4+ CD25+ regulatory T-cell levels in patients with melanoma. Clin Cancer Res (2003) 0.99
Structural basis of the iron storage function of frataxin from single-particle reconstruction of the iron-loaded oligomer. Biochemistry (2008) 0.98
Doxorubicin paradoxically protects cardiomyocytes against iron-mediated toxicity: role of reactive oxygen species and ferritin. J Biol Chem (2004) 0.98
Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model. Hum Mol Genet (2012) 0.97
Microelectronic DNA chip for hereditary hyperferritinemia cataract syndrome, a model for large-scale analysis of disorders of iron metabolism. Hum Mutat (2006) 0.97
Structural description of the active sites of mouse L-chain ferritin at 1.2 A resolution. J Biol Inorg Chem (2002) 0.97
Mitochondrial ferritin in the substantia nigra in restless legs syndrome. J Neuropathol Exp Neurol (2009) 0.97