Published in Science on July 30, 2004
Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Res (2011) 2.89
The beginning of kinesin's force-generating cycle visualized at 9-A resolution. J Cell Biol (2007) 1.97
Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain. Proc Natl Acad Sci U S A (2006) 1.85
High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations. EMBO J (2006) 1.73
Phosphate release in F1-ATPase catalytic cycle follows ADP release. Nat Chem Biol (2010) 1.65
ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism. J Biol Chem (2009) 1.64
Internal strain regulates the nucleotide binding site of the kinesin leading head. Proc Natl Acad Sci U S A (2007) 1.50
Large conformational changes in a kinesin motor catalyzed by interaction with microtubules. Mol Cell (2006) 1.48
Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport. J Cell Biol (2011) 1.41
Eg5 steps it up! Cell Div (2006) 1.18
The mechanisms of kinesin motor motility: lessons from the monomeric motor KIF1A. Nat Rev Mol Cell Biol (2009) 1.16
Structures of kinesin motor proteins. Cell Motil Cytoskeleton (2009) 1.11
Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins. Mol Cell (2012) 1.08
Loop L5 acts as a conformational latch in the mitotic kinesin Eg5. J Biol Chem (2010) 1.02
A kinesin-13 mutant catalytically depolymerizes microtubules in ADP. J Cell Biol (2008) 1.01
De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy. Ann Clin Transl Neurol (2015) 0.98
Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy. J Cell Biol (2012) 0.98
Mutant kinesin-2 motor subunits increase chromosome loss. Mol Biol Cell (2005) 0.98
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins. Elife (2014) 0.97
Kinesin-73 is a processive motor that localizes to Rab5-containing organelles. J Biol Chem (2010) 0.96
Dominant transmission of de novo KIF1A motor domain variant underlying pure spastic paraplegia. Eur J Hum Genet (2015) 0.93
Mechanical design of translocating motor proteins. Cell Biochem Biophys (2009) 0.90
Timing of inorganic phosphate release modulates the catalytic activity of ATP-driven rotary motor protein. Nat Commun (2014) 0.90
Large-scale evaluation of dynamically important residues in proteins predicted by the perturbation analysis of a coarse-grained elastic model. BMC Struct Biol (2009) 0.89
Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality. PLoS One (2014) 0.88
The family-specific K-loop influences the microtubule on-rate but not the superprocessivity of kinesin-3 motors. Mol Biol Cell (2014) 0.88
A structural perspective on the dynamics of kinesin motors. Biophys J (2011) 0.86
Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization. J Biol Chem (2012) 0.85
A second tubulin binding site on the kinesin-13 motor head domain is important during mitosis. PLoS One (2013) 0.84
Multiple conformations of the nucleotide site of Kinesin family motors in the triphosphate state. J Mol Biol (2011) 0.83
X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding. EMBO J (2015) 0.83
Kinesin tail domains are intrinsically disordered. Proteins (2012) 0.82
Modulation of the kinesin ATPase cycle by neck linker docking and microtubule binding. J Biol Chem (2010) 0.81
De novo KIF1A mutations cause intellectual deficit, cerebellar atrophy, lower limb spasticity and visual disturbance. J Hum Genet (2015) 0.79
Motor proteins transporting cargos. Eur Phys J E Soft Matter (2005) 0.79
A cool look at the structural changes in kinesin motor domains. J Cell Sci (2007) 0.78
Rab6 regulation of the kinesin family KIF1C motor domain contributes to Golgi tethering. Elife (2015) 0.78
Novel De Novo Mutations in KIF1A as a Cause of Hereditary Spastic Paraplegia With Progressive Central Nervous System Involvement. J Child Neurol (2016) 0.78
Intrinsic Disorder in the Kinesin Superfamily. Biophys Rev (2013) 0.78
Structure-based molecular simulations reveal the enhancement of biased Brownian motions in single-headed kinesin. PLoS Comput Biol (2013) 0.77
Deprotonated imidodiphosphate in AMPPNP-containing protein structures. Acta Crystallogr D Biol Crystallogr (2011) 0.77
Initiation of the power stroke in muscle: insights from the phosphate analog AlF4. Proc Natl Acad Sci U S A (2005) 0.77
Multiscale method for modeling binding phenomena involving large objects: application to kinesin motor domains motion along microtubules. Sci Rep (2016) 0.76
Kinesin is an evolutionarily fine-tuned molecular ratchet-and-pawl device of decisively locked direction. Biophys J (2007) 0.76
Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines. Biophys Rev (2015) 0.75
Chemomechanical coupling of F1-ATPase under hydrolysis conditions. Biophysics (Nagoya-shi) (2012) 0.75
The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry. Elife (2017) 0.75
Autosomal dominant transmission of complicated hereditary spastic paraplegia due to a dominant negative mutation of KIF1A, SPG30 gene. Sci Rep (2017) 0.75
Kinesin transports RNA: isolation and characterization of an RNA-transporting granule. Neuron (2004) 6.71
A standardized kinesin nomenclature. J Cell Biol (2004) 4.43
Nodal flow and the generation of left-right asymmetry. Cell (2006) 3.52
Analysis of the kinesin superfamily: insights into structure and function. Trends Cell Biol (2005) 3.51
FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature (2005) 3.50
Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites. Nature (2002) 3.16
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
Mechanism of nodal flow: a conserved symmetry breaking event in left-right axis determination. Cell (2005) 3.01
A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops. Cell (2004) 2.78
Disruption of KIF17-Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo release. Nat Cell Biol (2007) 2.40
Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head. J Cell Biol (2003) 2.39
The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol (2005) 2.13
Effects of extracranial-intracranial bypass for patients with hemorrhagic moyamoya disease: results of the Japan Adult Moyamoya Trial. Stroke (2014) 2.12
Efficient TALEN construction and evaluation methods for human cell and animal applications. Genes Cells (2013) 1.99
Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell (2003) 1.95
KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity. Cell (2006) 1.91
High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations. EMBO J (2006) 1.73
KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons. J Neurosci (2003) 1.64
Routine use of intravenous low-dose recombinant tissue plasminogen activator in Japanese patients: general outcomes and prognostic factors from the SAMURAI register. Stroke (2009) 1.63
Dynein and kinesin share an overlapping microtubule-binding site. EMBO J (2004) 1.57
Prediction of coronary artery disease in patients undergoing carotid endarterectomy. J Neurosurg (2005) 1.55
Processivity of the single-headed kinesin KIF1A through biased binding to tubulin. Nature (2003) 1.55
Intracranial hemorrhage during dabigatran treatment. Circ J (2014) 1.54
MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. J Cell Biol (2002) 1.52
Blood pressure changes during the initial week after different subtypes of ischemic stroke. Stroke (2006) 1.50
KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD. Nat Cell Biol (2008) 1.49
Recurrent small-artery disease in hyperhomocysteinemia: widowers' stroke syndrome? Intern Med (2004) 1.47
Prospective cohort study of gastrointestinal complications and vascular diseases in patients taking aspirin: rationale and design of the MAGIC Study. Cardiovasc Drugs Ther (2011) 1.46
Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transport. J Cell Biol (2011) 1.41
Efficient identification of TALEN-mediated genome modifications using heteroduplex mobility assays. Genes Cells (2013) 1.41
Relative systolic blood pressure reduction and clinical outcomes in hyperacute intracerebral hemorrhage: the SAMURAI-ICH observational study. J Hypertens (2015) 1.40
Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. Proc Natl Acad Sci U S A (2002) 1.33
Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin. Nat Struct Mol Biol (2008) 1.29
Three-dimensional structures of the flagellar dynein-microtubule complex by cryoelectron microscopy. J Cell Biol (2007) 1.27
Three-dimensional structure of cytoplasmic dynein bound to microtubules. Proc Natl Acad Sci U S A (2007) 1.23
Quantitative assay for TALEN activity at endogenous genomic loci. Biol Open (2013) 1.22
Ruby-Helix: an implementation of helical image processing based on object-oriented scripting language. J Struct Biol (2006) 1.20
CREM-dependent transcription in male germ cells controlled by a kinesin. Science (2002) 1.20
9-Angström structure of a microtubule-bound mitotic motor. J Mol Biol (2009) 1.19
KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor. Dev Cell (2011) 1.19
Tau binding to microtubules does not directly affect microtubule-based vesicle motility. J Neurosci Res (2007) 1.17
The mechanisms of kinesin motor motility: lessons from the monomeric motor KIF1A. Nat Rev Mol Cell Biol (2009) 1.16
KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. Cell (2009) 1.14
Molecular motor KIF17 is fundamental for memory and learning via differential support of synaptic NR2A/2B levels. Neuron (2011) 1.14
Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion. J Neurol Sci (2004) 1.14
Left-right determination: involvement of molecular motor KIF3, cilia, and nodal flow. Cold Spring Harb Perspect Biol (2009) 1.13
Reduced estimated glomerular filtration rate is associated with stroke outcome after intravenous rt-PA: the Stroke Acute Management with Urgent Risk-Factor Assessment and Improvement (SAMURAI) rt-PA registry. Cerebrovasc Dis (2010) 1.11
β-Tubulin mutations that cause severe neuropathies disrupt axonal transport. EMBO J (2013) 1.10
Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes. Am J Med Genet A (2006) 1.08
The effect of weekends and holidays on stroke outcome in acute stroke units. Cerebrovasc Dis (2005) 1.08
Morphological classification of mobile plaques and their association with early recurrence of stroke. Cerebrovasc Dis (2010) 1.07
Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environment. Neuron (2012) 1.07
KIF19A is a microtubule-depolymerizing kinesin for ciliary length control. Dev Cell (2012) 1.06
Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy. Neuron (2012) 1.02
Intracellular transport of single-headed molecular motors KIF1A. Phys Rev Lett (2005) 1.02
Analysis of the mouse transcriptome for genes involved in the function of the nervous system. Genome Res (2003) 1.00
Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy. J Cell Biol (2012) 0.98
Mammalian sprouty proteins assemble into large monodisperse particles having the properties of intracellular nanobatteries. Proc Natl Acad Sci U S A (2005) 0.98
Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches. Proc Natl Acad Sci U S A (2012) 0.98
Hospital cost of ischemic stroke and intracerebral hemorrhage in Japanese stroke centers. Health Policy (2004) 0.98
Identification of the outer-inner dynein linker as a hub controller for axonemal dynein activities. Curr Biol (2013) 0.96
Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. J Biol Chem (2004) 0.95
Role of KIFC3 motor protein in Golgi positioning and integration. J Cell Biol (2002) 0.95
Risk factor profile and management of cerebrovascular patients in the REACH Registry. Cerebrovasc Dis (2008) 0.95
Cilia, KIF3 molecular motor and nodal flow. Curr Opin Cell Biol (2012) 0.94
The clinical features of adult unilateral moyamoya disease: does it have the same clinical characteristics as typical moyamoya disease? Cerebrovasc Dis (2008) 0.94
Nodal cilia dynamics and the specification of the left/right axis in early vertebrate embryo development. Biophys J (2005) 0.94
Deep venous thrombosis after acute intracerebral hemorrhage. J Neurol Sci (2008) 0.93
Kinesin-1/Hsc70-dependent mechanism of slow axonal transport and its relation to fast axonal transport. EMBO J (2010) 0.93
Genetically encoded system to track histone modification in vivo. Sci Rep (2013) 0.93
Impact of early blood pressure variability on stroke outcomes after thrombolysis: the SAMURAI rt-PA Registry. Stroke (2013) 0.92
Mechanosignaling between central apparatus and radial spokes controls axonemal dynein activity. J Cell Biol (2014) 0.92
Novel structural labeling method using cryo-electron tomography and biotin-streptavidin system. J Struct Biol (2013) 0.92
Lack of association between infectious burden and carotid atherosclerosis in Japanese patients. J Stroke Cerebrovasc Dis (2007) 0.91
Predisposing factors for acute deterioration of minor ischemic stroke. J Neurol Sci (2009) 0.90
Kinesin superfamily proteins (KIFs) in the mouse transcriptome. Genome Res (2003) 0.90
Structural basis for the ATP-induced isomerization of kinesin. J Mol Biol (2013) 0.90
A molecular motor, KIF13A, controls anxiety by transporting the serotonin type 1A receptor. Cell Rep (2013) 0.90
Risk score for predicting recurrence in patients with ischemic stroke: the Fukuoka stroke risk score for Japanese. Cerebrovasc Dis (2012) 0.89
Thrombolysis with 0.6 mg/kg intravenous alteplase for acute ischemic stroke in routine clinical practice: the Japan post-Marketing Alteplase Registration Study (J-MARS). Stroke (2010) 0.89
ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack. Stroke (2013) 0.89
Risk factor profiles, drug usage, and prevalence of aspirin-associated gastroduodenal injuries among high-risk cardiovascular Japanese patients: the results from the MAGIC study. J Gastroenterol (2013) 0.89
Extensive bihemispheric ischemia caused by acute occlusion of three major arteries to the brain. J Neurol Sci (2003) 0.88
Angiographic characteristics of radiation-induced carotid arterial stenosis. Angiology (2009) 0.88
Aromatase-knockout mouse carrying an estrogen-inducible enhanced green fluorescent protein gene facilitates detection of estrogen actions in vivo. Endocrinology (2003) 0.87
Babinski-Nageotte syndrome due to vertebral artery dissection. Intern Med (2003) 0.87
Mouse models of Charcot-Marie-Tooth disease. Trends Genet (2002) 0.87
Evaluation of distal extracranial internal carotid artery by transoral carotid ultrasonography in patients with severe carotid stenosis. AJNR Am J Neuroradiol (2002) 0.86