Published in J Mol Med (Berl) on April 13, 2014
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Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin. Circulation (2006) 1.49
Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia. Blood (2002) 1.49
Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes. Blood (2005) 1.44
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Characterization of mitochondrial ferritin in Drosophila. Proc Natl Acad Sci U S A (2006) 1.41
Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection. Antioxid Redox Signal (2012) 1.37
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Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia. Hum Mol Genet (2008) 1.30
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Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism. J Biol Chem (2002) 1.22
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Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart. Cancer Res (2001) 1.21
The expression of human mitochondrial ferritin rescues respiratory function in frataxin-deficient yeast. Hum Mol Genet (2004) 1.19
Mitochondrial ferritin expression in adult mouse tissues. J Histochem Cytochem (2007) 1.17
Molecular and cellular mechanisms of anthracycline cardiotoxicity. Cardiovasc Toxicol (2007) 1.17
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Structure of the adriamycin-cardiolipin complex. Role in mitochondrial toxicity. Biophys Chem (1990) 1.13
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Evidence for the presence of ferritin in plant mitochondria. Eur J Biochem (2004) 1.08
Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. Blood (2003) 1.06
Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis. J Neurosci (2009) 1.03
Left ventricular assist device support reverses altered cardiac expression and function of natriuretic peptides and receptors in end-stage heart failure. Cardiovasc Res (2004) 1.03
In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin. Blood (2006) 1.02
The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin. Biochim Biophys Acta (2007) 0.99
Anthracycline metabolism and toxicity in human myocardium: comparisons between doxorubicin, epirubicin, and a novel disaccharide analogue with a reduced level of formation and [4Fe-4S] reactivity of its secondary alcohol metabolite. Chem Res Toxicol (2000) 0.99
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Mitochondrial ferritin in the substantia nigra in restless legs syndrome. J Neuropathol Exp Neurol (2009) 0.97
Defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition. J Biol Chem (2006) 0.95
Role of hypoxia-inducible factors in the dexrazoxane-mediated protection of cardiomyocytes from doxorubicin-induced toxicity. Br J Pharmacol (2011) 0.94
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Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in Parkinson's disease. Antioxid Redox Signal (2010) 0.92
LC3-associated phagocytosis. Autophagy (2014) 0.92
Mitochondrial ferritin attenuates β-amyloid-induced neurotoxicity: reduction in oxidative damage through the Erk/P38 mitogen-activated protein kinase pathways. Antioxid Redox Signal (2012) 0.91
Anthracycline toxicity is potentiated by iron and inhibited by deferoxamine: studies in rat heart cells in culture. J Lab Clin Med (1993) 0.90
Role of iron in the potentiation of anthracycline cardiotoxicity: identification of heart cell mitochondria as a major site of iron-anthracycline interaction. J Lab Clin Med (1996) 0.87
Overexpression of mitochondrial ferritin sensitizes cells to oxidative stress via an iron-mediated mechanism. Antioxid Redox Signal (2009) 0.85
Mitochondrial ferritin in neurodegenerative diseases. Neurosci Res (2013) 0.85
Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation. Haematologica (2011) 0.84
Characterization of mitochondrial ferritin-deficient mice. Am J Hematol (2010) 0.83
IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice. J Mol Med (Berl) (2006) 0.82
Sequence variations in mitochondrial ferritin: distribution in healthy controls and different types of patients. Genet Test Mol Biomarkers (2010) 0.80
Effects of mitochondrial ferritin overexpression in normal and sideroblastic erythroid progenitors. Br J Haematol (2013) 0.79
Evaluation of testicular toxicology of doxorubicin based on microarray analysis of testicular specific gene expression. J Toxicol Sci (2011) 0.79
Protective effect of mitochondrial ferritin on cytosolic iron dysregulation induced by doxorubicin in HeLa cells. Mol Biol Rep (2013) 0.76
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PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell (2004) 3.87
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Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature (2002) 3.01
Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med (2002) 2.89
Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function. Immunity (2002) 2.25
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci Signal (2008) 2.19
Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J Biol Chem (2001) 2.06
p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis. Cancer Res (2006) 1.92
Hemopexin: structure, function, and regulation. DNA Cell Biol (2002) 1.75
Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury. J Clin Invest (2013) 1.73
Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin. Blood (2009) 1.66
Differential regulation of iron homeostasis during human macrophage polarized activation. Eur J Immunol (2010) 1.64
The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proc Natl Acad Sci U S A (2004) 1.59
STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas. Breast Cancer Res (2012) 1.56
Spontaneous regression of highly immunogenic Molluscum contagiosum virus (MCV)-induced skin lesions is associated with plasmacytoid dendritic cells and IFN-DC infiltration. J Invest Dermatol (2010) 1.55
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell (2011) 1.52
Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency. Haematologica (2006) 1.51
Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. Cardiovasc Res (2003) 1.51
Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia. Blood (2002) 1.49
Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter. Haematologica (2010) 1.47
An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1. Proc Natl Acad Sci U S A (2012) 1.45
Histopathological findings in the oral mucosa of celiac patients. Rev Esp Enferm Dig (2014) 1.39
RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload. Blood (2006) 1.38
Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis. Blood (2007) 1.36
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. J Clin Invest (2012) 1.36
Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases. Circulation (2013) 1.36
Iron regulatory proteins: from molecular mechanisms to drug development. Antioxid Redox Signal (2010) 1.35
Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis. Blood (2002) 1.34
Hemoglobin and heme scavenging. IUBMB Life (2005) 1.34
Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3). Br J Haematol (2002) 1.32
p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J Cell Sci (2004) 1.29
Mitochondrial ferritin: a new player in iron metabolism. Blood Cells Mol Dis (2003) 1.29
Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma. J Exp Med (2005) 1.27
Multiple pathways for mineral core formation in mammalian apoferritin. The role of hydrogen peroxide. Biochemistry (2003) 1.26
Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload. Am J Pathol (2008) 1.26
Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype. Trends Immunol (2011) 1.25
Whole-exome sequencing identifies tetratricopeptide repeat domain 7A (TTC7A) mutations for combined immunodeficiency with intestinal atresias. J Allergy Clin Immunol (2013) 1.25
Arginase pathway in human endothelial cells in pathophysiological conditions. J Mol Cell Cardiol (2004) 1.24
Functional antagonism between Sall4 and Plzf defines germline progenitors. Cell Stem Cell (2012) 1.24
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation. J Am Chem Soc (2014) 1.22
The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions. Blood (2011) 1.22
Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism. J Biol Chem (2002) 1.22
Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue. Diabetes (2012) 1.22
Mitochondrial ferritin. Int J Biochem Cell Biol (2004) 1.21
Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. Cell (2013) 1.21
New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. J Autoimmun (2008) 1.21
Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo. Blood (2010) 1.20
Analysis of the biologic functions of H- and L-ferritins in HeLa cells by transfection with siRNAs and cDNAs: evidence for a proliferative role of L-ferritin. Blood (2003) 1.20
Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin. J Mol Biol (2005) 1.20
Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload. Circ Res (2005) 1.19
The expression of human mitochondrial ferritin rescues respiratory function in frataxin-deficient yeast. Hum Mol Genet (2004) 1.19
Mitochondrial ferritin expression in adult mouse tissues. J Histochem Cytochem (2007) 1.17
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. Mol Biol Cell (2003) 1.16
Adenosine A2a receptor-mediated, normoxic induction of HIF-1 through PKC and PI-3K-dependent pathways in macrophages. J Leukoc Biol (2007) 1.16
Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells. Hepatology (2009) 1.15
Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload. Clin Chem (2003) 1.15
Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala. J Mol Biol (2004) 1.15
Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. Am J Pathol (2008) 1.14
Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals. J Biol Chem (2008) 1.13
Doxorubicin cardiotoxicity and the control of iron metabolism: quinone-dependent and independent mechanisms. Methods Enzymol (2004) 1.12
Ferrous ion binding to recombinant human H-chain ferritin. An isothermal titration calorimetry study. Biochemistry (2002) 1.12
mu-1,2-Peroxobridged di-iron(III) dimer formation in human H-chain ferritin. Biochem J (2002) 1.11
Neuroferritinopathy: a neurodegenerative disorder associated with L-ferritin mutation. Best Pract Res Clin Haematol (2005) 1.11
Type I interferon-dependent gene MxA in perinatal HIV-infected patients under antiretroviral therapy as marker for therapy failure and blood plasmacytoid dendritic cells depletion. J Transl Med (2008) 1.11
The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage. Free Radic Biol Med (2002) 1.11
Incidental inflammatory findings in nerves and in patients with neoplastic diseases evaluated by 18F-FDG-PET/CT. Hell J Nucl Med (2009) 1.10
Water-dispersible sugar-coated iron oxide nanoparticles. An evaluation of their relaxometric and magnetic hyperthermia properties. J Am Chem Soc (2011) 1.09
Antiangiogenic and antitumor activity of IDN 5390, a new taxane derivative. Clin Cancer Res (2002) 1.09
Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain. J Cell Biol (2002) 1.09
Heme-hemopexin complex attenuates neuronal cell death and stroke damage. J Cereb Blood Flow Metab (2009) 1.09
Claudin 4 identifies a wide spectrum of epithelial neoplasms and represents a very useful marker for carcinoma versus mesothelioma diagnosis in pleural and peritoneal biopsies and effusions. Virchows Arch (2007) 1.08
Biofortification for combating 'hidden hunger' for iron. Trends Plant Sci (2011) 1.07
Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility. Mol Biol Cell (2010) 1.07
Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression. J Cell Physiol (2009) 1.07
Relative contribution of iron genes, dysmetabolism and hepatitis C virus (HCV) in the pathogenesis of altered iron regulation in HCV chronic hepatitis. Haematologica (2007) 1.06
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. EMBO J (2007) 1.06
Design of water-based ferrofluids as contrast agents for magnetic resonance imaging. J Colloid Interface Sci (2011) 1.06
Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload. Hepatology (2005) 1.06
Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFN{gamma}: role of CD18, ICAM-1, and ICAM-3. Blood (2010) 1.05
p130Cas is an essential transducer element in ErbB2 transformation. FASEB J (2010) 1.05
RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice. J Clin Invest (2011) 1.04